Structural consequences of cyclophilin a binding on maturational refolding in human immunodeficiency virus type 1 capsid protein

Journal of Virology

Volumn 75, Issue 10, 2001, Pages 4721-4733

  Dietrich, L ^a   Ehrlich, L S ^a   LaGrassa, T J ^a   Ebbets Reed, D ^a   Carter, C ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSID PROTEIN; CYCLOPHILIN A; GAG PROTEIN; VIRUS PROTEIN;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHEMICAL MODIFICATION; CONTROLLED STUDY; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; VIRION; VIRUS CAPSID; VIRUS INFECTION;

ANIMALS; CAPSID; CERCOPITHECUS AETHIOPS; COS CELLS; CYCLOPHILIN A; CYSTEINE; GENE PRODUCTS, GAG; HIV-1; HUMANS; MUTAGENESIS; PEPTIDES; PHENYLALANINE; PRECIPITIN TESTS; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN PRECURSORS; RECOMBINANT FUSION PROTEINS; SULFHYDRYL COMPOUNDS; TRYPTOPHAN;

EID: 0035027292     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.10.4721-4733.2001     Document Type: Article

References (51)

1. A putative α-helical structure which overlaps the capsid-p2 boundary in the human immunodeficiency virus type 1 Gag precursor is crucial for viral particle assembly
2. Cells with high cyclophilin A content support replication of human immunodeficiency virus type 1 Gag mutants with decreased ability to incorporate cyclophilin A
3. Cyclophilin A-induced alterations of human immunodeficiency virus type 1 CA protein in vitro
4. Pseudotyping human immunodeficiency virus type 1 (HIV-1) by the glycoprotein vesicular stomatitis virus targets HIV-1 entry to an endocytic pathway and suppresses both the requirement for Nef and the sensitivity to cyclosporin A
5. Cellular proteins bound to immunodeficiency viruses: Implications for pathogenesis and vaccines
6. Constitutive production of nonenveloped human immunodeficiency virus type 1 particles by a mammalian cell line and effects of a protease inhibitor on particle maturation
7. Head-to-tail dimers and interdomain flexibility revealed by the crystal structure of HIV-1 capsid protein (p24) complexed with a monoclonal antibody Fab
8. Cyclophilin A is required for an early step in the life cycle of human immunodeficiency virus type 1 before the initiation of reverse transcription
9. The hydrophobic pocket of cyclophilin is the binding site for the human immunodeficiency virus type 1 Gag polyprotein
10. Effect of cyclosporin A on the replication cycle of human immunodeficiency virus type 1 derived from H9 and Molt-4 producer cells
11. Human cyclophilin has a significantly higher affinity for HIV-1 recombinant p55 than p24
12. Transfer of the HIV-1 cyclophilin-binding site to simian immunodeficiency virus from Macaca mulatta can confer both cyclosporin sensitivity and cyclosporin dependence
13. Backbone dynamics of the N-terminal domain of the HIV-1 capsid protein comparison with the G94D mutant conferring cyclosporin resistance/dependence
14. Active site residues of cyclophilin A are crucial for its incorporation into human immunodeficiency virus type 1 virions
15. The major homology region of the HIV-1 Gag precursor influences membrane affinity
16. Partitioning of HIV-1 Gag and Gag-related proteins to membranes
17. Expression in Escherichia coli and purification of human immunodeficiency virus type 1 capsid protein (p24)
18. Maturation-induced conformational changes of HIV-1 capsid protein and identification of two high affinity sites for cyclophilins in the C-terminal domain
19. Specific incorporation of cyclophilin A into HIV-1 virions
20. Isomerase and chaperone activity of prolyl isomerase in the folding of carbonic anhydrase
21. Cryo-electron microscopy reveals ordered domains in the immature HIV-1 particles
22. Crystal structure of human cyclophilin A bound to the amino-terminal domain of HIV-1 capsid
23. Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein
24. Structure of the amino-terminal core domain of the HIV-1 capsid protein
25. Cyclophilin: A specific cytosolic binding protein for cyclosporin A
26. Assembly-defective point mutants of the human immunodeficiency virus type 1 Gag precursor phenotypically expressed in recombinant baculovirus-infected cells
27. Model for lentivirus capsid core assembly based on crystal dimers of EIAV p26
28. A method for determining transmembrane protein structure
29. Human immunodeficiency virus type 1 Gag proteins are processed in two cellular compartments
30. The X-ray structure of a tetrapeptide bound to the active site of human cyclophilin A
31. Crystal structure of recombinant human T-cell cyclophilin A at 2.5 Å resolution
32. Solution structure of the capsid protein from the human T-cell leukemia virus type 1
33. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
34. Human and Escherichia coli cyclophilins: Sensitivity to inhibition by the immunosuppressant cyclosporin A correlates with a specific tryptophan residue
35. Absconding with the chaperone: Essential cyclophilin-Gag interaction in HIV virions
36. Human immunodeficiency virus type 1 gag protein binds to cyclophilins A and B
37. Structural analysis of human immunodeficiency virus type 1 Gag protein interactions, using cysteine-specific reagents
38. Crystal structure of dimeric HIV-1 capsid protein
39. Fullerene-like organization of the HIV-1 gag-protein shell in virus-like particles produced by recombinant baculovirus
40. Actin-binding cellular proteins inside human immunodeficiency virus type 1
41. Complete nucleotide sequence of the AIDS virus HTLV-III
42. Host cyclophilin A mediates HIV-1 attachment to target cells via heparans
43. Role of cyclophilin A in the uptake of HIV-1 by macrophages and T lymphocytes
44. Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus type 1 (HIV-1): Interference with early and late events in HIV-1 replication
45. Synthesis, assembly and processing of viral proteins
46. Structures of cyclophilin-ligand complexes
47. Functional association of cyclophilin A with HIV-1 virions
48. Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein
49. Human immunodeficiency virus type 1 replication is modulated by host cyclophilin A expression levels
50. Molecular recognition in the HIV-1 capsid/cyclophilin A complex
51. Active site mutants of human cyclophilin A separate peptidyl-prolyl isomerase activity from cyclosporin A binding and calcineurin inhibition