메뉴 건너뛰기




Volumn 37, Issue 5, 2013, Pages 357-364

Rationale and prospects of serum immunoglobulin free light chain (FLC) determination in chronic inflammatory disease;Razionale e prospettive della determinazione delle catene leggere libere del siero nelle patologie infiammatorie croniche

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN FREE LIGHT CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; UNCLASSIFIED DRUG;

EID: 84889246846     PISSN: 03930564     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (4)

References (78)
  • 1
    • 0001959377 scopus 로고
    • Papers on chemical pathology: Lecture III
    • Bence Jones H. Papers on chemical pathology: lecture III. Lancet 1847;2:88-92.
    • (1847) Lancet , vol.2 , pp. 88-92
    • Bence Jones, H.1
  • 2
    • 0001003335 scopus 로고
    • On immunity with special reference to cell life
    • Ehrlich P. On immunity with special reference to cell life. Proc Roy Soc Lond 1900;66:424-48.
    • (1900) Proc Roy Soc Lond , vol.66 , pp. 424-448
    • Ehrlich, P.1
  • 3
    • 85001403499 scopus 로고
    • An electrophoretic study of immune sera and purified antibody preparations
    • Tiselius A, Kabat EA. An electrophoretic study of immune sera and purified antibody preparations. J Exp Med 1939;69:119-31.
    • (1939) J Exp Med , vol.69 , pp. 119-131
    • Tiselius, A.1    Kabat, E.A.2
  • 4
    • 0006246988 scopus 로고
    • Proteins in multiple myeloma. III. Origin of Bence Jones protein
    • Putnam FW, Hardy S. Proteins in multiple myeloma. III. Origin of Bence Jones protein. J Biol Chem 1955;212:361-9.
    • (1955) J Biol Chem , vol.212 , pp. 361-369
    • Putnam, F.W.1    Hardy, S.2
  • 5
    • 0014690827 scopus 로고
    • Polymeric forms of free normal kappa and lambda chains of human immunoglobulin
    • Berggård I, Peterson PA. Polymeric forms of free normal kappa and lambda chains of human immunoglobulin. J Biol Chem 1969;244:4299-307.
    • (1969) J Biol Chem , vol.244 , pp. 4299-4307
    • Berggård, I.1    Peterson, P.A.2
  • 6
    • 73049153504 scopus 로고
    • The nature of Bence Jones proteins: Chemical similarities to polypeptide chains of myeloma globulins and normal γ-globulins
    • Edelman GM, Gaily JA. The nature of Bence Jones proteins: chemical similarities to polypeptide chains of myeloma globulins and normal γ-globulins. J Exp Med 1962;116:202-27.
    • (1962) J Exp Med , vol.116 , pp. 202-227
    • Edelman, G.M.1    Gaily, J.A.2
  • 7
    • 0015928987 scopus 로고
    • Structural studies of immunoglobulins
    • Porter RR. Structural studies of immunoglobulins. Science 1973;180:713-6.
    • (1973) Science , vol.180 , pp. 713-716
    • Porter, R.R.1
  • 8
    • 0016907440 scopus 로고
    • Bence Jones proteins and light chains of immunoglobulins (first of two parts)
    • Solomon A. Bence Jones proteins and light chains of immunoglobulins (first of two parts). N Engl J Med 1976;294:17-23.
    • (1976) N Engl J Med , vol.294 , pp. 17-23
    • Solomon, A.1
  • 9
    • 0018627528 scopus 로고
    • Free light chains of immunoglobulins in amyloidosis
    • Sølling J, Sølling K. Free light chains of immunoglobulins in amyloidosis. Acta Med Scand 1979;206:283-7.
    • (1979) Acta Med Scand , vol.206 , pp. 283-287
    • Sølling, J.1    Sølling, K.2
  • 10
    • 0013797229 scopus 로고
    • Immunological quantitation of antigens by single radial immunodiffusion
    • Mancini G, Carbonara AO, Heremans JF. Immunological quantitation of antigens by single radial immunodiffusion. Immunochemistry 1965;2:235-54.
    • (1965) Immunochemistry , vol.2 , pp. 235-254
    • Mancini, G.1    Carbonara, A.O.2    Heremans, J.F.3
  • 11
    • 0016826844 scopus 로고
    • Free light chains of immunoglobulins in normal serum and urine determined by radioimmunoassay
    • SøIling K. Free light chains of immunoglobulins in normal serum and urine determined by radioimmunoassay. Scand J Clin Lab Invest 1975;35:407-12.
    • (1975) Scand J Clin Lab Invest , vol.35 , pp. 407-412
    • SøIling, K.1
  • 12
    • 0020470654 scopus 로고
    • Radioimmunoassay of free light chains of immunoglobulins in urine
    • Robinson EL, Gowland E, Ward ID, et al. Radioimmunoassay of free light chains of immunoglobulins in urine. Clin Chem 1982;28:2254-8.
