Role of Autophagy in Glycogen Breakdown and Its Relevance to Chloroquine Myopathy

PLoS Biology

Volumn 11, Issue 11, 2013, Pages

  Zirin, Jonathan ^a   Nieuwenhuis, Joppe ^a   Perrimon, Norbert ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CHLOROQUINE; GLYCOGEN; GLYCOGEN SYNTHASE; PROTEIN ATG8; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; GLYCOGEN METABOLISM; GLYCOGEN SYNTHESIS; MYOPATHY; NONHUMAN; PROTEIN PROTEIN INTERACTION; SKELETAL MUSCLE; STARVATION;

AMINO ACID SEQUENCE; ANIMALS; AUTOPHAGY; CATALYTIC DOMAIN; CHLOROQUINE; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GLYCOGEN; GLYCOGEN SYNTHASE; GLYCOGENOLYSIS; LYSOSOMES; MOLECULAR SEQUENCE DATA; MUSCLES; MUSCULAR DISEASES; MUTATION, MISSENSE; PHAGOSOMES;

EID: 84889069304     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1001708     Document Type: Article

References (65)

1. Xie Z, Klionsky DJ, (2007) Autophagosome formation: core machinery and adaptations. Nat Cell Biol 9: 1102-1109.
2. Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y, (2004) In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 15: 1101-1111.
3. Malicdan MC, Nishino I, (2012) Autophagy in lysosomal myopathies. Brain Pathol 22: 82-88.
4. Malicdan MC, Noguchi S, Nonaka I, Saftig P, Nishino I, (2008) Lysosomal myopathies: an excessive build-up in autophagosomes is too much to handle. Neuromuscul Disord 18: 521-529.
5. Raben N, Plotz P, Byrne BJ, (2002) Acid alpha-glucosidase deficiency (glycogenosis type II, Pompe disease). Curr Mol Med 2: 145-166.
6. Smith J, Zellweger H, Afifi AK, (1967) Muscular form of glycogenosis, type II (Pompe). Neurology 17: 537-549.
7. Hers HG, (1963) alpha-Glucosidase deficiency in generalized glycogenstorage disease (Pompe's disease). Biochem J 86: 11-16.
8. van der Ploeg AT, Reuser AJ, (2008) Pompe's disease. Lancet 372: 1342-1353.
9. Raben N, Nagaraju K, Lee E, Kessler P, Byrne B, et al. (1998) Targeted disruption of the acid alpha-glucosidase gene in mice causes an illness with critical features of both infantile and adult human glycogen storage disease type II. J Biol Chem 273: 19086-19092.
10. Raben N, Baum R, Schreiner C, Takikita S, Mizushima N, et al. (2009) When more is less: excess and deficiency of autophagy coexist in skeletal muscle in Pompe disease. Autophagy 5: 111-113.
11. Nascimbeni AC, Fanin M, Masiero E, Angelini C, Sandri M, (2012) The role of autophagy in the pathogenesis of glycogen storage disease type II (GSDII). Cell Death Differ 19 (10) (): 1698-1708.
12. Raben N, Schreiner C, Baum R, Takikita S, Xu S, et al. (2010) Suppression of autophagy permits successful enzyme replacement therapy in a lysosomal storage disorder-murine Pompe disease. Autophagy 6: 1078-1089.
13. Nishino I, (2006) Autophagic vacuolar myopathy. Semin Pediatr Neurol 13: 90-95.
14. Casado E, Gratacos J, Tolosa C, Martinez JM, Ojanguren I, et al. (2006) Antimalarial myopathy: an underdiagnosed complication? Prospective longitudinal study of 119 patients. Ann Rheum Dis 65: 385-390.
15. Breckenridge AM, Winstanley PA, (1997) Clinical pharmacology and malaria. Ann Trop Med Parasitol 91: 727-733.
16. Meinao IM, Sato EI, Andrade LE, Ferraz MB, Atra E, (1996) Controlled trial with chloroquine diphosphate in systemic lupus erythematosus. Lupus 5: 237-241.
17. Katz SJ, Russell AS, (2011) Re-evaluation of antimalarials in treating rheumatic diseases: re-appreciation and insights into new mechanisms of action. Curr Opin Rheumatol 23: 278-281.
18. Stauber WT, Hedge AM, Trout JJ, Schottelius BA, (1981) Inhibition of lysosomal function in red and white skeletal muscles by chloroquine. Exp Neurol 71: 295-306.
