Connexin expression and gap-junctional intercellular communication in ES cells and iPS cells

Frontiers in Pharmacology

Volumn 4 JUL, Issue , 2013, Pages

  Oyamada, Masahito ^a   Takebe, Kumiko ^a   Endo, Aya ^a   Hara, Sachiko ^a   Oyamada, Yumiko ^b  

^a FUJI WOMEN'S UNIVERSITY   (Japan)

^b Tonan Hospital   (Japan)

Author keywords

Connexins; Differentiation; ES cells; Gap junctional intercellular communication; iPS cells; Pluripotency; Reprogramming

Indexed keywords

CONNEXIN 25; CONNEXIN 26; CONNEXIN 30; CONNEXIN 31; CONNEXIN 32; CONNEXIN 33; CONNEXIN 37; CONNEXIN 40; CONNEXIN 43; CONNEXIN 45; CONNEXIN 46; CONNEXIN 50; CONNEXIN 59; CONNEXIN 62; GAP JUNCTION PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG;

CELL ACTIVITY; CELL COMMUNICATION; CELL DIFFERENTIATION; EMBRYONIC STEM CELL; ENZYME REGULATION; GAP JUNCTION; HUMAN; NONHUMAN; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SHORT SURVEY;

EID: 84881576252     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2013.00085     Document Type: Short Survey

References (40)