    • (1982) Clin Chem , vol.28 , pp. 2254-2258
    • Robinson, E.L.1    Gowland, E.2    Ward, I.D.3
  • 14
    • 0025884695 scopus 로고
    • Immunoturbidimetric assay for estimating free light chains of immunoglobulins in urine and serum
    • Tillyer CR, Iqbal J, Raymond J, et al. Immunoturbidimetric assay for estimating free light chains of immunoglobulins in urine and serum. J Clin Pathol 1991;44:466-71.
    • (1991) J Clin Pathol , vol.44 , pp. 466-471
    • Tillyer, C.R.1    Iqbal, J.2    Raymond, J.3
  • 15
    • 0026582793 scopus 로고
    • Studies of Bence Jones proteins by immunonephelometry
    • Levinson SS. Studies of Bence Jones proteins by immunonephelometry. Ann Clin Lab Sci 1992;22:100-9.
    • (1992) Ann Clin Lab Sci , vol.22 , pp. 100-109
    • Levinson, S.S.1
  • 16
    • 0345024535 scopus 로고
    • Polymerism, polymorphism, and impurities in Bence-Jones proteins
    • Bernier GM, Putnam FW. Polymerism, polymorphism, and impurities in Bence-Jones proteins. Biochim Biophys Acta 1964;86:295-308.
    • (1964) Biochim Biophys Acta , vol.86 , pp. 295-308
    • Bernier, G.M.1    Putnam, F.W.2
  • 17
    • 0016998398 scopus 로고
    • Polymeric forms of free light chains in serum from normal individuals and from patients with renal diseases
    • Sølling K. Polymeric forms of free light chains in serum from normal individuals and from patients with renal diseases. Scand J Clin Lab Invest 1976;36:447-52.
    • (1976) Scand J Clin Lab Invest , vol.36 , pp. 447-452
    • Sølling, K.1
  • 18
    • 0028125256 scopus 로고
    • Free light chains of immunoglobulins: Clinical laboratory analysis
    • Levinson SS, Keren DF. Free light chains of immunoglobulins: clinical laboratory analysis. Clin Chem 1994;40:1869-78.
    • (1994) Clin Chem , vol.40 , pp. 1869-1878
    • Levinson, S.S.1    Keren, D.F.2
  • 19
    • 0035063345 scopus 로고    scopus 로고
    • Highly sensitive, automated immunoassay for immunoglobulin free light chains in serum and urine
    • Bradwell AR, Carr-Smith HD, Mead GP, et al. Highly sensitive, automated immunoassay for immunoglobulin free light chains in serum and urine. Clin Chem 2001;47:673-80
    • (2001) Clin Chem , vol.47 , pp. 673-680
    • Bradwell, A.R.1    Carr-Smith, H.D.2    Mead, G.P.3
  • 20
    • 84863755369 scopus 로고    scopus 로고
    • Extended use of serum free light chain as a biomarker in lymphoproliferative disorders: A comprehensive review
    • Charafeddine KM, Jabbour MN, Kadi RH, et al . Extended use of serum free light chain as a biomarker in lymphoproliferative disorders: a comprehensive review. Am J Clin Pathol 2012;137:890-7.
    • (2012) Am J Clin Pathol , vol.137 , pp. 890-897
    • Charafeddine, K.M.1    Jabbour, M.N.2    Kadi, R.H.3
  • 21
    • 77957689357 scopus 로고    scopus 로고
    • La misura delle catene leggere libere delle immunoglobuline nel siero: Aspetti analitici e clinici
    • Albertini R, Merlini G. La misura delle catene leggere libere delle immunoglobuline nel siero: aspetti analitici e clinici. Biochim Clin 2010;34:26-9.
    • (2010) Biochim Clin , vol.34 , pp. 26-29
    • Albertini, R.1    Merlini, G.2
  • 22
    • 60149096306 scopus 로고    scopus 로고
    • International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders
    • Dispenzieri A, Kyle RA, Merlini GP, et al. International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders. Leukemia 2009;23:215-24.
    • (2009) Leukemia , vol.23 , pp. 215-224
    • Dispenzieri, A.1    Kyle, R.A.2    Merlini, G.P.3
  • 23
    • 80051727075 scopus 로고    scopus 로고
    • N Latex FLC - New monoclonal high performance assays for the determination of free light chain κ and λ
    • Te Velthuis H, Knop I, Tam P, et al. N Latex FLC - new monoclonal high performance assays for the determination of free light chain κ and λ. Clin Chem Lab Med 2011;49:1323-32.
