메뉴 건너뛰기




Volumn 288, Issue 48, 2013, Pages 34930-34942

Mutations in the polybasic juxtamembrane sequence of both plasma membrane- and endoplasmic reticulum-localized epidermal growth factor receptors confer ligand-independent cell transformation

Author keywords

[No Author keywords available]

Indexed keywords

CYTOPLASMIC JUXTAMEMBRANE; ENDOPLASMIC RETICULUM; EPIDERMAL GROWTH FACTOR RECEPTORS; ONCOGENIC POTENTIAL; RECEPTOR-TYROSINE KINASE; SINGLE-POINT MUTATION; TRANSFORMING ACTIVITY; TYROSINE PHOSPHORYLATION;

EID: 84889072451     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.513333     Document Type: Article
Times cited : (8)

References (55)
  • 1
    • 77953896432 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Lemmon, M. A., and Schlessinger, J. (2010) Cell signaling by receptor tyrosine kinases. Cell 141, 1117-1134
    • (2010) Cell , vol.141 , pp. 1117-1134
    • Lemmon, M.A.1    Schlessinger, J.2
  • 2
    • 0035902180 scopus 로고    scopus 로고
    • Oncogenic kinase signalling
    • Blume-Jensen, P., and Hunter, T. (2001) Oncogenic kinase signalling. Nature 411, 355-365
    • (2001) Nature , vol.411 , pp. 355-365
    • Blume-Jensen, P.1    Hunter, T.2
  • 3
    • 0034644539 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Schlessinger, J. (2000) Cell signaling by receptor tyrosine kinases. Cell 103, 211-225
    • (2000) Cell , vol.103 , pp. 211-225
    • Schlessinger, J.1
  • 5
    • 67549145398 scopus 로고    scopus 로고
    • Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment
    • Jura, N., Endres, N. F., Engel, K., Deindl, S., Das, R., Lamers, M. H., Wemmer, D. E., Zhang, X., and Kuriyan, J. (2009) Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment. Cell 137, 1293-1307
    • (2009) Cell , vol.137 , pp. 1293-1307
    • Jura, N.1    Endres, N.F.2    Engel, K.3    Deindl, S.4    Das, R.5    Lamers, M.H.6    Wemmer, D.E.7    Zhang, X.8    Kuriyan, J.9
  • 7
    • 0030462362 scopus 로고    scopus 로고
    • Mutation of dileucine residues in the juxtamembrane region alters EGF receptor expression
    • Morrison, P., Chung, K. C., and Rosner, M. R. (1996) Mutation of dileucine residues in the juxtamembrane region alters EGF receptor expression. Biochemistry 35, 14618-14624
    • (1996) Biochemistry , vol.35 , pp. 14618-14624
    • Morrison, P.1    Chung, K.C.2    Rosner, M.R.3
  • 8
    • 0037064048 scopus 로고    scopus 로고
    • The epidermal growth factor receptor juxtamembrane domain has multiple basolateral plasma membrane localization determinants, including a dominant signal with a poly proline core
    • He, C., Hobert, M., Friend, L., and Carlin, C. (2002) The epidermal growth factor receptor juxtamembrane domain has multiple basolateral plasma membrane localization determinants, including a dominant signal with a poly proline core. J. Biol. Chem. 277, 38284-38293
    • (2002) J. Biol. Chem , vol.277 , pp. 38284-38293
    • He, C.1    Hobert, M.2    Friend, L.3    Carlin, C.4
  • 9
    • 34249845380 scopus 로고    scopus 로고
    • Characterization of a novel tripartite nuclear localization sequence in the EGFR family
    • Hsu, S. C., and Hung, M. C. (2007) Characterization of a novel tripartite nuclear localization sequence in the EGFR family. J. Biol. Chem. 282, 10432-10440
    • (2007) J. Biol. Chem , vol.282 , pp. 10432-10440
    • Hsu, S.C.1    Hung, M.C.2
  • 10
    • 0345195976 scopus 로고    scopus 로고
