Correlation of baseline quantitative plasma human immunodeficiency (HIV) type 1 RNA viral load with clinical status and CD4+ T-cell counts in treatment-naïve HIV-positive patients in Singapore

Annals of the Academy of Medicine Singapore

Volumn 29, Issue 6, 2000, Pages 708-713

  Ho, Bch ^a   Laudette Aboulhab, J ^a   Se Thoe, S Y ^b   Chan, S P ^a   Ling, A E ^b   Leo, Y S ^a  

^a TAN TOCK SENG HOSPITAL   (Singapore)

^b SINGAPORE GENERAL HOSPITAL   (Singapore)

Author keywords

AIDS; HIV 1 infection; Reverse transcriptase polytnerase chain reaction

Indexed keywords

VIRUS RNA;

ADULT; AGED; ARTICLE; BLOOD; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; COMPARATIVE STUDY; FEMALE; HOSPITALIZATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; ISOLATION AND PURIFICATION; MALE; MIDDLE AGED; PROBABILITY; PROGNOSIS; REFERENCE VALUE; RETROSPECTIVE STUDY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; SINGAPORE; VIROLOGY; VIRUS LOAD;

ADULT; AGED; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; MALE; MIDDLE AGED; PROBABILITY; PROGNOSIS; REFERENCE VALUES; RETROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, VIRAL; SENSITIVITY AND SPECIFICITY; SEVERITY OF ILLNESS INDEX; SINGAPORE; VIRAL LOAD;

EID: 0034330463     PISSN: 03044602     EISSN: 29724066     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. O'Brien W A, Hartigan P M, Martin D, Esinhart J, Hill A, Benoit S, et al. Changes in plasma HIV-1 RNA and CD4+ lymphocyte counts and the risk of progression to AIDS. N Engl J Med 1996; 334:426-31.
2. Mellors J W, Rinaldo C R Jr, Gupta P, White R M, Todd J A, Kingsley L A. Prognosis in HIV-1 infection predicted by the quantity of virus in plasma. Science 1996; 272:1167-70.
3. Katzenstein D A, Hammer S M, Hughes M D, Gundacker H, Jackson J B, Fiscus S, et al. The relation of virologie and immunologic markers to clinical outcomes after nucleoside therapy in HIV-infected adults with 200 to 500 CD4 cells per cubic millimeter. N Engl J Med 1996; 335:1091-8.
4. Ho D D, Neumann A U, Perelson A S, Wen C, Leonard J M, Markowitz M. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 1995; 373:123-6.
5. Wei X, Ghosh S K, Taylor M E, Johnson V A, Emini E A, Deutsch P, et al. Viral dynamics in human immunodefiency virus type 1 infection. Nature 1995; 373:117-22.
6. Steketee R W, Abrams E J, Thea D M, Brown T M, Lambert G, Orloff S, et al. Early detection of perinatal human immunodeficiency virus (HIV) type 1 infection using HIV RNA amplification and detection. J Infect Dis 1997; 175:707-11.
7. Centers for Disease Control and Prevention. 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. MMWR 1992; 41(RR-17).
8. Roche Diagnostic Systems. Amplicor HIV-1 Monitor Test version 1.5. Product insert.
9. Parekh B, Phillips S, Granade T C, Baggs J, Hu D J, Respess R. Impact of HIV type 1 subtype variation on viral RNA quantitation. AIDS Res Hum Retroviruses 1999; 15:133-42.
10. Triques K, Coste J, Perret J L, Segarra C, Mpoudi E, Reynes J, et al. Efficiencies of four versions of the Amplicor HIV-1 Monitor test for quantification of different subtypes of human immunodeficiency virus type 1. J Clin Microbiol 1999; 37:110-6.
11. Michael N L, Herman S A, Kwok S, Dreyer K, Wong J, Christopherson C, et al. Development of calibrated viral load standards for group M subtypes of human immunodeficiency virus type 1 and performance of an improved AMPLICOR HIV-1 MONITOR test with isolate of diverse subtypes. J Clin Microbiol 1999; 37:2557-63.
12. Clark S J, Saag M S, Decker WD, Campbell-Hill S, Roberson J L, Veldkamp P J, et al. High titers of cytopathic virus in plasma of patients with symptomatic primary HIV-1 infection. N Engl J Med 1991; 324:954-60.
13. Daar E S, Moudgil T, Meyer R, Ho D D. Transient high levels of viremia in patients with primary human immunodeficiency virus type 1 infection. N Engl J Med 1991; 324:961-4.
14. Fauci A S, Schnittman S M, Poli G, Koenig S, Pantaleo G. Immunopathogenic mechanisms in human immunodeficiency virus (HIV) infection. Ann Intern Med 1991; 114:678-93.
15. Bowen D L, Lane H C, Fauci A S. Immunopathogenesis of the acquired immunodeficiency syndrome. Ann Intern Med 1985; 103:704-9.
16. Coste J, Montes B, Reynes J, Peeters M, Segarra C, Vendrell J P, et al. Comparative evaluation of three assays for the quantitation of human immunodeficiency virus type 1 RNA in plasma. J Med Virol 1996; 50:293-302.
17. Hodara V, Monticelli A, Pampuro S, Salomon H, Jauregui Rueda H, Libonatti O. HIV-1 viral load: comparative evaluation of three commercially available assays in Argentina. Acta Physiol Pharmacol Ther Latinoam 1998; 48:107-13.
18. Holguin A, de Mendoza C, Soriano V. Comparison of three different commercial methods for measuring plasma viraemia in patients infected with non-B HIV-1 subtypes. Eur J Clin Microbiol Infect Dis 1999; 18:256-9.
19. Se-Thoe S Y, Lin R V T P, Ling A E, Oh H M L, Monteiro E H,Snodgrass I, et al. Genotype characterisation of human immunodeficiency virus Type 1 (HIV-1). SGH Proceedings 1996; 5:33-7.
20. Se-Thoe S Y, Foley B T, Chan S Y, Lin R V T P, Oh H M L, Ling A E, et al. Analysis of sequence diversity in the C2-V3 regions of the external glycoproteins of HIV Type 1 in Singapore. AIDS Res Hum Retrovirus 1998; 14:1601-4.
21. Panel on Clinical Practices for Treatment of HIV Infection. Guidelines for the use of antiretroviral agents in HI V-infected adults and adolescents. US: Department of Health and Human Services and the Henry J Kaiser Family Foundation, May 5 1999.
22. Schnittman S M, Greenhouse J J, Psallidopoulos M C, Baseler M, Salzman N P, Fauci A S, et al. Increasing viral burden in CD4+ T cells from patients with human immunodeficiency virus (HIV) infection reflects rapidly progressive immunosuppression and clinical disease. Ann Intern Med 1990; 113:438-43.