Is serum cholesterol a risk factor for asthma?

Lung India

Volumn 30, Issue 4, 2013, Pages 295-301

  Ramaraju, Karthikeyan ^a   Krishnamurthy, Srikanth ^a   Maamidi, Smrithi ^a   Kaza, Anupama Murthy ^a   Balasubramaniam, Nithilavalli ^a  

^a PSG INSTITUTE OF MEDICAL SCIENCES AND RESEARCH   (India)

Author keywords

Asthma; cholesterol; high sensitivity C reactive protein; indoor hygiene; inflammation

Indexed keywords

C REACTIVE PROTEIN; CHOLESTEROL; STEROID;

ADULT; AIR QUALITY; AMBIENT AIR; ARTICLE; ASTHMA; BODY MASS; CASE CONTROL STUDY; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSS-SECTIONAL STUDY; CROWDING (AREA); DISEASE ASSOCIATION; EMERGENCY WARD; ENVIRONMENTAL FACTOR; FEMALE; HOME ENVIRONMENT; HOSPITAL UTILIZATION; HUMAN; HYGIENE; INFLAMMATION; LABORATORY TEST; MALE; RISK FACTOR; RURAL AREA; SERUM; URBAN AREA; WHEEZING;

EID: 84889686315     PISSN: 09702113     EISSN: 0974598X     Source Type: Journal    
DOI: 10.4103/0970-2113.120604     Document Type: Article

References (42)

