MCH neurons are the primary sleep-promoting group

Sleep

Volumn 36, Issue 12, 2013, Pages 1779-1781

  Pelluru, Dheeraj ^a   Konadhode, Rodarani ^a   Shiromani, Priyattam J ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; HORMONE ANTAGONIST; MELANIN CONCENTRATING HORMONE; SEROTONIN;

ARTICLE; HUMAN; LATERAL HYPOTHALAMUS; MEAN CORPUSCULAR HEMOGLOBIN; NONHUMAN; PRIORITY JOURNAL; REM SLEEP; RODENT; SLEEP; SLEEP WAKING CYCLE;

ANIMALS; HUMANS; HYPOTHALAMIC HORMONES; MELANINS; NEURONS; PITUITARY HORMONES; SLEEP;

EID: 84889004807     PISSN: 01618105     EISSN: 15509109     Source Type: Journal    
DOI: 10.5665/sleep.3196     Document Type: Article

References (21)

1. Szymusiak R. New insights into melanin concentrating hormone and sleep: a critical topics forum. Sleep 2013;36:1765-6.
2. Fraigne JJ, Peever JH. Melanin-concentrating hormone neurons promote and stabilize sleep. Sleep 2013;36:1767-8.
3. Jones BE, Hassani OK. The role of Hcrt/Orx and MCH neurons in sleepwake state regulation. Sleep 2013;36:1769-72.
4. McGinty D, Alam N. MCH neurons: the end of the beginning. Sleep 2013;36:1773-4.
5. Luppi PH, Peyron C, Fort P. Role of MCH neurons in paradoxical (REM) sleep control. Sleep 2013;36:1775-6.
6. Blouin AM, Fried I, Wilson CL, et al. Human hypocretin and melaninconcentrating hormone levels are linked to emotion and social interaction. Nat Commun 2013;4:1547.
7. Konadhode RR, Pelluru D, Blanco-Centurion C, et al. Optogenetic stimulation of MCH neurons increases sleep. J Neurosci 2013;33:10257-63.
8. Jego S, Glasgow SD, Herrera CG, et al. Optogenetic identification of a rapid eye movement sleep modulatory circuit in the hypothalamus. Nat Neurosci 2013 Sep 22. doi: 10.1038/nn.3522. [Epub ahead of print].
9. Luppi PH, Clement O, Fort P. Paradoxical (REM) sleep genesis by the brainstem is under hypothalamic control. Curr Opin Neurobiol 2013;23:786-92.
10. Sherin JE, Shiromani PJ, McCarley RW, Saper CB. Activation of ventrolateral preoptic neurons during sleep. Science 1996;271:216-9.
11. Szymusiak R, Gvilia I, McGinty D. Hypothalamic control of sleep. Sleep Med 2007;8:291-301.
12. van den Pol AN, Acuna-Goycolea C, Clark KR, Ghosh PK. Physiological properties of hypothalamic MCH neurons identified with selective expression of reporter gene after recombinant virus infection. Neuron 2004;42:635-52.
13. John J, Wu MF, Boehmer LN, Siegel JM. Cataplexy-active neurons in the hypothalamus: implications for the role of histamine in sleep and waking behavior. Neuron 2004;42:619-34.
14. Portas CM, Thakkar M, Rainnie D, McCarley RW. Microdialysis perfusion of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) in the dorsal raphe nucleus decreases serotonin release and increases rapid eye movement sleep in the freely moving cat. J Neurosci 1996;16:2820-8.
15. Gerashchenko D, Salin-Pascual R, Shiromani PJ. Effects of hypocretinsaporin injections into the medial septum on sleep and hippocampal theta. Brain Res 2001;913:106-15.
16. Rao Y, Lu M, Ge F, et al. Regulation of synaptic efficacy in hypocretin/orexin-containing neurons by melanin concentrating hormone in the lateral hypothalamus. J Neurosci 2008;28:9101-10.
17. Sherin JE, Elmquist JK, Torrealba F, Saper CB. Innervation of histaminergic tuberomammillary neurons by GABAergic and galaninergic neurons in the ventrolateral preoptic nucleus of the rat. J Neurosci 1998;18:4705-21.
18. Kaur S, Thankachan S, Begum S, Liu M, Blanco-Centurion C, Shiromani PJ. Hypocretin-2 saporin lesions of the ventrolateral periaquaductal gray (vlPAG) increase REM sleep in hypocretin knockout mice. PloS One 2009;4:e6346.
19. Gao XB, Ghosh PK, van den Pol AN. Neurons synthesizing melaninconcentrating hormone identified by selective reporter gene expression after transfection in vitro: transmitter responses. J Neurophys 2003;90:3978-85.
20. Huang H, van den Pol AN. Rapid direct excitation and long-lasting enhancement of NMDA response by group I metabotropic glutamate receptor activation of hypothalamic melanin-concentrating hormone neurons. J Neurosci 2007;27:11560-72.
21. Kong D, Vong L, Parton LE, et al. Glucose stimulation of hypothalamic MCH neurons involves K(ATP) channels, is modulated by UCP2, and regulates peripheral glucose homeostasis. Cell Metab 2010;12:545-52.