NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33ING1b

EMBO Reports

Volumn 9, Issue 6, 2008, Pages 576-581

  Garate, Marco ^a   Wong, Ronald P C ^a   Campos, Eric I ^a   Wang, Yemin ^a   Li, Gang ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALPAIN; PROTEASOME; PROTEIN P33; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SERINE; TUMOR SUPPRESSOR PROTEIN;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL NUCLEUS; CELL STRESS; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONTROLLED STUDY; DNA REPAIR; GENOTOXICITY; HALF LIFE TIME; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; ULTRAVIOLET IRRADIATION;

ACETYLCYSTEINE; ANIMALS; CELL CYCLE; CELL LINE, TUMOR; CYCLOHEXIMIDE; CYSTEINE PROTEINASE INHIBITORS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUPEPTINS; NAD(P)H DEHYDROGENASE (QUINONE); NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; SERINE; TUMOR SUPPRESSOR PROTEINS; ULTRAVIOLET RAYS;

EID: 44649168869     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2008.48     Document Type: Article

References (22)

1. Asher G, Shaul Y (2005) p53 proteasomal degradation: Poly-ubiquitination is not the whole story. Cell Cycle 4: 1015-1018
2. Asher G, Tsvetkov P, Kahana C, Shaul Y (2005a) A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73. Genes Dev 19: 316-321
3. Asher G, Bercovich Z, Tsvetkov P, Shaul Y, Kahana C (2005b) 20S proteasomal degradation of ornithine decarboxylase is regulated by NQO1. Mol Cell 17: 645-655
4. Campos EI, Chin MY, Kuo WH, Li G (2004) Biological functions of the ING family tumor suppressors. Cell Mol Life Sci 61: 2597-2613
5. Chehab NH, Malikzay A, Stavridi ES, Halazonetis TD (1999) Phosphorylation of Ser 20 mediates stabilization of human p53 in response to DNA damage. Proc Natl Acad Sci USA 96: 13777-13782
6. Cheung KJ Jr, Li G (2001) The tumor suppressor ING1: Structure and function. Exp Cell Res 268: 1-6
7. Cheung KJ Jr, Li G (2002) p33(ING1) enhances UVB-induced apoptosis in melanoma cells. Exp Cell Res 279: 291-298
8. Cheung KJ Jr, Bush JA, Jia W, Li G (2000) Expression of the novel tumour suppressor p33(ING1) is independent of p53. Br J Cancer 83: 1468-1472
9. Cheung KJ Jr, Mitchell D, Lin P, Li G (2001) The tumor suppressor candidate p33(ING1) mediates repair of UV-damaged DNA. Cancer Res 61: 4974-4977
10. Cuervo AM, Hu W, Lim B, Dice JF (1998) IκB is a substrate for a selective pathway of lysosomal proteolysis. Mol Biol Cell 9: 1995-2010
11. Doyon Y, Selleck W, Lane WS, Tan S, Cote J (2004) Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Mol Cell Biol 24: 1884-1896
12. Feng X, Hara Y, Riabowol K (2002) Different HATS of the ING1 gene family. Trends Cell Biol 12: 532-538
13. Garate M, Campos EI, Bush JA, Xiao H, Li G (2007) Phosphorylation of the tumor suppressor p33ING1b at Ser 126 influences its protein stability and proliferation of melanoma cells. FASEB J 21: 3705-3716
14. Garkavtsev I, Kazarov A, Gudkov A, Riabowol K (1996) Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation. Nat Genet 14: 415-420
15. Grossman SR, Deato ME, Brignone C, Chan HM, Kung AL, Tagami H, Nakatani Y, Livingston DM (2003) Polyubiquitination of p53 by a ubiquitin ligase activity of p300. Science 300: 342-344
16. Hasan UA, Caux C, Perrot I, Doffin AC, Menetrier-Caux C, Trinchieri G, Tommasino M, Vlach J (2007) Cell proliferation and survival induced by Toll-like receptors is antagonized by type I IFNs. Proc Natl Acad Sci USA 104: 8047-8052
17. Kataoka H et al (2003) ING1 represses transcription by direct DNA binding and through effects on p53. Cancer Res 63: 5785-5792
18. Razidlo GL, Kortum RL, Haferbier JL, Lewis RE (2004) Phosphorylation regulates KSR1 stability, ERK activation, and cell proliferation. J Biol Chem 279: 47808-47814
19. Scott M, Bonnefin P, Vieyra D, Boisvert FM, Young D, Bazett-Jones DP, Riabowol K (2001) UV-induced binding of ING1 to PCNA regulates the induction of apoptosis. J Cell Sci 114: 3455-3462
20. Tsai KK, Yuan ZM (2003) c-Abl stabilizes p73 by a phosphorylation-augmented interaction. Cancer Res 63: 3418-3424
21. Wang Y, Li G (2006) ING3 promotes UV-induced apoptosis via Fas/caspase-8 pathway in melanoma cells. J Biol Chem 281: 11887-11893
22. Zhang YW, Ottemess DM, Chiang GG, Xie W, Liu YC, Mercurio F, Abraham RT (2005) Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway. Mol Cell 19: 607-618