Synthesis and antiproliferative activity of new derivatives containing the polycyclic system 5,7:7,13-dimethanopyrazolo[3,4-b]pyrazolo[3′,4′:2, 3]azepino[4,5-f]azocine

European Journal of Medicinal Chemistry

Volumn 72, Issue , 2014, Pages 1-9

  Maggio, Benedetta ^a   Raffa, Demetrio ^a   Raimondi, Maria Valeria ^a   Cusimano, Maria Grazia ^a   Plescia, Fabiana ^a   Cascioferro, Stella ^a   Cancemi, Gabriella ^a   Lauricella, Marianna ^a   Carlisi, Daniela ^a   Daidone, Giuseppe ^a  

^a UNIVERSITY OF PALERMO   (Italy)

Author keywords

5,7:7,13 Dimethanopyrazolo 3,4 b pyrazolo 3 ,4 :2,3 azepino 4, 5 f azocine derivatives; Antiproliferative activity; G0 G1 arrest; pRb

Indexed keywords

1 (4 CHLOROPHENYL) N,3 DIMETHYL 1H PYRAZOL 5 AMINE; 1 (4 METHOXYPHENYL) N,3 DIMETHYL 1H PYRAZOL 5 AMINE; 1,4,5,8,11,13A HEPTAMETHYL 3,9 DIPHENYL 3,4,5,6,6A,8,9,12,13,13A DECAHYDRO 5,7:7,13 DIMETHANOPYRAZOLO[3,4 B]PYRAZOLO[3',4':2,3]AZEPINO[4,5 F]AZOCINE; 1,4,5,8,11,13A HEXAMETHYL 12 METHYLENE 3,9 DI P TOLYL 3,4,5,6,6A,8,9,12,13,13A DECAHYDRO 5,7:7,13 DIMETHANOPYRAZOLO[3,4 B]PYRAZOLO[3',4':2,3]AZEPINO[4,5 F]AZOCINE; 3,9 BIS(3 CHLOROPHENYL) 1,4,5,8,11,13A HEXAMETHYL 12 METHYLENE 3,4,5,6,6A,8,9,12,13,13A DECAHYDRO 5,7:7,13 DIMETHANOPYRAZOLO[3,4 B]PYRAZOLO[3',4':2,3]AZEPINO[4,5 F]AZOCINE; 3,9 BIS(4 CHLOROPHENYL) 1,4,5,8,11,13A HEXAMETHYL 12 METHYLENE 3,4,5,6,6A,8,9,12,13,13A DECAHYDRO 5,7:7,13 DIMETHANOPYRAZOLO[3,4 B]PYRAZOLO[3',4':2,3]AZEPINO[4,5 F]AZOCINE; 3,9 BIS(4 METHOXYPHENYL) 1,4,5,8,11,13A HEPTAMETHYL 12 METHYLENE 3,4,5,6,6A,8,9,12,13,13A DECAHYDRO 5,7:7,13 DIMETHANOPYRAZOLO[3,4 B]PYRAZOLO[3',4':2,3]AZEPINO[4,5 F]AZOCINE; 3,9 BIS(4 METHOXYPHENYL) 1,4,5,8,11,13A HEXAMETHYL 12 METHYLENE 3,4,5,6,6A,8,9,12,13,13A DECAHYDRO 5,7:7,13 DIMETHANOPYRAZOLO[3,4 B]PYRAZOLO[3',4':2,3]AZEPINO[4,5 F]AZOCINE; 3,9 DIPHENYL 1,4,5,8,11,13A HEXAMETHYL 12 METHYLENE 3,4,5,6,6A,8,9,12,13A DECAHYDRO 5,7:7,13 DIMETHANOPYRAZOLO[3,4 B]PYRAZOLO[3',4':2,3]AZEPINO[4,5 F]AZOCINE; 4,5,8,13A TETRAMETHYL 12 METHYLENE 1,3,9,11 TETRAPHENYL 3,4,5,6,6A,8,9,12,13,13A DECAHYDRO 5,7:7,13 DIMETHANOPYRAZOLO[3,4 B]PYRAZOLO[3',4':2,3]AZEPINO[4,5 F]AZOCINE; ACTIVATED CARBON; ANTINEOPLASTIC AGENT; AZOCINE DERIVATIVE; HYDROGEN; N [1 (4 CHLOROPHENYL) 3 METHYL 1H PYRAZOL 5 YL] N METHYLACETAMIDE; N [1 (4 METHOXYPHENYL) 3 METHYL 1H PYRAZOL 5 YL] N METHYLACETAMIDE; PALLADIUM; UNCLASSIFIED DRUG; FUSED HETEROCYCLIC RINGS; POLYCYCLIC HYDROCARBON;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BRAIN CANCER; BREAST CANCER; COLON CANCER; CONTROLLED STUDY; DRUG SYNTHESIS; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; KIDNEY CANCER; LEUKEMIA; LUNG CANCER; LUNG NON SMALL CELL CANCER; MELANOMA; OVARY CANCER; PROSTATE CANCER; WESTERN BLOTTING; CELL CYCLE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; HL 60 CELL LINE; K562 CELL LINE; MCF 7 CELL LINE; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HL-60 CELLS; HUMANS; K562 CELLS; MCF-7 CELLS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; POLYCYCLIC COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84889593319     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.11.016     Document Type: Article

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