Increased plasmacytoid dendritic cells and RORγt-expressing immune effectors in cutaneous acute graft-versus-host disease

Journal of Leukocyte Biology

Volumn 94, Issue 6, 2013, Pages 1337-1343

  Malard, Florent ^a,b   Bossard, Céline ^b,c   Brissot, Eolia ^a,b   Chevallier, Patrice ^b   Guillaume, Thierry ^b   Delaunay, Jacques ^b   Mosnier, Jean François ^b,c   Moreau, Philippe ^a,b,d   Grégoire, Marc ^a   Gaugler, Béatrice ^e,f,g,h   Mohty, Mohamad ^a,b,d  

^a CNRS   (France)

^b NANTES UNIVERSITY HOSPITAL   (France)

^c UNIVERSITÉ DE NANTES   (France)

^d Centre D'Investigation Clinique en Cancérologie CI2C   (France)

^e France   (France)

^f UNIVERSITÉ DE FRANCHE COMTÉ   (France)

^g ETABLISSEMENT FRANÇAIS DU SANG   (France)

^h Plateforme de Biomonitoring   (France)

Author keywords

Allogeneic stem cell transplantation; Th17 cells; Type I interferon

Indexed keywords

CD161 ANTIGEN; CHEMOKINE RECEPTOR CCR6; RETINOID RELATED ORPHAN RECEPTOR GAMMA;

ACUTE GRAFT VERSUS HOST DISEASE; ADOLESCENT; ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CELL COUNT; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN BIOPSY; TH17 CELL;

ALLOGENEIC STEM CELL TRANSPLANTATION; TH17 CELLS; TYPE I INTERFERON;

ACUTE DISEASE; ADOLESCENT; ADULT; AGED; ALLOGRAFTS; DENDRITIC CELLS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GRAFT VS HOST DISEASE; HEMATOLOGIC NEOPLASMS; HUMANS; INTERFERON TYPE I; LECTINS, C-TYPE; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; MYXOVIRUS RESISTANCE PROTEINS; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY B; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; PLASMA CELLS; RECEPTORS, CCR6; RECEPTORS, IMMUNOLOGIC; SKIN DISEASES; STEM CELL TRANSPLANTATION; TH17 CELLS;

EID: 84888794996     PISSN: 07415400     EISSN: 19383673     Source Type: Journal    
DOI: 10.1189/jlb.0513295     Document Type: Article

References (40)

