Meclofenamic acid blocks the gap junction communication between the retinal pigment epithelial cells

Human and Experimental Toxicology

Volumn 32, Issue 11, 2013, Pages 1164-1169

  Ning, N ^a,b   Wen, Y ^c   Li, Y ^a,b   Li, J ^a,b  

^a SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANDONG UNIVERSITY   (China)

^c Shandong Shierming Eye Hospital   (China)

Author keywords

gap junction; meclofenamic acid; Retinal pigment epithelium; side effects

Indexed keywords

ACETYLSALICYLIC ACID; FLUFENAMIC ACID; LUCIFER YELLOW; MECLOFENAMIC ACID;

ARTICLE; CELL COMMUNICATION; CELL MEMBRANE CONDUCTANCE; DRUG EFFECT; GAP JUNCTION; HUMAN; HUMAN CELL; IMAGE ANALYSIS; PATCH CLAMP; PIGMENT CELL; PIGMENT EPITHELIUM; PRIORITY JOURNAL; WHOLE CELL;

GAP JUNCTION; MECLOFENAMIC ACID; RETINAL PIGMENT EPITHELIUM; SIDE EFFECTS;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL COMMUNICATION; CELL LINE; EPITHELIAL CELLS; GAP JUNCTIONS; HUMANS; MECLOFENAMIC ACID; RETINAL PIGMENT EPITHELIUM;

EID: 84888998560     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327112472997     Document Type: Article

References (29)

1. Gamulescu MA, Schalke B, Schuierer G, Gabel VP. Optic neuritis with visual field defect-possible Ibuprofen-related toxicity. Ann Pharmacother. 2006 ; 40: 571-573
2. Coulter DM, Clark DW. Disturbance of vision by COX-2 inhibitors. Expert Opin Drug Saf. 2004 ; 3: 607-614
3. Nicastro NJ. Visual disturbances associated with over-the-counter ibuprofen in three patients. Ann Ophthalmol. 1989 ; 21: 447-450
4. Hamburger HA, Beckman H, Thompson R. Visual evoked potentials and ibuprofen (Motrin) toxicity. Ann Ophthalmol. 1984 ; 16: 328-329
5. Collum LM, Bowen DI. Ocular side-effects of Ibuprofen. Br J Ophthalmol. 1971 ; 55: 472-427
6. Palmer CA. Toxic amblyopia from ibuprofen. Br Med J. 1972 ; 3: 765
7. Li J, Zhang N, Ye B, Ju W, Orser B, Fox JE, et al. Non-steroidal anti-inflammatory drugs increase insulin release from beta cells by inhibiting ATP-sensitive potassium channels. Br J Pharmacol. 2007 ; 151: 483-493
8. Li J, Xiang YY, Ye L, Tsui LC, Macdonald JF, Hu J, et al. Nonsteroidal anti-inflammatory drugs upregulate function of wild-type and mutant CFTR. Eur Respir J. 2008 ; 32: 334-343
9. Voilley N, de Weille J, Mamet J, Lazdunski M. Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors. J Neurosci. 2001 ; 21: 8026-8033
10. Ottolia M, Toro L. Potentiation of large conductance KCa channels by niflumic, flufenamic, and mefenamic acids. Biophys J. 1994 ; 67: 2272-2279
11. Woodward RM, Polenzani L, Miledi R. Effects of fenamates and other nonsteroidal anti-inflammatory drugs on rat brain GABAA receptors expressed in Xenopus oocytes. J Pharmacol Exp Ther. 1994 ; 268: 806-817
12. Veruki ML, Hartveit E. Meclofenamic acid blocks electrical synapses of retinal AII amacrine and on-cone bipolar cells. J Neurophysiol. 2009 ; 101: 2339-2347
13. Harks EG, de Roos AD, Peters PH, de Haan LH, Brouwer A, Ypey DL, et al. Fenamates: a novel class of reversible gap junction blockers. J Pharmacol Exp Ther. 2001 ; 298: 1033-1041
14. Pocrnich CE, Shao Q, Liu H, Feng MM, Harasym S, Savage M, et al. The effect of connexin43 on the level of vascular endothelial growth factor in human retinal pigment epithelial cells. Graefes Arch Clin Exp Ophthalmol. 2011 ; 250: 515-522
15. Wittig D, Wang X, Walter C, Gerdes HH, Funk RH, Roehlecke C. Multi-level communication of human retinal pigment epithelial cells via tunneling nanotubes. PLoS One. 2012 ; 7: e33195
16. de Roos AD, van Zoelen EJ, Theuvenet AP. Determination of gap junctional intercellular communication by capacitance measurements. Pflugers Arch. 1996 ; 431: 556-563
17. Lo CW, Gilula NB. Gap junctional communication in the post-implantation mouse embryo. Cell. 1979 ; 18: 411-422
18. Simon AM, Goodenough DA. Diverse functions of vertebrate gap junctions. Trends Cell Biol. 1998 ; 8: 477-483
19. Evans WH, Martin PE. Gap junctions: structure and function (Review). Mol Membr Biol. 2002 ; 19: 121-136
20. Pearson RA, Dale N, Llaudet E, Mobbs P. ATP released via gap junction hemichannels from the pigment epithelium regulates neural retinal progenitor proliferation. Neuron. 2005 ; 46: 731-744
21. Kojima A, Nakahama K, Ohno-Matsui K, Shimada N, Mori K, Iseki S, et al. Connexin 43 contributes to differentiation of retinal pigment epithelial cells via cyclic AMP signaling. Biochem Biophys Res Commun. 2008 ; 366: 532-538
22. Sinkkonen ST, Mansikkamaki S, Moykkynen T, Luddens H, Uusi-Oukari M, Korpi ER. Receptor subtype-dependent positive and negative modulation of GABA(A) receptor function by niflumic acid, a nonsteroidal anti-inflammatory drug. Mol Pharmacol. 2003 ; 64: 753-763
23. Halliwell RF, Thomas P, Patten D, James CH, Martinez-Torres A, Miledi R, Smart TG. Subunit-selective modulation of GABAA receptors by the non-steroidal anti-inflammatory agent, mefenamic acid. Eur J Neurosci. 1999 ; 11: 2897-2905
24. Bannwarth B, Netter P, Pourel J, Royer RJ, Gaucher A. Clinical pharmacokinetics of nonsteroidal anti-inflammatory drugs in the cerebrospinal fluid. Biomed Pharmacother. 1989 ; 43: 121-126
25. Pan F, Mills SL, Massey SC. Screening of gap junction antagonists on dye coupling in the rabbit retina. Vis Neurosci. 2007 ; 24: 609-618
26. Schraermeyer U, Heimann K. Current understanding on the role of retinal pigment epithelium and its pigmentation. Pigment Cell Res. 1999 ; 12: 219-236
27. Steinberg RH. Interactions between the retinal pigment epithelium and the neural retina. Doc Ophthalmol. 1985 ; 60: 327-346
28. Bok D. The retinal pigment epithelium: a versatile partner in vision. J Cell Sci Suppl. 1993 ; 17: 189-195
29. Eagle RC. Mechanisms of maculopathy. Ophthalmology. 1984 ; 91: 613-625