Genomic DNA pooling strategy for next-generation sequencing-based rare variant discovery in abdominal aortic aneurysm regions of interest - Challenges and limitations

Journal of Cardiovascular Translational Research

Volumn 4, Issue 3, 2011, Pages 271-280

  Harakalova, Magdalena ^a   Nijman, Isaäc J ^a   Medic, Jelena ^a   Mokry, Michal ^a   Renkens, Ivo ^a   Blankensteijn, Jan D ^b   Kloosterman, Wigard ^a   Baas, Annette F ^a   Cuppen, Edwin ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Abdominal aortic aneurysm; Common disease; Genomic DNA pooling; Rare variants; SOLiD next generation sequencing; Targeted genomic enrichment

Indexed keywords

GENOMIC DNA;

ABDOMINAL AORTA ANEURYSM; ADULT; ARTICLE; CHROMOSOME 9P; CONTROLLED STUDY; COST CONTROL; DNA MICROARRAY; DNA SEQUENCE; FALSE POSITIVE RESULT; FEMALE; GENE FREQUENCY; GENE IDENTIFICATION; GENE LOCUS; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PILOT STUDY; PRIORITY JOURNAL;

AGED; AORTIC ANEURYSM, ABDOMINAL; AORTIC RUPTURE; CHROMOSOMES, HUMAN, PAIR 9; DNA BARCODING, TAXONOMIC; DNA MUTATIONAL ANALYSIS; FALSE POSITIVE REACTIONS; FEMALE; GENE EXPRESSION PROFILING; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HETEROZYGOTE; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MALE; MUTATION; NETHERLANDS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; PILOT PROJECTS; PROGNOSIS; REPRODUCIBILITY OF RESULTS;

EID: 79960556069     PISSN: 19375387     EISSN: 19375395     Source Type: Journal    
DOI: 10.1007/s12265-011-9263-5     Document Type: Article

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