The single-nucleotide polymorphism (GPX4c718t) in the glutathione peroxidase 4 gene influences endothelial cell function: Interaction with selenium and fatty acids

Molecular Nutrition and Food Research

Volumn 57, Issue 12, 2013, Pages 2185-2194

  Crosley, Lynne K ^a   Bashir, Shabina ^a   Nicol, Fergus ^a   Arthur, John R ^a   Hesketh, John E ^b   Sneddon, Alan A ^a  

^a ROWETT RESEARCH INSTITUTE   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Endothelial; Glutathione peroxidase 4; Monocyte; Selenium; Single nucleotide polymorphism

Indexed keywords

ARACHIDONIC ACID; FATTY ACID; GLUTATHIONE PEROXIDASE; GLUTATHIONE PEROXIDASE 1; OSTEOPROTEGERIN; PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; PHOSPHOLIPID-HYDROPEROXIDE GLUTATHIONE PEROXIDASE; SELENIUM; TNFRSF11B PROTEIN, HUMAN; UNSATURATED FATTY ACID; VASCULAR CELL ADHESION MOLECULE 1;

3' UNTRANSLATED REGION; ADULT; ARTICLE; CELL ADHESION; CYTOLOGY; DRUG EFFECT; ENDOTHELIAL; ENDOTHELIUM CELL; ENZYMOLOGY; GENETICS; HOMOZYGOTE; HUMAN; LIPID PEROXIDATION; MALE; METABOLISM; MIDDLE AGED; MONOCYTE; SINGLE NUCLEOTIDE POLYMORPHISM; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR ENDOTHELIUM;

ENDOTHELIAL; GLUTATHIONE PEROXIDASE 4; MONOCYTE; SELENIUM; SINGLE NUCLEOTIDE POLYMORPHISM;

3' UNTRANSLATED REGIONS; ADULT; ARACHIDONIC ACID; CELL ADHESION; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FATTY ACIDS; FATTY ACIDS, UNSATURATED; GLUTATHIONE PEROXIDASE; HOMOZYGOTE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; LIPID PEROXIDATION; MALE; MIDDLE AGED; MONOCYTES; OSTEOPROTEGERIN; POLYMORPHISM, SINGLE NUCLEOTIDE; SELENIUM; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84889005256     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201300216     Document Type: Article

References (32)

