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Volumn 72, Issue 14, 2012, Pages 1825-1831

Interferon-free hepatitis C therapy: How close are we?

Author keywords

ABT 072; ABT 333; ABT 450; Alisporivir; Asunaprevir; Balapiravir; BI 201335; BI 207127; BMS 986094; Boceprevir; Calcineurin inhibitors; Daclatasvir; Danoprevirritonavir; Erythropoietins; GS 5885; GS 9256; GS 9451; Hepatitis C; Hepatitis C protease inhibitors; Hepatitis C virus NS 5 protein inhibitors; Interferon alpha; Lomibuvir; Mericitabine; MK 5172; Peginterferon alfa; PSI 938; Ribavirin; Ritonavir; Setrobuvir; Simeprevir; Sofosbuvir; Tegobuvir; Telaprevir; Valopicitabine

Indexed keywords

ABT 072; ABT 333; ABT 450; ALISPORIVIR; ANA 598505; ANTIVIRUS AGENT; ASUNAPREVIR; BALAPIRAVIR; BI 207127; BMS 986094; BOCEPREVIR; DACLATASVIR; DANOPREVIR; FALDAPREVIR; GS 5885; GS 7977; GS 9256; GS 9451; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; INTERFERON; INX 189; MERICITABINE; MK 5172; PEGINTERFERON; PSI 938; RIBAVIRIN; RITONAVIR; SETROBUVIR; SIMEPREVIR; SOFOSBUVIR; TEGOBUVIR; TELAPREVIR; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALOPICITABINE; VX 22;

EID: 84866062357     PISSN: 00126667     EISSN: 11791950     Source Type: Journal    
DOI: 10.2165/11635560-000000000-00000     Document Type: Review
Times cited : (23)

References (36)
  • 1
    • 79951594372 scopus 로고    scopus 로고
    • Drugs in development for viral hepatitis: Care and caution
    • Pockros PJ. Drugs in development for viral hepatitis: care and caution. Drugs 2011; 71 (3): 263-71
    • (2011) Drugs , vol.71 , Issue.3 , pp. 263-271
    • Pockros, P.J.1
  • 2
    • 84872769725 scopus 로고    scopus 로고
    • Safety of telaprevir or boceprevir in combination with peginterferon alfa/ribavirin, in cirrhotic non re-sponders: First results of the French early access program (ANRS CO20-CUPIC) [abstract no. 8]
    • Apr 18-22; Barcelona
    • Hezode C, Dorival C, Zoulim F, ANRS CO20 CUPIC study group. Safety of telaprevir or boceprevir in combination with peginterferon alfa/ribavirin, in cirrhotic non re-sponders: first results of the French early access program (ANRS CO20-CUPIC) [abstract no. 8]. 47th Annual Meeting of the European Association for the Study of the Liver; 2012 Apr 18-22; Barcelona
    • (2012) 47th Annual Meeting of the European Association for the Study of the Liver
    • Hezode, C.1    Dorival, C.2    Zoulim, F.3
  • 3
    • 84866131783 scopus 로고    scopus 로고
    • Preliminary results of twice daily dosing (Q12 hr) of telaprevir (TVR) for treatment naive and previously treated patients with genotype 1 HCV: Comparable RVR, eRVR and SVR12 to standard daily dosing at Q8 hr [abstract no. 1830]
    • Nov 9-13; Boston (MA)
    • Pockros PJ, Hunt D, Scherschel A. Preliminary results of twice daily dosing (Q12 hr) of telaprevir (TVR) for treatment naive and previously treated patients with genotype 1 HCV: comparable RVR, eRVR and SVR12 to standard daily dosing at Q8 hr [abstract no. 1830]. 63rd Annual Meeting of the American Association for the Study of Liver Diseases; 2012 Nov 9-13; Boston (MA)
    • (2012) 63rd Annual Meeting of the American Association for the Study of Liver Diseases
    • Pockros, P.J.1    Hunt, D.2    Scherschel, A.3
  • 4
    • 79959438789 scopus 로고    scopus 로고
    • Telaprevir for previously untreated chronic hepatitis C virus infection
    • Jacobson IM, McHutchison JG, Dusheiko G, et al. Telaprevir for previously untreated chronic hepatitis C virus infection. N Engl J Med 2011; 364: 2405-16
    • (2011) N Engl J Med , vol.364 , pp. 2405-2416
    • Jacobson, I.M.1    McHutchison, J.G.2    Dusheiko, G.3
