The mechanism of the opening of the blood-brain barrier by borneol: A pharmacodynamics and pharmacokinetics combination study

Journal of Ethnopharmacology

Volumn 150, Issue 3, 2013, Pages 1096-1108

  Yu, Bin ^a   Ruan, Ming ^b   Dong, Xiaoping ^c   Yu, Yun ^a   Cheng, Haibo ^a  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b NANJING XIAOZHUANG UNIVERSITY   (China)

^c NANJING GENERAL HOSPITAL OF NANJING MILITARY COMMAND   (China)

Author keywords

ATP binding cassette proteins; Blood brain barrier; Borneol; Tissue specific; Ultrastructure

Indexed keywords

BORNEOL; BREAST CANCER RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 4; MULTIDRUG RESISTANCE PROTEIN 5; RHODAMINE 123; VERAPAMIL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CORTEX; BRAIN HOMOGENATE; BRAIN TISSUE; CAPILLARY ENDOTHELIAL CELL; CONTROLLED STUDY; CORPUS STRIATUM; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; ENDOTHELIUM CELL; FLUORESCENCE IMAGING; HIPPOCAMPUS; HYPOTHALAMUS; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; MESANGIUM CELL; NONHUMAN; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIGHT JUNCTION; TIME TO MAXIMUM PLASMA CONCENTRATION; ULTRASTRUCTURE;

ANIMALIA; RATTUS;

ANIMALS; BLOOD-BRAIN BARRIER; BORNANES; BRAIN; MALE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN; RATS; RATS, SPRAGUE-DAWLEY; RHODAMINE 123; VERAPAMIL;

EID: 84889091233     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2013.10.028     Document Type: Article

References (39)