    • The human epidermal growth factor receptor contains a juxtamembrane calmodulin-binding site
    • Martín-Nieto, J., and Villalobo, A. (1998) The human epidermal growth factor receptor contains a juxtamembrane calmodulin-binding site. Biochemistry 37, 227-236
    • (1998) Biochemistry , vol.37 , pp. 227-236
    • Martín-Nieto, J.1    Villalobo, A.2
  • 11
    • 22244449320 scopus 로고    scopus 로고
    • An electrostatic engine model for autoinhibition and activation of the epidermal growth factor receptor (EGFR/ErbB) family
    • McLaughlin, S., Smith, S. O., Hayman, M. J., and Murray, D. (2005) An electrostatic engine model for autoinhibition and activation of the epidermal growth factor receptor (EGFR/ErbB) family. J. Gen. Physiol. 126, 41-53
    • (2005) J. Gen. Physiol , vol.126 , pp. 41-53
    • McLaughlin, S.1    Smith, S.O.2    Hayman, M.J.3    Murray, D.4
  • 15
    • 0033860695 scopus 로고    scopus 로고
    • The EGF receptor. A nexus for trafficking and signaling
    • Carpenter, G. (2000) The EGF receptor. A nexus for trafficking and signaling. Bioessays 22, 697-707
    • (2000) Bioessays , vol.22 , pp. 697-707
    • Carpenter, G.1
  • 16
    • 0021705725 scopus 로고
    • Characterization of epidermal growth factor receptor gene expression in malignant and normal human cell lines
    • Xu, Y. H., Richert, N., Ito, S., Merlino, G. T., Pastan, I. (1984) Characterization of epidermal growth factor receptor gene expression in malignant and normal human cell lines. Proc. Natl. Acad. Sci. U.S.A. 81, 7308-7312
    • (1984) Proc. Natl. Acad. Sci. U.S.A. , vol.81 , pp. 7308-7312
    • Xu, Y.H.1    Richert, N.2    Ito, S.3    Merlino, G.T.4    Pastan, I.5
  • 18
    • 0022422394 scopus 로고
    • Human tumor cell lines with EGF receptor gene amplification in the absence of aberrant sized mRNAs
    • King, C. R., Kraus, M. H., Williams, L. T., Merlino, G. T., Pastan, I. H., and Aaronson, S. A. (1985) Human tumor cell lines with EGF receptor gene amplification in the absence of aberrant sized mRNAs. Nucleic Acids Res. 13, 8477-8486
    • (1985) Nucleic Acids Res , vol.13 , pp. 8477-8486
    • King, C.R.1    Kraus, M.H.2    Williams, L.T.3    Merlino, G.T.4    Pastan, I.H.5    Aaronson, S.A.6
  • 19
    • 0023301170 scopus 로고
    • Over-expression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms
    • Kraus, M. H., Popescu, N. C., Amsbaugh, S. C., and King, C. R. (1987) Over-expression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms. EMBO J. 6, 605-610
    • (1987) EMBO J. , vol.6 , pp. 605-610
    • Kraus, M.H.1    Popescu, N.C.2    Amsbaugh, S.C.3    King, C.R.4
  • 20
    • 0023948602 scopus 로고
    • Amplification and expression of the epidermal growth factor receptor gene in human glioma xenografts
    • Humphrey, P. A., Wong, A. J., Vogelstein, B., Friedman, H. S., Werner, M. H., Bigner, D. D., and Bigner, S. H. (1988) Amplification and expression of the epidermal growth factor receptor gene in human glioma xenografts. Cancer Res. 48, 2231-2238
    • (1988) Cancer Res , vol.48 , pp. 2231-2238
    • Humphrey, P.A.1    Wong, A.J.2    Vogelstein, B.3    Friedman, H.S.4    Werner, M.H.5    Bigner, D.D.6    Bigner, S.H.7
  • 22
    • 14644412873 scopus 로고    scopus 로고
    • Prognostic effect of epidermal growth factor receptor and EGFRvIII in glioblastoma multiforme patients
