Retinal vascular parameter variations in patients with human immunodeficiency virus

Investigative Ophthalmology and Visual Science

Volumn 54, Issue 13, 2013, Pages 7962-7967

  Tan, Petrina B ^a   Hee, Owen K ^a   Cheung, Carol ^b,d   Yeo, Tun Kuan ^a   Agrawal, Rupesh ^a   Ng, James ^a   Lim, Tock Han ^a   Wong, Tien Yin ^b,c   Teoh, Stephen C ^a  

^a TAN TOCK SENG HOSPITAL   (Singapore)

^b SINGAPORE EYE RESEARCH INSTITUTE   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d DUKE NUS MEDICAL SCHOOL   (Singapore)

Author keywords

HIV; Retinal vasculature; Tortuosity

Indexed keywords

ADULT; ARTICLE; CASE CONTROL STUDY; CD4 LYMPHOCYTE COUNT; CLINICAL EXAMINATION; CONTROLLED STUDY; EYE PHOTOGRAPHY; FEMALE; FOLLOW UP; FUNDUS CAMERA; HEMODYNAMIC PARAMETERS; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RETINA BLOOD FLOW; RETINAL VASCULAR BRANCHING; RETINAL VASCULAR CALIBER; RETINAL VASCULAR FRACTAL DIMENSION; RETINAL VASCULAR TORTUOSITY; VIRUS LOAD;

HIV; RETINAL VASCULATURE; TORTUOSITY;

ADULT; ARTERIOLES; FEMALE; FOLLOW-UP STUDIES; HIV; HIV INFECTIONS; HUMANS; MALE; MICROCIRCULATION; MIDDLE AGED; RETINAL VESSELS; RETROSPECTIVE STUDIES; RNA, VIRAL; VENULES;

EID: 84889563324     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.13-13081     Document Type: Article

References (38)

