Immunoglobulin free light chains are increased in hypersensitivity pneumonitis and idiopathic pulmonary fibrosis

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Kormelink, Tom Groot ^a   Pardo, Annie ^b   Knipping, Karen ^a,c   Buendía Roldán, Ivette ^d   García de Alba, Carolina ^d   Blokhuis, Bart R ^a   Selman, Moises ^d   Redegeld, Frank A ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^c DANONE RESEARCH   (Netherlands)

^d INSTITUTO NACIONAL DE ENFERMEDADES RESPIRATORIAS   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN FREE LIGHT CHAIN; IMMUNOGLOBULIN G; TRYPTASE; UNCLASSIFIED DRUG;

ADULT; AGED; ALLERGIC PNEUMONITIS; ARTICLE; B LYMPHOCYTE; BLOOD ANALYSIS; CELL ACTIVATION; CELL COUNT; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FIBROSING ALVEOLITIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG LAVAGE; LUNG PARENCHYMA; MALE; MAST CELL; MAST CELL ACTIVATION; PLASMA CELL;

ADULT; AGED; ALVEOLITIS, EXTRINSIC ALLERGIC; BRONCHOALVEOLAR LAVAGE FLUID; CASE-CONTROL STUDIES; FEMALE; GENE EXPRESSION REGULATION; HUMANS; IDIOPATHIC PULMONARY FIBROSIS; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN LIGHT CHAINS; LUNG; MALE; MAST CELLS; MIDDLE AGED; PLASMA CELLS; RESPIRATORY FUNCTION TESTS; TRYPTASES;

EID: 80053326660     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025392     Document Type: Article

References (42)