  • 5
    • 79953173221 scopus 로고    scopus 로고
    • Boceprevir for untreated chronic HCV genotype 1 infection
    • Poordad F, McCone J, Bacon BR, et al. Boceprevir for untreated chronic HCV genotype 1 infection. N Engl J Med 2011; 364: 1195-206
    • (2011) N Engl J Med , vol.364 , pp. 1195-1206
    • Poordad, F.1    McCone, J.2    Bacon, B.R.3
  • 6
    • 79953176289 scopus 로고    scopus 로고
    • Boceprevir for previously treated chronic HCV genotype 1 infection
    • Bacon BR, Gordon SC, Lawitz E, et al. Boceprevir for previously treated chronic HCV genotype 1 infection. N Engl J Med 2011; 364: 1207-17
    • (2011) N Engl J Med , vol.364 , pp. 1207-1217
    • Bacon, B.R.1    Gordon, S.C.2    Lawitz, E.3
  • 7
    • 79959381354 scopus 로고    scopus 로고
    • Telaprevir for retreatment of HCV infection
    • Zeuzem S, Andreone P, Pol S, et al. Telaprevir for retreatment of HCV infection. N Engl J Med 2011; 364: 1-12
    • (2011) N Engl J Med , vol.364 , pp. 1-12
    • Zeuzem, S.1    Andreone, P.2    Pol, S.3
  • 8
    • 79960720836 scopus 로고    scopus 로고
    • Vertex Pharmaceuticals Inc Cambridge (MA): Vertex Pharmaceuticals Incorporated 2012 Jun [online] [Accessed 2012 Aug 22]
    • Vertex Pharmaceuticals Inc. Highlights of prescribing information: INCIVEK™ (telaprevir) film coated tablets, for oral use. Cambridge (MA): Vertex Pharmaceuticals Incorporated, 2012 Jun [online]. Available from URL: http://pi.vrtx.com/files/uspi-telaprevir.pdf [Accessed 2012 Aug 22]
    • Highlights of Prescribing Information: INCIVEK™ (Telaprevir) Film Coated Tablets for Oral Use
  • 9
    • 79960720836 scopus 로고    scopus 로고
    • Merck Sharp & Dohme Corp Whitehouse Station (NJ): Merck Sharp & Dohme Corp. [online] [Accessed Aug 22]
    • Merck Sharp & Dohme Corp. Highlights of prescribing information: VICTRELIS® (boceprevir) capsules for oral use. Whitehouse Station (NJ): Merck Sharp & Dohme Corp., [online]. Available from URL: http://www.merck.com/product/usa/pi-circulars/v/victrelis/victrelis-pi.pdf [Accessed Aug 22]
    • Highlights of Prescribing Information: VICTRELIS® (Boceprevir) Capsules for Oral Use
  • 10
    • 84873069563 scopus 로고    scopus 로고
    • Boceprevir + pegylated interferon + ribavirin for the treatment of HCVHIV-co-infected patients: End of treatment (week-48) interim results [abstract no 47]
    • Apr 18-22; Barcelona
    • Mallolas J, Pol S, Rivero A, et al. Boceprevir + pegylated interferon + ribavirin for the treatment of HCV/HIV-co-infected patients: end of treatment (week-48) interim results [abstract no 47]. 47th Annual Meeting of the European Association for the Study of the Liver; 2012 Apr 18-22; Barcelona
    • (2012) 47th Annual meeting of the European Association for the study of the liver
    • Mallolas, J.1    Pol, S.2    Rivero, A.3
  • 11
    • 79959561437 scopus 로고    scopus 로고
    • Effect of telaprevir on the pharmacokinetics of cyclosporine and tacrolimus
    • Garg V, van Heeswijk R, Lee JE, et al. Effect of telaprevir on the pharmacokinetics of cyclosporine and tacrolimus. He-patology 2011; 54 (1): 20-7
    • (2011) He-patology , vol.54 , Issue.1 , pp. 20-27
    • Garg, V.1    Van Heeswijk, R.2    Lee, J.E.3
  • 12
    • 84880934465 scopus 로고    scopus 로고
    • Efficacy and safety of protease inhibitors for severe hepatitis recurrence after liver transplantation: A first multicentric experience [LB abstract no. 1422]
    • Apr 18-22; Barcelona
    • Coilly A, Roche B, Botta-Fridlund D, et al. Efficacy and safety of protease inhibitors for severe hepatitis recurrence after liver transplantation: a first multicentric experience [LB abstract no. 1422]. 47th Annual Meeting of the European Association for the Study of the Liver; 2012 Apr 18-22; Barcelona