    • (2011) Clin Chem Lab Med , vol.49 , pp. 1323-1332
    • Te Velthuis, H.1    Knop, I.2    Tam, P.3
  • 24
    • 0014019613 scopus 로고
    • Synthesis of excess light chains of γ globulin by rabbit lymph node cells
    • Shapiro AL. Synthesis of excess light chains of γ globulin by rabbit lymph node cells. Nature 1966;211:243-5.
    • (1966) Nature , vol.211 , pp. 243-245
    • Shapiro, A.L.1
  • 25
    • 5644264939 scopus 로고    scopus 로고
    • Purification and characterization of a stimulator of plasmin generation from the antiangiogenic agent Neovastat: Identification as immunoglobulin kappa light chain
    • Boivin D, Provençal M, Gendron S, et al. Purification and characterization of a stimulator of plasmin generation from the antiangiogenic agent Neovastat: identification as immunoglobulin kappa light chain. Arch Biochem Biophys 2004;431:197-206.
    • (2004) Arch Biochem Biophys , vol.431 , pp. 197-206
    • Boivin, D.1    Provençal, M.2    Gendron, S.3
  • 26
    • 0028127014 scopus 로고
    • Proteolytic activity of an antibody light chain
    • Sun M, Gao QS, Li L, et al. Proteolytic activity of an antibody light chain. J Immunol 1994;153:5121-6.
    • (1994) J Immunol , vol.153 , pp. 5121-5126
    • Sun, M.1    Gao, Q.S.2    Li, L.3
  • 27
    • 0034732941 scopus 로고    scopus 로고
    • Monoclonal antibody light chain with prothrombinase activity
    • Thiagarajan P, Dannenbring R, Matsuura K, et al. Monoclonal antibody light chain with prothrombinase activity. Biochemistry 2000;39:6459-65.
    • (2000) Biochemistry , vol.39 , pp. 6459-6465
    • Thiagarajan, P.1    Dannenbring, R.2    Matsuura, K.3
  • 28
    • 0032875669 scopus 로고    scopus 로고
    • Nephritogenic lambda light chain dimer: A unique human miniautoantibody against complement factor H
    • Jokiranta TS, Solomon A, Pangburn MK, et al. Nephritogenic lambda light chain dimer: a unique human miniautoantibody against complement factor H. J Immunol 1999;163:4590-6.
    • (1999) J Immunol , vol.163 , pp. 4590-4596
    • Jokiranta, T.S.1    Solomon, A.2    Pangburn, M.K.3
  • 29
    • 0037383839 scopus 로고    scopus 로고
    • Immunoglobulin free light chains and mast cells: Pivotal role in T-cell-mediated immune reactions?
    • Redegeld FA, Nijkamp FP. Immunoglobulin free light chains and mast cells: pivotal role in T-cell-mediated immune reactions? Trends Immunol 2003;24:181-5
    • (2003) Trends Immunol , vol.24 , pp. 181-185
    • Redegeld, F.A.1    Nijkamp, F.P.2
  • 30
    • 0035854524 scopus 로고    scopus 로고
    • Building novel binding ligands to B7.1 and B7.2 based on human antibody single variable light chain domains
    • Van den Beucken T, Van Neer N, Sablon E, et al. Building novel binding ligands to B7.1 and B7.2 based on human antibody single variable light chain domains. J Mol Biol 2001;310:591-601.
    • (2001) J Mol Biol , vol.310 , pp. 591-601
    • Van Den Beucken, T.1    Van Neer, N.2    Sablon, E.3
  • 31
    • 0021806879 scopus 로고
    • Binding of N-formylated chemotactic peptides in crystals of the Mcg light chain dimer: Similarities with neutrophil receptors
    • Edmundson AB, Ely KR. Binding of N-formylated chemotactic peptides in crystals of the Mcg light chain dimer: similarities with neutrophil receptors. Mol Immunol 1985;22:463-75.
    • (1985) Mol Immunol , vol.22 , pp. 463-475
    • Edmundson, A.B.1    Ely, K.R.2
  • 32
    • 0023226209 scopus 로고
    • The binding of opioid peptides to the Mcg light chain dimer: Flexible keys and adjustable locks
    • Edmundson AB, Ely KR, Herron JN, et al. The binding of opioid peptides to the Mcg light chain dimer: flexible keys and adjustable locks. Mol Immunol 1987;24:915-35.
    • (1987) Mol Immunol , vol.24 , pp. 915-935
    • Edmundson, A.B.1    Ely, K.R.2    Herron, J.N.3
  • 33
    • 0036065632 scopus 로고    scopus 로고
    • Immunoglobulin-free light chains elicit immediate hypersensitivity-like responses
    • Redegeld FA, van der Heijden MW, Kool M, et al. Immunoglobulin-free light chains elicit immediate hypersensitivity-like responses. Nat Med 2002;8:694-701.
