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Volumn 8, Issue 12, 2013, Pages 1978-1985

Para-substituted 2-phenyl-3,4-dihydroquinazolin-4-ones as potent and selective tankyrase inhibitors

(8) Haikarainen, Teemu a Koivunen, Jarkko a Narwal, Mohit a,b Venkannagari, Harikanth a Obaji, Ezeogo a Joensuu, Päivi a Pihlajaniemi, Taina a Lehtiö, Lari a

a UNIVERSITY OF OULU (Finland)

b ÅBO AKADEMI UNIVERSITY (Finland)

Author keywords

inhibitors; structural biology; structure activity relationships; tankyrase; Wnt signaling

Indexed keywords

4(3H) QUINAZOLINONE DERIVATIVE; NICOTINAMIDE; PHENYL GROUP; TANKYRASE; TANKYRASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROPHOBICITY; PRIORITY JOURNAL; SUBSTITUTION REACTION; WNT SIGNALING PATHWAY; X RAY CRYSTALLOGRAPHY;

INHIBITORS; STRUCTURAL BIOLOGY; STRUCTURE-ACTIVITY RELATIONSHIPS; TANKYRASE; WNT SIGNALING;

BINDING SITES; CATALYTIC DOMAIN; CELL LINE; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HEK293 CELLS; HUMANS; HYDROGEN BONDING; PROTEIN BINDING; QUINAZOLINONES; STATIC ELECTRICITY; STRUCTURE-ACTIVITY RELATIONSHIP; TANKYRASES; WNT SIGNALING PATHWAY;

EID: 84889880241 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201300337 Document Type: Article

Times cited : (34)

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