    • Heimberger, A. B., Hlatky, R., Suki, D., Yang, D., Weinberg, J., Gilbert, M., Sawaya, R., and Aldape, K. (2005) Prognostic effect of epidermal growth factor receptor and EGFRvIII in glioblastoma multiforme patients. Clin. Cancer Res. 11, 1462-1466
    • (2005) Clin. Cancer Res , vol.11 , pp. 1462-1466
    • Heimberger, A.B.1    Hlatky, R.2    Suki, D.3    Yang, D.4    Weinberg, J.5    Gilbert, M.6    Sawaya, R.7    Aldape, K.8
  • 23
    • 14444288522 scopus 로고    scopus 로고
    • The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling
    • Huang, H. S., Nagane, M., Klingbeil, C. K., Lin, H., Nishikawa, R., Ji, X. D., Huang, C. M., Gill, G. N., Wiley, H. S., and Cavenee, W. K. (1997) The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling. J. Biol. Chem. 272, 2927-2935
    • (1997) J. Biol. Chem , vol.272 , pp. 2927-2935
    • Huang, H.S.1    Nagane, M.2    Klingbeil, C.K.3    Lin, H.4    Nishikawa, R.5    Ji, X.D.6    Huang, C.M.7    Gill, G.N.8    Wiley, H.S.9    Cavenee, W.K.10
  • 24
    • 0031961980 scopus 로고    scopus 로고
    • Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptor
    • Moscatello, D. K., Holgado-Madruga, M., Emlet, D. R., Montgomery, R. B., and Wong, A. J. (1998) Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptor. J. Biol. Chem. 273, 200-206
    • (1998) J. Biol. Chem , vol.273 , pp. 200-206
    • Moscatello, D.K.1    Holgado-Madruga, M.2    Emlet, D.R.3    Montgomery, R.B.4    Wong, A.J.5
  • 25
    • 0032579405 scopus 로고    scopus 로고
    • Constitutive activation of c-Jun-N-terminal kinase by a mutant epidermal growth factor receptor
    • Antonyak, M. A., Moscatello, D. K., and Wong, A. J. (1998) Constitutive activation of c-Jun-N-terminal kinase by a mutant epidermal growth factor receptor. J. Biol. Chem. 273, 2817-2822
    • (1998) J. Biol. Chem , vol.273 , pp. 2817-2822
    • Antonyak, M.A.1    Moscatello, D.K.2    Wong, A.J.3
  • 26
    • 0028927012 scopus 로고
    • Altered subcellular location of an activated and tumour- associated epidermal growth factor receptor
    • Ekstrand, A. J., Liu, L., He, J., Hamid, M. L., Longo, N., Collins, V. P., and James, C. D. (1995) Altered subcellular location of an activated and tumour- associated epidermal growth factor receptor. Oncogene 10, 1455-1460
    • (1995) Oncogene , vol.10 , pp. 1455-1460
    • Ekstrand, A.J.1    Liu, L.2    He, J.3    Hamid, M.L.4    Longo, N.5    Collins, V.P.6    James, C.D.7
  • 28
    • 0030832167 scopus 로고    scopus 로고
    • Cell surface localization and density of the tumor associated variant of the epidermal growth factor receptor, EGFRvIII
    • Wikstrand, C. J., McLendon, R. E., Friedman, A. H., and Bigner, D. D. (1997) Cell surface localization and density of the tumor associated variant of the epidermal growth factor receptor, EGFRvIII. Cancer Res. 57, 4130-4140
    • (1997) Cancer Res , vol.57 , pp. 4130-4140
    • Wikstrand, C.J.1    McLendon, R.E.2    Friedman, A.H.3    Bigner, D.D.4
  • 29
    • 18144426053 scopus 로고    scopus 로고
    • The antitumor monoclonal antibody 806 recognizes a high-mannose form of the EGF receptor that reaches the cell surface when cells overexpress the receptor
    • Johns, T. G., Mellman, I., Cartwright, G. A., Ritter, G., Old, L. J., Burgess, A. W., and Scott, A. M. (2005) The antitumor monoclonal antibody 806 recognizes a high-mannose form of the EGF receptor that reaches the cell surface when cells overexpress the receptor. FASEB J. 19, 780-782
    • (2005) FASEB J. , vol.19 , pp. 780-782
