Overexpression of HIF-2 α, TWIST, and CXCR4 is associated with lymph node metastasis in papillary thyroid carcinoma

Clinical and Developmental Immunology

Volumn 2013, Issue , 2013, Pages

  Wang, Ni ^a   Luo, Hao Jun ^a   Yin, Guo Bing ^a   Dong, Chao Ran ^a   Xu, Man ^a   Chen, George G ^b   Liu, Zhi Min ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; HYPOXIA INDUCIBLE FACTOR 2ALPHA; MESSENGER RNA; TRANSCRIPTION FACTOR TWIST; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; ENDOTHELIAL PAS DOMAIN CONTAINING PROTEIN 1; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1;

ADULT; ARTICLE; CANCER PATIENT; CANCER STAGING; CANCER SURGERY; CLINICAL INDICATOR; CONTROLLED STUDY; CORRELATIONAL STUDY; DISEASE ASSOCIATION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; NODULAR HYPERPLASIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THYROID CARCINOMA; THYROIDECTOMY; TUMOR VOLUME; UPREGULATION; AGED; CARCINOMA; GENETICS; METABOLISM; MIDDLE AGED; PATHOLOGY; PROGNOSIS; THYROID TUMOR;

ADULT; AGED; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CARCINOMA; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; RECEPTORS, CXCR4; RNA, MESSENGER; THYROID NEOPLASMS; TWIST TRANSCRIPTION FACTOR;

EID: 84888868518     PISSN: 17402522     EISSN: 17402530     Source Type: Journal    
DOI: 10.1155/2013/589423     Document Type: Article

References (25)

