IL-7 receptor α expressing B cells act proinflammatory in collagen-induced arthritis and are inhibited by sympathetic neurotransmitters

Annals of the Rheumatic Diseases

Volumn 73, Issue 1, 2014, Pages 306-312

  Pongratz, Georg ^a   Anthofer, Judith M ^a   Melzer, Madlen ^a   Anders, Sven ^a   Grässel, Susanne ^a   Straub, Rainer H ^a  

^a UNIVERSITY HOSPITAL REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; COLLAGEN ANTIBODY; COLLAGEN TYPE 2; COLLAGEN TYPE 2 ANTIBODY; INTERLEUKIN 17; INTERLEUKIN 17 RECEPTOR; INTERLEUKIN 17 RECEPTOR ALPHA; NEUROTRANSMITTER; NORADRENALIN; STAT5 PROTEIN; TERBUTALINE; UNCLASSIFIED DRUG;

ADRENERGIC SYSTEM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTHRITIS; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; BIOACCUMULATION; CELL MATURATION; CELL TRANSFER; IN VITRO STUDY; LYMPHOCYTE FUNCTION; MALE; MOUSE; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SYNOVIUM;

ARTHRITIS; B CELLS; RHEUMATOID ARTHRITIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; B-LYMPHOCYTES; CELLS, CULTURED; DISEASE MODELS, ANIMAL; HUMANS; HYDROCORTISONE; INTERLEUKIN-7; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED DBA; NOREPINEPHRINE; OSTEOARTHRITIS; RECEPTORS, INTERLEUKIN-7; SIGNAL TRANSDUCTION; SYMPATHETIC NERVOUS SYSTEM; SYMPATHOMIMETICS;

EID: 84889676152     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2012-202944     Document Type: Article

References (41)

