Co-extrusion as manufacturing technique for multilayer mini-matrices with dual drug release

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 85, Issue 3 PART B, 2013, Pages 1157-1163

  Dierickx, L ^a   Remon, J P ^a   Vervaet, C ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

Dual release; Hot melt co extrusion; Multiparticulate dosage form; Polycaprolactone; Polyethylene oxide

Indexed keywords

DICLOFENAC; ETHYL CELLULOSE; EUDRAGIT; FLURBIPROFEN; MOTIFENE; POLYCAPROLACTONE; POLYOX; POVIDONE; SOLUPLUS; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG RELEASE; EXPERIMENTAL DOG; HYDROPHILICITY; IN VITRO STUDY; IN VIVO STUDY; LIPOPHILICITY; LOADING DRUG DOSE; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PELLET EXTRUSION; SCANNING ELECTRON MICROSCOPY; SOLID PHASE EXTRACTION; SUSTAINED DRUG RELEASE; X RAY DIFFRACTION;

DUAL RELEASE; HOT-MELT CO-EXTRUSION; MULTIPARTICULATE DOSAGE FORM; POLYCAPROLACTONE; POLYETHYLENE OXIDE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; DICLOFENAC; DOGS; DRUG CARRIERS; DRUG COMPOUNDING; MALE; MICROSCOPY, ELECTRON, SCANNING; POLYESTERS; POLYETHYLENE GLYCOLS; POLYMERS; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; X-RAY DIFFRACTION;

EID: 84889078597     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2013.01.023     Document Type: Article

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