Albumin is recycled from the primary urine by tubular transcytosis

Journal of the American Society of Nephrology

Volumn 24, Issue 12, 2013, Pages 1966-1980

  Tenten, Verena ^a   Menzel, Sylvia ^a   Kunter, Uta ^a   Sicking, Eva Maria ^a   Van Roeyen, Claudia R C ^a   Sanden, Silja K ^a   Kaldenbach, Michaela ^a,b   Boor, Peter ^a   Fuss, Astrid ^a   Uhlig, Sandra ^a   Lanzmich, Regina ^a   Willemsen, Brigith ^c   Dijkman, Henry ^c   Grepl, Martin ^d   Wild, Klemens ^e   Kriz, Wilhelm ^f   Smeets, Bart ^a   Floege, Jürgen ^a   Moeller, Marcus J ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b Divisions of Gastroentereology   (Germany)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d RWTH AACHEN UNIVERSITY   (Germany)

^e UNIVERSITY OF HEIDELBERG   (Germany)

^f MEDICAL FACULTY MANNHEIM HEIDELBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; DOXYCYCLINE; FC RECEPTOR; IMMUNOGLOBULIN G; ANTIINFECTIVE AGENT; MEMBRANE PROTEIN; PODOCIN; SERUM ALBUMIN; SIGNAL PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DEGRADATION; GENE DELETION; GLOMERULUS FILTRATION; KIDNEY FUNCTION; KIDNEY PROXIMAL TUBULE; KIDNEY TRANSPLANTATION; LYSOSOME; MOUSE; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; TRANSCYTOSIS; TRANSGENIC MOUSE; TUBULAR TRANSCYTOSIS; URINE; ALBUMINURIA; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; DRUG EFFECTS; ENDOCYTOSIS; GENE EXPRESSION; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; RAT; TRANSGENIC RAT;

ALBUMINURIA; ANIMALS; ANTI-BACTERIAL AGENTS; DOXYCYCLINE; ENDOCYTOSIS; GENE EXPRESSION; HUMANS; IMMUNOGLOBULIN G; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY TRANSPLANTATION; KIDNEY TUBULES, PROXIMAL; LYSOSOMES; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MODELS, BIOLOGICAL; PODOCYTES; PROTEIN STRUCTURE, TERTIARY; RATS; RATS, TRANSGENIC; SERUM ALBUMIN; TRANSCYTOSIS;

EID: 84889052729     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2013010018     Document Type: Article

References (49)

