Effects of orally administering the antimicrobial peptide buforin II on small intestinal mucosal membrane integrity, the expression of tight junction proteins and protective factors in weaned piglets challenged by enterotoxigenic Escherichia coli

Animal Feed Science and Technology

Volumn 186, Issue 3-4, 2013, Pages 177-185

  Tang, Z R ^a,b   Deng, H ^a   Zhang, X L ^a   Zen, Y ^c   Xiao, D F ^d   Sun, W Z ^a   Zhang, Z ^a  

^a SOUTHWEST UNIVERSITY   (China)

^b Chongqing Engg Research Center for Herbivores Resource Protection and Utilization   (China)

^c Hunan Microbiology Institute   (China)

^d HUNAN AGRICULTURAL UNIVERSITY   (China)

Author keywords

Antimicrobial peptide; Buforin II; Intestinal mucosal membrane integrity; Protective factors; Tight junction proteins; Weaned piglets

Indexed keywords

ANIMALIA; ESCHERICHIA COLI; GLYCINE MAX; PICHIA PASTORIS; SUIDAE; SUS; ZEA MAYS;

EID: 84888819306     PISSN: 03778401     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.anifeedsci.2013.10.012     Document Type: Article

References (23)

1. Cash H.L., Whitham C.V., Behrendt C.L., Hooper L.V. Symbiotic bacteria direct expression of an intestinal bactericidal lectin. Science 2006, 313:1126-1130.
2. Ferrara N., Gerber H.P., LeCouter J. The biology of VEGF and its receptors. Nat. Med. 2003, 9:669-676.
3. Gislason J., Iyer S., Hutchens T.W., Lonnerdal B. Lactoferrin receptors in piglet small intestine: lactoferrin binding properties, ontogeny, and regional distribution in the gastrointestinal tract. J. Nutr. Biochem. 1993, 4:528-533.
4. Heuer O.E., Hammerum A.M., Collignon P., Wegener H.C. Human health hazard from antimicrobial-resistant enterococciin animals and food. Clin. Infect. Dis. 2006, 43:911-916.
5. Johne B., Fagerhol M.K., Lyberg T., Prydz H., Brandtzaeg P., Naess-Andresen C.F., Dale I. Functional and clinical aspects of the myelomonocyte protein calprotectin. Mol. Pathol. 1997, 50:113-123.
6. Kido J., Kido R., Suryono Kataoka M., Fagerhol M.K., Nagata T. Calprotectin release from human neutrophils is induced by Porphyromonas gingivalis lipopolysaccharide via the CD14-Toll-like receptor-nuclear factor kappa B pathway. J. Periodontal Res. 2003, 38:557-563.
7. Kiers J.L., Meijer J.C., Nout M.J.R., Rombouts F.M., Nabuurs M.J.A., van der Meulen J.V.D. Effect of fermented soya beans on diarrhoea and feed efficiency in weaned piglets. J. Appl. Microbiol. 2003, 95:545-552.
8. Kobayashi S., Chikushi A., Tougu S., Imura Y., Nishida M., Yano Y., Matsuzaki K. Membrane translocation mechanism of the antimicrobial peptide buforin 2. Biochemistry 2004, 43:15610-15616.
9. Kobayashi S., Takeshima K., Park C.B., Kim S.C., Matsuzaki K. Interactions of the novel antimicrobial peptide buforin 2 with lipid bilayers: proline as a translocation promoting factor. Biochemistry 2000, 39:8648-8654.
10. Marion J., Petersen Y.M., Romé V., Thomas F., Sangild P.T., Dividich J.L., Huërou-Luron I.L. Early weaning stimulates intestinal brush border enzyme activities in piglets, mainly at the posttranscriptional level. J. Pediatr. Gastroenterol. Nutr. 2005, 41:401-410.
11. Matsumoto K., Nakamura T. Roles of HGF as a pleiotropic factor in organ regeneration. EXS. 1993, 65:225-249.
12. Montagne L., Cavaney F.S., Hampson D.J., Lallès J.P., Pluske J.R. Effect of diet composition on postweaning colibacillosis in piglets. J. Anim. Sci. 2004, 82:2364-2374.
13. National Research Council Nutrient Requirements of Swine 1998, The National Academics Press, Washington, DC. 10th revised ed.
14. Nisapakultorn K., Ross K.F., Herzberg M.C. Calprotectin expression inhibits bacterial binding to mucosal epithelial cells. Infect. Immun. 2001, 69:3692-3696.
15. Park C.B., Kim H.S., Kim S.C. Mechanism of action of the antimicrobial peptide buforin II: buforin II kills microorganisms by penetrating the cell membrane and inhibiting cellular functions. Biochem. Biophys. Res. Commun. 1998, 244-253.
16. Park C.B., Kim M.S., Kim S.C. A novel antimicrobial peptide from Bufo bufo gargarizans. Biochem. Biophys. Res. Commun. 1996, 218:408-413.
17. Simonovic I., Rosenberg J., Koutsouris A., Hecht G. Enteropathogenic Escherichia coli dephosphorylates and dissociates occludin from intestinal epithelial tight junctions. Cell. Microbiol. 2000, 2:305-315.
18. Swidsinski A., Ladhoff A., Pernthaler A., Swidsinski S., Loening-Baucke V., Ortner M., Weber J., Hoffmann U., Schreiber S., Dietel M., Lochs H. Mucosal flora in inflammatory bowel disease. Gastroenterology 2002, 122:44-54.
19. Tang Z.R., Yin Y.L., Zhang Y.M., Huang R.L., Sun Z.H., Li T.J., Chu W.Y., Kong X.F., Li L.L., Geng M.M., Tu Q. Effects of dietary supplementation with an expressed fusion peptide bovine lactoferricin-lactoferrampin on performance, immune function and intestinal mucosal morphology in piglets weaned at age 21 d. Br. J. Nutr. 2009, 101:998-1005.
20. Verstegen M.W., Williams B.A. Alternatives to the use of antibiotics as growth promoters for monogastric animals. Anim. Biotechnol. 2002, 13:113-127.
21. Wang Y.H., Xu M., Wang F.N., Yu Z.P., Yao J.H., Zan Z.S., Yang F.X. Effect of dietary starch on rumen and small intestine morphology and digesta pH in goats. Livest. Sci. 2009, 122:48-52.
22. Wigg A.J., Roberts-Thomson I.C., Dymock R.B., McCarthy P.J., Grose R.H., Cummins A.G. The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor α in the pathogenesis of non-alcoholic steatohepatitis. Gut 2001, 48:206-211.
23. Yamachika T., Werther J.L., Bodian C., Babyatsky M., Tatematsu M., Yamamura Y., Chen A., Itzkowitz S. Intestinal trefoil factor: a marker of poor prognosis in gastric carcinoma. Clin. Cancer Res. 2002, 8:1092-1099.