Genetically encoded immunophotosensitizer 4D5scFv-miniSOG is a highly selective agent for targeted photokilling of tumor cells in vitro

Theranostics

Volumn 3, Issue 11, 2013, Pages 831-840

  Mironova, Kristina E ^a   Proshkina, Galina M ^a   Ryabova, Anastasiya V ^b   Stremovskiy, Oleg A ^a   Lukyanov, Sergey A ^a,c   Petrov, Rem V ^a   Deyev, Sergey M ^a,c  

^a SHEMYAKIN OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY   (Russian Federation)

^b PROKHOROV GENERAL PHYSICS INSTITUTE   (Russian Federation)

^c PRIVOLZHSKY RESEARCH MEDICAL UNIVERSITY   (Russian Federation)

Author keywords

HER2 neu; Immunophototoxin; Phototoxicity; Single chain variable fragment.; Tumor targeted delivery

Indexed keywords

4D5 SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY MINI SINGLET OXYGEN GENERATOR; CYTOTOXIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FLAVOPROTEIN; JO 1 ANTIBODY; PACLITAXEL; PHOTOSENSITIZING AGENT; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; SINGLET OXYGEN; UNCLASSIFIED DRUG;

ARTICLE; BINDING KINETICS; BREAST ADENOCARCINOMA; CELL KILLING; CONTROLLED STUDY; CYTOTOXICITY; DRUG CONJUGATION; ENDOCYTOSIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; PASSIVE TRANSPORT; PHOTOACTIVATION; PHOTODYNAMIC THERAPY; REPRODUCIBILITY; TUMOR CELL;

HER2/NEU; IMMUNOPHOTOTOXIN; PHOTOTOXICITY; SINGLE-CHAIN VARIABLE FRAGMENT.; TUMOR-TARGETED DELIVERY;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; HUMANS; IMMUNOTOXINS; INHIBITORY CONCENTRATION 50; LIGHT; LUMINESCENT PROTEINS; MOLECULAR TARGETED THERAPY; NEOPLASMS; PHOTOSENSITIZING AGENTS; RECEPTOR, ERBB-2; SINGLE-CHAIN ANTIBODIES;

EID: 84888797993     PISSN: None     EISSN: 18387640     Source Type: Journal    
DOI: 10.7150/thno.6715     Document Type: Article

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