1. Peters T Jr: Serumalbumin: Recent progress in the understanding of its structure and biosynthesis. Clin Chem 23: 5-12, 1977
2. Haraldsson B, Nyström J, Deen WM: Properties of the glomerular barrier and mechanisms of proteinuria. Physiol Rev 88: 451-487, 2008
3. Tojo A, Endou H: Intrarenal handling of proteins in rats using fractional micropuncture technique. Am J Physiol 263: F601-F606, 1992
4. Norden AG, Lapsley M, Lee PJ, Pusey CD, Scheinman SJ, Tam FW, Thakker RV, Unwin RJ, Wrong O: Glomerular protein sieving and implications for renal failure in Fanconi syndrome. Kidney Int 60: 1885- 1892, 2001
5. Christensen EI, Birn H, Rippe B, Maunsbach AB: Controversies in nephrology: Renal albumin handling, facts, and artifacts! Kidney Int 72: 1192-1194, 2007
6. Jarad G, Miner JH: Update on the glomerular filtration barrier. Curr Opin Nephrol Hypertens 18: 226-232, 2009
7. Russo LM, Sandoval RM, McKee M, Osicka TM, Collins AB, Brown D, Molitoris BA, ComperWD: The normal kidney filters nephrotic levels of albumin retrieved by proximal tubule cells: Retrieval is disrupted in nephrotic states. Kidney Int 71: 504-513, 2007
8. Birn H, Christensen EI: Renal albumin absorption in physiology and pathology. Kidney Int 69: 440-449, 2006
9. Maunsbach AB: Albumin absorption by renal proximal tubule cells. Nature 212: 546-547, 1966
10. Weyer K, StormT, Shan J, Vainio S, Kozyraki R, Verroust PJ, Christensen EI, Nielsen R: Mouse model of proximal tubule endocytic dysfunction. Nephrol Dial Transplant 26: 3446-3451, 2011
11. Gekle M: Renal tubule albumin transport. Annu Rev Physiol 67: 573-594, 2005
12. Gekle M, Mildenberger S, Freudinger R, Silbernagl S: Endosomal alkalinization reduces Jmax and Km of albumin receptor-mediated endocytosis in OK cells. Am J Physiol 268: F899-F906, 1995
13. Gekle M, Mildenberger S, Freudinger R, Silbernagl S: Functional characterization of albumin binding to the apical membrane of OK cells. Am J Physiol 271: F286-F291, 1996
14. Norden AG, Unwin RJ: Is the albumin retrieval hypothesis a paradigm shift for nephrology? J AmSoc Nephrol 23: 569-571, 2012
15. Pollock CA, Poronnik P: Albumin transport and processing by the proximal tubule: Physiology and pathophysiology. Curr Opin Nephrol Hypertens 16: 359-364, 2007
16. Haraldsson B: Tubular reabsorption of albumin: It's all about cubilin. J Am Soc Nephrol 21: 1810-1812, 2010
17. de Borst MH: On the origin of albuminuria. Kidney Int 72: 1409, 2007
18. Russo LM, Bakris GL, ComperWD: Renal handling of albumin: A critical review of basic concepts and perspective. Am J Kidney Dis 39: 899-919, 2002
19. Christensen EI, Verroust PJ: Interstitial fibrosis: Tubular hypothesis versus glomerular hypothesis. Kidney Int 74: 1233-1236, 2008
20. Moeller MJ, Sanden SK, Soofi A, Wiggins RC, Holzman LB: Two gene fragments that direct podocyte-specific expression in transgenic mice. J Am Soc Nephrol 13: 1561-1567, 2002
21. Dechadilok P, Deen WM: Hindrance factors for diffusion and convection in pores. Ind Eng Chem Res 45: 6953-6959, 2006
22. Rippe B, Haraldsson B: Transport of macromolecules across microvascular walls: The two-pore theory. Physiol Rev 74: 163-219, 1994
23. Hausmann R, Grepl M, Knecht V, Moeller MJ: The glomerular filtration barrier function: New concepts. CurrOpinNephrol Hypertens 21: 441- 449, 2012
24. Hausmann R, Kuppe C, EggerH, Schweda F, Knecht V, ElgerM,Menzel S, Somers D, Braun G, Fuss A, Uhlig S, Kriz W, Tanner G, Floege J, Moeller MJ: Electrical forces determine glomerular permeability. J Am Soc Nephrol 21: 2053-2058, 2010
25. Moeller MJ, Tenten V: Renal albumin filtration: Alternative models to the standard physical barriers. Nat Rev Nephrol 9: 266-277, 2013
26. Shigehara T, Zaragoza C, Kitiyakara C, Takahashi H, Lu H, Moeller M, Holzman LB, Kopp JB: Inducible podocyte-specific gene expression in transgenic mice. J Am Soc Nephrol 14: 1998-2003, 2003
27. Roopenian DC, ChristiansonGJ, Sproule TJ, Brown AC, Akilesh S, Jung N, Petkova S, Avanessian L, Choi EY, Shaffer DJ, Eden PA, Anderson CL: The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs. J Immunol 170: 3528-3533, 2003
28. Chaudhury C, Mehnaz S, Robinson JM, Hayton WL, Pearl DK, Roopenian DC, Anderson CL: The major histocompatibility complexrelated Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan. J Exp Med 197: 315-322, 2003
