Complement protein C3 exacerbates prion disease in a mouse model of chronic wasting disease

International Immunology

Volumn 25, Issue 12, 2013, Pages 697-702

  Michel, Brady ^a   Ferguson, Adam ^a   Johnson, Theodore ^a   Bender, Heather ^a   Meyerett Reid, Crystal ^a   Christy Wyckoff, A ^a   Pulford, Bruce ^a   Telling, Glenn C ^a   Zabel, Mark D ^a  

^a Veterinary Dentistry and Oral Surgery   (United States)

Author keywords

CWD; Innate immunity; Prpres

Indexed keywords

COMPLEMENT COMPONENT C3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; CHRONIC WASTING DISEASE; COMPLEMENT ACTIVATION; COMPLEMENT SYSTEM; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE COURSE; DISEASE EXACERBATION; FOLLICULAR DENDRITIC CELL; GENE AMPLIFICATION; INCUBATION TIME; INNATE IMMUNITY; MOUSE; NONHUMAN; PRION; PRION DISEASE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FOLDING; PROTEIN FUNCTION; SCORING SYSTEM; TRANSGENIC MOUSE;

CWD; INNATE IMMUNITY; PRPRES;

ANIMALS; COMPLEMENT C3; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; MICE; MICE, KNOCKOUT; PRIONS; SPLEEN; WASTING DISEASE, CHRONIC;

EID: 84888802857     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxt034     Document Type: Article

References (35)

