Topical fenticonazole in dermatology and gynaecology: Current role in therapy

Drugs

Volumn 68, Issue 15, 2008, Pages 2183-2194

  Veraldi, Stefano ^a   Milani, Rodolfo ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b SAN GERARDO HOSPITAL   (Italy)

Author keywords

Azoles, therapeutic use; Dermatomycoses, treatment; Pityriasis versicolor, treatment; Tinea, treatment; Vulvovaginal candidiasis, treatment

Indexed keywords

BIFONAZOLE; CICLOPIROXOLAMINE; CLOTRIMAZOLE; ECONAZOLE; FENTICONAZOLE; MICONAZOLE; NAFTIFINE; PLACEBO;

AEROSOL; ANTIFUNGAL ACTIVITY; APPLICATION SITE EDEMA; APPLICATION SITE ERYTHEMA; BURNING SENSATION; CANDIDA ALBICANS; CANDIDIASIS; CREAM; DERMATOMYCOSIS; DRUG EFFICACY; DRUG WITHDRAWAL; HUMAN; MYCOSIS; OUTCOME ASSESSMENT; POWDER; REVIEW; SINGLE DRUG DOSE; SKIN IRRITATION; TINEA; TINEA VERSICOLOR; TRICHOMONAS VAGINALIS; TRICHOMONIASIS; UNSPECIFIED SIDE EFFECT; VAGINA CANDIDIASIS; VAGINITIS;

ADMINISTRATION, TOPICAL; ANTIFUNGAL AGENTS; CANDIDIASIS, VULVOVAGINAL; CLINICAL TRIALS AS TOPIC; DERMATOMYCOSES; FEMALE; HUMANS; IMIDAZOLES; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TRICHOMONAS VAGINITIS;

ARTHRODERMATACEAE; BACTERIA (MICROORGANISMS); CANDIDA; CANDIDA ALBICANS; PROTOZOA; TRICHOMONAS; TRICHOMONAS VAGINALIS;

EID: 53549096249     PISSN: 00126667     EISSN: 00126667     Source Type: Journal    
DOI: 10.2165/00003495-200868150-00007     Document Type: Review

References (52)

