Enhanced estrogen receptor beta (ERβ) selectivity of fluorinated carborane-containing ER modulators

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 24, 2013, Pages 6555-6558

  Ohta, Kiminori ^a   Ogawa, Takumi ^a   Kaise, Asako ^a   Endo, Yasuyuki ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Carborane; Estrogen receptor; Fluorine; Subtype selectivity

Indexed keywords

CARBORANE DERIVATIVE; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; SELECTIVE ESTROGEN RECEPTOR MODULATOR;

ARTICLE; BINDING AFFINITY; CELL PROLIFERATION; CHEMICAL MODIFICATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DEMETHYLATION; DRUG SELECTIVITY; DRUG SYNTHESIS; FLUORINATION; HYDROGEN BOND; HYDROPHOBICITY; STRUCTURE ACTIVITY RELATION;

CARBORANE; ESTROGEN RECEPTOR; FLUORINE; SUBTYPE SELECTIVITY;

BORANES; BORON COMPOUNDS; CELL PROLIFERATION; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGEN RECEPTOR MODULATORS; FLUORINE; HALOGENATION; HUMANS; MCF-7 CELLS; PHENOLS; PROTEIN BINDING;

EID: 84888864778     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.10.067     Document Type: Article

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