    • (2002) Nat Med , vol.8 , pp. 694-701
    • Redegeld, F.A.1    Van Der Heijden, M.W.2    Kool, M.3
  • 34
    • 0036433583 scopus 로고    scopus 로고
    • Endocytosis of light chains induces cytokines through activation of NFkappaB in human proximal tubule cells
    • Sengul S, Zwizinski C, Simon EE, et al. Endocytosis of light chains induces cytokines through activation of NFkappaB in human proximal tubule cells. Kidney Int 2002;62:1977-88.
    • (2002) Kidney Int , vol.62 , pp. 1977-1988
    • Sengul, S.1    Zwizinski, C.2    Simon, E.E.3
  • 35
    • 2342459810 scopus 로고    scopus 로고
    • Different types of glomerulopathic light chains interact with mesangial cells using a common receptor but exhibit different intracellular trafficking patterns
    • Teng J, Russell WJ, Gu X, et al. Different types of glomerulopathic light chains interact with mesangial cells using a common receptor but exhibit different intracellular trafficking patterns. Lab Invest 2004;84:440-51.
    • (2004) Lab Invest , vol.84 , pp. 440-451
    • Teng, J.1    Russell, W.J.2    Gu, X.3
  • 36
    • 33947183940 scopus 로고    scopus 로고
    • Conventional light chains inhibit the autonomous signaling capacity of the B cell receptor
    • Meixlsperger S, Köhler F, Wossning T, et al. Conventional light chains inhibit the autonomous signaling capacity of the B cell receptor. Immunity 2007;26:323-33.
    • (2007) Immunity , vol.26 , pp. 323-333
    • Meixlsperger, S.1    Köhler, F.2    Wossning, T.3
  • 37
    • 80053423537 scopus 로고    scopus 로고
    • Polyclonal immunoglobulin free light chains as a potential biomarker of immune stimulation and inflammation
    • Hutchison CA, Landgren O. Polyclonal immunoglobulin free light chains as a potential biomarker of immune stimulation and inflammation. Clin Chem 2011;57:1387-9
    • (2011) Clin Chem , vol.57 , pp. 1387-1389
    • Hutchison, C.A.1    Landgren, O.2
  • 38
    • 0013958519 scopus 로고
    • Increase of L-chain proteins in the sera of patients with systemic lupus erythematosus and the synovial fluids of patients with peripheral rheumatoid arthritis
    • Epstein WV, Tan M. Increase of L-chain proteins in the sera of patients with systemic lupus erythematosus and the synovial fluids of patients with peripheral rheumatoid arthritis. Arthritis Rheum 1966;9:713-9.
    • (1966) Arthritis Rheum , vol.9 , pp. 713-719
    • Epstein, W.V.1    Tan, M.2
  • 39
    • 0014353171 scopus 로고
    • Free immunoglobulin light chains in connective tissue diseases
    • Cooper A, Bluestone R. Free immunoglobulin light chains in connective tissue diseases. Ann Rheum Dis 1968;27:537-43.
    • (1968) Ann Rheum Dis , vol.27 , pp. 537-543
    • Cooper, A.1    Bluestone, R.2
  • 40
    • 0019420691 scopus 로고
    • Free light chains of immunoglobulins in serum from patients with rheumatoid arthritis, sarcoidosis, chronic infections and pulmonary cancer
    • Sølling K, Sølling J, Rømer FK. Free light chains of immunoglobulins in serum from patients with rheumatoid arthritis, sarcoidosis, chronic infections and pulmonary cancer. Acta Med Scand 1981;209:473-7.
    • (1981) Acta Med Scand , vol.209 , pp. 473-477
    • Sølling, K.1    Sølling, J.2    Rømer, F.K.3
  • 41
    • 33846001611 scopus 로고    scopus 로고
    • Serum immunoglobulin free light chain assessment in rheumatoid arthritis and primary Sjögren syndrome
    • Gottenborg JE, Aucouturier F, Goetz J, et al. Serum immunoglobulin free light chain assessment in rheumatoid arthritis and primary Sjögren syndrome. Ann Rheum Dis 2007;66:23-7.
    • (2007) Ann Rheum Dis , vol.66 , pp. 23-27
    • Gottenborg, J.E.1    Aucouturier, F.2    Goetz, J.3
  • 42
    • 0034082664 scopus 로고    scopus 로고
    • Urine free light chains in SLE: Clonal markers of B-cell activity and potential link to in vivo secreted Ig
    • Hopper JE, Golbus J, Meyer C, et al. Urine free light chains in SLE: clonal markers of B-cell activity and potential link to in vivo secreted Ig. J Clin Immunol 2000;20:123-37.
