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Drugs in development for viral hepatitis: Care and caution
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Drugs
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Pockros, P.J.1
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Safety of telaprevir or boceprevir in combination with peginterferon alfa/ribavirin, in cirrhotic non re-sponders: First results of the French early access program (ANRS CO20-CUPIC) [abstract no. 8]
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Apr 18-22; Barcelona
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Hezode C, Dorival C, Zoulim F, ANRS CO20 CUPIC study group. Safety of telaprevir or boceprevir in combination with peginterferon alfa/ribavirin, in cirrhotic non re-sponders: first results of the French early access program (ANRS CO20-CUPIC) [abstract no. 8]. 47th Annual Meeting of the European Association for the Study of the Liver; 2012 Apr 18-22; Barcelona
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Hezode, C.1
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Zoulim, F.3
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84866131783
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Preliminary results of twice daily dosing (Q12 hr) of telaprevir (TVR) for treatment naive and previously treated patients with genotype 1 HCV: Comparable RVR, eRVR and SVR12 to standard daily dosing at Q8 hr [abstract no. 1830]
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Nov 9-13; Boston (MA)
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Pockros PJ, Hunt D, Scherschel A. Preliminary results of twice daily dosing (Q12 hr) of telaprevir (TVR) for treatment naive and previously treated patients with genotype 1 HCV: comparable RVR, eRVR and SVR12 to standard daily dosing at Q8 hr [abstract no. 1830]. 63rd Annual Meeting of the American Association for the Study of Liver Diseases; 2012 Nov 9-13; Boston (MA)
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63rd Annual Meeting of the American Association for the Study of Liver Diseases
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Pockros, P.J.1
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Telaprevir for previously untreated chronic hepatitis C virus infection
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Vertex Pharmaceuticals Inc. Highlights of prescribing information: INCIVEK™ (telaprevir) film coated tablets, for oral use. Cambridge (MA): Vertex Pharmaceuticals Incorporated, 2012 Jun [online]. Available from URL: http://pi.vrtx.com/files/uspi-telaprevir.pdf [Accessed 2012 Aug 22]
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Highlights of Prescribing Information: INCIVEK™ (Telaprevir) Film Coated Tablets for Oral Use
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Merck Sharp & Dohme Corp. Highlights of prescribing information: VICTRELIS® (boceprevir) capsules for oral use. Whitehouse Station (NJ): Merck Sharp & Dohme Corp., [online]. Available from URL: http://www.merck.com/product/usa/pi-circulars/v/victrelis/victrelis-pi.pdf [Accessed Aug 22]
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Highlights of Prescribing Information: VICTRELIS® (Boceprevir) Capsules for Oral Use
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10
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Boceprevir + pegylated interferon + ribavirin for the treatment of HCVHIV-co-infected patients: End of treatment (week-48) interim results [abstract no 47]
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Apr 18-22; Barcelona
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Mallolas J, Pol S, Rivero A, et al. Boceprevir + pegylated interferon + ribavirin for the treatment of HCV/HIV-co-infected patients: end of treatment (week-48) interim results [abstract no 47]. 47th Annual Meeting of the European Association for the Study of the Liver; 2012 Apr 18-22; Barcelona
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Mallolas, J.1
Pol, S.2
Rivero, A.3
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Effect of telaprevir on the pharmacokinetics of cyclosporine and tacrolimus
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Garg V, van Heeswijk R, Lee JE, et al. Effect of telaprevir on the pharmacokinetics of cyclosporine and tacrolimus. He-patology 2011; 54 (1): 20-7
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He-patology
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Garg, V.1
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Efficacy and safety of protease inhibitors for severe hepatitis recurrence after liver transplantation: A first multicentric experience [LB abstract no. 1422]
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Apr 18-22; Barcelona
