Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 49, 2013, Pages

  Rath, Poonam ^a,b   Huang, Chengdong ^c   Wang, Tao ^d   Wang, Tianzhi ^e   Li, Huilin ^c,d   Prados Rosales, Rafael ^f   Elemento, Olivier ^g   Casadevall, Arturo ^f   Nathan, Carl F ^a,b  

^a Departments of Immunology and Microbiology   (Colombia)

^b Weill Cornell Graduate School of Biomedical Sciences   (United States)

^c STONY BROOK UNIVERSITY   (United States)

^d BROOKHAVEN NATIONAL LABORATORY   (United States)

^e University of Texas Medical Branch School of Medicine   (United States)

^f ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^g WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPROTEIN; LPQH PROTEIN; MEMBRANE PROTEIN; SODC PROTEIN; TOLL LIKE RECEPTOR 2; UNCLASSIFIED DRUG; VESICULOGENESIS AND IMMUNE RESPONSE REGULATOR;

ANIMAL CELL; ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; CONTROLLED STUDY; FEMALE; GENETIC CODE; GENETIC REGULATION; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOMODULATION; MACROPHAGE; MEMBRANE VESICLE; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN STRUCTURE; QUANTITATIVE ANALYSIS;

MACROPHAGES; TLR2;

ANIMALS; BACTERIAL PROTEINS; FEMALE; HOST-PATHOGEN INTERACTIONS; IMMUNOMODULATION; LIPOPROTEINS; MACROPHAGES; MAGNETIC RESONANCE SPECTROSCOPY; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, ELECTRON, SCANNING; MODELS, MOLECULAR; MYCOBACTERIUM TUBERCULOSIS; PROTEIN FOLDING; TOLL-LIKE RECEPTOR 2; TRANSPORT VESICLES;

EID: 84889637802     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1320118110     Document Type: Article

References (48)

