Intestinal antispasmodic effects of Helichrysum italicum (Roth) Don ssp. italicum and chemical identification of the active ingredients

Journal of Ethnopharmacology

Volumn 150, Issue 3, 2013, Pages 901-906

  Rigano, Daniela ^a   Formisano, Carmen ^a   Senatore, Felice ^a   Piacente, Sonia ^b   Pagano, Ester ^a   Capasso, Raffaele ^a   Borrelli, Francesca ^a   Izzo, Angelo A ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF SALERNO   (Italy)

Author keywords

Acetophenones; Antispasmodic drugs; Asteraceae; Helichrysum italicum ssp. italicum; Intestinal motility

Indexed keywords

12 ACETOXYTREMETONE; 2,3 DIHYDRO 2 [1 (HYDROXYMETHYL)ETHENYL] 5 BENZOFURANYL] ETHANONE; BARIUM CHLORIDE; CROTON OIL; DIGESTIVE TRACT SPASMOLYTIC AGENT; HELICHRYSUM ITALICUM EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOASSAY; CONTROLLED STUDY; FLOWER; FRACTIONATION; GASTROINTESTINAL TRANSIT; HELICHRYSUM; HELICHRYSUM ITALICUM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; ILEUM; IN VITRO STUDY; IN VIVO STUDY; INTESTINAL DYSMOTILITY; INTESTINE CONTRACTION; INTESTINE MOTILITY; MALE; MOUSE; NONHUMAN; SPASMOLYSIS;

ASTERACEAE; HELICHRYSUM ITALICUM; MUS;

ACETOPHENONES; ANTISPASMODIC DRUGS; ASTERACEAE; HELICHRYSUM ITALICUM SSP. ITALICUM; INTESTINAL MOTILITY;

ANIMALS; CROTON OIL; FLOWERS; GASTROINTESTINAL TRANSIT; HELICHRYSUM; ILEUM; INFLAMMATION; MALE; MICE; MICE, INBRED ICR; MUSCLE CONTRACTION; PARASYMPATHOLYTICS; PHYTOCHEMICALS; PHYTOTHERAPY; PLANT EXTRACTS;

EID: 84889085190     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2013.09.034     Document Type: Article

References (28)