19. Yoon YH, Cho KS, Hwang JJ, Lee SJ, Choi JA, et al. (2010) Induction of lysosomal dilatation, arrested autophagy, and cell death by chloroquine in cultured ARPE-19 cells. Invest Ophthalmol Vis Sci 51: 6030-6037.
20. Eadie MJ, Ferrier TM, (1966) Chloroquine myopathy. J Neurol Neurosurg Psychiatry 29: 331-337.
21. Mastaglia FL, Papadimitriou JM, Dawkins RL, Beveridge B, (1977) Vacuolar myopathy associated with chloroquine, lupus erythematosus and thymoma. Report of a case with unusual mitochondrial changes and lipid accumulation in muscle. J Neurol Sci 34: 315-328.
22. Kumamoto T, Ueyama H, Watanabe S, Murakami T, Araki S, (1993) Effect of denervation on overdevelopment of chloroquine-induced autophagic vacuoles in skeletal muscles. Muscle Nerve 16: 819-826.
23. Kotoulas OB, Phillips MJ, (1971) Fine structural aspects of the mobilization of hepatic glycogen. I. Acceleration of glycogen breakdown. Am J Pathol 63: 1-22.
24. Kotoulas OB, Kalamidas SA, Kondomerkos DJ, (2004) Glycogen autophagy. Microsc Res Tech 64: 10-20.
25. Schiaffino S, Hanzlikova V, (1972) Autophagic degradation of glycogen in skeletal muscles of the newborn rat. J Cell Biol 52: 41-51.
26. Schiaffino S, Mammucari C, Sandri M, (2008) The role of autophagy in neonatal tissues: just a response to amino acid starvation? Autophagy 4: 727-730.
27. Yorimitsu T, Klionsky DJ, (2005) Autophagy: molecular machinery for self-eating. Cell Death Differ 12 Suppl 2: 1542-1552.
28. Yang Z, Klionsky DJ, (2011) Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol 22: 124-131.
29. Tong J, Yan X, Yu L, (2010) The late stage of autophagy: cellular events and molecular regulation. Protein Cell 1: 907-915.
30. Raben N, Hill V, Shea L, Takikita S, Baum R, et al. (2008) Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease. Hum Mol Genet 17: 3897-3908.
31. Takikita S, Myerowitz R, Zaal K, Raben N, Plotz PH, (2009) Murine muscle cell models for Pompe disease and their use in studying therapeutic approaches. Mol Genet Metab 96: 208-217.
32. Zirin J, Perrimon N, (2010) Drosophila as a model system to study autophagy. Semin Immunopathol 32: 363-372.
33. Chang YY, Neufeld TP, (2011) Autophagy takes flight in Drosophila. FEBS Lett 584: 1342-1349.
34. Mizushima N, Noda T, Yoshimori T, Tanaka Y, Ishii T, et al. (1998) A protein conjugation system essential for autophagy. Nature 395: 395-398.
35. Damian MS, (2008) Myopathies in the adult patient. Medicine 36: 658-664.
36. Mastaglia FL, Argov Z, (2007) Toxic and iatrogenic myopathies. Handb Clin Neurol 86: 321-341.
37. Ruaud AF, Lam G, Thummel CS, (2011) The Drosophila NR4A nuclear receptor DHR38 regulates carbohydrate metabolism and glycogen storage. Mol Endocrinol 25: 83-91.
38. Juhasz G, Csikos G, Sinka R, Erdelyi M, Sass M, (2003) The Drosophila homolog of Aut1 is essential for autophagy and development. FEBS Lett 543: 154-158.
39. Ziviani E, Tao RN, Whitworth AJ, (2010) Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin. Proc Natl Acad Sci U S A 107: 5018-5023.
40. Tanner EA, Blute TA, Brachmann CB, McCall K, (2011) Bcl-2 proteins and autophagy regulate mitochondrial dynamics during programmed cell death in the Drosophila ovary. Development 138: 327-338.
41. Laplante M, Sabatini DM, (2012) mTOR signaling in growth control and disease. Cell 149: 274-293.
42. Proud CG, (2006) Regulation of protein synthesis by insulin. Biochem Soc Trans 34: 213-216.
43. Mizushima N, (2010) The role of the Atg1/ULK1 complex in autophagy regulation. Curr Opin Cell Biol 22: 132-139.
44. Behrends C, Sowa ME, Gygi SP, Harper JW, (2010) Network organization of the human autophagy system. Nature 466: 68-76.