    • Johns, T.G.1    Mellman, I.2    Cartwright, G.A.3    Ritter, G.4    Old, L.J.5    Burgess, A.W.6    Scott, A.M.7
  • 31
    • 12544255563 scopus 로고    scopus 로고
    • Activation of the epidermal growth factor receptor by respiratory syncytial virus results in increased inflammation and delayed apoptosis
    • Monick, M. M., Cameron, K., Staber, J., Powers, L. S., Yarovinsky, T. O., Koland, J. G., and Hunninghake, G. W. (2005) Activation of the epidermal growth factor receptor by respiratory syncytial virus results in increased inflammation and delayed apoptosis. J. Biol. Chem. 280, 2147-2158
    • (2005) J. Biol. Chem , vol.280 , pp. 2147-2158
    • Monick, M.M.1    Cameron, K.2    Staber, J.3    Powers, L.S.4    Yarovinsky, T.O.5    Koland, J.G.6    Hunninghake, G.W.7
  • 32
    • 23444461435 scopus 로고    scopus 로고
    • Transmembrane sequences are determinants of immunoreceptor signaling
    • Gosse, J.A., Wagenknecht-Wiesner, A., Holowka, D., Baird, B. (2005) Transmembrane sequences are determinants of immunoreceptor signaling. J. Immunol. 175, 2123-2131
    • (2005) J. Immunol , vol.175 , pp. 2123-2131
    • Gosse, J.A.1    Wagenknecht-Wiesner, A.2    Holowka, D.3    Baird, B.4
  • 33
    • 0024336222 scopus 로고
    • Characterization of glycoproteins and their associated oligosaccharides through the use of endoglycosidases
    • Maley, F., Trimble, R. B., Tarentino, A. L., and Plummer, T. H., Jr. (1989) Characterization of glycoproteins and their associated oligosaccharides through the use of endoglycosidases. Anal. Biochem. 180, 195-204
    • (1989) Anal. Biochem , vol.180 , pp. 195-204
    • Maley, F.1    Trimble, R.B.2    Tarentino, A.L.3    Plummer Jr., T.H.4
  • 34
    • 33644841289 scopus 로고    scopus 로고
    • Electrostatic interactions of peptides flanking the tyrosine kinase domain in the epidermal growth factor receptor provides a model for intracellular dimerization and autophosphorylation
    • Aifa, S., Miled, N., Frikha, F., Aniba, M. R., Svensson, S. P., and Rebai, A. (2006) Electrostatic interactions of peptides flanking the tyrosine kinase domain in the epidermal growth factor receptor provides a model for intracellular dimerization and autophosphorylation. Proteins 62, 1036- 1043
    • (2006) Proteins , vol.62 , pp. 1036-1043
    • Aifa, S.1    Miled, N.2    Frikha, F.3    Aniba, M.R.4    Svensson, S.P.5    Rebai, A.6
  • 35
    • 33750340121 scopus 로고    scopus 로고
    • Structure of the membrane reconstituted transmembrane-juxtamembrane peptide EGFR (622-660) and its interaction with Ca2+/calmodulin
    • Sato, T., Pallavi, P., Golebiewska, U., McLaughlin, S., and Smith, S. O. (2006) Structure of the membrane reconstituted transmembrane-juxtamembrane peptide EGFR (622-660) and its interaction with Ca2+/calmodulin. Biochemistry 45, 12704-12714
    • (2006) Biochemistry , vol.45 , pp. 12704-12714
    • Sato, T.1    Pallavi, P.2    Golebiewska, U.3    McLaughlin, S.4    Smith, S.O.5
  • 36
    • 37649013040 scopus 로고    scopus 로고
    • Epidermal growth factor receptor juxtamembrane region regulated allosteric tyrosine kinase activation
    • Thiel, K. W., and Carpenter G. (2007) Epidermal growth factor receptor juxtamembrane region regulated allosteric tyrosine kinase activation. Proc. Natl. Acad. Sci. U.S.A. 104, 19238-19243
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 19238-19243
    • Thiel, K.W.1    Carpenter, G.2
  • 39
    • 0000943342 scopus 로고
