In vitro and in vivo study of CJY, an isoflavone, on P-glycoprotein function in rats

Journal of Chemotherapy

Volumn 20, Issue 3, 2008, Pages 361-367

  He, Ling ^a   Ji, Bian Sheng ^b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b HENAN UNIVERSITY   (China)

Author keywords

Blood brain barrier; CJY; P glycoprotein

Indexed keywords

GLYCOPROTEIN P; GLYCOPROTEIN P INHIBITOR; ISOFLAVONE CJY; ISOFLAVONE DERIVATIVE; RHODAMINE 123; VERAPAMIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN HOMOGENATE; CAPILLARY ENDOTHELIUM; CONTROLLED STUDY; DRUG DOSE COMPARISON; ENDOTHELIUM CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; RAT; SPECTROFLUOROMETRY; SPECTROPHOTOMETER;

EID: 47349084845     PISSN: 1120009X     EISSN: None     Source Type: Journal    
DOI: 10.1179/joc.2008.20.3.361     Document Type: Article

References (21)

1. Germann UA. P-glycoprotein-a mediator of multidrug resistance in tumour cells. Eur J Cancer 1996; 32A (6): 927-44.
2. Gottesman MM, Pastan I. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 1993;62: 385-427.
3. Childs S, Ling V. The MDR superfamily of genes and its biological implications. Important Adv Oncol 1994;21-36.
4. Elsinga PH, Hendrikse NH, Bart J, Vaalburg W, van Waarde A. PET Studies on P-glycoprotein function in the blood-brain barrier: how it affects uptake and binding of drugs within the CNS. Curr Pharm Des 2004;10 (13):1493-503.
5. Cisternino S, Rousselle C, Debray M, Scherrmann JM. In vivo saturation of the transport of vinblastine and colchicine by P-glycoprotein at the rat blood-brain barrier. Pharm Res 2003;20(10):1607-11.
6. Zhao YL, Du J, Kanazawa H et al. Effect of endotoxin on doxorubicin transport across blood-brain barrier and P-glycoprotein function in mice. Eur J Pharmacol 2002;445 (1-2):115-23.
7. Sakata A, Tamai I, Kawazu K et al. In vivo evidence for ATP-dependent and P-glycoprotein-mediated transport of cyclosporin A at the blood-brain barrier. Biochem Pharmacol. 1994;48 (10): 1989-92.
8. Twentyman PR. Modification of cytotoxic drug resistance by non-immuno-suppressive cyclosporins. Br J Cancer 1988; 57 (3): 254-58.
9. Aszalos A, Thompson K, Yin JJ, Ross DD. Combinations of P-glycoprotein blockers, verapamil, PSC833, and cremophor act differently on the multidrug resistance associated protein (MRP) and on P-glycoprotein (Pgp). Anticancer Res. 1999; 19(2A): 1053-64.
10. Kitagawa S. Inhibitory effects of polyphenols on p-glycoprotein-mediated transport. Biol Pharm Bull 2006; 29: 1-6
11. Patanasethanont D, Nagai J, Yumoto R et al. Effects of Kaempferia parviflora extracts and their flavone constituents on P-glycoprotein function. J Pharm Sci. 2007 Jan;96(l):223-33
12. Ferte J, Kuhnel JM, Chapuis G, Rolland Y, Lewin G, Schwaller MA. Flavonoid-related modulators of multidrug resistance: synthesis, pharmacological activity, and structure-activity relationships. J Med Chem 1999;42(3):478-89
13. Abbott NJ, Hughes CC, Revest PA, Greenwood J. Development and characterisation of a rat brain capillary endothelial culture: towards an in vitro blood-brain barrier. J Cell Sci. 1992;103(Pt1):23-37.
14. Fontaine M, Elmquist WF, Miller DW. Use of rhodamine 123 to examine the functional activity of P-glycoprotein in primary cultured brain microvessel endothelial cell monolayers. Life Sci 1996;59(18): 1521-31.
15. Sarver JG, Klis WA, Byers JP, Erhardt PW. Microplate screening of the differential effects of test agents on Hoechst 33342, rhodamine 123, and rhodamine 6G accumulation in breast cancer cells that overexpress P-glycoprotein. J Biomol Screen 2002;7(1):29-34.
16. Bagge M, Hansen S, Nielsen E, Berg K. Re-examination and further development of a precise and rapid dye method for measuring cell growth /cell kill. J Immunol Meth 1998; 119: 203-210.
17. Zhu HJ, Liu GQ. Effect of E6, a novel calmodulin inhibitor, on activity of P-glycoprotein in purified primary cultured rat brain microvessel endothelial cells. Acta Pharmacol Sin. 2003; 24 (11): 1143-9
18. He L, Liu GQ.Effects of various principles from Chinese herbal medicine on rhodamine123 accumulation in brain capillary endothelial cells. Acta Pharmacol Sin. 2002; 23 (7).-591-6.
19. Green LJ, Marder P, Slapak CA. Modulation by LY335979 of P-glycoprotein function in multidrug-resistant cell lines and human natural killer cells. Biochem Pharmacol 2001;61 (11):1393-9.
20. Ji BS, He L. CJY, an isoflavone, reverses P-glycoprotein-mediated multidrug-resistance in doxorubicin-resistant human myelogenous leukaemia (K562/DOX) cells. J Pharm Pharmacol. 2007;59(7):1011-5.
21. Martin C, Berridge G, Higgins CF, Callaghan R. The multi-drug resistance reversal agent SR33557 and modulation of vinca alkaloid binding to P-glycoprotein by an allosteric interaction. Br J Pharmacol. 1997; 122 (4):765-71.