Mind the gap! connexins and pannexins in physiology, pharmacology and disease

Frontiers in Pharmacology

Volumn 4 NOV, Issue , 2013, Pages

  Salameh, Aida ^a   Blanke, Katja ^a   Dhein, Stefan ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Arrhythmia; Cancer; Connexin; Hemichannels; Inborn heart disease; Mutation; Pannexin; Stem cells

Indexed keywords

CONNEXIN 40; CONNEXIN 43; CONNEXIN 45; GAP JUNCTION PROTEIN; PANNEXIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL GROWTH; CELL INTERACTION; CELL TRANSFORMATION; CONGENITAL HEART DISEASE; CYTOSOL; DISEASES; EMBRYONIC STEM CELL; GAP JUNCTION; GENE EXPRESSION REGULATION; HOMEOSTASIS; HUMAN; MEDICAL RESEARCH; NEUROLOGIC DISEASE; NONHUMAN; PHARMACOLOGY; PHYSIOLOGY; PROTEIN DEFECT; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; SYMPTOM;

EID: 84889685342     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2013.00144     Document Type: Article

References (20)

1. Axelsen, L. N., Calloe, K., Holstein-Rathlou, N. H., and Schak Nielsen, M. (2013). Managing the complexity of communication; regulation of gap junctions by post-translational modification. Front. Pharmacol. 4:130. doi: 10.3389/fphar.2013.00130
2. Beyer, E. C., Lin, X., and Veenstra, R. D. (2013a). Interfering amino terminal peptides and functional implications for heteromeric gap junction formation. Front. Pharmacol. 4:67. doi: 10.3389/fphar.2013.00067
3. Beyer, E. C., Ebihara, L., and Berthoud, V. M. (2013b). Connexin mutants and cataracts. Front. Pharmacol. 4:43. doi: 10.3389/fphar.2013.00043
4. Blanke, K., Dähnert, I., and Salameh, A. (2013). Role of connexins in infantile hemangiomas. Front. Pharmacol. 4:41. doi: 10.3389/fphar.2013.00041
5. Boengler, K., Ungefug, E., Heusch, G., Leybaert, L., and Schulz, R. (2013). Connexin 43 impacts on mitochondrial potassium uptake. Front. Pharmacol. 4:73. doi: 10.3389/fphar.2013.00073
6. Cone, A. C., Ambrosi, C., Scemes, E., Martone, M. E., and Sosinsky, G. E. (2013). A comparative antibody analysis of pannexin1 expression in four rat brain regions reveals varying subcellular localizations. Front. Pharmacol. 4:6. doi: 10.3389/fphar.2013.00006
7. De Bock, M., Kerrebrouck, M., Wang, N., and Leybaert, L. (2013). Neurological manifestations of oculodentodigital dysplasia: a Cx43 channelopathy of the central nervous system. Front. Pharmacol. 4:120. doi: 10.3389/fphar.2013.00120
8. Giaume, C., Leybaert, L., Naus, C. C., and Sáez, J. C. (2013). Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles. Front. Pharmacol. 4:88. doi: 10.3389/fphar.2013.00088
9. Hanstein, R., Negoro, H., Patel, N. K., Charollais, A., Meda, P., Spray, D. C., et al. (2013). Promises and pitfalls of a Pannexin1 transgenic mouse line. Front. Pharmacol. 4:61. doi: 10.3389/fphar.2013.00061
10. Jeyaraman, M. M., Fandrich, R. R., and Kardami, E. (2013). Together and apart: inhibition of DNA synthesis by connexin-43 and its relationship to transforming growth factor β. Front. Pharmacol. 4:90. doi: 10.3389/fphar.2013.00090
11. Kaufman, J., Gordon, C., Bergamaschi, R., Wang, H. Z., Cohen, I. S., Valiunas, V., et al. (2013). The effects of the histone deacetylase inhibitor 4-phenylbutyrate on gap junction conductance and permeability. Front. Pharmacol. 4:111. doi: 10.3389/fphar.2013.00111
12. Kopanic, J. L., Al-Mugotir, M., Zach, S., Das, S., Grosely, R., and Sorgen, P. L. (2013). An Escherichia coli strain for expression of the connexin45 carboxyl terminus attached to the 4th transmembrane domain. Front. Pharmacol. 4:106. doi: 10.3389/fphar.2013.00106
13. Oyamada, M., Takebe, K., Endo, A., Hara, S., and Oyamada, Y. (2013). Connexin expression and gap-junctional intercellular communication in ES cells and iPS cells. Front. Pharmacol. 4:85. doi: 10.3389/fphar.2013.00085
14. Salameh, A., Blanke, K., and Daehnert, I. (2013). Role of connexins in human congenital heart disease: the chicken and egg problem. Front. Pharmacol. 4:70. doi: 10.3389/fphar.2013.00070
15. Söhl, G., Hombach, S., Degen, J., and Odermatt, B. (2013). The oligodendroglial precursor cell line Oli-neu represents a cell culture system to examine functional expression of the mouse gap junction gene connexin29 (Cx29). Front. Pharmacol. 4:83. doi: 10.3389/fphar.2013.00083
16. Spath, C., Schlegel, F., Leontyev, S., Mohr, F. W., and Dhein, S. (2013). Inverse relationship between tumor proliferation markers and connexin expression in a malignant cardiac tumor originating from mesenchymal stem cell engineered tissue in a rat in vivo model. Front. Pharmacol. 4:42. doi: 10.3389/fphar.2013.00042
17. Valiunas, V. (2013). Cyclic nucleotide permeability through unopposed connexion hemichannels. Front. Pharmacol. 4:75. doi: 10.3389/fphar.2013.00075
18. Végh, A., Gönczi, M., Miskolczi, G., and Kovács, M. (2013). Regulation of gap junctions by nitric oxide influences the generation of arrhythmias resulting from acute ischemia and reperfusion in vivo. Front. Pharmacol. 4:76. doi: 10.3389/fphar.2013.00076
19. Verheule, S., and Kaese, S. (2013). Connexin diversity in the heart: insights from transgenic mouse models. Front. Pharmacol. 4:81. doi: 10.3389/fphar.2013.00081
20. Xu, Q., Lin, X., Andrews, L., Patel, D., Lampe, P. D., and Veenstra, R. D. (2013). Histone deacetylase inhibition reduces cardiac connexin43 expression and gap junction communication. Front. Pharmacol. 4:44. doi: 10.3389/fphar.2013.00044