Accurate detection of subclonal single nucleotide variants in whole genome amplified and pooled cancer samples using HaloPlex target enrichment

BMC Genomics

Volumn 14, Issue 1, 2013, Pages

  Berglund, Eva C ^a   Lindqvist, Carl M ^a   Hayat, Shahina ^a   Övernäs, Elin ^a   Henriksson, Niklas ^a   Nordlund, Jessica ^a   Wahlberg, Per ^a   Forestier, Erik ^b,c   Lönnerholm, Gudmar ^a,c   Syvänen, Ann Christine ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UMEÅ UNIVERSITY   (Sweden)

^c Nordic Society of Pediatric Hematology and Oncology (NOPHO)   (Sweden)

Author keywords

Deep sequencing; HaloPlex; Non indexed pooling; Single nucleotide variant; Target enrichment; Whole genome amplification

Indexed keywords

GENOMIC DNA;

ACCURACY; ACUTE LYMPHOBLASTIC LEUKEMIA; ALLELE; ARTICLE; BONE MARROW; GENE AMPLIFICATION; GENE SEQUENCE; GENE TECHNOLOGY; GENETIC VARIABILITY; HALOPLEX TARGET ENRICHMENT TECHNOLOGY; HUMAN; HUMAN TISSUE; NEOPLASM; POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; SUBCLONAL SINGLE NUCLEOTIDE VARIANT;

ALLELES; CHILD; CHILD, PRESCHOOL; GENE FREQUENCY; GENOME, HUMAN; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; GERM CELLS; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; NEOPLASMS; POLYMORPHISM, SINGLE NUCLEOTIDE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 84889054428     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-14-856     Document Type: Article

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