1. NHLBI/WHO workshop report: Global Strategy for asthma management and prevention. Global Initiative for Asthma (revised 2006). Available from: Http://www.ginasthma.org. [Accessed 2012 Jan 27
2. Stirling RG, Chung KF. Severe asthma: Definition and mechanisms. Allergy 2001;56:825-40
3. Global Initiative for Asthma, 2011. Global strategy for asthma management and prevention. Available from: Http://www.ginasthma.org/guidelines-ginareport- global-strategy-for-Asthma.html. [Accessed 2012 Jan 15
4. Stokes KY, Cooper D, Tailor A, Granger DN. Hypercholesterolemia promotes inflammation and microvascular dysfunction: Role of nitric oxide and superoxide. Free Radic Biol Med 2002;33:1026-36
5. Scalia R, Appel JZ 3rd, Lefer AM. Leukocyte-endothelium interaction during the early stages of hypercholesterolemia in the rabbit: Role of P-selectin, ICAM-1, and VCAM-1. Arterioscler Thromb Vasc Biol 1998;18:1093-100
6. Engström G, Lind P, Hedblad B, Stavenow L, Janzon L, Lindgärde F. Effects of cholesterol and inflammation-sensitive plasma proteins on incidence of myocardial infarction and stroke in men. Circulation 2002;105:2632-7
7. Gupta P, Vijayan VK, Bansal SK. Sphingomyelin metabolism in erythrocyte membrane in asthma. J Asthma 2010;47:966-71
8. Fessler MB, Arndt PG, Frasch SC, Lieber JG, Johnson CA, Murphy RC, et al. Lipid rafts regulate lipopolysaccharide-induced activation of Cdc 42 and inflammatory functions of the human neutrophil. J Biol Chem 2004;279:39989-98
9. Baumruker T, Csonga R, Pursch E, Pfeffer A, Urtz N, Sutton S, et al. Activation of mast cells by incorporation of cholesterol into rafts. Int Immunol 2003;15:1207-18
10. Baldán A, Gomes AV, Ping P, Edwards PA. Loss of ABCG1 results in chronic pulmonary inflammation. J Immunol 2008;180:3560-8
11. Wojcik AJ, Skaflen MD, Srinivasan S, Hedrick CC. A critical role for ABCG1 in macrophage inflammation and lung homeostasis. J Immunol 2008;180:4273-82
12. Goldklang M, Golovatch P, Zelonina T, Trischler J, Rabinowitz D, Lemaître V, et al. Activation of the TLR4 signaling pathway and abnormal cholesterol efflux lead to emphysema in ApoE-Deficient mice. Am J Physiol Lung Cell Mol Physiol 2012;302:L1200-8
13. Robertson AK, Zhou X, Strandvik B, Hansson GK. Severe hypercholesterolaemia leads to strong Th2 responses to an exogenous antigen. Scand J Immunol 2004;59:285-93
14. Yeh YF, Huang SL. Enhancing effect of dietary cholesterol and inhibitory effect of pravastatin on allergic pulmonary inflammation. J Biomed Sci 2004;11:599-606
15. Yeh YF, Huang SL. Dietary cholesterol enhances pulmonary eosinophilic inflammation in a murine model of asthma. Int Arch Allergy Immunol 2001;125:329-34
16. Imamura M, Okunishi K, Ohtsu H, Nakagome K, Harada H, Tanaka R, et al. Pravastatin attenuates allergic airway inflammation by suppressing antigen sensitisation, interleukin 17 production and antigen presentation in the lung. Thorax 2009;64:44-9
17. Kim DY, Ryu SY, Lim JE, Lee YS, Ro JY. Anti-inflammatory mechanism of simvastatin in mouse allergic asthma model. Eur J Pharmacol 2007;557:76-86
18. Zeki AA, Franzi L, Last J, Kenyon NJ. Simvastatin inhibits airway hyperreactivity: Implications for the mevalonate pathway and beyond. Am J Respir Crit Care Med 2009;180:731-40
19. Zeki AA, Bratt JM, Rabowsky M, Last JA, Kenyon NJ. Simvastatin inhibits goblet cell hyperplasia and lung arginase in a mouse model of allergic asthma: A novel treatment for airway remodeling? Transl Res 2010;156:335-49
20. McKay A, Leung BP, McInnes IB, Thomson NC, Liew FY. A novel antiinflammatory role of simvastatin in a murine model of allergic asthma. J Immunol 2004;172:2903-8
21. Schäfer T, Ruhdorfer S, Weigl L, Wessner D, Heinrich J, Döring A, et al. Intake of unsaturated fattyacids and HDL cholesterol levels are associated with manifestations of atopy in adults. Clin Exp Allergy 2003;33:1360-7
22. Picado C, Deulofeu R, Lleonart R, Agustí M, Casals E, Quintó L, et al. Lipid and protein metabolism in asthma. Effects of diet and corticosteroid therapy. Allergy 1999;54:569-75
23. Al-Shawwa B, Al-Huniti N, Titus G, Abu-Hasan M. Hypercholesterolemia is a potential risk factor for asthma. J Asthma 2006;43:231-3
24. Shenoi A, Kumar L, Sarihyan S, Gangully NK. High density lipoprotein cholesterol and total cholesterol in children with asthma and allergic rhinitis. Acta Paediatr 1992;81:150-2
25. Fessler MB, Massing MW, Spruell B, Jaramillo R, Draper DW, Madenspacher JH, et al. Novel relationship of serum cholesterol with asthma and wheeze in the United States. J Allergy Clin Immunol 2009;124:967-74.e1-15
26. NHLBI. National asthma education and prevention program. Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. Full Report, 2007. Available from: Http://www.nhlbi.nih.gov/guidelines/ asthma/asthgdln.pdf/. [Accessed 2012 Feb 01
27. Kumar P. Social classification-need for constant updating. Indian J Community Med 1993;18:60-1
28. Agarwal A. Social classification: The need to update in the present scenario. Indian J Community Med 2008;33:50-1
29. Park K. Environment and health. In: Park K, editor. Text book of Preventive and Social Medicine. 17th ed. Jabalpur: M/S Banarsidas Bhanot Publishers; 2002. p. 528
30. Study group, European Atherosclerosis Society. Strategies for the prevention of coronary heart disease: A policy statement of the European atherosclerosis society. Eur Heart J 1987;8:77-88
31. Cleeman JL. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). USA: NIH Publication No 01-3670;2001
32. Turpeinen M, Sorva R, Juntunen-Backman K. Changes in carbohydrate and lipid metabolism in children with asthma inhaling budesonide. J Allergy Clin Immunol 1991;88:384-9
33. Barnes PJ, Pedersen S, Busse WW. Efficacy and safety of inhaled corticosteroids. New developments. Am J Respir Crit Care Med 1998;157:S1-53
34. Gowdy KM, Fessler MB. Emerging roles for cholesterol and lipoproteins in lung disease. Pulm Pharmacol Ther 2012; PMID: 22706330. [epub ahead of print
35. Fessler MB, Parks JS. Intracellular lipid flux and membrane microdomains as organizing principles in inflammatory cell signaling. J Immunol 2011;187:1529-35
36. Zhu X, Owen JS, Wilson MD, Li H, Griffiths GL, Thomas MJ, et al. Macrophage ABCA1 reduces MyD88-Dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol. J Lipid Res 2010;51:3196-206
37. Diomede L, Albani D, Sottocorno M, Donati MB, Bianchi M, Fruscella P, et al. In vivo anti-inflammatory effect of statins is mediated by nonsterol mevalonate products. Arterioscler Thromb Vasc Biol 2001;21:1327-32
38. Menzies D, Nair A, Meldrum KT, Fleming D, Barnes M, Lipworth BJ. Simvastatin does not exhibit therapeutic anti-inflammatory effects in asthma. J Allergy Clin Immunol 2007;119:328-35
39. Cowan DC, Cowan JO, Palmay R, Williamson A, Taylor DR. Simvastatin in the treatment of asthma: Lack of steroid-sparing effect. Thorax 2010;65:891-6
40. Hothersall EJ, Chaudhuri R, McSharry C, Donnelly I, Lafferty J, McMahon AD, et al. Effects of atorvastatin added to inhaled corticosteroids on lung function and sputum cell counts in atopic asthma. Thorax 2008;63:1070-5
41. Moini A, Azimi G, Farivar A. Evaluation of atorvastatin for the treatment of patients with asthma: A double-blind randomized clinical trial. Allergy Asthma Immunol Res 2012;4:290-4
42. Bonetti PO, Lerman LO, Napoli C, Lerman A. Statin effects beyond lipid lowering-Are they clinically relevant? Eur Heart J 2003;24:225-48