Astragaloside IV attenuates myocardial fibrosis by inhibiting TGF-β1 signaling in coxsackievirus B3-induced cardiomyopathy

European Journal of Pharmacology

Volumn 658, Issue 2-3, 2011, Pages 168-174

  Chen, Ping ^a,b   Xie, Yeqing ^a   Shen, E ^a   Li, Gary G ^b   Yu, Yong ^a   Zhang, Cassie B ^b   Yang, Yingzhen ^a   Zou, Yunzeng ^a   Ge, Junbo ^a   Chen, Ruizhen ^a   Chen, Haozhu ^a  

^a FUDAN UNIVERSITY   (China)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Astragaloside IV; Coxsackievirus B3; Dilated cardiomyopathy; Myocardial fibrosis; TGF 1; Viral myocarditis

Indexed keywords

AMINO TERMINAL TELOPEPTIDE; ASTRAGALOSIDE IV; COLLAGEN TYPE 1; COLLAGEN TYPE 3; PROCOLLAGEN C PROTEINASE; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; COLLAGEN SYNTHESIS; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; COXSACKIE VIRUS B3; DRUG EFFECT; ECHOCARDIOGRAPHY; ENZYME BLOOD LEVEL; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART MUSCLE NECROSIS; HISTOLOGY; IN VITRO STUDY; INFLAMMATORY INFILTRATE; MALE; MORTALITY; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SURVIVAL RATE; VIRUS MYOCARDITIS;

ANIMALS; CARDIOMYOPATHY, DILATED; COLLAGEN; DOWN-REGULATION; ENTEROVIRUS B, HUMAN; FIBROSIS; MALE; MICE; MICE, INBRED BALB C; MYOCARDITIS; MYOCARDIUM; SAPONINS; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA1; TRITERPENES;

EID: 79953780961     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.02.040     Document Type: Article

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