The differential effects of statins on the risk of developing pancreatic cancer: A case-control study in two centres in the United Kingdom

Digestive Diseases and Sciences

Volumn 58, Issue 11, 2013, Pages 3308-3312

  Carey, F J ^a   Little, M W ^b   Pugh, T F G ^b   Ndokera, R ^c   Ing, H ^c   Clark, A ^b   Dennison, A ^c   Metcalfe, M S ^c   Robinson, R J ^c   Hart, A R ^b  

^a NORFOLK AND NORWICH UNIVERSITY HOSPITAL   (United Kingdom)

^b UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^c LEICESTER GENERAL HOSPITAL   (United Kingdom)

Author keywords

Case control study; Epidemiology; Pancreatic cancer; Statins; Subgroups

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ADULT; AGED; ARTICLE; BASAL CELL CARCINOMA; CASE CONTROL STUDY; CONTROLLED STUDY; FEMALE; GENDER; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS CANCER; PRIORITY JOURNAL; SMOKING; UNITED KINGDOM;

ADULT; AGED; CARCINOMA, BASAL CELL; CASE-CONTROL STUDIES; FEMALE; GREAT BRITAIN; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERCHOLESTEROLEMIA; MALE; MIDDLE AGED; ODDS RATIO; PANCREATIC NEOPLASMS; RISK FACTORS; SKIN NEOPLASMS;

EID: 84889607070     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-013-2778-7     Document Type: Article

References (34)

1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics. CA Cancer J Clin. 2005;55:74-108.
2. Axtell L, Asire A, Myers MH. Cancer Patient Survival, Report No. 5. Bethesda, USA: Department of Health, Education and Welfare. 1976.
3. Rachet B, Maringe C, Nur U, et al. Population-based cancer survival trends in England and Wales up to 2007: an assessment of the NHS cancer plan for England. Lancet Oncol. 2009;10:351e69.
4. Cancer Research UK. Cancer Stats - Cancer Statistics for the UK. 2008. http://info.cancerresearchuk.org. Accessed 4 July 2013.
5. Anderson KE, Potter J, Mack T. Pancreatic cancer. In: Schottenfield D, Fraumeni JF, eds. Cancer Epidemiology and Prevention. New York: Oxford University Press; 2006:721-762.
6. Hart A, Kennedy H, Harvey I. Pancreatic cancer: a review of the evidence on causation. Clin Gastroenterol Hepatol. 2008;6:275-282.
7. Lin Y, Tamakoshi A, Kawamura T, et al. A prospective cohort study of cigarette smoking and pancreatic cancer in Japan. Cancer Causes Control. 2002;13:249-254.
8. Lynch SM, Vrieling A, Lubin JH, et al. Cigarette smoking and pancreatic cancer. A pooled analysis from the pancreatic cancer cohort consortium. Am J Epidemiol. 2009;170:403-413.
9. Vrieling A, Bueno-de-Mesquita H, et al. Cigarette smoking, environmental tobacco smoke exposure and pancreatic cancer risk in the European prospective investigation into cancer and nutrition. Int J Cancer. 2009;126:2394-2403.
10. Blackford A, Parmigiani G, et al. Genetic mutations associated with cigarette smoking in pancreatic cancer. Cancer Res. 2009;69:3681-3688.
11. Ben Q, Xu M, Maojin N. Diabetes mellitus and risk of pancreatic cancer. A meta-analysis of cohort studies. Eur J Cancer. 2011;47:1928-1937.
12. Loren L, Antonella Z, et al. Diabetes mellitus, other medical conditions and pancreatic cancer: a case-control study. Diabetes Metab Res Rev. 2011;27:255-261.
13. Christine H, Wasif SM. Diabetes and pancreatic cancer. J Pancreas. 2011;12:330-333.
14. Gbelcová H, Lenícek M, Zelenka J, et al. Differences in antitumour effects of various statins on human pancreatic cancer. Int J Cancer. 2008;122:1214-1221.
15. Laufs U, Adam O. Acute effect of statins. J Am Coll Cardiol. 2012;59:71-73.
16. Bu DX, Griffin G, Lichtman AH. Mechanisms for the anti-inflammatory effects of statins. Curr Opin Lipidol. 2011;22:165-170.
17. Bonovas S, Filioussi K, Sitaras NM. Statins are not associated with a reduced risk of pancreatic cancer at the population level, when taken at low doses for managing hypercholesterolaemia: evidence from a meta-analysis of 12 studies. Am J Gastroenterol. 2008;103:2646-2651.
18. Khurana V, Sheth A, Caldito G, et al. Statins reduce the risk of pancreatic cancer in humans: a case-control study of half a million veterans. Pancreas. 2007;34:260-265.
19. Bradley MC, Hughes CM, Cantwell MM, Murray LJ. Statins and pancreatic cancer: a nested case-control study. Cancer Causes Control. 2010;21:2093-2100.
20. American Cancer Society, American Joint Committee on Cancer (AJCC). Pancreatic Cancer Staging, 7th ed. New York: Springer. 2010.
21. Li D, Xie K, Wolff R, et al. Pancreatic cancer. Lancet. 2004;363:1049-1057.
22. Stamm JA, Ornstein DL. The role of statins in cancer prevention and treatment. Oncology (Williston Park). 2005;19:735-750.
23. Schmid R, et al. HMG-CoA reductase inhibitors for the treatment of pancreatic cancer. Gastroenterology. 2002;122:565-567.
24. Newman A, Clutterbuck RD, et al. A comparison of the effect of the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors simvastatin, Iovastatin and pravastatin on leukemic and normal bone marrow progenitors. Leuk Lymphoma. 1997;24:533-537.
25. Kusama T, Mukai M, et al. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors reduce human pancreatic cancer cell invasion and metastasis. Gastroenterology. 2002;122:308-317.
26. Kusama T, Mukai M, Iwasaki T, et al. Inhibition of epidermal growth factor-induced RhoA translocation and invasion of human pancreatic cancer cells by 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. Cancer Res. 2001;61:4885-4891.
27. Adhami VM. Pancreatic cancer and inflammation. Am J Biomed Sci. 2010;2:322-328.
28. Pala FS, Gurkan H. The role of free radicals in the ethiopathogenesis of diseases. Adv Mol Biol. 2008;1:1-9.
29. Whitcomb DC. Inflammation and cancer V. Chronic pancreatitis and pancreatic cancer. Am J Physiol Gastrointest Liver Physiol. 2004;287:315-319.
30. Banim P, Luben R, et al. Dietary antioxidants and the aetiology of pancreatic cancer: a cohort study using data from food diaries and biomarkers. Gut. 2012. doi: 10.1136/gutjnl-2011-301908.
31. Hamilton PK, Hughes SM, Plumb RD, et al. Statins have beneficial effect on platelet free radical activity and intracellular distribution of GTPases in hyperlipidaemia. Clin Sci. 2010;118:359-366.
32. Hippisley-Cox J. Unintended effects of statins in men and women in England and Wales: population based cohort study using QResearch database. Br Med J. 2010;340:2197.
33. Thun MJ, Jacobs EJ, Patrono C. The role of aspirin in cancer prevention. Nat Rev Clin Oncol. 2012;9:259-267.
34. Diabetes UK. Reports and Statistics. Diabetes in the UK 2012. http://www.diabetes.org.uk/Professionals/Publications-reports-and-resources/ Reports-statistics-and-case-studies/Reports/Diabetes-in-the-UK-2012/. Accessed 4 July 2013.