Expression of integrin alpha 10 is transcriptionally activated by pRb in mouse osteoblasts and is downregulated in multiple solid tumors

Cell Death and Disease

Volumn 4, Issue 11, 2013, Pages

  Engel, B E ^a   Welsh, E ^a   Emmons, M F ^a   Santiago Cardona, P G ^b   Cress, W D ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b PONCE SCHOOL OF MEDICINE   (Puerto Rico)

Author keywords

Integrin; Oestosarcoma; pRb

Indexed keywords

ALPHA INTEGRIN; ALPHA INTEGRIN 10; COLLAGEN BINDING PROTEIN; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F1; TRANSCRIPTION FACTOR E2F3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL CYCLE REGULATION; CELL MEMBRANE; DOWN REGULATION; MOUSE; MULTIPLE CANCER; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOBLAST; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SOLID TUMOR; TRANSCRIPTION INITIATION; TRANSCRIPTION INITIATION SITE; UPREGULATION;

ANIMALS; ANTIGENS, CD; BREAST NEOPLASMS; E2F1 TRANSCRIPTION FACTOR; E2F3 TRANSCRIPTION FACTOR; INTEGRIN ALPHA CHAINS; INTEGRIN BETA4; LUNG NEOPLASMS; MELANOMA; MICE; OSTEOBLASTS; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; RETINOBLASTOMA PROTEIN;

EID: 84889591794     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.461     Document Type: Article

References (38)

