Lichen secondary metabolites as DNA-interacting agents

Toxicology in Vitro

Volumn 28, Issue 2, 2014, Pages 182-186

  Plsikova J ^a   Stepankova, J ^b   Kasparkova, J ^b   Brabec, V ^b   Backor, M ^a   Kozurkova, M ^a  

^a P J AFÁRIK UNIVERSITY   (Slovakia)

^b INSTITUTE OF BIOPHYSICS   (Czech Republic)

Author keywords

DNA binding; Lichens; Topoisomerase I, II

Indexed keywords

ATRANORIN; DNA; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); GYROPHORIC ACID; NATURAL PRODUCT; PHYSCION; UNCLASSIFIED DRUG; USNIC ACID;

ARTICLE; BINDING AFFINITY; BIOCHEMISTRY; CONTROLLED STUDY; DNA CLEAVAGE; DRUG DNA INTERACTION; DRUG STRUCTURE; ELECTROPHORESIS; HUMAN; IN VITRO STUDY; LICHEN (ORGANISM); NONHUMAN; SEPARATION TECHNIQUE; ULTRAVIOLET SPECTROSCOPY;

DNA-BINDING; LICHENS; TOPOISOMERASE I, II;

ANIMALS; BENZOATES; BENZOFURANS; CATTLE; CIRCULAR DICHROISM; DNA; EMODIN; HUMANS; HYDROXYBENZOATES; INTERCALATING AGENTS; KINETICS; LICHENS; NUCLEIC ACID CONFORMATION; SPECTROPHOTOMETRY, ULTRAVIOLET; TOPOISOMERASE I INHIBITORS; TOPOISOMERASE II INHIBITORS;

EID: 84889676147     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2013.11.003     Document Type: Article

References (20)

1. Ahmadjian V. The Lichen Symbiosis 1993, Wiley, New York, pp. 1-6.
2. Arafa R.K., Brun R., Wenzler T., Tanious F.A., Wilson W.D., Stephens C.E., Boykin D.W. Synthesis, DNA affinity and protozoal activity of fused ring dicationic compounds and their prodrugs. J. Med. Chem. 2005, 48:5480-5488.
3. Asahina Y., Shibata S. Chemistry of Lichen Substances 1954, Japan Society for the Promotion of Science, Tokyo, 240pp.
4. Bačkorová M., Bačkor M., Mikeš J., Jendželovský R., Fedoročko P. Variable responses of different human cancer cells to the lichen compounds parietin, atranorin, usnic acid and gyrophoric acid. Toxicol. in Vitro 2011, 25:37-44.
5. Bačkorová M., Jendželovský R., Kello M., Bačkor M., Mikeš J., Fedoročko P. Lichen secondary metabolites are responsible for induction of apoptosis in HT-29 and A2780 human cancer cell lines. Toxicol. in Vitro 2012, 26:462-468.
6. Bugni T.S., Andjelic C.D., Pole A.R., Rai P., Ireland C.M., Barrows L.R. Biologically active components of a papua new guinea analgesic and antiinflammatory lichen preparation. Fitoterapia 2009, 80:270-273.
7. Busa J. Octave 2006, Technical University in Košice, Košice.
8. Cardarelli M., Serino G., Campanella L., Ercole P., De Cicco-Nardone F., Alesiani O., Rossiello F. Antimitotic effects of usnic acid on different biological systems. Cell. Mol. Life Sci. 1997, 53:667-672.
9. Chauhan M., Banerjee K., Arjmand F. DNA binding studies of novel Copper (II) complexes containing l-tryptophan as chiral auxiliary: in vitro antitumor activity of Cu-Sn2 complex in human neuroblastoma cells. Inorg. Chem. 2007, 46:3072-3082.
10. Hale L.J. The pattern of growth of Clytia johnstoni. J. Embryol. Exp. Morphol. 1973, 29:283-309.
11. Huneck S., Yoshimura I. Identification of Lichen Substances 1996, Springer, Berlin Heidelberg, New York.
12. Ihara T., Ikegami T., Fujii T., Kitamura Y., Sueda S., Takagi M., Jyo A. Metal iondirected cooperative DNA binding of small molecules. J. Inorg. Biochem. 2006, 100:1744-1754.
13. Jenkins T.C. Optical absorbance and fluorescence techniques for measuring DNA-drug interactions. Drug-DNA Interaction Protocols 1997, 195-218. Human Press, Totowa, New Jersey. K.R. Fox (Ed.).
14. Kristmundsdottir T., Jonsdottir E., Ogmundsdottir H.M., Ingolfsdottir K. Solubilization of poorly soluble lichen metabolites for biological testing on cell lines. Eur. J. Pharm. Sci. 2005, 24:539-543.
15. McGhee J.D., von Hippel P.H. Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to aone-dimensional homogeneous lattice. J. Mol. Biol. 1974, 86:469-489.
16. Muller K. Pharmaceutically relevant metabolites from lichens. Appl. Microbiol. Biotechnol. 2001, 56:9-16.
17. Reid R.J., Benedetti P., Bjornsti M.A. Yeast as a model organism for studying the actions of DNA topoisomerase-targeted drugs. Biochim. Biophys. Acta. 1998, 1400:289-300.
18. Rodger A., Marington R., Geeves M.A., Hicks M., de Alwis L., Halsall D.J., Dafforn T.R. Looking at long molecules in solution: what happens when they are subjected to Couette flow. Phys. Chem. Chem. Phys. 2006, 8:3161-3171.
19. Russo A., Piovano M., Lombardo L., Vanella L., Cardile V., Garbarino J. Pannarin inhibits cell growth and induces cell death in human prostate carcinoma DU-145 cells. Anti-Cancer Drugs 2006, 17:1163-1169.
20. Solhaug K.A., Gausalaa Y. Parietin, a photoprotective secondary product of the lichen Xanthoria parietina. Oecologia 1996, 108:412-418.