1. Selman M, (2010) Idiopathic interstitial pneumonias. In: Mason R, Broaddus V, editors. Murray & Nadal's Textbook of Respiratory Medicine Philadelphia Elsevier Inc pp. 1356-1397.
2. American Thoracic Society, European Respiratory Society (2002) American thoracic Society/European respiratory society international multidisciplinary consensus classification of the idiopathic interstitial pneumonias. this joint statement of the american thoracic society (ATS), and the european respiratory society (ERS) was adopted by the ATS board of directors, june 2001 and by the ERS executive committee, june 2001. Am J Respir Crit Care Med 165 (2): 277-304.
3. Selman M, King TE, Pardo A, (2001) Idiopathic pulmonary fibrosis: Prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Ann Intern Med 134 (2): 136-51.
4. Gross TJ, Hunninghake GW, (2001) Idiopathic pulmonary fibrosis. N Engl J Med 345 (7): 517-525.
5. Bjoraker JA, Ryu JH, Edwin MK, Myers JL, Tazelaar HD, et al. (1998) Prognostic significance of histopathologic subsets in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 157 (1): 199-203.
6. Selman M, (2004) Hypersensitivity pneumonitis: A multifaceted deceiving disorder. Clin Chest Med 25 (3): 531-47.
7. Fink JN, Ortega HG, Reynolds HY, Cormier YF, Fan LL, et al. (2005) Needs and opportunities for research in hypersensitivity pneumonitis. Am J Respir Crit Care Med 171 (7): 792-798.
8. Akashi T, Takemura T, Ando N, Eishi Y, Kitagawa M, et al. (2009) Histopathologic analysis of sixteen autopsy cases of chronic hypersensitivity pneumonitis and comparison with idiopathic pulmonary fibrosis/usual interstitial pneumonia. Am J Clin Pathol 131 (3): 405-415.
9. Churg A, Muller NL, Flint J, Wright JL, (2006) Chronic hypersensitivity pneumonitis. Am J Surg Pathol 30 (2): 201-208.
10. Barrera L, Mendoza F, Zuniga J, Estrada A, Zamora AC, et al. (2008) Functional diversity of T-cell subpopulations in subacute and chronic hypersensitivity pneumonitis. Am J Respir Crit Care Med 177 (1): 44-55.
11. Drent M, Wagenaar S, van Velzen-Blad H, Mulder PG, Hoogsteden HC, et al. (1993) Relationship between plasma cell levels and profile of bronchoalveolar lavage fluid in patients with subacute extrinsic allergic alveolitis. Thorax 48 (8): 835-9.
12. McSharry C, (2003) B lymphocytes in allergic alveolitis. Clin Exp Allergy 33 (2): 159-162.
13. Hunt LW, Colby TV, Weiler DA, Sur S, Butterfield JH, (1992) Immunofluorescent staining for mast cells in idiopathic pulmonary fibrosis: Quantification and evidence for extracellular release of mast cell tryptase. Mayo Clin Proc 67 (10): 941-8.
14. Inoue Y, KT E Jr, Barker E, Daniloff E, Newman LS, (2002) Basic fibroblast growth factor and its receptors in idiopathic pulmonary fibrosis and lymphangioleiomyomatosis. Am J Respir Crit Care Med 166 (5): 765-73.
15. Pesci A, Bertorelli G, Gabrielli M, Olivieri D, (1993) Mast cells in fibrotic lung disorders. Chest 103 (4): 989-96.
16. Pesci A, Bertorelli G, Olivieri D, (1991) Mast cells in bronchoalveolar lavage fluid and in transbronchial biopsy specimens of patients with farmer's lung disease. Chest 100 (5): 1197-202.
17. Soler P, Nioche S, Valeyre D, Basset F, Benveniste J, et al. (1987) Role of mast cells in the pathogenesis of hypersensitivity pneumonitis. Thorax 42 (8): 565-72.
18. Walls AF, Bennett AR, Godfrey RC, Holgate ST, Church MK, (1991) Mast cell tryptase and histamine concentrations in bronchoalveolar lavage fluid from patients with interstitial lung disease. Clin Sci (Lond) 81 (2): 183-8.
19. Akers IA, Parsons M, Hill MR, Hollenberg MD, Sanjar S, et al. (2000) Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2. Am J Physiol Lung Cell Mol Physiol 278 (1): L193-201.
20. Araya J, Nishimura SL, (2010) Fibrogenic reactions in lung disease. Annu Rev Pathol 5: 77-98.
21. Inoue Y, KT E Jr, Tinkle SS, Dockstader K, Newman LS, (1996) Human mast cell basic fibroblast growth factor in pulmonary fibrotic disorders. Am J Pathol 149 (6): 2037-54.
22. Redegeld FA, van der Heijden MW, Kool M, Heijdra BM, Garssen J, et al. (2002) Immunoglobulin-free light chains elicit immediate hypersensitivity-like responses. Nat Med 8 (7): 694-701.
23. Groot Kormelink T, Tekstra J, Thurlings RM, Boumans MH, Vos K, et al. (2010) Decrease in immunoglobulin free light chains in patients with rheumatoid arthritis upon rituximab (anti-CD20) treatment correlates with decrease in disease activity. Ann Rheum Dis 69: 2137-2144.
24. Rijnierse A, Redegeld FA, Blokhuis BR, Van der Heijden MW, Te Velde AA, et al. (2010) Ig-free light chains play a crucial role in murine mast cell-dependent colitis and are associated with human inflammatory bowel diseases. J Immunol 185 (1): 653-9.
25. Kraneveld AD, Kool M, van Houwelingen AH, Roholl P, Solomon A, et al. (2005) Elicitation of allergic asthma by immunoglobulin free light chains. Proc Natl Acad Sci U S A 102 (5): 1578-83.
26. Powe DG, Groot Kormelink T, Sisson M, Blokhuis BJ, Kramer MF, et al. (2010) Evidence for the involvement of free light chain immunoglobulins in allergic and nonallergic rhinitis. J Allergy Clin Immunol 125 (1): 139-45 e1-3.
27. [Anonymous] (2000) American Thoracic Society. idiopathic pulmonary fibrosis: Diagnosis and treatment. International consensus statement: American Thoracic Society (ATS), and the European Respiratory Society (ERS). Am J Respir Crit Care Med 161 (2 Pt 1): 646-664.
28. Katzenstein AL, Mukhopadhyay S, Myers JL, (2008) Diagnosis of usual interstitial pneumonia and distinction from other fibrosing interstitial lung diseases. Hum Pathol 39 (9): 1275-1294.
29. Gotway MB, Freemer MM, King TE Jr, (2007) Challenges in pulmonary fibrosis. 1: Use of high resolution CT scanning of the lung for the evaluation of patients with idiopathic interstitial pneumonias. Thorax 62 (6): 546-553.
30. Pardo A, Gibson K, Cisneros J, Richards TJ, Yang Y, et al. (2005) Up-regulation and profibrotic role of osteopontin in human idiopathic pulmonary fibrosis. PLoS Med 2 (9): e251.
31. Cohen G, Rudnicki M, Schmaldienst S, Horl WH, (2002) Effect of dialysis on serum/plasma levels of free immunoglobulin light chains in end-stage renal disease patients. Nephrol Dial Transplant 17 (5): 879-883.
32. Solling K, (1977) Normal values for free light chains in serum different age groups. Scand J Clin Lab Invest 37 (1): 21-5.
33. Wolff F, Thiry C, Willems D, (2007) Assessment of the analytical performance and the sensitivity of serum free light chains immunoassay in patients with monoclonal gammopathy. Clin Biochem 40 (5-6): 351-354 10.1016/j.clinbiochem.2006.11.011.
34. Ishida T, Matsui Y, Matsumura Y, Fujimori N, Furutani M, (1995) Bronchoalveolar mast cells in summer-type hypersensitivity pneumonitis: Increase in numbers and ultrastructural evidence of degranulation. Intern Med 34 (5): 357-63.
35. Bjermer L, Engstrom-Laurent A, Lundgren R, Rosenhall L, Hallgren R, (1988) Bronchoalveolar mastocytosis in farmer's lung is related to the disease activity. Arch Intern Med 148 (6): 1362-1365.
36. Galli SJ, Tsai M, (2008) Mast cells: Versatile regulators of inflammation, tissue remodeling, host defense and homeostasis. J Dermatol Sci 49 (1): 7-19.
37. Stewart JP, Egan JJ, Ross AJ, Kelly BG, Lok SS, et al. (1999) The detection of epstein-barr virus DNA in lung tissue from patients with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 159 (4 Pt 1): 1336-1341.
38. Tang YW, Johnson JE, Browning PJ, Cruz-Gervis RA, Davis A, et al. (2003) Herpesvirus DNA is consistently detected in lungs of patients with idiopathic pulmonary fibrosis. J Clin Microbiol 41 (6): 2633-2640.
39. Vannella KM, Moore BB, (2008) Viruses as co-factors for the initiation or exacerbation of lung fibrosis. Fibrogenesis Tissue Repair 1 (1): 2.
40. Matsumori A, Shimada M, Jie X, Higuchi H, Groot Kormelink T, et al. (2010) Effects of free immunoglobulin light chains on viral myocarditis. Circ Res 106 (9): 1533-40.
41. Rangel-Moreno J, Hartson L, Navarro C, Gaxiola M, Selman M, et al. (2006) Inducible bronchus-associated lymphoid tissue (iBALT) in patients with pulmonary complications of rheumatoid arthritis. J Clin Invest 116 (12): 3183-3194.
42. Holt PG, Strickland DH, Wikstrom ME, Jahnsen FL, (2008) Regulation of immunological homeostasis in the respiratory tract. Nat Rev Immunol 8 (2): 142-152.