1. Grabstein KH, Waldschmidt TJ, Finkelman FD, et al. Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody. J Exp Med 1993;178:257-64. (Pubitemid 23173261)
2. Sudo T, Nishikawa S, Ohno N, et al. Expression and function of the interleukin 7 receptor in murine lymphocytes. Proc Natl Acad Sci USA 1993;90:9125-9. (Pubitemid 23306464)
3. Hartgring SA, van Roon JA, Wenting-van WM, et al. Elevated expression of interleukin-7 receptor in inflamed joints mediates interleukin-7-induced immune activation in rheumatoid arthritis. Arthritis Rheum 2009;60:2595-605.
4. Hikida M, Nakayama Y, Yamashita Y, et al. Expression of recombination activating genes in germinal center B cells: involvement of interleukin 7 (IL-7) and the IL-7 receptor. J Exp Med 1998;188:365-72. (Pubitemid 28357764)
5. Shibata H, Tani-ichi S, Lee HC, et al. Induction of the IL-7 receptor alpha chain in mouse peripheral B cells by glucocorticoids. Immunol Lett 2007;111:45-50. (Pubitemid 47017474)
6. Badot V, Durez P, Van den Eynde BJ, et al. Rheumatoid arthritis synovial fibroblasts produce a soluble form of the interleukin-7 receptor in response to pro-inflammatory cytokines. J Cell Mol Med 2011;15:2335-42.
7. Goodwin RG, Friend D, Ziegler SF, et al. Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. Cell 1990;60:941-51.
8. Leonard WJ, Shores EW, Love PE. Role of the common cytokine receptor gamma chain in cytokine signaling and lymphoid development. Immunol Rev 1995;148:97-114. (Pubitemid 26010544)
9. Milne CD, Paige CJ. IL-7: a key regulator of B lymphopoiesis. Semin Immunol 2006;18:20-30. (Pubitemid 43238333)
10. Pickens SR, Chamberlain ND, Volin MV, et al. Characterization of interleukin-7 and interleukin-7 receptor in the pathogenesis of rheumatoid arthritis. Arthritis Rheum 2011;63:2884-93.
11. van Roon JA, Verweij MC, Wijk MW, et al. Increased intraarticular interleukin-7 in rheumatoid arthritis patients stimulates cell contact-dependent activation of CD4(+) T cells and macrophages. Arthritis Rheum 2005;52:1700-10. (Pubitemid 40852878)
12. van Roon JA, Glaudemans KA, Bijlsma JW, et al. Interleukin 7 stimulates tumour necrosis factor alpha and Th1 cytokine production in joints of patients with rheumatoid arthritis. Ann Rheum Dis 2003;62:113-19. (Pubitemid 36135385)
13. Harada S, Yamamura M, Okamoto H, et al. Production of interleukin-7 and interleukin-15 by fibroblast-like synoviocytes from patients with rheumatoid arthritis. Arthritis Rheum 1999;42:1508-16. (Pubitemid 30265610)
14. Leistad L, Ostensen M, Faxvaag A. Detection of cytokine mRNA in human, articular cartilage from patients with rheumatoid arthritis and osteoarthritis by reverse transcriptase-polymerase chain reaction. Scand J Rheumatol 1998;27:61-7. (Pubitemid 28116472)
15. Shimaoka Y, Attrep JF, Hirano T, et al. Nurse-like cells from bone marrow and synovium of patients with rheumatoid arthritis promote survival and enhance function of human B cells. J Clin Invest 1998;102:606-18. (Pubitemid 28376163)
16. Tomita T, Takeuchi E, Toyosaki-Maeda T, et al. Establishment of nurse-like stromal cells from bone marrow of patients with rheumatoid arthritis: indication of characteristic bone marrow microenvironment in patients with rheumatoid arthritis. Rheumatology (Oxford) 1999;38:854-63. (Pubitemid 29507368)
17. Timmer TC, Baltus B, Vondenhoff M, et al. Inflammation and ectopic lymphoid structures in rheumatoid arthritis synovial tissues dissected by genomics technology: identification of the interleukin-7 signaling pathway in tissues with lymphoid neogenesis. Arthritis Rheum 2007;56:2492-502. (Pubitemid 47237268)
18. Hartgring SA, Willis CR, Bijlsma JW, et al. Interleukin-7-aggravated joint inflammation and tissue destruction in collagen-induced arthritis is associated with T-cell and B-cell activation. Arthritis Res Ther 2012;14:R137.
19. Härle P, Möbius D, Carr DJ, et al. An opposing time-dependent immune-modulating effect of the sympathetic nervous system conferred by altering the cytokine profile in the local lymph nodes and spleen of mice with type II collagen-induced arthritis. Arthritis Rheum 2005;52:1305-13. (Pubitemid 40530141)
20. Pongratz G, Melzer M, Straub RH. The sympathetic nervous system stimulates anti-inflammatory B cells in collagen-type II-induced arthritis. Ann Rheum Dis 2012;71:432-9.
21. Sanders VM. The beta2-adrenergic receptor on T and B lymphocytes: do we understand it yet? Brain Behav Immun 2012;26:195-200.
22. Pongratz G, McAlees JW, Conrad DH, et al. The level of IgE produced by a B cell is regulated by norepinephrine in a p38 MAPK- and CD23-dependent manner. J Immunol 2006;177:2926-38. (Pubitemid 44277808)
23. Härle P, Pongratz G, Albrecht J, et al. An early sympathetic nervous system influence exacerbates collagen-induced arthritis via CD4+CD25+ cells. Arthritis Rheum 2008;58:2347-55.
24. Straub RH, Rauch L, Fassold A, et al. Neuronally released sympathetic neurotransmitters stimulate splenic interferon-gamma secretion from T cells in early type II collagen-induced arthritis. Arthritis Rheum 2008;58:3450-60.
25. Capellino S, Cosentino M, Wolff C, et al. Catecholamine-producing cells in the synovial tissue during arthritis: modulation of sympathetic neurotransmitters as new therapeutic target. Ann Rheum Dis 2010;69:1853-60.
26. Capellino S, Weber K, Gelder M, et al. First appearance and location of catecholaminergic cells during experimental arthritis and elimination by chemical sympathectomy. Arthritis Rheum 2012;64:1110-18.
27. Fassold A, Falk W, Anders S, et al. Soluble neuropilin-2, a nerve repellent receptor, is increased in rheumatoid arthritis synovium and aggravates sympathetic fiber repulsion and arthritis. Arthritis Rheum 2009;60:2892-901.
28. Krutzik PO, Nolan GP. Intracellular phospho-protein staining techniques for flow cytometry: monitoring single cell signaling events. Cytometry A 2003;55:61-70. (Pubitemid 37522508)
29. Miller LE, Justen HP, Scholmerich J, et al. The loss of sympathetic nerve fibers in the synovial tissue of patients with rheumatoid arthritis is accompanied by increased norepinephrine release from synovial macrophages. FASEB J 2000;14:2097-107.
30. Hartgring SA, Willis CR, Alcorn D, et al. Blockade of the interleukin-7 receptor inhibits collagen-induced arthritis and is associated with reduction of T cell activity and proinflammatory mediators. Arthritis Rheum 2010;62:2716-25.
31. Pongratz G, Straub RH. Role of Peripheral Nerve Fibres in Acute and Chronic Inflammation in Arthritis. Nat Rev Rheum 2013;9:117-26.
32. Kohm AP, Tang Y, Sanders VM, et al. Activation of antigen-specific CD4+ Th2 cells and B cells in vivo increases norepinephrine release in the spleen and bone marrow. J Immunol 2000;165:725-33. (Pubitemid 30484738)
33. Goetz CA, Harmon IR, O'Neil JJ, et al. STAT5 activation underlies IL7 receptor-dependent B cell development. J Immunol 2004;172:4770-8. (Pubitemid 38456398)
34. Lundström W, Fewkes NM, Mackall CL. IL-7 in human health and disease. Semin Immunol 2012;24:218-24.
35. Stuart JM, Dixon FJ. Serum transfer of collagen-induced arthritis in mice. J Exp Med 1983;158:378-92. (Pubitemid 13049395)
36. Terato K, Hasty KA, Reife RA, et al. Induction of arthritis with monoclonal antibodies to collagen. J Immunol 1992;148:2103-8.
37. Fujimoto M, Naka T, Nakagawa R, et al. Defective thymocyte development and perturbed homeostasis of T cells in STAT-induced STAT inhibitor-1/ suppressors of cytokine signaling-1 transgenic mice. J Immunol 2000;165:1799-806. (Pubitemid 30643129)
38. Fleming HE, Milne CD, Paige CJ. CD45-deficient mice accumulate Pro-B cells both in vivo and in vitro. J Immunol 2004;173:2542-51. (Pubitemid 39063113)
39. Venkitaraman AR, Cowling RJ. Interleukin-7 induces the association of phosphatidylinositol 3-kinase with the alpha chain of the interleukin-7 receptor. Eur J Immunol 1994;24:2168-74. (Pubitemid 24276551)
40. Crawley JB, Rawlinson L, Lali FV, et al. T cell proliferation in response to interleukins 2 and 7 requires p38MAP kinase activation. J Biol Chem 1997;272:15023-7. (Pubitemid 27251779)
41. Weyand CM. Immunopathologic aspects of rheumatoid arthritis: who is the conductor and who plays the immunologic instrument? J Rheumatol Suppl 2007;79:9-14. (Pubitemid 47067971)