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Coilly A, Roche B, Botta-Fridlund D, et al. Efficacy and safety of protease inhibitors for severe hepatitis recurrence after liver transplantation: a first multicentric experience [LB abstract no. 1422]. 47th Annual Meeting of the European Association for the Study of the Liver; 2012 Apr 18-22; Barcelona
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Coilly, A.1
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Potent viral suppression with all-oral combination of daclatasvir (NS5A inhibitor) and GS-7977 (NS5B inhibitor), +/riba-virin, in treatment-naive patients with chronic HCV GT1, 2, or 3 [abstract no. 1422]
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Apr 18-22; Barcelona
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Sulkowski M, Gardiner D, Lawitz E, et al. Potent viral suppression with all-oral combination of daclatasvir (NS5A inhibitor) and GS-7977 (NS5B inhibitor), +/-riba-virin, in treatment-naive patients with chronic HCV GT1, 2, or 3 [abstract no. 1422]. 47th Annual Meeting of the European Association for the Study of the Liver; 2012 Apr 18-22; Barcelona
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47th Annual Meeting of the European Association for the Study of the Liver
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Sulkowski, M.1
Gardiner, D.2
Lawitz, E.3
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Prevalence of hepatitis C virus variants resistant to NS3 protease inhibitors or the NS5A inhibitor (BMS-790052) in hepatitis patients with genotype 1b
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Suzuki F, Sezaki H, Akuta N, et al. Prevalence of hepatitis C virus variants resistant to NS3 protease inhibitors or the NS5A inhibitor (BMS-790052) in hepatitis patients with genotype 1b. J Clin Virol 2012 Aug; 54 (4): 352-4
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Dual oral combination therapy with the NS5A inhibitor BMS-790052 and the NS3 protease inhibitor BMS-650032 achieved 90% sustained virologic response (SVR12) in HCV genotype 1b-infected null responders [abstract no. LB-4]
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Nov 4-8; San Francisco (CA)
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Chayama K, Takahashi S, Kawakami Y, et al. Dual oral combination therapy with the NS5A inhibitor BMS-790052 and the NS3 protease inhibitor BMS-650032 achieved 90% sustained virologic response (SVR12) in HCV genotype 1b-infected null responders [abstract no. LB-4]. 62nd Annual Meeting of the American Association for the Study of Liver Diseases; 2011 Nov 4-8; San Francisco (CA)
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Chayama, K.1
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84866139228
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A 12-week interferon-free regimen of ABT-450r ABT-072 and ribavirin was well tolerated and achieved sustained virologic response in 91% treatment-naive HCV IL28B-CC genotype-1-infected subjects [abstract no. 13]
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Apr 18-22; Barcelona
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Lawitz E, Poordad F, Kowdley KV, et al. A 12-week interferon-free regimen of ABT-450/r, ABT-072, and ribavirin was well tolerated and achieved sustained virologic response in 91% treatment-naive HCV IL28B-CC genotype-1-infected subjects [abstract no. 13]. 47th Annual Meeting of the European Association for the Study of the Liver; 2012 Apr 18-22; Barcelona
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47th Annual Meeting of the European Association for the Study of the Liver
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Lawitz, E.1
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18
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12-week interferon-free regimen of ABT-450r+ABT-333+ribavirin achieved SVR12 in more than 90% of treatment-naive HCV genotype-1-infected subjects and 47% of previous non-responders [abstract no. 1399]
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Apr 18-22; Barcelona
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Poordad F, Lawitz E, Kowdley KV, et al. 12-Week interferon-free regimen of ABT-450/r+ABT-333+ribavirin achieved SVR12 in more than 90% of treatment-naive HCV genotype-1-infected subjects and 47% of previous non-responders [abstract no. 1399]. 47th Annual Meeting of the European Association for the Study of the Liver; 2012 Apr 18-22; Barcelona
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Poordad, F.1
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Efficacy of the protease inhibitor BI 201335 polymerase inhibitor BI 207127 and ribavirin in patients with chronic HCV infection
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Zeuzem S, Asselah T, Angus P, et al. Efficacy of the protease inhibitor BI 201335, polymerase inhibitor BI 207127, and ribavirin in patients with chronic HCV infection. Gastro-enterology 2011 Dec; 141 (6): 2047-55