    • (2012) 47th Annual meeting of the European Association for the study of the liver
    • Coilly, A.1    Roche, B.2    Botta-Fridlund, D.3
  • 13
    • 84866106658 scopus 로고    scopus 로고
    • Potent viral suppression with all-oral combination of daclatasvir (NS5A inhibitor) and GS-7977 (NS5B inhibitor), +/riba-virin, in treatment-naive patients with chronic HCV GT1, 2, or 3 [abstract no. 1422]
    • Apr 18-22; Barcelona
    • Sulkowski M, Gardiner D, Lawitz E, et al. Potent viral suppression with all-oral combination of daclatasvir (NS5A inhibitor) and GS-7977 (NS5B inhibitor), +/-riba-virin, in treatment-naive patients with chronic HCV GT1, 2, or 3 [abstract no. 1422]. 47th Annual Meeting of the European Association for the Study of the Liver; 2012 Apr 18-22; Barcelona
    • (2012) 47th Annual Meeting of the European Association for the Study of the Liver
    • Sulkowski, M.1    Gardiner, D.2    Lawitz, E.3
  • 15
    • 84863860109 scopus 로고    scopus 로고
    • Prevalence of hepatitis C virus variants resistant to NS3 protease inhibitors or the NS5A inhibitor (BMS-790052) in hepatitis patients with genotype 1b
    • Aug
    • Suzuki F, Sezaki H, Akuta N, et al. Prevalence of hepatitis C virus variants resistant to NS3 protease inhibitors or the NS5A inhibitor (BMS-790052) in hepatitis patients with genotype 1b. J Clin Virol 2012 Aug; 54 (4): 352-4
    • (2012) J Clin Virol , vol.54 , Issue.4 , pp. 352-354
    • Suzuki, F.1    Sezaki, H.2    Akuta, N.3
  • 16
    • 84872608402 scopus 로고    scopus 로고
    • Dual oral combination therapy with the NS5A inhibitor BMS-790052 and the NS3 protease inhibitor BMS-650032 achieved 90% sustained virologic response (SVR12) in HCV genotype 1b-infected null responders [abstract no. LB-4]
    • Nov 4-8; San Francisco (CA)
    • Chayama K, Takahashi S, Kawakami Y, et al. Dual oral combination therapy with the NS5A inhibitor BMS-790052 and the NS3 protease inhibitor BMS-650032 achieved 90% sustained virologic response (SVR12) in HCV genotype 1b-infected null responders [abstract no. LB-4]. 62nd Annual Meeting of the American Association for the Study of Liver Diseases; 2011 Nov 4-8; San Francisco (CA)
    • (2011) 62nd Annual Meeting of the American Association for the Study of Liver Diseases
    • Chayama, K.1    Takahashi, S.2    Kawakami, Y.3
  • 17
    • 84866139228 scopus 로고    scopus 로고
    • A 12-week interferon-free regimen of ABT-450r ABT-072 and ribavirin was well tolerated and achieved sustained virologic response in 91% treatment-naive HCV IL28B-CC genotype-1-infected subjects [abstract no. 13]
    • Apr 18-22; Barcelona
    • Lawitz E, Poordad F, Kowdley KV, et al. A 12-week interferon-free regimen of ABT-450/r, ABT-072, and ribavirin was well tolerated and achieved sustained virologic response in 91% treatment-naive HCV IL28B-CC genotype-1-infected subjects [abstract no. 13]. 47th Annual Meeting of the European Association for the Study of the Liver; 2012 Apr 18-22; Barcelona
    • (2012) 47th Annual Meeting of the European Association for the Study of the Liver
    • Lawitz, E.1    Poordad, F.2    Kowdley, K.V.3
  • 18
    • 84867402085 scopus 로고    scopus 로고
    • 12-week interferon-free regimen of ABT-450r+ABT-333+ribavirin achieved SVR12 in more than 90% of treatment-naive HCV genotype-1-infected subjects and 47% of previous non-responders [abstract no. 1399]
    • Apr 18-22; Barcelona