29. Roopenian DC, Akilesh S: FcRn: The neonatal Fc receptor comes of age. Nat Rev Immunol 7: 715-725, 2007
30. Dijkman HB,Gerlofs-Nijland ME, van der Laak JA,Wetzels JF, Groenen PJ, Assmann KJ: Podocyte changes after induction of acute albuminuria in mice by anti-aminopeptidase AmAb. Nephron, ExpNephrol 94: e85-e93, 2003
31. Robinson RR, Lecocq FR, Phillippi PJ, Glenn WG: Fixed and reproducible orthostatic proteinuria. III. Effect of induced renal hemodynamic alterations upon urinary protein excretion. J Clin Invest 42: 100-110, 1963
32. Ferrell N, Ricci KB, Groszek J, Marmerstein JT, Fissell WH: Albumin handling by renal tubular epithelial cells in a microfluidic bioreactor. Biotechnol Bioeng 109: 797-803, 2012
33. Scott WN, Maude DL, Shehadeh I, Solomon AK: Inulin and albumin absorption from the proximal tubule in necturus kidney. Science 146: 1588-1590, 1964
34. Park CH, Maack T: Albumin absorption and catabolism by isolated perfused proximal convoluted tubules of the rabbit. J Clin Invest 73: 767-777, 1984
35. Eppel GA,Osicka TM, Pratt LM, Jablonski P, Howden BO, Glasgow EF, Comper WD: The return of glomerular-filtered albumin to the rat renal vein. Kidney Int 55: 1861-1870, 1999
36. Gudehithlu KP, Pegoraro AA, Dunea G, Arruda JA, Singh AK: Degradation of albumin by the renal proximal tubule cells and the subsequent fate of its fragments. Kidney Int 65: 2113-2122, 2004
37. Weyer K, Nielsen R, Christensen EI, Birn H: Generation of urinary albumin fragments does not require proximal tubular uptake. J Am Soc Nephrol 23: 591-596, 2012
38. Sandoval RM, Wagner MC, Patel M, Campos-Bilderback SB, Rhodes GJ, Wang E, Wean SE, Clendenon SS, Molitoris BA: Multiple factors influence glomerular albumin permeability in rats. J Am Soc Nephrol 23: 447-457, 2012
39. Anderson CL, Chaudhury C, Kim J, Bronson CL, Wani MA, Mohanty S: Perspective-FcRn transports albumin: Relevance to immunology and medicine. Trends Immunol 27: 343-348, 2006
40. SaravM,Wang Y, Hack BK, Chang A, Jensen M, Bao L,Quigg RJ: Renal FcRn reclaims albumin but facilitates elimination of IgG. J Am Soc Nephrol 20: 1941-1952, 2009
41. Haymann JP, Levraud JP, Bouet S, Kappes V, Hagège J, Nguyen G, Xu Y, Rondeau E, Sraer JD: Characterization and localization of the neonatal Fc receptor in adult human kidney. J Am Soc Nephrol 11: 632-639, 2000
42. Akilesh S, Huber TB, Wu H, Wang G, Hartleben B, Kopp JB, Miner JH, Roopenian DC, Unanue ER, Shaw AS: Podocytes use FcRn to clear IgG from the glomerular basement membrane. Proc Natl Acad Sci U S A 105: 967-972, 2008
43. Kacskovics I, Kis Z, Mayer B, West AP Jr, Tiangco NE, Tilahun M, Cervenak L, Bjorkman PJ,Goldsby RA, SzenciO, HammarströmL: FcRn mediates elongated serum half-life of human IgG in cattle. Int Immunol 18: 525-536, 2006
44. Kobayashi N, Suzuki Y, Tsuge T, Okumura K, Ra C, Tomino Y: FcRnmediated transcytosis of immunoglobulin G in human renal proximal tubular epithelial cells. Am J Physiol Renal Physiol 282: F358-F365, 2002
45. Appel D, Kershaw DB, Smeets B, Yuan G, Fuss A, Frye B, Elger M, Kriz W, Floege J, Moeller MJ: Recruitment of podocytes from glomerular parietal epithelial cells. J Am Soc Nephrol 20: 333-343, 2009
46. KabganiN,Grigoleit T, Schulte K, Sechi A, Sauer-Lehnen S, Tag C, Boor P, Kuppe C, Warsow G, Schordan S, Mostertz J, Chilukoti RK, Homuth G, Endlich N, Tacke F, Weiskirchen R, Fuellen G, Endlich K, Floege J, Smeets B,MoellerMJ: Primary cultures of glomerular parietal epithelial cells or podocytes with proven origin. PLoS One 7: e34907, 2012
47. Kunter U, Floege J, von Jürgensonn AS, Stojanovic T, Merkel S, Gröne HJ, Ferran C: Expression of A20 in the vesselwall of rat-kidney allografts correlates with protection from transplant arteriosclerosis. Transplantation 75: 3-9, 2003
48. Nicholls A, Sharp KA, Honig B: Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons. Proteins 11: 281-296, 1991
49. Sicking EM, Fuss A, Uhlig S, Jirak P, Dijkman H, Wetzels J, Engel DR, Urzynicok T, Heidenreich S, Kriz W, Kurts C, Ostendorf T, Floege J, Smeets B, Moeller MJ: Subtotal ablation of parietal epithelial cells induces crescent formation. J Am Soc Nephrol 23: 629-640, 2012