    • Agar suspension culture for the selective assay of cells transformed by polyoma virus
    • Macpherson, I., and Montagnier, L. (1964) Agar suspension culture for the selective assay of cells transformed by polyoma virus. Virology 23, 291-294
    • (1964) Virology , vol.23 , pp. 291-294
    • MacPherson, I.1    Montagnier, L.2
  • 40
    • 17444403242 scopus 로고    scopus 로고
    • Structural basis for inhibition of the epidermal growth factor receptor by Cetuximab
    • Li, S., Schmitz, K. R., Jeffrey, P. D., Wiltzius, J. J., Kussie, P., and Ferguson, K. M. (2005) Structural basis for inhibition of the epidermal growth factor receptor by Cetuximab. Cancer Cell 7, 301-311
    • (2005) Cancer Cell , vol.7 , pp. 301-311
    • Li, S.1    Schmitz, K.R.2    Jeffrey, P.D.3    Wiltzius, J.J.4    Kussie, P.5    Ferguson, K.M.6
  • 42
    • 0019332971 scopus 로고
    • Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes
    • Ushiro, H., and Cohen, S. (1980) Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes. J. Biol. Chem. 255, 8363-8365
    • (1980) J. Biol. Chem , vol.255 , pp. 8363-8365
    • Ushiro, H.1    Cohen, S.2
  • 43
    • 37049185280 scopus 로고
    • Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells
    • Merlino, G. T., Xu, Y. H., Ishii, S., Clark, A. J., Semba, K., Toyoshima, K., Yamamoto, T., and Pastan, I. (1984) Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells. Science 224, 417-419
    • (1984) Science , vol.224 , pp. 417-419
    • Merlino, G.T.1    Xu, Y.H.2    Ishii, S.3    Clark, A.J.4    Semba, K.5    Toyoshima, K.6    Yamamoto, T.7    Pastan, I.8
  • 45
    • 67349270856 scopus 로고    scopus 로고
    • Trafficking of receptor tyrosine kinases to the nucleus
    • Carpenter, G., and Liao, H.J. (2009) Trafficking of receptor tyrosine kinases to the nucleus. Exp. Cell Res. 315, 1556-1566
    • (2009) Exp. Cell Res , vol.315 , pp. 1556-1566
    • Carpenter, G.1    Liao, H.J.2
  • 46
    • 0021166294 scopus 로고
    • Subcellular localization of the v-erb-B protein, the product of a transforming gene of avian erythroblastosis virus
    • Privalsky, M.L., and Bishop, J.M. (1984) Subcellular localization of the v-erb-B protein, the product of a transforming gene of avian erythroblastosis virus. Virology 135, 356-368
    • (1984) Virology , vol.135 , pp. 356-368
    • Privalsky, M.L.1    Bishop, J.M.2
  • 47
    • 0023241481 scopus 로고
    • On the tertiary structure of the extracellular domains of the epidermal growth factor and insulin receptors
    • Bajaj, M., Waterfield, M. D., Schlessinger, J., Taylor, W. R., and Blundell, T. (1987) On the tertiary structure of the extracellular domains of the epidermal growth factor and insulin receptors. Biochim. Biophys. Acta 916, 220-226
    • (1987) Biochim. Biophys. Acta , vol.916 , pp. 220-226
    • Bajaj, M.1    Waterfield, M.D.2    Schlessinger, J.3    Taylor, W.R.4    Blundell, T.5
  • 48
    • 2942516509 scopus 로고    scopus 로고
    • The relationship between the L1 and L2 domains of the insulin and epidermal growth factor receptors and leucine-rich repeat modules
    • Ward, C. W., and Garrett, T. P. (2001) The relationship between the L1 and L2 domains of the insulin and epidermal growth factor receptors and leucine-rich repeat modules. BMC Bioinformatics 2, 4
    • (2001) BMC Bioinformatics , vol.2 , pp. 4
    • Ward, C.W.1    Garrett, T.P.2
  • 49
    • 0030812940 scopus 로고    scopus 로고
