Isoproterenol-induced activation of MAPK, NFκB and JAK/STAt pathway in mouse myocardium

Acta Physiologica Sinica

Volumn 55, Issue 4, 2003, Pages 449-453

  Yin, Feng ^a   Zhu, Yun ^a   Li, Ping ^a   Han, Qi De ^a   Zhang, You Yi ^a  

^a PEKING UNIVERSITY THIRD HOSPITAL   (China)

Author keywords

Isoproterenol; JAK STAT; Mitogen activted protein kinase (MAPK); Myocardium; NF B

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOPRENALINE; MITOGEN ACTIVATED PROTEIN KINASE; STAT PROTEIN; STAT3 PROTEIN;

ARTICLE; DRUG ACTIVITY; ENZYME ACTIVATION; HEART HYPERTROPHY; HEART LEFT VENTRICLE; HEART VENTRICLE REMODELING; IN VIVO STUDY; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; HEART; ISOPROTERENOL; JANUS KINASE 1; MALE; MICE; MICE, INBRED BALB C; MITOGEN-ACTIVATED PROTEIN KINASES; MYOCARDIUM; NF-KAPPA B; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TIME FACTORS;

EID: 0042825329     PISSN: 03710874     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Dzimiri N. Regulation of β-adrenoceptor signaling in cardiac function and disease. Pharmacol Rev 1999;51(3): 465-501.
2. Morisco C, Zebrowski D, Condorelli G, Tsichlis P, Vatner SF, Sadoshima J. The Akt-glycogen synthase kinase 3β pathway regulates transcription of atrial natriuretic factor induced by β-adrenergic receptor stimulation in cardiac myocytes. J Biol Chem 2000;275:14466-14475.
3. Schreiber E, Matthias P, Müller MM, Schaffner W. Rapid detection of octamer binding proteins with "mini-extracts" prepared from a small number of cells. Nucleic Acids Res 1989;17:6419.
4. Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham heart study. N Engl J Med 1990;322:1561-1566.
5. Simpson P, McGrath A, Savion S. Myocyte hypertrophy in neonatal rat heart cultures and its regulation by serum and by catecholamines. Circ Res 1982;51:781-801.
6. Yamazaki T, Komuro I, Zou Y, Kudoh S, Shiojima I, Hiroi Y, Mizuno T, Aikawa R, Takano H, Yazaki Y. Norepinephrine induces the raf-1 kinase/mitogen activated protein kinase cascade through both (1- and β-adrenoceptors. Circulation 1997;95:1260-1268.
7. Molkentin JD, Wdorn G. Cytoplasmic signaling pathways that regulate cardiac hypertrophy. Annu Rev Physiol 2001;63:391-426.
8. Aoki H, Izumo S, Sadoshima J. Angiotensin II activates RhoA in cardiac myocytes: a critical role of RhoA in angiotensin II-induced premyofibril formation. Circ Res 1998;82(6):666-676.
9. Ruwhof C, van der Laarse A. Mechanical stress-induced cardiac hypertrophy: mechanisms and signal transduction pathways. Cardiovasc Res 2000;7(1):23-37.
10. Purcell NH, Tang G, Yu C, Mercurio F, DiDonato JA, Lin A. Activation of NF-kappa B is required for hypertrophic growth of primary rat neonatal ventricular cardiomyocytes. Proc Natl Acad Sci USA 2001;98(12):6668-6673.
11. Siebenlist U, Franzoso G, Brown K. Structure, regulation and function of NF-κB. Annu Rev Cell Biol 1994;10:405-436.
12. Darnell JE Jr. STATs and gene regulation. Science 1997;277:1630-1635.
13. Kunisada K, Tone E, Fujio Y, Matsui H. Activation of gp130 transduces hypertrophic signals via STAT3 in cardiac myocytes. Circulation 98:346-352.
14. Pan J, Fukuda K, Sato T, Matsuzaki J, Kodama H, Sano M, Takahashi T, Kato T, Ogawa S. Mechanical stretch activates the Jak/STAT pathway in rat cardiomyocytes. Circ Res 1999;84:1127-1136.
15. Takeda K, Kaisho T, Yoshida N, Takeda J, Kishimoto T, Akira S. Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. J Immunol 1998;161:4652-4660.