    • (2000) J Clin Immunol , vol.20 , pp. 123-137
    • Hopper, J.E.1    Golbus, J.2    Meyer, C.3
  • 43
    • 0024431465 scopus 로고
    • Clinical relapse in systemic lupus erythematosus: Correlation with antecedent elevation of urinary free light chain immunoglobulin
    • Hopper JE, Sequeira W, Martellotto J, et al. Clinical relapse in systemic lupus erythematosus: correlation with antecedent elevation of urinary free light chain immunoglobulin. J Clin Immunol 1989;9:338-50.
    • (1989) J Clin Immunol , vol.9 , pp. 338-350
    • Hopper, J.E.1    Sequeira, W.2    Martellotto, J.3
  • 44
    • 79958842178 scopus 로고    scopus 로고
    • Serum free light chains as biomarker for systemic lupus erythematus disease activity
    • Aggarwal R, Sequeira W, Kokebie R, et al. Serum free light chains as biomarker for systemic lupus erythematus disease activity. Arthritis Care Res 2011;63:891-8.
    • (2011) Arthritis Care Res , vol.63 , pp. 891-898
    • Aggarwal, R.1    Sequeira, W.2    Kokebie, R.3
  • 45
    • 33749331884 scopus 로고    scopus 로고
    • Long-term comparison of rituximab treatment for refractory systemic lupus erythematosus and vasculitis
    • Smith KGC, Jones RB, Burns SM, et al. Long-term comparison of rituximab treatment for refractory systemic lupus erythematosus and vasculitis. Arthitis Rheum 2006;54:2970-82.
    • (2006) Arthitis Rheum , vol.54 , pp. 2970-2982
    • Smith, K.G.C.1    Jones, R.B.2    Burns, S.M.3
  • 46
    • 79959733511 scopus 로고    scopus 로고
    • Normalization of serum free light chains in patients with systemic lupus erythematosus upon rituximab treatment and correlation with biological disease activity
    • Chice L, Cournac JM, Mancini J, et al. Normalization of serum free light chains in patients with systemic lupus erythematosus upon rituximab treatment and correlation with biological disease activity. Clin Rheumatol 2011;30:685-9.
    • (2011) Clin Rheumatol , vol.30 , pp. 685-689
    • Chice, L.1    Cournac, J.M.2    Mancini, J.3
  • 47
    • 78649748637 scopus 로고    scopus 로고
    • Decrease in immunoglobulin free light chains in patients with rheumatoid arthritis upon rituximab (anti-CD20) treatment correlates with decrease in disease activity
    • Groot Kormelink T, Tekstra J, Thurlings RM, et al. Decrease in immunoglobulin free light chains in patients with rheumatoid arthritis upon rituximab (anti-CD20) treatment correlates with decrease in disease activity. Ann Rheum Dis 2010;69:2137-44.
    • (2010) Ann Rheum Dis , vol.69 , pp. 2137-2144
    • Groot Kormelink, T.1    Tekstra, J.2    Thurlings, R.M.3
  • 48
    • 0036065632 scopus 로고    scopus 로고
    • Immunoglobulin-free light chains elicit immediate hypersensitivity-like responses
    • Redegeld FA, van der Heijden MW, Kool M, et al. Immunoglobulin-free light chains elicit immediate hypersensitivity-like responses. Nat Med 2002;8:694-701.
    • (2002) Nat Med , vol.8 , pp. 694-701
    • Redegeld, F.A.1    Van Der Heijden, M.W.2    Kool, M.3
  • 49
    • 33644746124 scopus 로고    scopus 로고
    • Free immunoglobulin light chains as target in the treatment of chronic inflammatory diseases
    • Van der Heijden M, Kraneveld A, Redegeld F. Free immunoglobulin light chains as target in the treatment of chronic inflammatory diseases. Eur J Pharmacol 2006;533:319-26.
    • (2006) Eur J Pharmacol , vol.533 , pp. 319-326
    • Van Der Heijden, M.1    Kraneveld, A.2    Redegeld, F.3
  • 50
    • 41349097051 scopus 로고    scopus 로고
    • Free immunoglobulin light chains: A novel target in the therapy of inflammatory diseases
    • Thio M, Blokhuis BR, Nijkamp FP, et al. Free immunoglobulin light chains: a novel target in the therapy of inflammatory diseases. Trends Pharmacol Sci 2008;29:170-4.
    • (2008) Trends Pharmacol Sci , vol.29 , pp. 170-174
    • Thio, M.1    Blokhuis, B.R.2    Nijkamp, F.P.3
  • 51
    • 33846411787 scopus 로고    scopus 로고
    • Topical application of F991, an immunoglobulin free light chain antagonist, prevents development of contact sensitivity in mice
    • van Houwelingen AH, Kaczynska K, Kraneveld AD, et al. Topical application of F991, an immunoglobulin free light chain antagonist, prevents development of contact sensitivity in mice. Clin Exp Allergy 2007;37:270-5.