1. Hay I. D., Thompson G. B., Grant C. S., Bergstralh E. J., Dvorak C. E., Gorman C. A., Maurer M. S., McIver B., Mullan B. P., Oberg A. L., Powell C. C., Van Heerden J. A., Goellner J. R., Papillary thyroid carcinoma managed at the Mayo Clinic during six decades (1940-1999): temporal trends in initial therapy and long-term outcome in 2444 consecutively treated patients. World Journal of Surgery 2002 26 8 879 885 2-s2.0-0036691093 10.1007/s00268-002-6612-1 (Pubitemid 36920280)
2. Harris A. L., Hypoxia: a key regulatory factor in tumour growth. Nature Reviews Cancer 2002 2 1 38 47 2-s2.0-0036359548 (Pubitemid 37328806)
3. Lu X., Kang Y., Hypoxia and hypoxia-inducible factors: master regulators of metastasis. Clinical Cancer Research 2010 16 24 5928 5935 2-s2.0-78650373860 10.1158/1078-0432.CCR-10-1360
4. Gordan J. D., Simon M. C., Hypoxia-inducible factors: central regulators of the tumor phenotype. Current Opinion in Genetics and Development 2007 17 1 71 77 2-s2.0-33846199233 10.1016/j.gde.2006.12.006 (Pubitemid 46109295)
5. Keith B., Johnson R. S., Simon M. C., HIF1 α and HIF2 α: sibling rivalry in hypoxic tumour growth and progression. Nature Reviews Cancer 2012 12 1 9 22 2-s2.0-84655161946 10.1038/nrc3183
6. Qing G., Simon M. C., Hypoxia inducible factor-2 α: a critical mediator of aggressive tumor phenotypes. Current Opinion in Genetics and Development 2009 19 1 60 66 2-s2.0-60949102817 10.1016/j.gde.2008.12.001
7. Gort E. H., Van Haaften G., Verlaan I., Groot A. J., Plasterk R. H. A., Shvarts A., Suijkerbuijk K. P. M., Van Laar T., Van Der Wall E., Raman V., Van Diest P. J., Tijsterman M., Vooijs M., The TWIST1 oncogene is a direct target of hypoxia-inducible factor-2 α Oncogene 2008 27 11 1501 1510 2-s2.0-40449114805 10.1038/sj.onc.1210795 (Pubitemid 351347879)
8. Imtiyaz H. Z., Williams E. P., Hickey M. M., Patel S. A., Durham A. C., Yuan L., Hammond R., Gimotty P. A., Keith B., Simon M. C., Hypoxia-inducible factor 2 α regulates macrophage function in mouse models of acute and tumor inflammation. Journal of Clinical Investigation 2010 120 8 2699 2714 2-s2.0-77955295091 10.1172/JCI39506
9. Jin F., Ji H., Jia C., Synergistic antitumor effects of endostar in combination with oxaliplatin via inhibition of HIF and CXCR4 in the colorectal cell line SW1116. PLoS One 2012 7 10 e47161
10. Yang J., Mani S. A., Donaher J. L., Ramaswamy S., Itzykson R. A., Come C., Savagner P., Gitelman I., Richardson A., Weinberg R. A., Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 2004 117 7 927 939 2-s2.0-2942707848 10.1016/j.cell.2004.06.006 (Pubitemid 38798858)
11. Qin Q., Xu Y., He T., Qin C., Xu J., Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms. Cell Research 2012 22 1 90 106 2-s2.0-84855478714 10.1038/cr.2011.144
12. Mani S. A., Guo W., Liao M., Eaton E. N., Ayyanan A., Zhou A. Y., Brooks M., Reinhard F., Zhang C. C., Shipitsin M., Campbell L. L., Polyak K., Brisken C., Yang J., Weinberg R. A., The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008 133 4 704 715 2-s2.0-43049165453 10.1016/j.cell.2008.03.027 (Pubitemid 351636299)
13. Zlotnik A., Chemokines and cancer. International Journal of Cancer 2006 119 9 2026 2029 2-s2.0-33748873913 10.1002/ijc.22024 (Pubitemid 44423657)
14. Zlotnik A., Involvement of chemokine receptors in organ-specific metastasis. Contributions to Microbiology 2006 13 191 199 2-s2.0-33746086397
15. Spano J. P., Andre F., Morat L., Sabatier L., Besse B., Combadiere C., Deterre P., Martin A., Azorin J., Valeyre D., Khayat D., Le Chevalier T., Soria J.-C., Chemokine receptor CXCR4 and early-stage non-small cell lung cancer: pattern of expression and correlation with outcome. Annals of Oncology 2004 15 4 613 617 2-s2.0-2342432307 10.1093/annonc/mdh136 (Pubitemid 38559598)
16. Salvucci O., Bouchard A., Baccarelli A., Deschenes J., Sauter G., Simon R., Bianchi R., Basik M., The role of CXCR4 receptor expression in breast cancer: a large tissue microarray study. Breast Cancer Research and Treatment 2006 97 3 275 283 2-s2.0-33745334601 10.1007/s10549-005-9121-8 (Pubitemid 43945757)
17. Akashi T., Koizumi K., Tsuneyama K., Saiki I., Takano Y., Fuse H., Chemokine receptor CXCR4 expression and prognosis in patients with metastatic prostate cancer. Cancer Science 2008 29 3 539 542 2-s2.0-38949185673 10.1111/j.1349-7006.2007.00712.x (Pubitemid 351228571)
18. Kim J., Takeuchi H., Lam S. T., Turner R. R., Wang H., Kuo C., Foshag L., Bilchik A. J., Hoon D. S. B., Chemokine receptor CXCR4 expression in colorectal cancer patients increases the risk for recurrence and for poor survival. Journal of Clinical Oncology 2005 23 12 2744 2753 2-s2.0-18444401114 10.1200/JCO.2005.07.078 (Pubitemid 46179464)
19. Castellone M. D., Guarino V., De Falco V., Carlomagno F., Basolo F., Faviana P., Kruhoffer M., Orntoft T., Russell J. P., Rothstein J. L., Fusco A., Santoro M., Melillo R. M., Functional expression of the CXCR4 chemokine receptor is induced by RET/PTC oncogenes and is a common event in human papillary thyroid carcinomas. Oncogene 2004 23 35 5958 5967 2-s2.0-4043161468 10.1038/sj.onc.1207790 (Pubitemid 39093540)
20. Lang B. H., Lo C., Chan W., Lam K., Wan K., Staging systems for papillary thyroid carcinoma: a review and comparison. Annals of Surgery 2007 245 3 366 378 2-s2.0-34247614170 10.1097/01.sla.0000250445.92336.2a (Pubitemid 46673133)
21. Kononen J., Bubendorf L., Kallioniemi A., Bärlund M., Schraml P., Leighton S., Torhorst J., Mihatsch M. J., Sauter G., Kallioniemi O., Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nature Medicine 1998 4 7 844 847 2-s2.0-0031822837 10.1038/nm0798-844 (Pubitemid 28331029)
22. Livak K. J., Schmittgen T. D., Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method. Methods 2001 25 4 402 408 2-s2.0-0035710746 10.1006/meth.2001.1262 (Pubitemid 34164012)
23. Raval R. R., Lau K. W., Tran M. G. B., Sowter H. M., Mandriota S. J., Li J., Pugh C. W., Maxwell P. H., Harris A. L., Ratcliffe P. J., Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Molecular and Cellular Biology 2005 25 13 5675 5686 2-s2.0-20744445650 10.1128/MCB.25.13.5675-5686.2005 (Pubitemid 40853601)
24. Giatromanolaki A., Koukourakis M. I., Sivridis E., Turley H., Talks K., Pezzella F., Gatter K. C., Harris A. L., Relation of hypoxia inducible factor 1 α and 2 α in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival. British Journal of Cancer 2001 85 6 881 890 2-s2.0-0035860147 10.1054/bjoc.2001.2018 (Pubitemid 33010557)
25. Holmquist-Mengelbier L., Fredlund E., Löfstedt T., Noguera R., Navarro S., Nilsson H., Pietras A., Vallon-Christersson J., Borg Å., Gradin K., Poellinger L., Påhlman S., Recruitment of HIF-1 α and HIF-2 α to common target genes is differentially regulated in neuroblastoma: HIF-2 α promotes an aggressive phenotype. Cancer Cell 2006 10 5 413 423 2-s2.0-33750630119 10.1016/j.ccr.2006.08.026 (Pubitemid 44693470)