1. Cella, M., Jarrossay, D., Facchetti, F., Alebardi, O., Nakajima, H., Lanzavecchia, A., Colonna, M. (1999) Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat. Med. 5, 919-923.
2. Gilliet, M., Conrad, C., Geiges, M., Cozzio, A., Thurlimann, W., Burg, G., Nestle, F. O., Dummer, R. (2004) Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors. Arch. Dermatol. 140, 1490-1495.
3. Gregorio, J., Meller, S., Conrad, C., Di Nardo, A., Homey, B., Lauerma, A., Arai, N., Gallo, R. L., Digiovanni, J., Gilliet, M. (2010) Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons. J. Exp. Med. 207, 2921-2930.
4. Guiducci, C., Tripodo, C., Gong, M., Sangaletti, S., Colombo, M. P., Coffman, R. L., Barrat, F. J. (2010) Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9. J. Exp. Med. 207, 2931-2942.
5. Bossard, C., Malard, F., Arbez, J., Chevallier, P., Guillaume, T., Delaunay, J., Mosnier, J. F., Tiberghien, P., Saas, P., Mohty, M., Gaugler, B. (2012) Plasmacytoid dendritic cells and Th17 immune response contribution in gastrointestinal acute graft-versus-host disease. Leukemia 26, 1471-1474.
6. Holler, E., Kolb, H. J., Mittermuller, J., Kaul, M., Ledderose, G., Duell, T., Seeber, B., Schleuning, M., Hintermeier-Knabe, R., Ertl, B., et al. (1995) Modulation of acute graft-versus-host-disease after allogeneic bone marrow transplantation by tumor necrosis factor alpha (TNF alpha) release in the course of pretransplant conditioning: role of conditioning regimens and prophylactic application of a monoclonal antibody neutralizing human TNF alpha (MAK 195F). Blood 86, 890-899.
7. Yi, T., Zhao, D., Lin, C. L., Zhang, C., Chen, Y., Todorov, I., LeBon, T., Kandeel, F., Forman, S., Zeng, D. (2008) Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graft-versushost disease. Blood 112, 2101-2110.
8. Kappel, L. W., Goldberg, G. L., King, C. G., Suh, D. Y., Smith, O. M., Ligh, C., Holland, A. M., Grubin, J., Mark, N. M., Liu, C., Iwakura, Y., Heller, G., van den Brink, M. R. (2009) IL-17 contributes to CD4-mediated graft-versus-host disease. Blood 113, 945-952.
9. Carlson, M. J., West, M. L., Coghill, J. M., Panoskaltsis-Mortari, A., Blazar, B. R., Serody, J. S. (2009) In vitro-differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestations. Blood 113, 1365-1374.
10. Yu, Y., Wang, D., Liu, C., Kaosaard, K., Semple, K., Anasetti, C., Yu, X. Z. (2011) Prevention of GVHD while sparing GVL effect by targeting Th1 and Th17 transcription factor T-bet and RORgammat in mice. Blood 118, 5011-5020.
11. Broady, R., Yu, J., Chow, V., Tantiworawit, A., Kang, C., Berg, K., Martinka, M., Ghoreishi, M., Dutz, J., Levings, M. K. (2010) Cutaneous GVHD is associated with the expansion of tissue-localized Th1 and not Th17 cells. Blood 116, 5748-5751.
12. Dander, E., Balduzzi, A., Zappa, G., Lucchini, G., Perseghin, P., Andre, V., Todisco, E., Rahal, D., Migliavacca, M., Longoni, D., Solinas, G., Villa, A., Berti, E., Mina, P. D., Parma, M., Allavena, P., Biagi, E., Rovelli, A., Biondi, A., D'Amico, G. (2009) Interleukin-17-producing T-helper cells as new potential player mediating graft-versus-host disease in patients undergoing allogeneic stem-cell transplantation. Transplantation 88, 1261-1272.
13. Ratajczak, P., Janin, A., Peffault de Latour, R., Leboeuf, C., Desveaux, A., Keyvanfar, K., Robin, M., Clave, E., Douay, C., Quinquenel, A., Pichereau, C., Bertheau, P., Mary, J. Y., Socie, G. (2010) Th17/Treg ratio in human graft-versus-host disease. Blood 116, 1165-1171.
14. Swiecki, M., and Colonna, M. (2010) Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance. Immunol. Rev. 234, 142-162.
15. Yu, C. F., Peng, W. M., Oldenburg, J., Hoch, J., Bieber, T., Limmer, A., Hartmann, G., Barchet, W., Eis-Hubinger, A. M., Novak, N. (2010) Human plasmacytoid dendritic cells support Th17 cell effector function in response to TLR7 ligation. J. Immunol. 184, 1159-1167.
16. Glucksberg, H., Storb, R., Fefer, A., Buckner, C. D., Neiman, P. E., Clift, R. A., Lerner, K. G., Thomas, E. D. (1974) Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-Amatched sibling donors. Transplantation 18, 295-304.
17. Lerner, K. G., Kao, G. F., Storb, R., Buckner, C. D., Clift, R. A., Thomas, E. D. (1974) Histopathology of graft-vs.-host reaction (GvHR) in human recipients of marrow from HL-A-matched sibling donors. Transplant. Proc. 6, 367-371.
18. Ghoreishi, M., Martinka, M., Dutz, J. P. (2010) Type I interferon signature in the scalp lesions of alopecia areata. Br. J. Dermatol. 163, 57-62.
19. Scheler, M., Wenzel, J., Tuting, T., Takikawa, O., Bieber, T., von Bubnoff, D. (2007) Indoleamine 2,3-dioxygenase (IDO): the antagonist of type I interferon-driven skin inflammation? Am. J. Pathol. 171, 1936-1943.
20. Aebi, M., Fah, J., Hurt, N., Samuel, C. E., Thomis, D., Bazzigher, L., Pavlovic, J., Haller, O., Staeheli, P. (1989) cDNA structures and regulation of two interferon-induced human Mx proteins. Mol. Cell Biol. 9, 5062-5072.