1. Aasen, T., Raya, A., Barrero, M. J., Garreta, E., Consiglio, A., Gonzalez, F., et al. (2008). Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes. Nat. Biotechnol. 26, 1276-1284. doi: 10.1038/nbt.1503
2. Baharvand, H., Azarnia, M., Parivar, K., and Ashtiani, S. K. (2005). The effect of extracellular matrix on embryonic stem cell-derived cardiomyocytes. J. Mol. Cell. Cardiol. 38, 495-503. doi: 10.1016/j.yjmcc.2004.12.011
3. Bhattacharya, B., Miura, T., Brandenberger, R., Mejido, J., Luo, Y., Yang, A. X., et al. (2004). Gene expression in human embryonic stem cell lines: unique molecular signature. Blood 103, 2956-2964. doi: 10.1182/blood-2003-09-3314
4. Boyer, L. A., Lee, T. I., Cole, M. F., Johnstone, S. E., Levine, S. S., Zucker, J. P., et al. (2005). Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122, 947-956. doi: 10.1016/j.cell.2005.08.020
5. Carpenter, M. K., Rosler, E. S., Fisk, G. J., Brandenberger, R., Ares, X., Miura, T., et al. (2004). Properties of four human embryonic stem cell lines maintained in a feeder-free culture system. Dev. Dyn. 229, 243-258. doi: 10.1002/dvdy.10431
6. Chaudhary, K. W., Barrezueta, N. X., Bauchmann, M. B., Milici, A. J., Beckius, G., Stedman, D. B., et al. (2006). Embryonic stem cells in predictive cardiotoxicity: laser capture microscopy enables assay development. Toxicol. Sci. 90, 149-158. doi: 10.1093/toxsci/kfj078
7. Egashira, K., Nishii, K., Nakamura, K., Kumai, M., Morimoto, S., and Shibata, Y. (2004). Conduction abnormality in gap junction protein connexin45-deficient embryonic stem cell-derived cardiac myocytes. Anat. Rec. A Discov. Mol. Cell Evol. Biol. 280, 973-979. doi: 10.1002/ar.a.20110
8. Evans, M. J., and Kaufman, M. H. (1981). Establishment in culture of pluripotential cells from mouse embryos. Nature 292, 154-156. doi: 10.1038/292154a0
9. Fijnvandraat, A. C., Van Ginneken, A. C., Schumacher, C. A., Boheler, K. R., Lekanne Deprez, R. H., Christoffels, V. M., et al. (2003). Cardiomyocytes purified from differentiated embryonic stem cells exhibit characteristics of early chamber myocardium. J. Mol. Cell. Cardiol. 35, 1461-1472. doi: 10.1016/j.yjmcc.2003.09.011
10. Huettner, J. E., Lu, A., Qu, Y., Wu, Y., Kim, M., and McDonald, J. W. (2006). Gap junctions and connexon hemichannels in human embryonic stem cells. Stem Cells 24, 1654-1667. doi: 10.1634/stemcells.2005-0003
11. Kalimi, G. H., and Lo, C. W. (1988). Communication compartments in the gastrulating mouse embryo. J. Cell Biol. 107, 241-255. doi: 10.1083/jcb.107.1.241
12. Kalimi, G. H., and Lo, C. W. (1989). Gap junctional communication in the extraembryonic tissues of the gastrulating mouse embryo. J. Cell Biol. 109, 3015-3026. doi: 10.1083/jcb.109.6.3015
13. Ke, Q., Li, L., Cai, B., Liu, C., Yang, Y., Gao, Y., et al. (2013). Connexin 43 is involved in the generation of human-induced pluripotent stem cells. Hum. Mol. Genet. 22, 2221-2233. doi: 10.1093/hmg/ddt074
14. Lo, C. W., and Gilula, N. B. (1979). Gap junctional communication in the preimplantation mouse embryo. Cell 18, 399-409. doi: 10.1016/0092-8674(79)90059-X
15. Lundy, S. D., Zhu, W. Z., Regnier, M., and Laflamme, M. A. (2013). Structural and functional maturation of cardiomyocytes derived from human pluripotent stem cells. Stem Cells Dev. doi: 10.1089/scd.2012.0490. [Epub ahead of print].
16. Martinez-Fernandez, A., Nelson, T. J., Yamada, S., Reyes, S., Alekseev, A. E., Perez-Terzic, C., et al. (2009). iPS programmed without c-MYC yield proficient cardiogenesis for functional heart chimerism. Circ. Res. 105, 648-656. doi: 10.1161/CIRCRESAHA.109.203109
17. Matsuura, K., Masuda, S., Haraguchi, Y., Yasuda, N., Shimizu, T., Hagiwara, N., et al. (2011). Creation of mouse embryonic stem cell-derived cardiac cell sheets. Biomaterials 32, 7355-7362. doi: 10.1016/j.biomaterials.2011.05.042
18. Mauritz, C., Schwanke, K., Reppel, M., Neef, S., Katsirntaki, K., Maier, L. S., et al. (2008). Generation of functional murine cardiac myocytes from induced pluripotent stem cells. Circulation 118, 507-517. doi: 10.1161/CIRCULATIONAHA.108.778795
19. Oyamada, M., Oyamada, Y., Komatsu, K., Mori, M., and Takamatsu, T. (2000). In vitro cardiomyocytic differentiation of mouse embryonic stem cells deficient in gap junction protein connexin43. Card. Vasc. Regen. 1, 54-64.
20. Oyamada, M., Takebe, K., and Oyamada, Y. (2013). Regulation of connexin expression by transcription factors and epigenetic mechanisms. Biochim. Biophys. Acta 1828, 118-133. doi: 10.1016/j.bbamem.2011.12.031