1. Garber G. An overview of fungal infections. Drugs 2001; 61 Suppl. 1: 1-12
2. Fromtling RA. Overview of medically important antifungal azole derivatives. Clin Microbiol Rev 1988 Apr; 1 (2): 187-217
3. Veronese M, Salvaterra M, Barzaghi D. Fenticonazole, a new imidazole derivative with antibacterial and antifungal activity: in vitro study. Arzneimittelforschung 1981; 31 (12): 2133-7
4. Naud P, Matos J, Hammes L, et al. Efficacy and tolerability of fenticonazol for bacterial vaginosis treatment: double-blind study, randomized, prospective, compared to placebo [in Portugese]. Rev Bras Med 2003; 60 (1-2): 67-70
5. Costa A, Veronese M, Ruggeri P, et al. Ultrastructural findings of Candida albicans blastoconidia submitted to the action of fenticonazole. Arzneimittelforschung 1989 Feb; 39 (2): 230-3
6. Costa AL, Valenti A, Veronese M. Study of the morphofunctional alterations produced by fenticonazole on strains of Candida albicans, using the scanning electron microscope (S.E.M). Mykosen 1984 Jan; 27 (1): 29-35
7. Angiolella L, De Bernardis F, Bromuro C, et al. The effect of antimycotics on secretory acid proteinase of Candida albicans. J Chemother 1990 Feb; 2 (1): 55-61
8. Ghannoum M, Abu Elteen K. Correlative relationship between proteinase production, adherence and pathogenicity of various strains of Candida albicans. J Med Vet Mycol 1986 Oct; 24 (5): 407-13
9. Cohen J. Review of the latest treatments of vulvovaginal mycoses: role of fenticonazole nitrate (Lomexin) in their treatment [in French]. Contracept Fertil Sex 1997 May; 25 (5): 396-403
10. Jones BM, Geary I, Lee ME, et al. Comparison of the in vitro activities of fenticonazole, other imidazoles, metronidazole, and tetracycline against organisms associated with bacterial vaginosis and skin infections. Antimicrob Agents Chemother 1989 Jun; 33 (6): 970-2
11. Albanese G, Di Cintio R, Giorgetti P, et al. Recurrent tinea pedis: a double blind study on the prophylactic use of fenticonazole powder. Mycoses 1992 May-Jun; 35 (5-6): 157-9
12. Altmeyer P, Luther H, Klaschka F, et al. A double-blind clinical trial of fenticonazole cream versus naftifine cream applied once daily in patients with cutaneous mycosis. Curr Ther Res Clin Exp 1990; 47 (1): 32-42
13. Altmeyer P, Nolting S, Kuhlwein A, et al. Effect of fenticonazole spray in cutaneous mycosis: a double-blind clinical trial versus cyclopyroxolamine spray. J Int Med Res 1990 Jan-Feb; 18 (1): 61-7
14. Aste N, Pau M, Cordaro CI, et al. Double-blind study with fenticonazole or bifonazole lotions in pityriasis versicolor. Int J Clin Pharmacol Res 1988; 8 (4): 271-3
15. Athow-Frost TA, Freeman K, Mann TA, et al. Clinical evaluation of fenticonazole cream in cutaneous fungal infections: a comparison with miconazole cream. Curr Med Res Opin 1986; 10 (2): 107-16
16. Clerico R, Ribuffo A. Efficacy and tolerance of fenticonazole versus miconazole cream. Int J Clin Pharmacol Res 1987; 7 (1): 77-81
17. Finzi A, Fioroni A, Monici Preti P, et al. A double blind evaluation of fenticonazole cream 2% and clotrimazole cream 1% in dermatomycoses. Mykosen 1986 Jan; 29 (1): 41-4
18. Jung EG, Bisco A, Azzollini E, et al. Fenticonazole cream once daily in dermatomycosis, a double-blind controlled trial versus bifonazole. Dermatologica 1988; 177 (2): 104-8
19. Kokoschka EM, Niebauer G, Mounari M, et al. Treatment of dermatomycoses with topical fenticonazole and econazole. Mykosen 1986 Jan; 29 (1): 45-50
20. Leiste D, Braun W, Fegeler W, et al. A double-blind clinical trial of fenticonazole (2%) spray versus naftifine (1%) spray in patients with cutaneous mycoses. Curr Med Res Opin 1989; 11 (9): 567-75
21. Odeh F, Fabry H, Kuhlwein A, et al. A double-blind clinical trial with a single daily application of fenticonzole lotion versus econazole lotion in patients with cutaneous mycosis. Curr Ther Res Clin Exp 1990; 47: 22-31
22. Rabbiosi G, Di Silverio A, Mosca M, et al. Treatment of Pityriasis versicolor with foam formulation of two different imidazole derivatives, fenticonazole and econazole. Derm Clin 1989; 3: 169-74
23. Stetter H. Fenticonazole (2% cream) in the treatment of skin diseases due to dermatophytes. Acta Therapeutica 1984; 10: 241-8
24. Vannini P, Difonzo EM, Cordaro CI, et al. New therapeutic approach in skin mycoses: a comparative trial once versus twice daily application of fenticonazole in comparison to miconazole. Mycoses 1988 May; 31 (5): 280-4
25. Aste N, Pau M, Zucca M, et al. Clinical experience with fenticonazole 2% formulation in the treatment of dermatomycoses and pityriasis versicolor. Int J Clin Pharmacol Res 1987; 7 (6): 503-6
26. Di Silverio A, Mosca M, Brandozzi G, et al. Efficacy of fenticonazole in patients with pityriasis versicolor [in Italian]. G Ital Dermatol Venereol 1989 Sep; 124 (9): XLVII-L
27. Fioroni A, Altomare GF, Finzi AF. Esperienza con fenticonazolo crema in unica applicazione giornaliera nelle Fenmicosi superficiali. Ann It Derm Clin Sper 1987; 41: 311-6