21. Ferrara, J. L., Levine, J. E., Reddy, P., Holler, E. (2009) Graft-versus-host disease. Lancet 373, 1550-1561.
22. Martinez, O. M., Villanueva, J., Abtahi, S., Beatty, P. R., Esquivel, C. O., Krams, S. M. (1998) CD30 expression identifies a functional alloreactive human T-lymphocyte subset. Transplantation 65, 1240-1247.
23. Cheng, H., Tian, J., Li, Z., Zeng, L., Pan, B., Song, G., Chen, W., Xu, K. (2012) TH17 cells are critical for skin-specific pathological injury in acute graft-versus-host disease. Transplant. Proc. 44, 1412-1418.
24. Acosta-Rodriguez, E. V., Rivino, L., Geginat, J., Jarrossay, D., Gattorno, M., Lanzavecchia, A., Sallusto, F., Napolitani, G. (2007) Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat. Immunol. 8, 639-646.
25. Kleinschek, M. A., Boniface, K., Sadekova, S., Grein, J., Murphy, E. E., Turner, S. P., Raskin, L., Desai, B., Faubion, W. A., de Waal Malefyt, R., Pierce, R. H., McClanahan, T., Kastelein, R. A. (2009) Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation. J. Exp. Med. 206, 525-534.
26. Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., Littman, D. R. (2006) The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17 T helper cells. Cell 126, 1121-1133.
27. Hirota, K., Duarte, J. H., Veldhoen, M., Hornsby, E., Li, Y., Cua, D. J., Ahlfors, H., Wilhelm, C., Tolaini, M., Menzel, U., Garefalaki, A., Potocnik, A. J., Stockinger, B. (2011) Fate mapping of IL-17-producing T cells in inflammatory responses. Nat. Immunol. 12, 255-263.
28. Nistala, K., Adams, S., Cambrook, H., Ursu, S., Olivito, B., de Jager, W., Evans, J. G., Cimaz, R., Bajaj-Elliott, M., Wedderburn, L. R. (2010) Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment. Proc. Natl. Acad. Sci. U. S. A. 107, 14751-14756.
29. Van der Waart, A. B., van der Velden, W. J., van Halteren, A. G., Leenders, M. J., Feuth, T., Blijlevens, N. M., van der Voort, R., Dolstra, H. (2012) decreased levels of circulating IL17-producing CD161(+)CCR6(+)Tcellsareassociatedwithgraft-versus-hostdisease after allogeneic stem cell transplantation. PLoS. One. 7, e50896.
30. Pantelyushin, S., Haak, S., Ingold, B., Kulig, P., Heppner, F. L., Navarini, A. A., Becher, B. (2012) Rorgammat innate lymphocytes and gammadelta T cells initiate psoriasiform plaque formation in mice. J Clin Invest. 122, 2252-2256.
31. Mohty, M., Blaise, D., Faucher, C., Bardou, V. J., Gastaut, J. A., Viens, P., Olive, D., Gaugler, B. (2005) Impact of plasmacytoid dendritic cells on outcome after reduced-intensity conditioning allogeneic stem cell transplantation. Leukemia 19, 1-6.
32. Van der Fits, L., Mourits, S., Voerman, J. S., Kant, M., Boon, L., Laman, J. D., Cornelissen, F., Mus, A. M., Florencia, E., Prens, E. P., Lubberts, E. (2009) Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis. J. Immunol. 182, 5836-5845.
33. Zeiser, R., Nguyen, V. H., Hou, J. Z., Beilhack, A., Zambricki, E., Buess, M., Contag, C. H., Negrin, R. S. (2007) Early CD30 signaling is critical for adoptively transferred CD4 CD25 regulatory T cells in prevention of acute graft-versus-host disease. Blood 109, 2225-2233.
34. Blazar, B. R., Levy, R. B., Mak, T. W., Panoskaltsis-Mortari, A., Muta, H., Jones, M., Roskos, M., Serody, J. S., Yagita, H., Podack, E. R., Taylor, P. A. (2004) CD30/CD30 ligand (CD153) interaction regulates CD4 T cell-mediated graft-versus-host disease. J. Immunol. 173, 2933-2941.
35. Chen, Y. B., McDonough, S., Hasserjian, R., Chen, H., Coughlin, E., Illiano, C., Park, I. S., Jagasia, M., Spitzer, T. R., Cutler, C. S., Soiffer, R. J., Ritz, J. (2012) Expression of CD30 in patients with acute graft-versus-host disease. Blood 120, 691-696.
36. Sun, X., Yamada, H., Shibata, K., Muta, H., Tani, K., Podack, E. R., Yoshikai, Y. (2010) CD30 ligand/CD30 plays a critical role in Th17 differentiation in mice. J. Immunol. 185, 2222-2230.
37. Lande, R., Gregorio, J., Facchinetti, V., Chatterjee, B., Wang, Y. H., Homey, B., Cao, W., Su, B., Nestle, F. O., Zal, T., Mellman, I., Schroder, J. M., Liu, Y. J., Gilliet, M. (2007) Plasmacytoid dendritic cells sense selfDNA coupled with antimicrobial peptide. Nature 449, 564-569.
38. Paczesny, S., Braun, T. M., Levine, J. E., Hogan, J., Crawford, J., Coffing, B., Olsen, S., Choi, S. W., Wang, H., Faca, V., Pitteri, S., Zhang, Q., Chin, A., Kitko, C., Mineishi, S., Yanik, G., Peres, E., Hanauer, D., Wang, Y., Reddy, P., Hanash, S., Ferrara, J. L. (2010) Elafin is a biomarker of graft-versus-host disease of the skin. Sci. Transl. Med. 2, 13ra2.
39. Ganguly, D., Chamilos, G., Lande, R., Gregorio, J., Meller, S., Facchinetti, V., Homey, B., Barrat, F. J., Zal, T., Gilliet, M. (2009) Self-RNAantimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8. J. Exp. Med. 206, 1983-1994.
40. Leonardi, C., Matheson, R., Zachariae, C., Cameron, G., Li, L., Edson-Heredia, E., Braun, D., Banerjee, S. (2012) Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis. N. Engl. J. Med. 366, 1190-1199.