1. Gutierrez MC, et al. (2005) Ancient origin and gene mosaicism of the progenitor of Mycobacterium tuberculosis. PLoS Pathog 1(1):e5
2. Daniel TM (2006) The history of tuberculosis. Respir Med 100(11):1862-1870
3. Anonymous (2010) WHO global tuberculosis control report 2010. Summary. Cent Eur J Public Health 18(4):237
4. Dye C, Williams BG (2010) The population dynamics and control of tuberculosis. Science 328(5980):856-861
5. Kaufmann SH (2006) Envisioning future strategies for vaccination against tuberculosis. Nat Rev Immunol 6(9):699-704
6. Ernst JD(2012) The immunological life cycle of tuberculosis. Nat Rev Immunol 12(8):581-591
7. Jamieson AM, et al. (2013) Role of tissue protection in lethal respiratory viral-bacterial coinfection. Science 340(6137):1230-1234
8. Medzhitov R, Schneider DS, Soares MP (2012) Disease tolerance as a defense strategy. Science 335(6071):936-941
9. Comas I, et al. (2010) Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved. Nat Genet 42(6):498-503
10. Wu K, et al. (2012) Improved control of tuberculosis and activation of macrophages in mice lacking protein kinase R. PLoS ONE 7(2):e30512
11. Tobin DM, et al. (2012) Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections. Cell 148(3):434-446
12. Kumar D, et al. (2010) Genome-wide analysis of the host intracellular network that regulates survival of Mycobacterium tuberculosis. Cell 140(5):731-743
13. Dao DN, et al. (2008) Mycolic acid modification by the mmaA4 gene of M. tuberculosis modulates IL-12 production. PLoS Pathog 4(6):e1000081
14. Rengarajan J, et al. (2008) Mycobacterium tuberculosis Rv2224c modulates innate immune responses. Proc Natl Acad Sci USA 105(1):264-269
15. Madan-Lala R, Peixoto KV, Re F, Rengarajan J (2011) Mycobacterium tuberculosis Hip1 dampens macrophage proinflammatory responses by limiting toll-like receptor 2 activation. Infect Immun 79(12):4828-4838
16. Newton SM, et al. (2006) A deletion defining a common Asian lineage of Mycobacterium tuberculosis associates with immune subversion. Proc Natl Acad Sci USA 103(42): 15594-15598
17. Beaulieu AM, et al. (2010) Genome-wide screen for Mycobacterium tuberculosis genes that regulate host immunity. PLoS ONE 5(12):e15120
18. Thoma-Uszynski S, et al. (2001) Induction of direct antimicrobial activity through mammalian toll-like receptors. Science 291(5508):1544-1547
19. Feltcher ME, Braunstein M (2012) Emerging themes in SecA2-mediated protein export. Nat Rev Microbiol 10(11):779-789
20. Feltcher ME, Sullivan JT, Braunstein M (2010) Protein export systems of Mycobacterium tuberculosis: Novel targets for drug development? Future Microbiol 5(10): 1581-1597
21. Beatty WL, et al. (2000) Trafficking and release of mycobacterial lipids from infected macrophages. Traffic 1(3):235-247
22. Prados-Rosales R, et al. (2011) Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice. J Clin Invest 121(4):1471-1483
23. Piddington DL, et al. (2001) Cu,Zn superoxide dismutase of Mycobacterium tuberculosis contributes to survival in activated macrophages that are generating an oxidative burst. Infect Immun 69(8):4980-4987
24. Vogt G, Nathan C (2011) In vitro differentiation of human macrophages with enhanced antimycobacterial activity. J Clin Invest 121(10):3889-3901
25. Venugopal A, et al. (2011) Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes. Cell Host Microbe 9(1):21-31
26. Bryk R, Lima CD, Erdjument-Bromage H, Tempst P, Nathan C (2002) Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein. Science 295(5557):1073-1077
27. Bryk R, et al. (2008) Selective killing of nonreplicating mycobacteria. Cell Host Microbe 3(3):137-145
28. Wang T, Darwin KH, Li H (2010) Binding-induced folding of prokaryotic ubiquitin-like protein on the Mycobacterium proteasomal ATPase targets substrates for degradation. Nat Struct Mol Biol 17(11):1352-1357
29. Grupi A, Haas E (2011) Segmental conformational disorder and dynamics in the intrinsically disordered protein α-synuclein and its chain length dependence. J Mol Biol 405(5):1267-1283
30. Feltcher ME, Gibbons HS, Ligon LS, Braunstein M (2013) Protein export by the mycobacterial SecA2 system is determined by the preprotein mature domain. J Bacteriol 195(4):672-681
31. McBride A, Konowich J, Salgame P (2013) Host defense and recruitment of Foxp+ T regulatory cells to the lungs in chronic Mycobacterium tuberculosis infection requires toll-like receptor 2. PLoS Pathog 9(6):e1003397
32. London E, Feligenson GW (1978) A convenient and sensitive fluorescence assay for phospholipid vesicles using diphenylhexatriene. Anal Biochem 88(1):203-211
33. Crowley JT, et al. (2013) Lipid exchange between Borrelia burgdorferi and host cells. PLoS Pathog 9(1):e1003109
34. MacDonald IA, Kuehn MJ (2012) Offense and defense: Microbial membrane vesicles play both ways. Res Microbiol 163(9-10):607-618
35. Shen Y, et al. (2012) Outer membrane vesicles of a human commensal mediate immune regulation and disease protection. Cell Host Microbe 12(4):509-520
36. Deatherage BL, Cookson BT (2012) Membrane vesicle release in bacteria, eukaryotes, and archaea: A conserved yet underappreciated aspect of microbial life. Infect Immun 80(6):1948-1957
37. Choi DS, et al. (2011) Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa. Proteomics 11(16):3424-3429
38. Pierson T, et al. (2011) Proteomic characterization and functional analysis of outer membrane vesicles of Francisella novicida suggests possible role in virulence and use as a vaccine. J Proteome Res 10(3):954-967
39. Wessel AK, Liew J, Kwon T, Marcotte EM, Whiteley M (2013) Role of Pseudomonas aeruginosa peptidoglycan-associated outer membrane proteins in vesicle formation. J Bacteriol 195(2):213-219
40. Schwechheimer C, Kuehn MJ (2013) Synthetic effect between envelope stress and lack of outer membrane vesicle production in Escherichia coli. J Bacteriol 195(18):4161-4173
41. Gordon J, White RG (1971) Surface peptido-glycolipid filaments on Mycobacterium leprae. Clin Exp Immunol 9(4):539-547
42. Alteri CJ, et al. (2007) Mycobacterium tuberculosis produces pili during human infection. Proc Natl Acad Sci USA 104(12):5145-5150
43. Singh PP, Smith VL, Karakousis PC, Schorey JS (2012) Exosomes isolated from mycobacteria- infected mice or cultured macrophages can recruit and activate immune cells in vitro and in vivo. J Immunol 189(2):777-785
44. Liu PT, et al. (2009) Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses. PLoS ONE 4(6):e5810
45. Jung YJ, Ryan L, LaCourse R, North RJ (2005) Properties and protective value of the secondary versus primary T helper type 1 response to airborne Mycobacterium tuberculosis infection in mice. J Exp Med 201(12):1915-1924
46. Sambandamurthy VK, et al. (2005) Long-term protection against tuberculosis following vaccination with a severely attenuated double lysine and pantothenate auxotroph of Mycobacterium tuberculosis. Infect Immun 73(2):1196-1203
47. Blumenthal A, Trujillo C, Ehrt S, Schnappinger D (2010) Simultaneous analysis of multiple Mycobacterium tuberculosis knockdown mutants in vitro and in vivo. PLoS ONE 5(12):e15667
48. Tian J, Bryk R, Itoh M, Suematsu M, Nathan C (2005) Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: Identification of alpha-ketoglutarate decarboxylase. Proc Natl Acad Sci USA 102(30):10670-10675