1. Mozaffarian, D., Appel, L. J., Van Horn, L., Components of a cardioprotective diet: new insights. Circulation 2011, 123, 2870-2891.
2. Phillips, C. M., Nutrigenetics and metabolic disease: current status and implications for personalised nutrition. Nutrients 2013, 5, 32-57.
3. Akbaraly, N. T., Arnaud, J., Hininger-Favier, I., Gourlet, V. et al., Selenium and mortality in the elderly: results from the EVA study. Clin. Chem. 2005, 51, 2117-2123.
4. Lubos, E., Sinning, C. R., Schnabel, R. B., Wild, P. S. et al., Serum selenium and prognosis in cardiovascular disease: results from the AtheroGene study. Atherosclerosis 2010, 209, 271-277.
5. Rayman, M. P., Selenium and human health. Lancet 2012, 379, 1256-1268.
6. Bellinger, F.P, Raman, A. V., Reeves, M. A., Berry, M. J., Regulation and function of selenoproteins in human disease. Biochem. J. 2009, 422, 11-22.
7. Bermano, G., Nicol, F., Dyer, J. A., Sunde, R. A. et al., Tissue-specific regulation of selenoenzyme gene expression during selenium deficiency in rats. Biochem. J. 1995, 311, 425-430.
8. Hesketh, J. E., Nutrigenomics and selenium; gene expression patterns, physiological targets and genetics. Annu. Rev. Nutr. 2008, 28, 157-177.
9. Méplan, C., Crosley, L. K., Nicol, F., Horgan, G. W. et al., Functional effects of a common single-nucleotide polymorphism (GPX4c718t) in the glutathione peroxidase 4 gene: interaction with sex. Am. J. Clin. Nutr. 2008, 87, 1019-1027.
10. Brigelius-Flohé, R., Maiorino, M., Glutathione peroxidases. Biochim. Biophys. Acta 2012, 1830, 3289-3303.
11. Villette, S., Kyle, J. A., Brown, K. M., Pickard, K. et al., A novel single nucleotide polymorphism in the 3′ untranslated region of human glutathione peroxidase 4 influences lipoxygenase metabolism. Blood Cells Mol. Dis. 2002, 29, 174-178.
12. Sutherland, A., Kim, D.-H., Relton, C., Anh, Y-O. et al., Polymorphisms in the selenoprotein S and 15-kDa selenoprotein genes are associated with altered susceptibility to colorectal cancer. Genes Nutr. 2010, 5, 215-223.
13. Bermano, G., Pagmantidis, V., Holloway, N., Kadri, S. et al., Evidence that a polymorphism within the 3'UTR of glutathione peroxidase 4 is functional and is associated with susceptibility to colorectal cancer. Genes Nutr. 2007, 2, 227-232.
14. Gautrey, H., Nicol, F., Sneddon, A. A., Hall, J. et al., A T/C polymorphism in the GPX4 3'UTR affects the selenoprotein expression pattern and cell viability in transfected Caco-2 cells. Biochim. Biophys. Acta 2011, 1810, 584-591.
15. Udler, M., Maia, A. T., Cebrian, A., Brown, C. et al., Common germline genetic variation in antioxidant defense genes and survival after diagnosis of breast cancer. J. Clin. Oncol. 2007, 25, 3015-3023.
16. Polonikov, A. V., Vialykh, E. K., Churnosov, M. I., Illig, T. et al., The C718T polymorphism in the 3'-untranslated region of glutathione peroxidase-4 gene is a predictor of cerebral stroke in patients with essential hypertension. Hypertens. Res. 2012, 35, 507-512.
17. Mata, P., Alonso, R., Lopez-Farre, A., Ordovas, J. M. et al., Effect of dietary fat saturation on LDL oxidation and monocyte adhesion to human endothelial cells in vitro. Arterioscler. Thromb. Vasc. Biol. 1996, 16, 1347-1355.
18. Sneddon, A. A., McLeod, E., Wahle, K. W., Arthur, J. R., Cytokine-induced monocyte adhesion to endothelial cells involves platelet-activating factor: suppression by conjugated linoleic acid. Biochim. Biophys. Acta 2006, 1761, 793-801.
19. Sneddon, A. A., Wu, H. C., Farquharson, A., Grant, I. et al., Regulation of selenoprotein GPX4 expression and activity in human endothelial cells by fatty acids, cytokines and antioxidants. Atherosclerosis 2003, 171, 57-65.
20. Libby, P., Inflammation in atherosclerosis. Nature 2002, 420, 868-874.
21. To, S. S., Schrieber, L., Effect of leukotriene B4 and prostaglandin E2 on the adhesion of lymphocytes to endothelial cells. Clin. Exp. Immunol. 1990, 81, 160-165.
22. Drummen, G. P., van Liebergen, L. C., Op den Kamp, J. A., Post, J. A., C11-BODIPY(581/591), an oxidation-sensitive fluorescent lipid peroxidation probe: (micro)spectroscopic characterization and validation of methodology. Free Radic. Biol. Med. 2002, 33, 473-490.
23. Gu, L., Okada, Y., Clinton, S. K., Gerard, C. et al., Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice. Mol. Cell. 1998, 2, 275-281.
24. Miller, S., Walker, S. W., Arthur, J. R., Nicol, F. et al., Selenite protects human endothelial cells from oxidative damage and induces thioredoxin reductase. Clin. Sci. (Lond). 2001, 100, 543-550.
25. Björnstedt, M., Hamberg, M., Kumar, S., Xue, J., Holmgren, A., Human thioredoxin reduces lipid hydroperoxides by NADPH and selenocysteine strongly stimulates the reaction via catalytically generated selenols. J. Biol. Chem. 1995, 270, 11761-11764.
26. Hayden, M. S., Ghosh, S., Shared principles in NF-kappaB signaling. Cell 2008, 132, 344-362.
27. Sneddon, A. A., Selenium and vascular health. Pure Appl. Chem. 2012, 84, 239-248.
28. Brigelius-Flohé, R., Maurer, S., Lötzer, K., Böl, G. et al., Overexpression of PHGPx inhibits hydroperoxide-induced oxidation, NFkappaB activation and apoptosis and affects oxLDL-mediated proliferation of rabbit aortic smooth muscle cells. Atherosclerosis 2000, 152, 307-316.
29. Kretz-Remy, C., Arrigo, A. P., Selenium: a key element that controls NF-kappa B activation and I kappa B alpha half life. Biofactors 2001, 14, 117-125.
30. Gong, G., Méplan, C., Gautrey, H., Hall, J. et al., Differential effects of selenium and knock-down of glutathione peroxidases on TNFα and flagellin inflammatory responses in gut epithelial cells. Genes Nutr. 2012, 7, 167-178.
31. Mayer, K., Merfels, M., Muhly-Reinholz, M., Gokorsch, S. et al., Omega-3 fatty acids suppress monocyte adhesion to human endothelial cells: role of endothelial PAF generation. Am. J. Physiol. Heart Circ. Physiol. 2002, 283, H811-H818.
32. Thies, F., Garry, J. M., Yaqoob, P., Rerkasem, K. et al., Association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaques: a randomised controlled trial. Lancet 2003, 361, 477-485.