1. Knudsen ES, Wang JYJ. Targeting the RB-pathway in cancer therapy. Clin Cancer Res 2010; 16: 1094-1099
2. Batsche E, Muchardt C, Behrens J, Hurst HC, Cremisi C. RB and c-Myc activate expression of the E-cadherin gene in epithelial cells through interaction with transcription factor AP-2. Mol Cell Biol 1998; 18: 3647-3658
3. Nead MA, Baglia LA, Antinore MJ, Ludlow JW, McCance DJ. Rb binds c-Jun and activates transcription. EMBO J 1998; 17: 2342-2352
4. Decary S, Decesse JT, Ogryzko V, Reed JC, Naguibneva I, Harel-Bellan A, et al. The retinoblastoma protein binds the promoter of the survival gene bcl-2 and regulates its transcription in epithelial cells through transcription factor AP-2. Mol Cell Biol 2002; 22: 7877-7888
5. Decesse JT, Medjkane S, Datto MB, Cremisi CE. RB regulates transcription of the p21/WAF1/CIP1 gene. Oncogene 2001; 20: 962-971
6. Nam EH, Lee Y, Park YK, Lee JW, Kim S. ZEB2 upregulates integrin alpha 5 expression through cooperation with Sp1 to induce invasion during epithelial-mesenchymal transition of human cancer cells. Carcinogenesis 2012; 33: 563-571
7. Van Aken EH, Papeleu P, De Potter P, Bruyneel E, Philippe J, Seregard S, et al. Structure and function of the N-cadherin/catenin complex in retinoblastoma. Invest Ophthalmol Vis Sci 2002; 43: 595-602
8. Kashima T, Kawaguchi J, Takeshita S, Kuroda M, Takanashi M, Horiuchi H, et al. Anomalous cadherin expression in osteosarcoma-possible relationships to metastasis and morphogenesis. Am J Pathol 1999; 155: 1549-1555
9. Rodriguez-Salas N, Palacios J, de Castro J, Moreno G, Gonzalez-Baron M, Gamallo C. Beta-catenin expression pattern in small cell lung cancer: Correlation with clinical and evolutive features. Histol and Histopathol 2001; 16: 353-358
10. Sosa-Garcia B, Gunduz V, Vazquez-Rivera V, Cress WD, Wright G, Bian H, et al. A role for the retinoblastoma protein as a regulator of mouse osteoblast cell adhesion: Implications for osteogenesis and osteosarcoma formation. PLoS One 2010; 5: 11
11. Guo WJ, Giancotti FG. Integrin signalling during tumour progression. Nat Rev Mol Cell Biol 2004; 5: 816-826
12. Barczyk M, Carracedo S, Gullberg D. Integrins. Cell Tissue Res 2010; 339: 269-280
13. Camper L, Hellman U, Lundgren-Akerlund E. Isolation, cloning, and sequence analysis of the integrin subunit alpha10, a beta1-Associated collagen binding integrin expressed on chondrocytes. J Biol Chem 1998; 273: 20383-20389
14. Camper L, Holmvall K, Wangnerud C, Aszodi A, Lundgren-Akerlund E. Distribution of the collagen-binding integrin alpha10beta1 during mouse development. Cell Tissue Res 2001; 306: 107-116
15. Varas L, Ohlsson LB, Honeth G, Olsson A, Bengtsson T, Wiberg C, et al. Alpha10 integrin expression is up-regulated on fibroblast growth factor-2-Treated mesenchymal stem cells with improved chondrogenic differentiation potential. Stem Cells Dev 2007; 16: 965-978
16. Bengtsson T, Aszodi A, Nicolae C, Hunziker EB, Lundgren-Akerlund E, Fassler R. Loss of alpha10beta1 integrin expression leads to moderate dysfunction of growth plate chondrocytes. J Cell Sci 2005; 118(Pt 5): 929-936
17. Croxton R, Ma Y, Cress WD. Differences in DNA binding properties between E2F1 and E2F4 specify repression of the Mcl-1 promoter. Oncogene 2002; 21: 1563-1570
18. Stark C, Breitkreutz BJ, Chatr-Aryamontri A, Boucher L, Oughtred R, Livstone MS, et al. The BioGRID Interaction Database: 2011 update. Nucleic Acids Res 2011; 39, Database issue D698-D704
19. Cartharius K, Frech K, Grote K, Klocke B, Haltmeier M, Klingenhoff A, et al. Matlnspector and beyond: Promoter analysis based on transcription factor binding sites. Bioinformatics 2005; 21: 2933-2942
20. Quandt K, Frech K, Karas H, Wingender E, Werner T. MatInd and MatInspector: New fast and versatile tools for detection of consensus matches in nucleotide sequence data. Nucleic Acids Res 1995; 23: 4878-4884
21. Wan X, Kim SY, Guenther LM, Mendoza A, Briggs J, Yeung C, et al. Beta4 integrin promotes osteosarcoma metastasis and interacts with ezrin. Oncogene 2009; 28: 3401-3411
22. Richardson AL, Wang ZGC, De Nicolo A, Lu X, Brown M, Miron A, et al. X chromosomal abnormalities in basal-like human breast cancer. Cancer Cell 2006; 9: 121-132
23. Haqq C, Nosrati M, Sudilovsky D, Crothers J, Khodabakhsh D, Pulliam BL, et al. The gene expression signatures of melanoma progression. Proc Natl Acad Sci U S A 2005; 102: 6092-6097
24. Hou J, Aerts J, den Hamer B, van IJcken W, den Bakker M, Riegman P, et al. Gene expression-based classification of non-small cell lung carcinomas and survival prediction. PLoS One 2010; 5: 4
25. Dyrskjot L, Kruhoffer M, Thykjaer T, Marcussen N, Jensen JL, Moller K, et al. Gene expression in the urinary bladder: A common carcinoma in situ gene expression signature exists disregarding histopathological classification. Cancer Res 2004; 64: 4040-4048
26. Jones J, Otu H, Spentzos D, Kolia S, Inan M, Beecken WD, et al. Gene signatures of progression and metastasis in renal cell cancer. Clin Cancer Res 2005; 11: 5730-5739
27. Landi MT, Dracheva T, Rotunno M, Figueroa JD, Liu H, Dasgupta A, et al. Gene Expression Signature of Cigarette Smoking and Its Role in Lung Adenocarcinoma Development and Survival. PLoS One 2008; 3: 2
28. Kaiser S, Park YK, Franklin JL, Halberg RB, Yu M, Jessen WJ, et al. Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. Genome Biol 2007; 8: 7
29. Sellers WR, Novitch BG, Miyake S, Heith A, Otterson GA, Kaye FJ, et al. Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth. Genes Dev 1998; 12: 95-106
30. Johnson JL, Pillai S, Pernazza D, Sebti SM, Lawrence NJ, Chellappan SP. Regulation of matrix metalloproteinase genes by E2F transcription factors: Rb-Raf-1 interaction as a novel target for metastatic disease. Cancer Res 2012; 72: 516-526
31. Wang CG, Hou XH, Mohapatra S, Ma YH, Cress WD, Pledger WJ, et al. Activation of p27(Kip1) expression by E2F1-A negative feedback mechanism. J Biol Chem 2005; 280: 12339-12343
32. Knudsen ES, Wang JY. Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation. Mol Cell Biol 1997; 17: 5771-5783
33. He Y, Armanious MK, Thomas MJ, Cress WD. Identification of E2F-3B, an alternative form of E2F-3 lacking a conserved N-Terminal region. Oncogene 2000; 19: 3422-3433
34. Ghosh N, Gyory I, Wright G, Wood J, Wright KL. Positive regulatory domain I binding factor 1 silences class II transactivator expression in multiple myeloma cells. J Biol Chem 2001; 276: 15264-15268
35. Flores AM, Kassatly RF, Cress WD. E2F-3 accumulation is regulated by polypeptide stability. Oncogene 1998; 16: 1289-1298
36. Chen L, Chen DT, Kurtyka C, Rawal B, Fulp WJ, Haura EB, et al. Tripartite motif containing 28 (Trim28) can regulate cell proliferation by bridging HDAC1/E2F interactions. J Biol Chem 2012; 287: 40106-40118
37. Hazlehurst LA, Valkov N, Wisner L, Storey JA, Boulware D, Sullivan DM, et al. Reduction in drug-induced DNA double-strand breaks associated with beta1 integrin-mediated adhesion correlates with drug resistance in U937 cells. Blood 2001; 98: 1897-1903
38. Eschrich SA, Hoerter AM. Libaffy: Software for processing Affymetrix GeneChip data. Bioinformatics 2007; 23: 1562-1564