    • (2007) Clin Exp Allergy , vol.37 , pp. 270-275
    • Van Houwelingen, A.H.1    Kaczynska, K.2    Kraneveld, A.D.3
  • 52
    • 0037103337 scopus 로고    scopus 로고
    • Key role for mast cells in nonatopic asthma
    • Kraneveld AD, van der Kleij HP, Kool M, et al. Key role for mast cells in nonatopic asthma. J Immunol 2002;169:2044-53.
    • (2002) J Immunol , vol.169 , pp. 2044-2053
    • Kraneveld, A.D.1    Van Der Kleij, H.P.2    Kool, M.3
  • 53
    • 13444255985 scopus 로고    scopus 로고
    • Elicitation of allergic asthma by immunoglobulin free light chains
    • Kraneveld AD, Kool M, van Houwelingen AH, et al. Elicitation of allergic asthma by immunoglobulin free light chains. Proc Natl Acad Sci USA 2005;102:1578-83.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 1578-1583
    • Kraneveld, A.D.1    Kool, M.2    Van Houwelingen, A.H.3
  • 54
    • 73149092965 scopus 로고    scopus 로고
    • Evidence for the involvement of free light chain immunoglobulins in allergic and nonallergic rhinitis
    • Powe DG, Groot Kormelink T, Sisson M, et al. Evidence for the involvement of free light chain immunoglobulins in allergic and nonallergic rhinitis. J Allergy Clin Immunol 2010;125:139-45.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 139-145
    • Powe, D.G.1    Groot Kormelink, T.2    Sisson, M.3
  • 55
    • 77949926027 scopus 로고    scopus 로고
    • Serum immunoglobulin free light chains in severe forms of atopic dermatitis
    • Kayserova J, Capkova S, Skalicka A, et al. Serum immunoglobulin free light chains in severe forms of atopic dermatitis. Scand J Immunol 2010;71:312-6.
    • (2010) Scand J Immunol , vol.71 , pp. 312-316
    • Kayserova, J.1    Capkova, S.2    Skalicka, A.3
  • 56
    • 80053326660 scopus 로고    scopus 로고
    • Immunoglobulin free light chains are increased in hypersensitivity pneumonitis and idiopathic pulmonary fibrosis
    • Groot Kormelink T, Pardo A, Knipping K, et al. Immunoglobulin free light chains are increased in hypersensitivity pneumonitis and idiopathic pulmonary fibrosis. PLoS One 2011;6:e25392.
    • (2011) PLoS One , vol.6
    • Groot Kormelink, T.1    Pardo, A.2    Knipping, K.3
  • 57
    • 84860182720 scopus 로고    scopus 로고
    • An association between neutrophils and immunoglobulin free light chains in the pathogenesis of chronic obstructive pulmonary disease
    • Braber S, Thio M, Blokhuis BR, et al. An association between neutrophils and immunoglobulin free light chains in the pathogenesis of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2012;185:817-24.
    • (2012) Am J Respir Crit Care Med , vol.185 , pp. 817-824
    • Braber, S.1    Thio, M.2    Blokhuis, B.R.3
  • 58
    • 77952875538 scopus 로고    scopus 로고
    • Contribution of IgE and immunoglobulin free light chain in the allergic reaction to cow's milk proteins
    • Schouten B, van Esch BC, van Thuijl AO, et al. Contribution of IgE and immunoglobulin free light chain in the allergic reaction to cow's milk proteins. J Allergy Clin Immunol 2010;125:1308-14.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 1308-1314
    • Schouten, B.1    Van Esch, B.C.2    Van Thuijl, A.O.3
  • 59
    • 2342591290 scopus 로고    scopus 로고
    • Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003
    • Johansson SG, Bieber T, Dahl R, et al. Revised nomenclature for allergy for global use: report of the Nomenclature Review Committee of the World Allergy Organization, October 2003. J Allergy Clin Immunol 2004;113:832-6.
    • (2004) J Allergy Clin Immunol , vol.113 , pp. 832-836
    • Johansson, S.G.1    Bieber, T.2    Dahl, R.3
  • 60
    • 84863991530 scopus 로고    scopus 로고
    • Role of serum free light chains in predicting HIV-associated non-Hodgkin lymphoma and Hodgkin's lymphoma and its correlation with antiretroviral therapy
    • ICONA Foundation Study Group
    • Bibas M, Trotta MP, Cozzi-Lepri A, et al. ICONA Foundation Study Group. Role of serum free light chains in predicting HIV-associated non-Hodgkin lymphoma and Hodgkin's lymphoma and its correlation with antiretroviral therapy. Am J Hematol 2012;87:749-53.
