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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 24, 2013, Pages 6829-6833

Novel Mps1 kinase inhibitors: From purine to pyrrolopyrimidine and quinazoline leads

(7) Bursavich, Matthew G a Dastrup, David a Shenderovich, Mark a Yager, Kraig M a Cimbora, Daniel M a Williams, Brandi a Kumar, D Vijay a

a Myrexis Inc (United States)

Author keywords

Cancer; Conformational restriction; Mps1; Protein kinase inhibitors; Purines; Pyrrolopyrimidines; Quinazoline; Scaffold hopping; Structure based design; TTK

Indexed keywords

PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PROTEIN MPS1; PURINE DERIVATIVE; PYRROLOPYRIMIDINE DERIVATIVE; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER RESEARCH; DRUG ACTIVITY; DRUG CONFORMATION; DRUG DESIGN; DRUG STRUCTURE; DRUG TARGETING; ENZYME INHIBITION;

CANCER; CONFORMATIONAL RESTRICTION; MPS1; PROTEIN KINASE INHIBITORS; PURINES; PYRROLOPYRIMIDINES; QUINAZOLINE; SCAFFOLD HOPPING; STRUCTURE-BASED DESIGN; TTK;

CELL CYCLE PROTEINS; CELL PROLIFERATION; DRUG DESIGN; HCT116 CELLS; HUMANS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PURINES; PYRIMIDINES; PYRROLES; QUINAZOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84888880276 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.10.008 Document Type: Article

Times cited : (14)

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