Magic angle spinning NMR reveals sequence-dependent structural plasticity, dynamics, and the spacer peptide 1 conformation in HIV-1 capsid protein assemblies

Journal of the American Chemical Society

Volumn 135, Issue 47, 2013, Pages 17793-17803

  Han, Yun ^a,b   Hou, Guangjin ^a,b   Suiter, Christopher L ^a,b   Ahn, Jinwoo ^b   Byeon, In Ja L ^b   Lipton, Andrew S ^c   Burton, Sarah ^c   Hung, Ivan ^d   Gorkov, Peter L ^d   Gan, Zhehong ^d   Brey, William ^d   Rice, David ^e,f   Gronenborn, Angela M ^b   Polenova, Tatyana ^a,b  

^a UNIVERSITY OF DELAWARE   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

^d FLORIDA STATE UNIVERSITY   (United States)

^e AGILENT TECHNOLOGIES   (United States)

^f STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONAL PLASTICITY; MAGIC ANGLE SPINNING NMR; PROTEOLYTIC CLEAVAGE; RANDOM COIL CONFORMATION; RESONANCE ASSIGNMENTS; SEQUENCE-DEPENDENT; STRUCTURAL CHARACTERIZATION; TUBULAR ASSEMBLIES;

CONFORMATIONS; MAGIC ANGLE SPINNING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLASTICITY; TUBULAR STEEL STRUCTURES;

PEPTIDES;

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BEVIRIMAT; CAPSID PROTEIN; GAG PROTEIN; SPACER PEPTIDE 1; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS RNA;

ARTICLE; CONFOCAL MICROSCOPY; CRYOELECTRON MICROSCOPY; DRUG TARGETING; HUMAN IMMUNODEFICIENCY VIRUS 1; MAGIC ANGLE SPINNING NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; PROTEIN DEGRADATION; STRUCTURE ANALYSIS; TRANSMISSION ELECTRON MICROSCOPY; VIRION; VIRUS CAPSID; VIRUS GENOME; X RAY DIFFRACTION;

AMINO ACID SEQUENCE; CAPSID PROTEINS; GENE PRODUCTS, GAG; HIV INFECTIONS; HIV-1; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION;

EID: 84889245959     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja406907h     Document Type: Article

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