    • A di-acidic signal required for selective export from the endoplasmic reticulum
    • Nishimura, N., and Balch, W.E. (1997) A di-acidic signal required for selective export from the endoplasmic reticulum. Science 277, 556-558
    • (1997) Science , vol.277 , pp. 556-558
    • Nishimura, N.1    Balch, W.E.2
  • 50
    • 0033959784 scopus 로고    scopus 로고
    • Efficient export of the vesicular stomatitis virus g protein from the endoplasmic reticulum requires a signal in the cytoplasmic tail that induces both tyrosine- based and di-acidic motifs
    • Sevier, C. S., Weisz, O. A., Davis, M., and Machamer, C. E. (2000) Efficient export of the vesicular stomatitis virus g protein from the endoplasmic reticulum requires a signal in the cytoplasmic tail that induces both tyrosine- based and di-acidic motifs. Mol. Biol. Cell 11, 13-22
    • (2000) Mol. Biol. Cell , vol.11 , pp. 13-22
    • Sevier, C.S.1    Weisz, O.A.2    Davis, M.3    MacHamer, C.E.4
  • 51
    • 0030787340 scopus 로고    scopus 로고
    • Receptor dimerization is not a factor in the signaling activity of a transforming variant epidermal growth factor receptor (EGFRvIII)
    • Chu, C. T., Everiss, K. D., Wikstrand, C. J., Batra, S. K., Kung, H. J., and Bigner, D. D. (1997) Receptor dimerization is not a factor in the signaling activity of a transforming variant epidermal growth factor receptor (EGFRvIII). Biochem. J 324, 855-861
    • (1997) Biochem. J , vol.324 , pp. 855-861
    • Chu, C.T.1    Everiss, K.D.2    Wikstrand, C.J.3    Batra, S.K.4    Kung, H.J.5    Bigner, D.D.6
  • 52
    • 0029861248 scopus 로고    scopus 로고
    • Controlling epidermal growth factor (EGF)-stimulated Ras activation in intact cells by a cell permeable peptide mimicking phosphorylated EGF receptor
    • Rojas, M., Yao, S., and Lin, Y. Z. (1996) Controlling epidermal growth factor (EGF)-stimulated Ras activation in intact cells by a cell permeable peptide mimicking phosphorylated EGF receptor. J. Biol. Chem. 271, 27456-27461
    • (1996) J. Biol. Chem , vol.271 , pp. 27456-27461
    • Rojas, M.1    Yao, S.2    Lin, Y.Z.3
  • 53
    • 0034680848 scopus 로고    scopus 로고
    • Epidermal growth factor-induced phosphatidylinositol 3-kinase activation andDNAsynthesis
    • Kong, M., Mounier, C., Wu, J., and Posner, B. I. (2000) Epidermal growth factor-induced phosphatidylinositol 3-kinase activation andDNAsynthesis. J. Biol. Chem. 275, 36035-36042
    • (2000) J. Biol. Chem , vol.275 , pp. 36035-36042
    • Kong, M.1    Mounier, C.2    Wu, J.3    Posner, B.I.4
  • 54
    • 0029666423 scopus 로고    scopus 로고
    • Transformational and altered signal transduction by a naturally occurring mutant EGF receptor
    • Moscatello, D. K., Montgomery, R. B., Sundareshan, P., McDanel, H., Wong, M. Y., and Wong, A. J. (1996) Transformational and altered signal transduction by a naturally occurring mutant EGF receptor. Oncogene 13, 85-96
    • (1996) Oncogene , vol.13 , pp. 85-96
    • Moscatello, D.K.1    Montgomery, R.B.2    Sundareshan, P.3    McDanel, H.4    Wong, M.Y.5    Wong, A.J.6
  • 55
    • 0025013547 scopus 로고
    • A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane
    • Hancock, J. F., Paterson, H., and Marshall, C. J. (1990) A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane. Cell 63, 133-139
    • (1990) Cell , vol.63 , pp. 133-139
    • Hancock, J.F.1    Paterson, H.2    Marshall, C.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.