21. Oyamada, Y., Komatsu, K., Kimura, H., Mori, M., and Oyamada, M. (1996). Differential regulation of gap junction protein (connexin) genes during cardiomyocytic differentiation of mouse embryonic stem cells in vitro. Exp. Cell Res. 229, 318-326. doi: 10.1006/excr.1996.0377
22. Parekkadan, B., Berdichevsky, Y., Irimia, D., Leeder, A., Yarmush, G., Toner, M., et al. (2008). Cell-cell interaction modulates neuroectodermal specification of embryonic stem cells. Neurosci. Lett. 438, 190-195. doi: 10.1016/j.neulet.2008.03.094
23. Pfannkuche, K., Liang, H., Hannes, T., Xi, J., Fatima, A., Nguemo, F., et al. (2009). Cardiac myocytes derived from murine reprogrammed fibroblasts: intact hormonal regulation, cardiac ion channel expression and development of contractility. Cell Physiol. Biochem. 24, 73-86. doi: 10.1159/000227815
24. Richards, M., Tan, S. P., Tan, J. H., Chan, W. K., and Bongso, A. (2004). The transcriptome profile of human embryonic stem cells as defined by SAGE. Stem Cells 22, 51-64. doi: 10.1634/stemcells.22-1-51
25. Robinton, D. A., and Daley, G. Q. (2012). The promise of induced pluripotent stem cells in research and therapy. Nature 481, 295-305. doi: 10.1038/nature10761
26. Sharovskaya, Y. Y. (2011). Intercellular interactions through gap junctions in embryonic stem cells. Biophysics 56, 86-89. doi: 10.1134/S0006350911010192
27. Sharovskaya, Y. Y., Lagarkova, M. A., Kiselev, S. L., and Chailakhyan, L. M. (2009). Gap junctional intercellular communication in human embryonic stem cells during spontaneous differentiation. Dokl. Biol. Sci. 427, 387-390.
28. Sharovskaya, Y. Y., Philonenko, E. S., Kiselev, S. L., and Lagarkova, M. A. (2012). De novo reestablishment of gap junctional intercellular communications during reprogramming to pluripotency and differentiation. Stem Cells Dev. 21, 2623-2629. doi: 10.1089/scd.2011.0707
29. Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., et al. (2007). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861-872. doi: 10.1016/j.cell.2007.11.019
30. Takahashi, K., and Yamanaka, S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676. doi: 10.1016/j.cell.2006.07.024
31. Thomson, J. A., Itskovitz-Eldor, J., Shapiro, S. S., Waknitz, M. A., Swiergiel, J. J., Marshall, V. S., et al. (1998). Embryonic stem cell lines derived from human blastocysts. Science 282, 1145-1147. doi: 10.1126/science.282.5391.1145
32. Todorova, M. G., Soria, B., and Quesada, I. (2008). Gap junctional intercellular communication is required to maintain embryonic stem cells in a non-differentiated and proliferative state. J. Cell. Physiol. 214, 354-362. doi: 10.1002/jcp.21203
33. Van Kempen, M., Van Ginneken, A., De Grijs, I., Mutsaers, N., Opthof, T., Jongsma, H., et al. (2003). Expression of the electrophysiological system during murine embryonic stem cell cardiac differentiation. Cell Physiol. Biochem. 13, 263-270. doi: 10.1159/000074541
34. Westfall, M. V., Pasyk, K. A., Yule, D. I., Samuelson, L. C., and Metzger, J. M. (1997). Ultrastructure and cell-cell coupling of cardiac myocytes differentiating in embryonic stem cell cultures. Cell Motil. Cytoskeleton 36, 43-54.
35. Wolvetang, E. J., Pera, M. F., and Zuckerman, K. S. (2007). Gap junction mediated transport of shRNA between human embryonic stem cells. Biochem. Biophys. Res. Commun. 363, 610-615. doi: 10.1016/j.bbrc.2007.09.035
36. Wong, R. C. B., Dottori, M., Koh, K. L. L., Nguyen, L. T. V., Pera, M. F., and Pebay, A. (2006). Gap junctions modulate apoptosis and colony growth of human embryonic stem cells maintained in a serum-free system. Biochem. Biophys. Res. Commun. 344, 181-188. doi: 10.1016/j.bbrc.2006.03.127
37. Wong, R. C., Pebay, A., Nguyen, L. T., Koh, K. L., and Pera, M. F. (2004). Presence of functional gap junctions in human embryonic stem cells. Stem Cells 22, 883-889. doi: 10.1634/stemcells.22-6-883
38. Wong, R. C. B., Pera, M. F., and Pebay, A. (2008). Role of gap junctions in embryonic and somatic stem cells. Stem Cell Rev. 4, 283-292. doi: 10.1007/s12015-008-9038-9
39. Worsdorfer, P., Maxeiner, S., Markopoulos, C., Kirfel, G., Wulf, V., Auth, T., et al. (2008). Connexin expression and functional analysis of gap junctional communication in mouse embryonic stem cells. Stem Cells 26, 431-439. doi: 10.1634/stemcells.2007-0482
40. Yamamoto, M., Tase, N., Okuno, T., Kondo, Y., Akiba, S., Shimozawa, N., et al. (2007). Monitoring of gene expression in differentiation of embryoid bodies from cynomolgus monkey embryonic stem cells in the presence of bisphenol A. J. Toxicol. Sci. 32, 301-310. doi: 10.2131/jts.32.301