Discovery of an irreversible HCV NS5B polymerase inhibitor

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 24, 2013, Pages 6585-6587

  Zeng, Qingbei ^a   Nair, Anilkumar G ^a   Rosenblum, Stuart B ^a   Huang, Hsueh Cheng ^a   Lesburg, Charles A ^a   Jiang, Yueheng ^a   Selyutin, Oleg ^a   Chan, Tin Yau ^a   Bennett, Frank ^a   Chen, Kevin X ^a   Venkatraman, Srikanth ^a   Sannigrahi, Mousumi ^a   Velazquez, Francisco ^a   Duca, Jose S ^a   Gavalas, Stephen ^a   Huang, Yuhua ^a   Pu, Haiyan ^a   Wang, Li ^a   Pinto, Patrick ^a   Vibulbhan, Bancha ^a   Agrawal, Sony ^a   Ferrari, Eric ^a   Jiang, Chuan Kui ^a   Li, Cheng ^a   Hesk, David ^a   Gesell, Jennifer ^a   Sorota, Steve ^a   Shih, Neng Yang ^a   Njoroge, F George ^a   Kozlowski, Joseph A ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

HCV; NS5B polymerase

Indexed keywords

ANTIVIRUS AGENT; BOCEPREVIR; NONSTRUCTURAL PROTEIN 5B; NS5B POLYMERASE INHIBITOR; RNA DIRECTED RNA POLYMERASE INHIBITOR; TELAPREVIR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONFORMATIONAL TRANSITION; COVALENT BOND; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SAFETY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME INACTIVATION; ENZYME INHIBITION; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; IC 50; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

HEPATITIS C VIRUS;

HCV; NS5B POLYMERASE;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; DOGS; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; ENZYME INHIBITORS; HAPLORHINI; HEPACIVIRUS; HUMANS; INDOLES; MALE; MOLECULAR DYNAMICS SIMULATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; QUINOLINES; RATS; RATS, SPRAGUE-DAWLEY; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84888858768     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.10.060     Document Type: Article

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