Inhibition of storage pathology in prenatal CLN5-deficient sheep neural cultures by lentiviral gene therapy

Neurobiology of Disease

Volumn 62, Issue , 2014, Pages 543-550

  Hughes, Stephanie M ^a,b   Hope, Katie M ^a   Xu, Janet Boyu ^c   Mitchell, Nadia L ^c   Palmer, David N ^c  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b UNIVERSITY OF OTAGO   (New Zealand)

^c LINCOLN UNIVERSITY   (New Zealand)

Author keywords

Batten disease; CLN5; Fluorescent storage bodies; Gene therapy; Lentiviral vector; Neural cell culture; Neuronal ceroid lipofuscinoses; Sheep; Transduction

Indexed keywords

LENTIVIRUS VECTOR; LYSOSOME ASSOCIATED MEMBRANE PROTEIN; MYC PROTEIN; PROTEIN CLN5; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CLN5 GENE; CONTROLLED STUDY; FETUS; GENE; GENE THERAPY; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; MICROGLIA; NERVE CELL CULTURE; NEURONAL CEROID LIPOFUSCINOSIS; NONHUMAN; PHAGOCYTOSIS; PRENATAL PERIOD; PRIORITY JOURNAL; PROTEIN SECRETION; SHEEP;

4′,6-DIAMIDINO-2-PHENYLINDOLE; AAV; ADENO-ASSOCIATED VIRUS; BATTEN DISEASE; CIDR; CLN5; CONTROLLED INTERNAL DRUG (PROGESTERONE) RELEASE DEVICE; DAPI; DAYS IN VITRO; DIV; ENDO H; ENDOGLYCOSIDASE H; FBS; FLUORESCENT STORAGE BODIES; FOETAL BOVINE SERUM; GENE THERAPY; GFAP; GFP; GLIAL FIBRILLARY ACIDIC PROTEIN; GREEN FLUORESCENT PROTEIN; LENTIVIRAL DERIVED VECTOR WITH A MYELOID SARCOMA VIRUS U3 ELEMENT; LENTIVIRAL VECTOR; LVMNDU3; M6P; M6PR; MANNOSE-6-PHOSPHATE; MANNOSE-6-PHOSPHATE RECEPTOR; MAP; MICROTUBULE ASSOCIATED PROTEIN; MOI; MULTIPLICITY OF INFECTION; NCL; NEURAL CELL CULTURE; NEURONAL CEROID LIPOFUSCINOSES; NEURONAL CEROID LIPOFUSCINOSIS; PAGE; PBS; PDI; PEPTIDE-N-GLYCOSIDASE F; PHOSPHATE BUFFERED SALINE, PH7.2; PNGASE F; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYVINYLIDENE FLUORIDE; PROTEIN DISULPHIDE ISOMERASE; PVDF; SDS; SHEEP; SODIUM DODECYL SULPHATE; TRANSDUCING UNITS; TRANSDUCTION; TU;

AMINO ACID SEQUENCE; ANIMALS; GENETIC THERAPY; HEK293 CELLS; HUMANS; LENTIVIRUS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; NEURONAL CEROID-LIPOFUSCINOSES; NEURONS; SHEEP;

EID: 84890035794     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2013.11.011     Document Type: Article

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