1. UNAIDS Global Progress Report. Global AIDS response progress reporting. 2011. Available at: http://www.unaids.org/en/ dataanalysis/knowyourresponse/globalaidsprogressreporting. Accessed September 30, 2012.
2. Wong TY, Klein R, Sharett AR, et al. Retinal arteriolar narrowing and risk of diabetes mellitus in middle-aged persons. JAMA. 2002;287:2528-2533.
3. Sasongko MB, Wang JJ, Donaghue KC, et al. Alterations in retinal microvascular geometry in young type 1 diabetes. Diabetes Care. 2010;33:1331-1336.
4. Wong TY, Shankar A, Klein R, et al. Retinal arteriolar narrowing, hypertension, and subsequent risk of diabetes mellitus. Arch Intern Med. 2005;165:1060-1065.
5. Cheung C, Tay WT, Mitchell P, et al. Quantitative and qualitative retinal microvascular characteristics and blood pressure. J Hypertens. 2011;29:1380-1391.
6. Patton N, Aslam TM, MacGillivray T, et al. Retinal image analysis: concepts, applications and potential. Prog Retin Eye Res. 2006;25:99-127.
7. Lai TY, Wong RL, Luk FO, et al. Ophthalmic manifestations and risk factors for mortality of HIV patients in the post-highly active anti-retroviral therapy era. Clin Experiment Ophthalmol. 2011;39:99-104.
8. Wang Z, Jia R, Ge S, et al. Ocular complications of human immunodeficiency virus infection in eastern china. Am J Ophthalmol. 2012;153:363-369.
9. Loo AV, Sujaya S, Peyman M, et al. Retinal manifestations of patients with human immunodeficiency virus, a multiethnics study in Malaysia. Int J Ophthalmol. 2011;4:641-643.
10. Gangaputra S, Kalyani PS, Fawzi AA, et al; Studies of the Ocular Complications of AIDS Research Group. Retinal vessel caliber among people with acquired immunodeficiency syndrome: relationships with disease-associated factors and mortality. Am J Ophthalmol. 2012;153:434-444.
11. Jochmans D. Novel HIV-1 reverse transcriptase inhibitors. Virus Res. 2008;134:171-185.
12. Cheung N, Tong L, Tikellis G, et al. Relationship of retinal vascular caliber with optic disc diameter in children. Invest Ophthalmol Vis Sci. 2007;48:4945-4948.
13. Cheung CY, Tay WT, Mitchell P, et al. Quantitative and qualitative retinal microvascular characteristics and blood pressure. J Hypertens. 2011;29:1380-1391.
14. Zamir M, Medeiros JA, Cunningham TK. Arterial bifurcations in the human retina. J Gen Physiol. 1979;74:537-548.
15. Liew G, Wang JJ, Cheung N, et al. The retinal vasculature as a fractal: methodology, reliability, and relationship to blood pressure. Ophthalmology. 2008;115:1951-1956.
16. Mainster MA. The fractal properties of retinal vessels: embryological and clinical implications. Eye. 1990;4:235-241.
17. Hart WE, Goldbaum M, Cote B, et al. Measurement and classification of retinal vascular tortuosity. Int J Med Inform. 1999;53:239-252.
18. Knudtson MD, Lee KE, Hubbard LD, et al. Revised formulas for summarizing retinal vessel diameters. Curr Eye Res. 2003;27: 143-149.
19. Ministry of Health Singapore. Update on the HIV/AIDS situation in Singapore. 2010. Available at: http://www.moh. gov.sg/mohcorp/diseases.aspx?id1/4420. Accessed September 30, 2012.
20. Boone MI, Farber ME, Jovanovic-Peterson L, Peterson CM. Increased retinal vascular tortuosity in gestational diabetes mellitus. Ophthalmology. 1989;96:251-254.
21. Incorvaia C, Parmeggiani F, Costagliola C, et al. Quantitative evaluation of the retinal venous tortuosity in chronic anaemic patients affected by beta-thalassaemia major. Eye. 2003;17: 324-329.
22. Cheung CY, Zheng Y, Hsu W, et al. Retinal vascular tortuosity, blood pressure, and cardiovascular risk factors. Ophthalmology. 2011;118:812-818.
23. Hellstrom A, Hard AL, Chen Y, et al. Ocular fundus morphology in preterm children: influence of gestational age, birth size, perinatal morbidity, and postnatal growth. Invest Ophthalmol Vi Sci. 1997; 38:1184-1192.
24. Ong YT, De Silva DA, Cheung CY, et al. Microvascular structure and network in the retina of patients with ischemic stroke. Stroke. 2013;44:2121-2127.
25. Cheung CY, Ong S, Ikram MK, et al. Retinal vascular fractal dimension is associated with cognitive dysfunction. J Stroke Cerebrovasc Dis. 2012; pii: S1052-S3057(12)00309-6.
26. Grinspoon S, Carr A. Cardiovascular risk and body-fat abnormalities in HIV-infected adults. N Engl J Med. 2005; 352:48-62.
27. Ren Z, Yao Q, Chen C. HIV-1 envelope glycoprotein 120 increases intercellular adhesion molecule-1 expression by human endothelial cells. Lab Invest. 2002;82:245-255.
28. Mavroudis CA, Majumder B, Loizides S, et al. Coronary artery disease and HIV; getting to the HAART of the matter. Int J Cardiol. 2013;167:1147-1153.
29. Griffith TM, Edwards DH, Davies RL, et al. EDRF coordinates the behaviour of vascular resistance vessels. Nature. 1987; 329:442-445.
30. Gidday JM, Zhu Y. Endothelium-dependent changes in retinal blood flow following ischemia. Curr Eye Res. 1998;17:798-807.
31. Goldman D, Popel AS. A computational study of the effect of capillary network anastomoses and tortuosity on oxygen transport. J Theor Biol. 2000;206:181-194.
32. Kim A, Dadgostar H, Holland GN, et al. Hemorheologic abnormalities associated with HIV infection: altered erythrocyte aggregation and deformability. Invest Ophthalmol Vis Sci. 2006;47:3927-3932.
33. Dadgostar H, Holland GN, Huang X, et al. Hemorheologic abnormalities associated with HIV infection: in vivo assessment of retinal microvascular blood flow. Invest Ophthalmol Vis Sci. 2006;47:3933-3938.
34. Nagaoka T, Yoshida A. Noninvasive evaluation of wall shear stress on retinal microcirculation in humans. Invest Ophthalmol Vis Sci. 2006;47:1113-1119.
35. Tufail A, Holland GN, Fisher TC, et al. Increased polymorphonuclear leucocyte rigidity in HIV infected individuals. Br J Ophthalmol. 2000;84:727-731.
36. Ho BC, Laudette-Aboulhab J, Se-Thoe SY, et al. Correlation of baseline quantitative plasma human immunodeficiency (HIV) type 1 RNA viral load with clinical status and CD4+ T-cell counts in treatment-naïve HIV-positive patients in Singapore. Ann Acad Med Singapore. 2000;29:708-713.
37. Pathai S, Weiss HA, Lawn SD, et al. Retinal arterioles narrow with increasing duration of anti-retroviral therapy in HIV infection: A novel estimator of vascular risk in HIV? PLoS One. 2012;7:e51405.
38. Stein JH, Klein MA, Bellehumeur JL, et al. Use of human immunodeficiency virus-1 protease inhibitors is associated with atherogenic lipoprotein changes and endothelial dysfunction. Circulation. 2001;104:257-262.