1. Williams, E. S. and Young, S. 1980. Chronic wasting disease of captive mule deer: a spongiform encephalopathy. J. Wildl. Dis. 16: 89.
2. Williams, E. S. and Young, S. 1982. Spongiform encephalopathy of Rocky Mountain elk. J. Wildl. Dis. 18: 465.
3. Prusiner, S. B. 1982. Novel proteinaceous infectious particles cause scrapie. Science 216: 136.
4. Miller, M. W. and Conner, M. M. 2005. Epidemiology of chronic wasting disease in free-ranging mule deer: spatial, temporal, and demographic influences on observed prevalence patterns. J. Wildl. Dis. 41: 275.
5. Williams, E. S. 2005. Chronic wasting disease. Vet. Pathol. 42: 530.
6. Gonzalez-Romero, D., Barria, M. A., Leon, P., Morales, R. and Soto, C. 2008. Detection of infectious prions in urine. FEBS Lett. 582: 3161.
7. Haley, N. J., Mathiason, C. K., Carver, S., Zabel, M., Telling, G. C. and Hoover, E. A. 2011. Detection of chronic wasting disease prions in salivary, urinary, and intestinal tissues of deer: potential mechanisms of prion shedding and transmission. J. Virol. 85: 6309.
8. Angers, R. C., Browning, S. R., Seward, T. S. et al. 2006. Prions in skeletal muscles of deer with chronic wasting disease. Science 311: 1117.
9. Mathiason, C. K., Hayes-Klug, J., Hays, S. A. et al. 2010. B cells and platelets harbor prion infectivity in the blood of deer infected with chronic wasting disease. J. Virol. 84: 5097.
10. O'Rourke, K. I., Zhuang, D., Lyda, A. et al. 2003. Abundant PrP(CWD) in tonsil from mule deer with preclinical chronic wasting disease. J. Vet. Diagn. Invest. 15: 320.
11. Gajdusek, D. C., Gibbs, C. J., Jr and Alpers, M. 1967. Transmission and passage of experimenal "kuru" to chimpanzees. Science 155: 212.
12. Kitamoto, T., Muramoto, T., Mohri, S., Doh-Ura, K. and Tateishi, J. 1991. Abnormal isoform of prion protein accumulates in follicular dendritic cells in mice with Creutzfeldt-Jakob disease. J. Virol. 65: 6292.
13. Brown, K. L., Stewart, K., Ritchie, D. L. et al. 1999. Scrapie replication in lymphoid tissues depends on prion protein-expressing follicular dendritic cells. Nat. Med. 5: 1308.
14. Krautler, N. J., Kana, V., Kranich, J. et al. 2012. Follicular dendritic cells emerge from ubiquitous perivascular precursors. Cell 150: 194.
15. Montrasio, F., Frigg, R., Glatzel, M. et al. 2000. Impaired prion replication in spleens of mice lacking functional follicular dendritic cells. Science 288: 1257.
16. McCulloch, L., Brown, K. L., Bradford, B. M. et al. 2011. Follicular dendritic cell-specific prion protein (PrP) expression alone is sufficient to sustain prion infection in the spleen. PLoS Pathog. 7: e1002402.
17. Klein, M. A., Frigg, R., Flechsig, E. et al. 1997. A crucial role for B cells in neuroinvasive scrapie. Nature 390: 687.
18. Mabbott, N. A., Young, J., McConnell, I. and Bruce, M. E. 2003. Follicular dendritic cell dedifferentiation by treatment with an inhibitor of the lymphotoxin pathway dramatically reduces scrapie susceptibility. J. Virol. 77: 6845.
19. Zabel, M. D., Heikenwalder, M., Prinz, M. et al. 2007. Stromal complement receptor CD21/35 facilitates lymphoid prion colonization and pathogenesis. J. Immunol. 179: 6144.
20. Michel, B., Meyerett-Reid, C., Johnson, T. et al. 2012. Incunabular immunological events in prion trafficking. Sci. Rep. 2: 440.
21. Ricklin, D., Hajishengallis, G., Yang, K. and Lambris, J. D. 2010. Complement: a key system for immune surveillance and homeostasis. Nat. Immunol. 11: 785.
22. Lambris, J. D. and Müller-Eberhard, H. J. 1986. The multifunctional role of C3: structural analysis of its interactions with physiological ligands. Mol. Immunol. 23: 1237.
23. Oliva, C., Turnbough, C. L., Jr and Kearney, J. F. 2009. CD14-Mac-1 interactions in Bacillus anthracis spore internalization by macrophages. Proc. Natl. Acad. Sci. U. S. A. 106: 13957.
24. Wang, M., Shakhatreh, M. A., James, D. et al. 2007. Fimbrial proteins of porphyromonas gingivalis mediate in vivo virulence and exploit TLR2 and complement receptor 3 to persist in macrophages. J. Immunol. 179: 2349.
25. Klein, M. A., Kaeser, P. S., Schwarz, P. et al. 2001. Complement facilitates early prion pathogenesis. Nat. Med. 7: 488.
26. Mabbott, N. A., Bruce, M. E., Botto, M., Walport, M. J. and Pepys, M. B. 2001. Temporary depletion of complement component C3 or genetic deficiency of C1q significantly delays onset of scrapie. Nat. Med. 7: 485.
27. Büeler, H., Fischer, M., Lang, Y. et al. 1992. Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein. Nature 356: 577.
28. Angers, R. C., Seward, T. S., Napier, D. et al. 2009. Chronic wasting disease prions in elk antler velvet. Emerg. Infect. Dis. 15: 696.
29. Meyerett, C., Michel, B., Pulford, B. et al. 2008. In vitro strain adaptation of CWD prions by serial protein misfolding cyclic amplification. Virology 382: 267.
30. Pulford, B., Spraker, T. R., Wyckoff, A. C. et al. 2012. Detection of PrPCWD in feces from naturally exposed Rocky Mountain elk (Cervus elaphus nelsoni) using protein misfolding cyclic amplification. J. Wildl. Dis. 48: 425.
31. Saborio, G. P., Permanne, B., Soto, C. 2001. Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding. Nature 411: 810.
32. Hasebe, R., Raymond, G. J., Horiuchi, M. and Caughey, B. 2012. Reaction of complement factors varies with prion strains in vitro and in vivo. Virology 423: 205.
33. Béringue, V., Herzog, L., Jaumain, E. et al. 2012. Facilitated crossspecies transmission of prions in extraneural tissue. Science 335: 472.
34. Gasque, P., Thomas, A., Fontaine, M. and Morgan, B. P. 1996. Complement activation on human neuroblastoma cell lines in vitro: route of activation and expression of functional complement regulatory proteins. J. Neuroimmunol. 66: 29
35. van Beek, J., Elward, K., Gasque, P. 2003. Activation of complement in the central nervous system: roles in neurodegeneration and neuroprotection. Ann. N. Y. Acad. Sci. 992: 56.