1. A. Angioni, A. Barra, M. Arlorio, J.D. Coisson, M.T. Russo, F. Pirisi, M.M. Satta, and P. Cabras Chemical composition, plant genetic differences, and antifungal activity of the essential oil of Helichrysum italicum G. Don ssp. microphyllum (Willd) Nym J. Agric. Food Chem. 51 2003 1030 1034
2. G. Appendino, M. Ottino, N. Marquez, F. Bianchi, A. Gianna, M. Ballero, O. Sterner, B.L. Fiebich, and E. Munoz Arzanol, an anti-inflammatory and anti-HIV-1 phloroglucinol α-pyrone from Helichrysum italicum ssp. microphyllum J. Nat. Prod. 70 2007 608 612 (Pubitemid 46797865)
3. F.M. Awah, N.N. Offor, A.C. Ndunaka, F.U. Okafor, and C.O. Enyabine Free radical scavenging activities and phenolic contents of the spices Thymus vulgaris (thyme), Helichrysum italicum (curry leaf) and Laurus nobilis (bay leaf) extracts J. Pharm. Res. 5 2012 3417 3421
4. M. Ballero, and A. Maxia Erboristeria Domani 300 2006 52 56
5. D. Bigovic, S. Brankovic, D. Kitic, M. Radenkovic, T. Jankovic, K. Savikin, and S. Zivanovic Relaxant effect of the ethanol extract of Helichrysum plicatum (Asteraceae) on isolated rat ileum contractions Molecules 15 2010 3391 3401
6. F. Bohlmann, C. Scheidges, C. Zdero, R.M. King, and H. Robinson Ent-Labdanes from Baccharis sternbergiana Phytochemistry 23 1984 1109 1111
7. F. Borrelli, N. Borbone, R. Capasso, D. Montesano, S. De Marino, G. Aviello, G. Aprea, S. Masone, and A.A. Izzo Potent relaxant effect of a Celastrus paniculatus extract in the rat and human ileum J. Ethnopharmacol. 122 2009 434 438
8. F. Borrelli, F. Capasso, R. Capasso, V. Ascione, G. Aviello, R. Longo, and A.A. Izzo Effect of Boswellia serrata on intestinal motility in rodents: inhibition of diarrhoea without constipation Br. J. Pharmacol. 148 2006 553 560 (Pubitemid 43882092)
9. M. Costa, J.B. Furness, and C.M.S. Humphreys Apamin distinguishes two types of relaxation mediated by enteric nerves in the guinea-pig gastrointestinal tract Naunyn-Schmiedeberg's Arch. Pharmacol. 332 1986 79 88 (Pubitemid 16149717)
10. J.R. Crist, X.D. He, and R.K. Goyal Both ATP and the peptide VIP are inhibitory neurotransmitters in guinea-pig ileum circular muscle J. Physiol. 447 1992 119 131
11. S. De Marino, N. Borbone, F. Gala, F. Zollo, G. Fico, R. Pagiotti, and M. Iorizzi New constituents of sweet Capsicum annuum L. fruits and evaluation of their biological activity J. Agric. Food Chem. 54 20 2006 7508 7516 (Pubitemid 44645765)
12. S. Jafri, and P.J. Pasricha Agents used for diarrhoea, constipation, and inflammatory bowel disease; agents used for biliary and pancreatic disease J.G. Hardman, L.E. Limbird, GOODMAN & GILMAN'S. The Pharmacological Basis of Therapeutics 10th ed. 2001 McGraw-Hill New York 1037 1058
13. S.M. Kupchan, R.W. Britton, M.F. Ziegler, and C.W. Sigel Bruceantin, a new potent antileukemic simaroubolide from Brucea antidysenterica J. Org. Chem. 38 1973 178 179
14. T. Garcia de Quesda, B. Rodriguez, and S. Valverde Constituents of Helichrysum stoechas Phytochemistry 11 1972 446 449
15. A.A. Izzo, R. Capasso, G. Aviello, F. Borrelli, B. Romano, F. Piscitelli, L. Gallo, F. Capasso, P. Orlando, and V. Di Marzo Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice Br. J. Pharmacol. 166 2012 1444 1460
16. V.I. Litvinenko, P. Popova, N.V. Popova, and V.N. Bubenchikova Medicinal plants and preparations derived from them Farmaseotychnyi Zhurnal 53 1992 83 84
17. R. Maffei Facino, M. Carini, L. Franzoi, O. Pirola, and E. Bosisio Phytochemical characterization and radical scavenger activity of flavonoids from Helichrysum italicum G. Don (Compositae) Pharmacol. Res. 22 1990 709 720
18. A. Nostro, M.A. Cannatelli, A.D. Musolino, F. Procopio, and V. Alonzo Helichrysum italicum extract interferes with the production of enterotoxins by Staphylococcus aureus Lett. Appl. Microbiol. 35 2002 181 184 (Pubitemid 35001972)
19. A. Nostro, M.A. Cannatelli, A. Marino, I. Picerno, F.C. Pizzimenti, M.E. Scoglio, and P. Spataro Evaluation of antiherpesvirus-1 and genotoxic activities of Helichrysum italicum extract New Microbiol. 26 2003 125 128 (Pubitemid 40081775)
20. T. Ohama, M. Hori, and H. Ozaki Mechanism of abnormal intestinal motility in inflammatory bowel disease: how smooth muscle contraction is reduced? J. Smooth Muscle Res. 43 2007 43 54
21. S. Pignatti Flora d'Italia 3 1982 42 (Edagricole, Bologna)
22. O. Pol, and M.M. Puig Reversal of tolerance to the antitransit effects of morphine during acute intestinal inflammation in mice Br. J. Pharmacol. 122 1997 1216 1222 (Pubitemid 27494239)
23. M.M. Puig, and O. Pol Peripheral effects of opioids in a model of chronic intestinal inflammation in mice J. Pharmacol. Exp. Ther. 287 1998 1068 1075 (Pubitemid 29131622)
24. Sala, A.; Recio, M.C.; Giner, R.M.; Máñez, S.; Rios, J.L.; 2001). New acetophenone glucosides isolated from extracts of Helichrysum italicum with anti-inflammatory activity. J. Nat. Prod. 64, 1360-1362. (Pubitemid 33029225)
25. A. Sala, M. del Carmen Recio, R.M. Giner, S. Máñez, H. Tournier, G. Schinella, and J.-L. Ríos Anti-inflammatory and antioxidant properties of Helichrysum italicum J. Pharm. Pharmacol. 54 2002 365 371 (Pubitemid 34232336)
26. A. Sala, M. del Carmen Recio, G. Schinella, S. Máñez, R.M. Giner, M. Cerdá Nicolás, and J.-L. Ríos New acetophenone glucosides isolated from extracts of Helichrysum italicum with antiinflammatory activity Eur. J. Pharmacol. 461 2003 53 61
27. A. Sala, M.C. Recio, G.R. Schinella, S. Máñez, R.M. Giner, and J.L. Rios A new dual inhibitor of arachidonate metabolism isolated from Helichrysum italicum Eur. J. Pharmacol. 460 2003 219 226 (Pubitemid 36139989)
28. O. Taglialatela-Scafati, F. Pollastro, G. Chianese, A. Minassi, S. Gibbons, W. Arunotayanun, B. Mabebie, M. Ballero, and G. Appendino Antimicrobial phenolics and unusual glycerides from Helichrysum italicum subsp. microphyllum J. Nat. Prod. 76 2013 346 353