Expanding the library and substrate diversity of the pyrrolysyl-tRNA synthetase to incorporate unnatural amino acids containing conjugated rings

ChemBioChem

Volumn 14, Issue 16, 2013, Pages 2100-2105

  Lacey, Vanessa K ^a   Louie, Gordon V ^a   Noel, Joseph P ^a,b   Wang, Lei ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Directed evolution; Genetic code expansion; Pyrrolysine; Small intelligent library; Unnatural amino acids

Indexed keywords

AMINO ACID; HYDROGEN; PYRROLYSYL TRANSFER RNA SYNTHETASE; TYROSINE TRANSFER RNA LIGASE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; ELECTROSPRAY; FLOW CYTOMETRY; GENE LIBRARY; HUMAN; HYDROGEN BOND; ION TRAP MASS SPECTROMETRY; METHANOSARCINA MAZEI; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL;

MAMMALIA;

DIRECTED EVOLUTION; GENETIC CODE EXPANSION; PYRROLYSINE; SMALL-INTELLIGENT LIBRARY; UNNATURAL AMINO ACIDS;

AMINO ACIDS; AMINO ACYL-TRNA SYNTHETASES; ANIMALS; DIRECTED MOLECULAR EVOLUTION; ESCHERICHIA COLI; GENE LIBRARY; GENETIC CODE; LYSINE; MYOGLOBIN; SUBSTRATE SPECIFICITY; WHALES;

EID: 84889603974     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201300400     Document Type: Article

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