    • Poordad F, Lawitz E, Kowdley KV, et al. 12-Week interferon-free regimen of ABT-450/r+ABT-333+ribavirin achieved SVR12 in more than 90% of treatment-naive HCV genotype-1-infected subjects and 47% of previous non-responders [abstract no. 1399]. 47th Annual Meeting of the European Association for the Study of the Liver; 2012 Apr 18-22; Barcelona
    • (2012) 47th Annual meeting of the European Association for the study of the liver
    • Poordad, F.1    Lawitz, E.2    Kowdley, K.V.3
  • 19
    • 81855228070 scopus 로고    scopus 로고
    • Efficacy of the protease inhibitor BI 201335 polymerase inhibitor BI 207127 and ribavirin in patients with chronic HCV infection
    • Dec
    • Zeuzem S, Asselah T, Angus P, et al. Efficacy of the protease inhibitor BI 201335, polymerase inhibitor BI 207127, and ribavirin in patients with chronic HCV infection. Gastro-enterology 2011 Dec; 141 (6): 2047-55
    • (2011) Gastro-enterology , vol.141 , Issue.6 , pp. 2047-2055
    • Zeuzem, S.1    Asselah, T.2    Angus, P.3
  • 20
    • 84866119318 scopus 로고    scopus 로고
    • Interferon-free treatment with a combination of mericitabine and danoprevir/R with or without ribavirin in treatment-naive HCV genotype 1-infected patients [abstract]
    • Gane EJ, Pockros P, Zeuzem S, et al. Interferon-free treatment with a combination of mericitabine and danoprevir/R with or without ribavirin in treatment-naive HCV genotype 1-infected patients [abstract]. J Hepatology 2012; 56 (Suppl. 2): S555
    • (2012) J Hepatology , vol.56 , Issue.SUPPL. 2
    • Gane, E.J.1    Pockros, P.2    Zeuzem, S.3
  • 22
    • 79951668580 scopus 로고    scopus 로고
    • Dual, triple, and quadruple combination treatment with a protease inhibitor (GS-9256) and a polymerase inhibitor (GS-9190) alone and in combination with ribavirin (RBV) or PEGIFN/RBV for up to 28 days in treatment-naive, genotype 1 HCV subjects [abstract no. LB1]
    • Oct 29-Nov 2; Boston (MA)
    • Zeuzem S, Buggisch P, Agarwal K, et al. Dual, triple, and quadruple combination treatment with a protease inhibitor (GS-9256) and a polymerase inhibitor (GS-9190) alone and in combination with ribavirin (RBV) or PEGIFN/RBV for up to 28 days in treatment-naive, genotype 1 HCV subjects [abstract no. LB1]. 61st Annual Meeting of the American Association for the Study of Liver Diseases; 2010 Oct 29-Nov 2; Boston (MA)
    • (2010) 61st Annual Meeting of the American Association for the Study of Liver Diseases
    • Zeuzem, S.1    Buggisch, P.2    Agarwal, K.3
  • 23
    • 84866139226 scopus 로고    scopus 로고
    • Alisporivir plus ribavirin is highly effective as interferon-free or interferon-add-on regimen in previously untreated HCV-GT2 or gt3 patients: SVR12 results from VITAL-1 phase 2b study [abstract No. LB 11]
    • Apr 18-22; Barcelona
    • Pawlotsky JM, Sarin SK, Foster G, et al. Alisporivir plus ribavirin is highly effective as interferon-free or interferon-add-on regimen in previously untreated HCV-GT2 or GT3 patients: SVR12 results from VITAL-1 phase 2b study [abstract no. LB 11]. 47th Annual Meeting of the European Association for the Study of the Liver; 2012 Apr 18-22; Barcelona
    • (2012) 47th Annual Meeting of the European Association for the Study of the Liver
    • Pawlotsky, J.M.1    Sarin, S.K.2    Foster, G.3
  • 24
    • 84866131787 scopus 로고    scopus 로고
    • High sustained virologic response rate in treatment-naive HCV genotype 1a and 1b patients treated for 12 weeks with an interferon-free all-oral quad regimen: Interim results [abstract no. 1421]
    • Apr 18-22; Barcelona