28. Persi A, Rebora A. Fenticonazole: a clinical trial. Mykosen 1985 Apr; 28 (4): 206-9
29. Pizzino D, Negosanti M, Morganti L, et al. Therapeutic efficacy of fenticonazole and in vitro assessment of its antifungal activity in comparison with other imidazole derivatives [in Italian]. G Ital Dermatol Venereol 1988 Sep; 123 (9): XLV-XLVIII
30. Sartani A, Cordaro CI, Panconesi E. A multicenter trial with a new imidazole derivative, fenticonazole, in superficial fungal skin infections. Curr Ther Res Clin Exp 1988; 43 (6): 1194-203
31. Clerico R. Therapeutical activity of a new imidazole, the fenticonazole, in superficial mycoses [in Italian]. Dermatol Clin 1986; 6: 87-90
32. Fioroni A, Terragni L, Vannini P, et al. Fenticonazole plasma levels during treatment with fenticonazole 2% cream and spray in patients with dermatomycoses. Curr Ther Res Clin Exp 1990; 47 (6): 997-1003
33. Fusetti M, Trimarchi I, Eibenstein A. New therapeutic acquisition in the treatment of otomycosis: an experimental study [in Italian]. Otorinolaringologia 1990; 40 (5): 393-8
34. Lepine J, Sacchetta A, Vargiu G, et al. Safety and efficacy on skin mycoses of a new imidazole derivate: fenticonazole. A report on 28 patients. Med Praxis 1984; 4: 1-7
35. Veronese M, Bertoncini A, Preti PM. Evaluation of the skin retention time of imidazole derivatives. Mykosen 1987 Aug; 30 (8): 386-90
36. Lopez-De-Blanc SA, Salati-De-Mugnolo N, Femopase FL, et al. Antifungal topical therapy in oral chronic candidosis: a comparative study. Med Oral 2002 Jul-Oct; 7 (4): 260-70
37. Brewster E, Preti PM, Ruffmann R, et al. Effect of fenticonazole in vaginal candidiasis: a double-blind clinical trial versus clotrimazole. J Int Med Res 1986; 14 (6): 306-10
38. Gorlero F, Bosco P, Barbieri M, et al. Fenticonazole ovules in the treatment of vaginal Trichomonas infections: a double-blind randomized pilot clinical trial. Curr Ther Res Clin Exp 1992; 51: 367-76
39. Gorlero F, Macchiavello S, Pellegatta L, et al. Evaluation of the efficacy and tolerability of two different dosages of fenticonazole vaginal ovules (600mg and 1000 mg) in patients with vaginal trichomoniasis: a controlled, double-blind, randomized clinical trial versus placebo. Curr Ther Res Clin Exp 1994; 55 (5): 510-8
40. Studd JW, Dooley MM, Welch CC, et al. Comparative clinical trial of fenticonazole ovule (600 mg) versus clotrimazole vaginal tablet (500 mg) in the treatment of symptomatic vaginal candidiasis. Curr Med Res Opin 1989; 11 (8): 477-84
41. Wiest W, Azzollini E, Ruffmann R. Comparison of single administration with an ovule of 600mg fenticonazole versus a 500mg clotrimazole vaginal pessary in the treatment of vaginal candidiasis. J Int Med Res 1989 Jul-Aug; 17 (4): 369-72
42. Belaisch J. Evaluation of the time response of a single dose administration of fenticonazole nitrate [in French]. Contracept Fertil Sex 1996 May; 24 (5): 417-22
43. Bukovsky I, Schneider D, Arieli S, et al. Fenticonazole in the treatment of vaginal trichomoniasis and vaginal mixed infections. Adv Ther 1991; 8: 166-71
44. Fernandez-Alba J, Valle-Gay A, Dibildox M, et al. Fenticonazole nitrate for treatment of vulvovaginitis: efficacy, safety, and tolerability of 1-gram ovules, administered as ultra-short 2-day regimen. J Chemother 2004 Apr; 16 (2): 179-86
45. Lawrence AG, Houang ET, Hiscock E, et al. Single dose therapy of vaginal candidiasis: a comparative trial of fenticonazole vaginal ovules versus clotrimazole vaginal tablets. Curr Med Res Opin 1990; 12 (2): 114-20
46. Munoz Reyes JR, Villanueva Reynoso C, Ramos CJ, et al. Efficacy and tolerance of 200mg of fenticonazole versus 400mg of miconazole in the intravaginal treatment of mycotic vulvovaginitis [in Spanish]. Ginecol Obstet Mex 2002 Feb; 70: 59-65
47. Sartani A, Cordaro C, Adinolfi G, et al. Short-term treatment of vaginal candidiasis: results of a multi-center study [in Italian]. Riv Ost Gin Perin 1988; 3 (2): 184-9
48. Schneider D, Caspi E, Arieli S, et al. Fenticonazole in the treatment of vaginal candidiasis. Adv Ther 1990; 7: 355-61
49. Wiest W, Ruffmann R. Short-term treatment of vaginal candidiasis with fenticonazole ovules: a three-dose schedule comparative trial. J Int Med Res 1987 Sep-Oct; 15 (5): 319-25
50. De Cecco L, Gorlero F, Marre Brunenghi MC, et al. Studio multicentrico sull'efficacia e tollerabilita del fenticonazolo nel trattamento delle vulvovaginiti da candida. Int J Drug Ther 1988; 5 (4): 296-301
51. Scalambrino S, Colombo M, Pellegrino A, et al. Efficacy and tolerability of intravaginal fenticonazole single therapeutic shot in low-recurrent vaginal trichomoniasis and candidiasis [in Italian]. Giorn Ital Mal Inf 1996; 2: 37-40
52. Scienza G, Bulgheroni C, Confalonieri C. Vaginiti recidivanti: efficacia e tollerabilita della terapia locale con fenticonazolo. G Ital Ost Gin 1987; 9 (9): 758-60