    • (2012) Am J Hematol , vol.87 , pp. 749-753
    • Bibas, M.1    Trotta, M.P.2    Cozzi-Lepri, A.3
  • 61
    • 77951679420 scopus 로고    scopus 로고
    • Immunologic and virologic predictors of AIDS-related non-Hodgkin lymphoma in the highly active antiretroviral therapy era
    • Engels EA, Pfeiffer RM, Landgren O, et al. Immunologic and virologic predictors of AIDS-related non-Hodgkin lymphoma in the highly active antiretroviral therapy era. J Acquir Immune Defic Syndr 2010;54:78-84.
    • (2010) J Acquir Immune Defic Syndr , vol.54 , pp. 78-84
    • Engels, E.A.1    Pfeiffer, R.M.2    Landgren, O.3
  • 62
    • 77649208373 scopus 로고    scopus 로고
    • Circulating serum free light chains as predictive markers of AIDSrelated lymphoma
    • Landgren O, Goedert JJ, Rabkin CS, et al. Circulating serum free light chains as predictive markers of AIDSrelated lymphoma. J Clin Oncol 2010;28:773-9.
    • (2010) J Clin Oncol , vol.28 , pp. 773-779
    • Landgren, O.1    Goedert, J.J.2    Rabkin, C.S.3
  • 63
    • 34250665021 scopus 로고    scopus 로고
    • Hepatitis C virus-related lymphoproliferative disorders: An overview
    • Zignego AL, Giannini C, Ferri C. Hepatitis C virus-related lymphoproliferative disorders: an overview. World J Gastroenterol 2007;13:2467-78.
    • (2007) World J Gastroenterol , vol.13 , pp. 2467-2478
    • Zignego, A.L.1    Giannini, C.2    Ferri, C.3
  • 64
    • 84875373355 scopus 로고    scopus 로고
    • Hepatitis C virus infection and autoimmune diseases
    • Paroli M, Iannucci G, Accapezzato D. Hepatitis C virus infection and autoimmune diseases. Int J Gen Med 2012;5:903-7.
    • (2012) Int J Gen Med , vol.5 , pp. 903-907
    • Paroli, M.1    Iannucci, G.2    Accapezzato, D.3
  • 65
    • 84879605861 scopus 로고    scopus 로고
    • B-cell frequency in HCV-related mixed cryoglobulinemia
    • Sansonno D, Russi S, Conteduca V, et al. B-cell frequency in HCV-related mixed cryoglobulinemia. Hepatology 2013;58:448.
    • (2013) Hepatology , vol.58 , pp. 448
    • Sansonno, D.1    Russi, S.2    Conteduca, V.3
  • 66
    • 19944429080 scopus 로고    scopus 로고
    • Incidence and characteristics of non-Hodgkin lymphomas in a multicenter case file of patients with hepatitis C virusrelated symptomatic mixed cryoglobulinemias
    • Monti G, Pioltelli P, Saccardo F, et al. Incidence and characteristics of non-Hodgkin lymphomas in a multicenter case file of patients with hepatitis C virusrelated symptomatic mixed cryoglobulinemias. Arch Intern Med 2005;165:101-5.
    • (2005) Arch Intern Med , vol.165 , pp. 101-105
    • Monti, G.1    Pioltelli, P.2    Saccardo, F.3
  • 67
    • 58349119131 scopus 로고    scopus 로고
    • Serum free light chain assessment in hepatitis C virus-related lymphoproliferative disorders
    • Terrier B, Sene D, Saadoun D, et al. Serum free light chain assessment in hepatitis C virus-related lymphoproliferative disorders. Ann Rheum Dis 2009;68:89-93.
    • (2009) Ann Rheum Dis , vol.68 , pp. 89-93
    • Terrier, B.1    Sene, D.2    Saadoun, D.3
  • 68
    • 77952422318 scopus 로고    scopus 로고
    • Effects of free immunoglobulin light chains on viral myocarditis
    • Matsumori A, Shimada M, Jie X, et al. Effects of free immunoglobulin light chains on viral myocarditis. Circ Res 2010;106:1533-40.
    • (2010) Circ Res , vol.106 , pp. 1533-1540
    • Matsumori, A.1    Shimada, M.2    Jie, X.3
  • 69
    • 0023394216 scopus 로고
    • Free light chains in multiple sclerosis and infections of the CNS
    • DeCarli C, Menegus MA, Rudick RA. Free light chains in multiple sclerosis and infections of the CNS. Neurology 1987;37:1334-8.
