Synthesis and initial biological evaluation of substituted 1-phenylamino-2-thio-4,5-dimethyl-1H-imidazole derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 24, 2013, Pages 6764-6768

  Yurttaş, Leyla ^a   Duran, Murat ^b   Demirayak, Şeref ^c   Gençer, Hülya Karaca ^a   Tunali, Yaǧmur ^a  

^a ANADOLU UNIVERSITY   (Turkey)

^b ESKISEHIR OSMANGAZI UNIVERSITY   (Turkey)

^c ISTANBUL MEDIPOL UNIVERSITY   (Turkey)

Author keywords

Anticancer; Antimicrobial; Brine Shrimp test; Imidazole

Indexed keywords

ANTINEOPLASTIC AGENT; CHLORAMPHENICOL; IMIDAZOLE DERIVATIVE; KETOCONAZOLE; NSC 722202; NSC 772200; NSC 772201; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTEMIA; ARTICLE; BACTERIAL STRAIN; CANDIDA; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; HUMAN CELL; IN VITRO STUDY; LETHALITY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR WEIGHT; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; SUBSTITUTION REACTION; TUMOR CELL LINE;

ARTEMIA;

ANTICANCER; ANTIMICROBIAL; BRINE-SHRIMP TEST; IMIDAZOLE;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTIFUNGAL AGENTS; ANTINEOPLASTIC AGENTS; ARTEMIA; CELL LINE, TUMOR; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HUMANS; IMIDAZOLES; MICROBIAL SENSITIVITY TESTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84888866546     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.10.024     Document Type: Article

References (23)

1. A. Bhatnagar, P.K. Sharma, and N. Kumar Int. J. PharmTech Res. 3 2011 268
2. A. Khalafi-Nezhad, M.N.S. Rad, H. Mohabatkar, Z. Asrari, and B. Hemmateenejad Bioorg. Med. Chem. 2005 1931 13
3. J.R. Kumar Pharmacophore 1 2010 167
4. F. Bellina, S. Cauteruccio, and R. Rossi Tetrahedron 63 2007 4571
5. M.S. Khan, S.A. Siddiqui, M.S.R.A. Siddiqui, U. Goswami, K.V. Srinivasan, and M.I. Khan Chem. Biol. Drug Des. 72 2008 197
6. A. Tafi, R. Costi, M. Botta, R. Di Santo, F. Corelli, S. Massa, A. Ciacci, F. Manetti, and M.J. Artico Med. Chem. 45 2002 2720
7. S. Veraldi, and R. Milani Drugs 68 2008 2183
8. G. Simonetti, S. Baffa, and N. Simonetti Int. J. Antimicrob. Agents 17 2001 389
9. S. Sharma, S. Gangal, and A. Rauf Eur. J. Med. Chem. 44 2009 1751
10. H.S. Jawaharmal, S. Lamba, G. Narwal, D.R. Singh, A. Saini, S. Kaur, and Narwal Indo-Global J. Pharm. Sci. 2 2012 147
11. U. Ucucu, N.G. Karaburun, and I. Isikdag Farmaco 56 2001 285
12. M.A. Iradyan, N.S. Iradyan, F.G. Arsenyan, and G.M. Stepanyan Pharm. Chem. J. 43 2009 439
13. S. Baroniya, Z. Anwer, P.K. Sharma, R. Dudhe, and N.Der. Kumar Pharm. Sin. 1 2010 172
14. K. Shalini, P.K. Sharma, and N.Der. Kumar Chem. Sin. 1 2010 36
15. P. Franchetti, S. Marchetti, L. Cappellacci, J.A. Yalowitz, H.N. Jayaram, B.M. Goldstein, and M. Grifantini Bioorg. Med. Chem. Lett. 11 2001 67
16. B. Bonaz, J. Boitard, P. Marteau, M. Lemann, B. Coffin, B. Flourie, J. Belaiche, G. Cadiot, E.H. Metman, A. Cortot, J.F. Colombel, and Getaid Aliment. Pharmacol. Ther. 18 2003 401
17. K. Breistol, J. Balzarini, M.L. Sandvold, F. Myhren, M. Martinsen, E. De Clercq, and O. Fodstad Cancer Res. 59 1999 2944
18. B.D. Chelson Semin. Oncol. 19 1992 695
19. M. Duran, and S. Demirayak Med. Chem. Res. 22 2013 4110
20. S. Demirayak, A.C. Karaburun, and N. Kiraz Eur. J. Med. Chem. 34 1999 275
21. N.S. El-Gohary, and M.I. Shaaban Eur. J. Med. Chem. 63 2013 185
22. B. Brayn, M. Timothy, and S. Tore General and Applied Toxicology 1993 Wiley Barcelona
23. J.M. Nguta, J.M. Mbaria, D.W. Gakuya, P.K. Gathumbi, J.D. Kabasa, and S.G. Kiama Open Conf. Proc. J. 3 2012 30