1. N.J. Abbott, A.A. Patabendige, D.E. Dolman, S.R. Yusof, and D.J. Begley Structure and function of the blood-brain barrier Neurobiol. Dis. 37 2010 13 25
2. E. Beaulieu, M. Demeule, L. Ghitescu, and R. Beliveau P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain Biochem. J. 326 1997 539 544 (Pubitemid 27417234)
3. Z. Cai, S. Hou, Y. Li, B. Zhao, Z. Yang, S. Xu, and J. Pu Effect of borneol on the distribution of gastrodin to the brain in mice via oral administration J. Drug Target. 16 2008 178 184 (Pubitemid 351266554)
4. X.H. Chen, Z.Z. Lin, A.M. Liu, J.T. Ye, Y. Luo, Y.Y. Luo, X.X. Mao, P.Q. Liu, and R.B. Pi The orally combined neuroprotective effects of sodium ferulate and borneol against transient global ischaemia in C57 BL/6J mice J. Pharm. Pharmacol. 62 2010 915 923
5. S. Cisternino, C. Rousselle, A. Lorico, G. Rappa, and J.M. Scherrmann Apparent lack of Mrp1-mediated efflux at the luminal side of mouse blood-brain barrier endothelial cells Pharm. Res. 20 2003 904 909 (Pubitemid 36628438)
6. H.C. Cooray, C.G. Blackmore, L. Maskell, and M.A. Barrand Localisation of breast cancer resistance protein in microvessel endothelium of human brain Neuroreport 13 2002 2059 2063 (Pubitemid 36005925)
7. E. Dahlin, A.S. Neely, A. Larsson, L. Bäckman, and L. Nyberg Transfer of learning after updating training mediated by the striatum Science 320 2008 1510 1512 (Pubitemid 351929433)
8. X.P. Dong, M. Ruan, B. Yu, L. Jin, D.Q. Zhu, and T.H. Fang Effects of borneol at different doses on concentration of geniposide in rat brains Chin. Tradit. Herbal Drugs 43 2012 1366 1370
9. N. Drion, P. Risede, N Cholet, C. Chanez, and J.M. Scherrmann Role of P-170 glycoprotein in colchicine brain uptake J. Neurosci. Res. 49 1997 80 88 (Pubitemid 27291179)
10. C.Y. Gao, X.R. Li, Y.H. Li, L.J. Wang, and M. Xue Pharmacokinetic interaction between puerarin and edaravone, and effect of borneol on the brain distribution kinetics of puerarin in Rats J. Pharm. Pharmacol. 62 2010 360 367
11. Y. Gilgun-Sherki, E. Melamed, and D. Offen Oxidative stress induced-neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier Neuropharmacology 40 2001 959 975 (Pubitemid 32530602)
12. P.L. Golden, and G.M. Pollack Blood-brain barrier efflux transport J. Pharm. Sci. 92 2003 1739 1753 (Pubitemid 37071809)
13. L. González-Mariscal, A. Betanzos, P. Nava, and B.E. Jaramillo Tight junction proteins Prog. Biophys. Mol. Biol. 81 2003 1 44 (Pubitemid 35436609)
14. L. He, and B.S. Ji In vitro and in vivo study of CJY, an isoflavone on P-glycoprotein function in rats J. Chemother. 20 2008 361 367 (Pubitemid 351998899)
15. Y.K. Hong, S.H. Park, S. Lee, S. Hwang, M.J. Lee, D. Kim, J.H. Lee, S.Y. Han, S.T. Kim, Y.K. Kim, S. Jeon, B.S. Koo, and K.S. Cho Neuroprotective effect of SuHeXiang Wan in Drosophila models of Alzheimer's disease J. Ethnopharmacol. 134 2011 1028 1032
16. M.V. Kokoeva, H. Yin, and J.S. Flier Neurogenesis in the hypothalamus of adult mice: potential role in energy balance Science 310 2005 679 683 (Pubitemid 41528161)
17. M. Leggas, M. Adachi, G.L. Scheffer, D. Sun, P. Wielinga, G. Du, K.E. Mercer, Y. Zhuang, J.C. Panetta, B. Johnston, R.J. Scheper, C.F. Stewart, and J.D. Schuetz Mrp4 confers resistance to topotecan and protects the brain from chemotherapy Mol. Cell. Biol. 24 2004 7612 7621 (Pubitemid 39121487)
18. P.Y. Lin, Y.S. Tang, and N.S. Wang Effects of Cinnabar and Realgar in Angong Niuhuang powder on heat shock protein, nitric oxide synthase and inflammatory cytokines in contusion cerebral edema Zhong yao cai 29 2006 458 461
19. Q.D. Liu, M.R. Liang, Z.X. Chen, M.R. Feng, and P. Zhao The influence of borneol on the passing of gentamycin through blood- brain barrier Guangzhou Zhongyiyao Daxue Xuebao 11 1994 37 40
20. Y. Liu, G.H. Tang, Y.H. Sun, X.J. Lin, C. Wei, G.Y. Yang, and J.R. Liu The protective role of Tongxinluo on blood-brain barrier after ischemia-reperfusion brain injury J. Ethnopharmacol. 23 2013 632 639
21. Y. Lu, S.Y. Du, J. Bai, P.Y. Li, R. Wen, and X.J. Zhao Bioavailability and brain-targeting of geniposide in gardenia-borneol co-compound by different administration routes in mice Int. J. Mol. Sci. 13 2012 14127 14135
22. C. Marie-Claire, C. Courtin, B.P. Roques, and F. Noble Cytoskeletal genes regulation by chronic morphine treatment in rat striatum Neuropsychopharmacology 29 2004 2208 2215 (Pubitemid 39578911)
23. A. Misra, S. Ganesh, A. Shahiwala, and S.P. Shah Drug delivery to the gentral nervous system: a review J. Pharm. Pharm. Sci. 6 2003 52 57
24. W.M. Pardridge The blood-brain barrier: bottleneck in brain drug development Neurorx 2 2005 3 14 (Pubitemid 40128022)
25. T.C. Pritchard, and K.D. Alloway Medical Neuroscience first ed. 1999 Hayes Barton Press Fence, North Carolina
26. J.S. Riceberg, and M.L. Shapiro Reward stability determines the contribution of orbitofrontal cortex to adaptive behavior J. Neurosci. 32 2012 16402 16409
27. R. Sane, S. Agarwal, R.K. Mittapalli, and W.F. Elmquist Saturable active efflux by p-glycoprotein and breast cancer resistance protein at the blood-brain barrier leads to nonlinear distribution of elacridar to the central nervous system J. Pharmacol. Exp. Ther. 345 2013 111 124
28. D. Sugiyama, H. Kusuhara, Y.J. Lee, and Y. Sugiyama Involvement of multidrug resistance associated protein 1(Mrp1) in the efflux transport of 17 beta estradiol-d-17beta-glucuronide (E217betaG) across the blood-brain barrier Pharm. Res. 20 2003 1394 1400 (Pubitemid 37164047)
29. B.L. Urquhart, and R.B. Kim Blood-brain barrier transporters and response to CNS-active drugs Eur. J. Clin. Pharmacol. 65 2009 1063 1070
30. USFDA, 2001. Guidance for Industry, Bioanalytical Method Validation. http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/ guidances/ucm070107.pdf2001.com.
31. M. Von Wedel-Parlow, P. Wölte, and H.J. Galla Regulation of major efflux transporters under inflammatory conditions at the blood-brain barrier in vitro J. Neurochem. 111 2009 111 118
32. G.E. Wimmer, and D. Shohamy Preference by association: how memory mechanisms in the hippocampus bias decisions Science 338 2012 270 273
33. B. Yu, T.H. Fang, L. Xu, and D.P. Yuan The effect of borneol on the intervention of shuluo in middle cerebral artery occlusion rats J. Chin. Microcirc. 13 2009 169 171
34. B. Yu, M. Ruan, Y. Sun, X.B. Cui, Y Yu, L.L Wang, and T.H. Fang Effect of borneol and electroacupuncture on the delivery of hyperforin in the rat brain Neural Regener. Res. 6 2011 1876 1882
35. B. Yu, M. Ruan, X.B Cui, J.M. Guo, L. Xu, and X.P. Dong Effects of borneol on the pharmacokinetics of geniposide in cortex, hippocampus, hypothalamus and striatum of conscious rat by simultaneous brain microdialysis coupled with UPLC-MS J. Pharm. Biomed. Anal. 77 2013 128 132
36. D.S. Zhang, M.D. Fu, C.L. Song, C.Y. Wang, X.C. Lin, and Y.L. Liu Expressions of apoptosis-related proteins in rats with focal cerebral ischemia after Angong Niuhuang sticker point application Neural Regener. Res. 7 2012 2347 2353
37. Y. Zhang, and W.M. Pardridge Delivery of beta-galactosidase tomouse brain via the blood-brain barrier transferrin receptor J. Pharmacol. Exp. Ther. 313 2005 1075 1081 (Pubitemid 40727011)
38. Y.Q. Zheng, M.J. Yao, J.X. Liu, W.T. Song, L. Li, S.B. Liu, Y. Hu, and J.X. Si Effect and mechanism of huatuo zaizao extractum on focal cerebral ischemia/reperfusion-induced blood-brain barrier injury in rats Zhongguo Zhong Yao Za Zhi 38 2013 585 590
39. H. Zhu, Z. Wang, Y. Xing, Y. Gao, T. Ma, L. Lou, J. Lou, Y. Gao, S. Wang, and Y. Wang Baicalin reduces the permeability of the blood-brain barrier during hypoxia in vitro by increasing the expression of tight junction proteins in brain microvascular endothelial cells J. Ethnopharmacol. 141 2012 14 20