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Interferon-free treatment with a combination of mericitabine and danoprevir/R with or without ribavirin in treatment-naive HCV genotype 1-infected patients [abstract]
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Gane EJ, Pockros P, Zeuzem S, et al. Interferon-free treatment with a combination of mericitabine and danoprevir/R with or without ribavirin in treatment-naive HCV genotype 1-infected patients [abstract]. J Hepatology 2012; 56 (Suppl. 2): S555
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Dual, triple, and quadruple combination treatment with a protease inhibitor (GS-9256) and a polymerase inhibitor (GS-9190) alone and in combination with ribavirin (RBV) or PEGIFN/RBV for up to 28 days in treatment-naive, genotype 1 HCV subjects [abstract no. LB1]
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Oct 29-Nov 2; Boston (MA)
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Zeuzem S, Buggisch P, Agarwal K, et al. Dual, triple, and quadruple combination treatment with a protease inhibitor (GS-9256) and a polymerase inhibitor (GS-9190) alone and in combination with ribavirin (RBV) or PEGIFN/RBV for up to 28 days in treatment-naive, genotype 1 HCV subjects [abstract no. LB1]. 61st Annual Meeting of the American Association for the Study of Liver Diseases; 2010 Oct 29-Nov 2; Boston (MA)
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Alisporivir plus ribavirin is highly effective as interferon-free or interferon-add-on regimen in previously untreated HCV-GT2 or gt3 patients: SVR12 results from VITAL-1 phase 2b study [abstract No. LB 11]
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Apr 18-22; Barcelona
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Pawlotsky JM, Sarin SK, Foster G, et al. Alisporivir plus ribavirin is highly effective as interferon-free or interferon-add-on regimen in previously untreated HCV-GT2 or GT3 patients: SVR12 results from VITAL-1 phase 2b study [abstract no. LB 11]. 47th Annual Meeting of the European Association for the Study of the Liver; 2012 Apr 18-22; Barcelona
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47th Annual Meeting of the European Association for the Study of the Liver
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Sarin, S.K.2
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High sustained virologic response rate in treatment-naive HCV genotype 1a and 1b patients treated for 12 weeks with an interferon-free all-oral quad regimen: Interim results [abstract no. 1421]
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Apr 18-22; Barcelona
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Sulkowski M, Rodriguez-Torres M, Lawitz E, et al. High sustained virologic response rate in treatment-naive HCV genotype 1a and 1b patients treated for 12 weeks with an interferon-free all-oral quad regimen: interim results [abstract no. 1421]. 47th Annual Meeting of the European Association for the Study of the Liver; 2012 Apr 18-22; Barcelona
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47th Annual Meeting of the European Association for the Study of the Liver
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Sulkowski, M.1
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Antiviral strategies in hepatitis C virus infection
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Nelson DR, Gane EJ, Jacobson IM, et al. VX-222/telaprevir in combination with peginterferon-alfa-2a and ribavirin in treatment-naive genotype 1 HCV patients treated for 12 weeks: Zenith study, SVR 12 interim analyses [abstract]. Hepatology 2011; 54: 1442
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100% rapid virologic response for PSI-7977+ribavirin in genotype 1 null responders (ELECTRON): Early viral decline similar to that observed in genotype 1 and genotype 2/3 treatment-naive patients [abstract no. 54LB]
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Gane EJ, Stedman C, Anderson J, et al. 100% rapid virologic response for PSI-7977+ribavirin in genotype 1 null responders (ELECTRON): early viral decline similar to that observed in genotype 1 and genotype 2/3 treatment-naive patients [abstract no. 54LB]. 19th Conference on Retroviruses and Opportunistic Infections; 2012 Mar 5-8; Seattle (WA)
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Gane EJ, Stedman CA, Hyland RH, et al. Once daily PSI7977 plus RBV: pegylated interferon-alfa not required for complete rapid viral response in treatment-naive patients with HCV GT2 or GT3 [abstract no. 34]. 62nd Annual Meeting of the American Association for the Study of Liver Disease (AASLD 2011); 2011 Nov 4-8; San Francisco (CA)
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62nd Annual Meeting of the American Association for the Study of Liver Disease (AASLD 2011)
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