    • (1987) Neurology , vol.37 , pp. 1334-1338
    • DeCarli, C.1    Menegus, M.A.2    Rudick, R.A.3
  • 70
    • 0017900589 scopus 로고
    • Determination of κ/λ immunoglobulin light chain ratios in CSF from patients with multiple sclerosis and other neurological diseases
    • Eickhoff K, Heipertz R, Wikström J. Determination of κ/λ immunoglobulin light chain ratios in CSF from patients with multiple sclerosis and other neurological diseases. Acta Neurol Scand 1978;57:385-95.
    • (1978) Acta Neurol Scand , vol.57 , pp. 385-395
    • Eickhoff, K.1    Heipertz, R.2    Wikström, J.3
  • 71
    • 0024362037 scopus 로고
    • Relative diagnostic value of cerebrospinal fluid kappa chains in MS: Comparison with other immunoglobulin tests
    • Rudick RA, French CA, Breton D, et al. Relative diagnostic value of cerebrospinal fluid kappa chains in MS: comparison with other immunoglobulin tests. Neurology 1989;39:964-8.
    • (1989) Neurology , vol.39 , pp. 964-968
    • Rudick, R.A.1    French, C.A.2    Breton, D.3
  • 72
    • 0021933155 scopus 로고
    • Multiple sclerosis: Free light chains in cerebrospinal fluid
    • Rudick RA, Peter DR, Bidlack JM, et al. Multiple sclerosis: free light chains in cerebrospinal fluid. Neurology 1985;35:1443-9.
    • (1985) Neurology , vol.35 , pp. 1443-1449
    • Rudick, R.A.1    Peter, D.R.2    Bidlack, J.M.3
  • 73
    • 0031664731 scopus 로고    scopus 로고
    • Intrathecal synthesis of free immunoglobulin light chains in multiple sclerosis
    • Krakauer M, Schaldemose Nielsen H, Jensen J et al. Intrathecal synthesis of free immunoglobulin light chains in multiple sclerosis. Acta Neurol Scand 1998;98:161-5.
    • (1998) Acta Neurol Scand , vol.98 , pp. 161-165
    • Krakauer, M.1    Schaldemose Nielsen, H.2    Jensen, J.3
  • 74
    • 4644307380 scopus 로고    scopus 로고
    • Kappa free light chains in cerebrospinal fluid as markers of intrathecal immunoglobulin synthesis
    • Fischer C, Arneth B, Koehler J, et al. Kappa free light chains in cerebrospinal fluid as markers of intrathecal immunoglobulin synthesis. Clin Chem 2004;50:1809-13.
    • (2004) Clin Chem , vol.50 , pp. 1809-1813
    • Fischer, C.1    Arneth, B.2    Koehler, J.3
  • 75
    • 56349116633 scopus 로고    scopus 로고
    • Elevated levels of kappa free light chains in CSF support the diagnosis of multiple sclerosis
    • Presslauer S, Milosavljevic D, Brücke T, et al. Elevated levels of kappa free light chains in CSF support the diagnosis of multiple sclerosis. J Neurol 2008;255:1508-14.
    • (2008) J Neurol , vol.255 , pp. 1508-1514
    • Presslauer, S.1    Milosavljevic, D.2    Brücke, T.3
  • 76
    • 84864828115 scopus 로고    scopus 로고
    • High levels of cerebrospinal fluid free kappa chains predict conversion to multiple sclerosis
    • Villar LM, Espiño M, Costa-Frossard L, et al. High levels of cerebrospinal fluid free kappa chains predict conversion to multiple sclerosis. Clin Chim Acta 2012;413:1813-6.
    • (2012) Clin Chim Acta , vol.413 , pp. 1813-1816
    • Villar, L.M.1    Espiño, M.2    Costa-Frossard, L.3
  • 77
    • 84875274795 scopus 로고    scopus 로고
    • Free light chains monomer-dimer patterns in the diagnosis of multiple sclerosis
    • Kaplan B, Golderman S, Yahalom G, et al. Free light chains monomer-dimer patterns in the diagnosis of multiple sclerosis. J Immunol Methods 2013;390:74-80.
    • (2013) J Immunol Methods , vol.390 , pp. 74-80
    • Kaplan, B.1    Golderman, S.2    Yahalom, G.3
  • 78
    • 0034256087 scopus 로고    scopus 로고
    • Evidence of cerebrospinal fluid free kappa light chains in AIDS patients with Toxoplasma gondii encephalitis
    • Contini C, Fainardi E, Cultrera R, et al. Evidence of cerebrospinal fluid free kappa light chains in AIDS patients with Toxoplasma gondii encephalitis. J Neuroimmunol 2000;108:221-6.
    • (2000) J Neuroimmunol , vol.108 , pp. 221-226
    • Contini, C.1    Fainardi, E.2    Cultrera, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.