NRH: Quinone oxidoreductase 2 (NQO2) protein competes with the 20 S proteasome to stabilize transcription factor CCAAT enhancer-binding protein α (C/EBPα), leading to protection against γ radiation-induced myeloproliferative disease

Journal of Biological Chemistry

Volumn 288, Issue 48, 2013, Pages 34799-34808

  Xu, Junkang ^a   Patrick, Brad Allen ^a   Jaiswal, Anil K ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COFACTORS; ENHANCER-BINDING PROTEINS; HL-60 CELLS; MYELOID DIFFERENTIATION; OXIDOREDUCTASES; PROTEASOMES; RADIATION-INDUCED; SITE DIRECTED MUTAGENESIS;

MAMMALS; PROTEINS;

RADIATION PROTECTION;

CCAAT ENHANCER BINDING PROTEIN ALPHA; DIHYDRONICOTINAMIDE RIBOSIDE QUINONE OXIDOREDUCTASE 1; DIHYDRONICOTINAMIDE RIBOSIDE QUINONE OXIDOREDUCTASE 2; OXIDOREDUCTASE; PROTEASOME; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING COMPETITION; BINDING SITE; CONTROLLED STUDY; EX VIVO STUDY; GAMMA RADIATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; MYELOPROLIFERATIVE DISORDER; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; RADIATION INJURY; RADIATION PROTECTION;

EID: 84888984200     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.495580     Document Type: Article

References (20)

1. Zhao, Q., Yang, X. L., Holtzclaw, W. D., and Talalay, P. (1997) Unexpected genetic and structural relationships of a long-forgotten flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase). Proc. Natl. Acad. Sci. U.S.A. 94, 1669-1674
2. Chen, S., Wu, K., and Knox, R. (2000) Structure-function studies of DTdiaphorase (NQO1) and NRH:quinone oxidoreductase (NQO2). Free Radic. Biol. Med. 3-4, 276-284
3. Bianchet, M. A., Foster, C., Faig, M., Talalay, P., and Amzel, L. M. (1999) Structure and mechanism of cytosolic quinone reductases. Biochem. Soc. Trans. 27, 610-615
4. Gong, X., Kole, L., Iskander, K., and Jaiswal, A. K. (2007) NRH:quinone oxidoreductase 2 and NAD(P)H:quinone oxidoreductase 1 protect tumor suppressor p53 against 20 S proteasomal degradation leading to stabilization and activation of p53. Cancer Res. 67, 5380-5388
5. Garate, M., Wong, R. P., Campos, E. I., Wang, Y., and Li, G. (2008) NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33(ING1b). EMBO Rep. 9, 576-581
6. Patrick, B. A., Gong, X., and Jaiswal, A. K. (2011) Disruption of NAD(P)H: quinone oxidoreductase 1 gene in mice leads to 20 S proteasomal degradation of p63 resulting in thinning of epithelium and chemical-induced skin cancer. Oncogene 30, 1098-1107
7. Long, D. J., 2nd, Iskander, K., Gaikwad, A., Arin, M., Roop, D. R., Knox, R., Barrios, R., and Jaiswal, A.K. (2002) Disruption of dihydronicotinamide riboside:quinone oxidoreductase 2 (NQO2) leads to myeloid hyperplasia of bone marrow and decreased sensitivity to menadione toxicity. J. Biol. Chem. 277, 46131-46139
8. Iskander, K., Barrios, R. J., and Jaiswal, A. K. (2009) NRH:quinone oxidoreductase 2-deficient mice are highly susceptible to radiation-induced B-cell lymphomas. Clin. Cancer Res. 15, 1534-1542
9. Scott, L. M., Civin, C. I., Rorth, P., and Friedman, A. D. (1992) A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells. Blood 80, 1725-1735
10. Klemsz, M. J., McKercher, S. R., Celada, A., Van Beveren, C., and Maki, R. A. (1990) The macrophage and B cell-specific transcription factor PU. 1 is related to the ets oncogene. Cell 61, 113-124
11. Pabst, T., Mueller, B. U., Zhang, P., Radomska, H. S., Narravula, S., Schnittger, S., Behre, G., Hiddemann, W., and Tenen, D. G. (2001) Dominantnegative mutations of CEBPA, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia. Nat. Genet. 27, 263-270
12. Fröhling, S., Schlenk, R. F., Stolze, I., Bihlmayr, J., Benner, A., Kreitmeier, S., Tobis, K., Döhner, H., and Döhner, K. (2004) CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics. Prognostic relevance and analysis of cooperating mutations. J. Clin. Oncol. 22, 624-633
13. Yeamans, C., Wang, D., Paz-Priel, I., Torbett, B. E., Tenen, D. G., and Friedman, A. D. (2007) C/EBPα binds and activates the PU. 1 distal enhancer to induce monocyte lineage commitment. Blood 110, 3136-3142
14. Xu, J., and Jaiswal, A. K. (2012) NAD(P)H:quinone oxidoreductase 1 (NQO1) competes with 20 S proteasome for binding with C/EBPα leading to its stabilization and protection against radiation-induced myeloproliferative disease. J. Biol. Chem. 287, 41608-41618
15. Iskander, K., Barrios, R. J., and Jaiswal, A. K. (2008) Disruption of NAD(P)H:quinone oxidoreductase 1 gene in mice leads to radiation-induced myeloproliferative disease. Cancer Res. 68, 7915-7922
16. Smith, M.T., Wang, Y., Skibola, C. F., Slater, D. J., Lo Nigro, L., Nowell, P. C., Lange, B. J., and Felix, C. A. (2002) Low NAD(P)H:quinone oxidoreductase activity is associated with increased risk of leukemia with MLL translocations in infants and children. Blood 100, 4590-4593
17. Rosenbauer, F., Wagner, K., Kutok, J. L., Iwasaki, H., Le Beau, M. M., Okuno, Y., Akashi, K., Fiering, S., and Tenen, D. G. (2004) Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU. 1. Nat. Genet. 36, 624-630
18. Kaspar, J. W., Niture, S. K., and Jaiswal, A. K. (2009) Nrf2:INrf2 (Keap1) signaling in oxidative stress. Free Radic. Biol. Med. 47, 1304-1309
19. Wang, W., and Jaiswal, A. K. (2004) Sp3 repression of polymorphic human NRH:quinone oxidoreductase 2 gene promoter. Free Radic. Biol. Med. 37, 1231-1243
20. Wang, W., Le, W. D., Pan, T., Stringer, J. L., and Jaiswal, A. K. (2008) Association of NRH:quinone oxidoreductase 2 gene promoter polymorphism with higher gene expression and increased susceptibility to Parkinson's disease. J. Gerontol. A Biol. Sci. Med. Sci. 63, 127-134