45. Noda NN, Kumeta H, Nakatogawa H, Satoo K, Adachi W, et al. (2008) Structural basis of target recognition by Atg8/LC3 during selective autophagy. Genes Cells 13: 1211-1218.
46. Roach PJ, Depaoli-Roach AA, Hurley TD, Tagliabracci VS, (2012) Glycogen and its metabolism: some new developments and old themes. Biochem J 441: 763-787.
47. Rylatt DB, Aitken A, Bilham T, Condon GD, Embi N, et al. (1980) Glycogen synthase from rabbit skeletal muscle. Amino acid sequence at the sites phosphorylated by glycogen synthase kinase-3, and extension of the N-terminal sequence containing the site phosphorylated by phosphorylase kinase. Eur J Biochem 107: 529-537.
48. Embi N, Rylatt DB, Cohen P, (1980) Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase. Eur J Biochem 107: 519-527.
49. Arndt V, Dick N, Tawo R, Dreiseidler M, Wenzel D, et al. (2010) Chaperone-assisted selective autophagy is essential for muscle maintenance. Curr Biol 20: 143-148.
50. Demontis F, Perrimon N, (2010) FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging. Cell 143: 813-825.
51. Shea L, Raben N, (2009) Autophagy in skeletal muscle: implications for Pompe disease. Int J Clin Pharmacol Ther 47 Suppl 1: S42-47.
52. DiMauro S, Spiegel R, (2011) Progress and problems in muscle glycogenoses. Acta Myol 30: 96-102.
53. Ozen H, (2007) Glycogen storage diseases: new perspectives. World J Gastroenterol 13: 2541-2553.
54. Knecht E, Criado-Garcia O, Aguado C, Gayarre J, Duran-Trio L, et al. (2012) Malin knockout mice support a primary role of autophagy in the pathogenesis of Lafora disease. Autophagy 8 (4) (): 701-703.
55. Criado O, Aguado C, Gayarre J, Duran-Trio L, Garcia-Cabrero AM, et al. (2012) Lafora bodies and neurological defects in malin-deficient mice correlate with impaired autophagy. Hum Mol Genet 21: 1521-1533.
56. Aguado C, Sarkar S, Korolchuk VI, Criado O, Vernia S, et al. (2010) Laforin, the most common protein mutated in Lafora disease, regulates autophagy. Hum Mol Genet 19: 2867-2876.
57. Puri R, Suzuki T, Yamakawa K, Ganesh S, (2012) Dysfunctions in endosomal-lysosomal and autophagy pathways underlie neuropathology in a mouse model for Lafora disease. Hum Mol Genet 21: 175-184.
58. Baskaran S, Chikwana VM, Contreras CJ, Davis KD, Wilson WA, et al. (2011) Multiple glycogen-binding sites in eukaryotic glycogen synthase are required for high catalytic efficiency toward glycogen. J Biol Chem 286: 33999-34006.
59. Baskaran S, Roach PJ, DePaoli-Roach AA, Hurley TD, (2010) Structural basis for glucose-6-phosphate activation of glycogen synthase. Proc Natl Acad Sci U S A 107: 17563-17568.
60. McBride A, Ghilagaber S, Nikolaev A, Hardie DG, (2009) The glycogen-binding domain on the AMPK beta subunit allows the kinase to act as a glycogen sensor. Cell Metab 9: 23-34.
61. McBride A, Hardie DG, (2009) AMP-activated protein kinase-a sensor of glycogen as well as AMP and ATP? Acta Physiol (Oxf) 196: 99-113.
62. Sinadinos C, Cowan CM, Wyttenbach A, Mudher A, (2012) Increased throughput assays of locomotor dysfunction in Drosophila larvae. J Neurosci Methods 203: 325-334.
63. Budnik V, Gorczyca M, Prokop A, (2006) Selected methods for the anatomical study of Drosophila embryonic and larval neuromuscular junctions. Int Rev Neurobiol 75: 323-365.
64. Ramachandran P, Budnik V, (2010) Electron microscopy of Drosophila larval neuromuscular junctions. Cold Spring Harb Protoc 2010: pdb prot5474.
65. Palanker L, Tennessen JM, Lam G, Thummel CS, (2009) Drosophila HNF4 regulates lipid mobilization and beta-oxidation. Cell Metab 9: 228-239.