    • Sulkowski M, Rodriguez-Torres M, Lawitz E, et al. High sustained virologic response rate in treatment-naive HCV genotype 1a and 1b patients treated for 12 weeks with an interferon-free all-oral quad regimen: interim results [abstract no. 1421]. 47th Annual Meeting of the European Association for the Study of the Liver; 2012 Apr 18-22; Barcelona
    • (2012) 47th Annual Meeting of the European Association for the Study of the Liver
    • Sulkowski, M.1    Rodriguez-Torres, M.2    Lawitz, E.3
  • 25
    • 84856410313 scopus 로고    scopus 로고
    • Antiviral strategies in hepatitis C virus infection
    • Sarrazin C, Hezode C, Zeuzem S, et al. Antiviral strategies in hepatitis C virus infection. J Hepatol 2012; 56 Suppl. 1: S88-100
    • (2012) J Hepatol , vol.56 , Issue.SUPPL. 1
    • Sarrazin, C.1    Hezode, C.2    Zeuzem, S.3
  • 26
    • 75149151884 scopus 로고    scopus 로고
    • Resistance to directantiviral agents in patients with hepatitis C virus infection
    • Sarrazin C, Zeuzem S. Resistance to directantiviral agents in patients with hepatitis C virus infection. Gastroenterology 2010: 138; 447-62
    • (2010) Gastroenterology , vol.138 , pp. 447-462
    • Sarrazin, C.1    Zeuzem, S.2
  • 27
    • 84865418147 scopus 로고    scopus 로고
    • VX-222telaprevir in combination with peginterferon-alfa-2a and ribavirin in treatment-naive genotype 1 HCV patients treated for 12 weeks: Zenith study SVR 12 interim analyses [abstract]
    • Nelson DR, Gane EJ, Jacobson IM, et al. VX-222/telaprevir in combination with peginterferon-alfa-2a and ribavirin in treatment-naive genotype 1 HCV patients treated for 12 weeks: Zenith study, SVR 12 interim analyses [abstract]. Hepatology 2011; 54: 1442
    • (2011) Hepatology , vol.54 , pp. 1442
    • Nelson, D.R.1    Gane, E.J.2    Jacobson, I.M.3
  • 28
    • 84872614959 scopus 로고    scopus 로고
    • 100% rapid virologic response for PSI-7977+ribavirin in genotype 1 null responders (ELECTRON): Early viral decline similar to that observed in genotype 1 and genotype 2/3 treatment-naive patients [abstract no. 54LB]
    • Mar 5-8; Seattle (WA)
    • Gane EJ, Stedman C, Anderson J, et al. 100% rapid virologic response for PSI-7977+ribavirin in genotype 1 null responders (ELECTRON): early viral decline similar to that observed in genotype 1 and genotype 2/3 treatment-naive patients [abstract no. 54LB]. 19th Conference on Retroviruses and Opportunistic Infections; 2012 Mar 5-8; Seattle (WA)
    • (2012) 19th Conference on Retroviruses and Opportunistic Infections
    • Gane, E.J.1    Stedman, C.2    Anderson, J.3
  • 29
    • 84855248040 scopus 로고    scopus 로고
    • Once daily PSI7977 plus RBV: Pegylated interferon-alfa not required for complete rapid viral response in treatment-naive patients with HCV GT2 or GT3 [abstract no. 34]
    • Nov 4-8; San Francisco (CA)
    • Gane EJ, Stedman CA, Hyland RH, et al. Once daily PSI7977 plus RBV: pegylated interferon-alfa not required for complete rapid viral response in treatment-naive patients with HCV GT2 or GT3 [abstract no. 34]. 62nd Annual Meeting of the American Association for the Study of Liver Disease (AASLD 2011); 2011 Nov 4-8; San Francisco (CA)
    • (2011) 62nd Annual Meeting of the American Association for the Study of Liver Disease (AASLD 2011)
    • Gane, E.J.1    Stedman, C.A.2    Hyland, R.H.3
  • 32
    • 77953416889 scopus 로고    scopus 로고
    • New direct acting antivirals (DAAs) in development for HCV infection
    • May
    • Pockros PJ. New direct acting antivirals (DAAs) in development for HCV infection. Therap Adv Gastroenterol 2010 May; 3 (3): 191-202
    • (2010) Therap Adv Gastroenterol , vol.3 , Issue.3 , pp. 191-202
    • Pockros, P.J.1


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