Sustained release of triamcinolone acetonide from an episcleral plaque of multilayered poly-ε-caprolactone matrix

Acta Biomaterialia

Volumn 10, Issue 1, 2014, Pages 126-133

  Meng, Yongchun ^a   Sun, Shumao ^a   Li, Jie ^a   Nan, Kaihui ^a   Lan, Bifei ^a   Jin, Yubin ^b   Chen, Hao ^a   Cheng, Lingyun ^a,c  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b Wenzhou Institute of Technology Testing and Calibration   (China)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Episcleral drug film; Poly caprolactone; Rabbit eyes; Transscleral drug delivery; Triamcinolone acetonide

Indexed keywords

CONTROLLED DRUG DELIVERY; DICHLOROMETHANE; DISEASES; DRUG PRODUCTS; FOURIER TRANSFORM INFRARED SPECTROSCOPY; OPHTHALMOLOGY; TARGETED DRUG DELIVERY; X RAY DIFFRACTION;

EPISCLERAL DRUG FILM; MATRIX; MULTI-LAYERED; POLY(Ε CAPROLACTONE); RABBIT EYES; RETINAL DISEASE; SUSTAINED RELEASE; TRANSSCLERAL DRUG DELIVERY; TREATMENT MODALITY; TRIAMCINOLONE ACETONIDE;

ACETONE;

POLYCAPROLACTONE; TRIAMCINOLONE ACETONIDE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CRYSTAL; DRUG ADMINISTRATION ROUTE; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; EYE; FILM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; INJECTION; NONHUMAN; PRIORITY JOURNAL; RABBIT; RETINA DISEASE; SCANNING ELECTRON MICROSCOPY; SUBTENON DRUG ADMINISTRATION; SUSTAINED DRUG RELEASE; TRANSSCLERAL DRUG DELIVERY; X RAY DIFFRACTION;

ORYCTOLAGUS CUNICULUS;

EPISCLERAL DRUG FILM; POLY-Ε-CAPROLACTONE; RABBIT EYES; TRANSSCLERAL DRUG DELIVERY; TRIAMCINOLONE ACETONIDE;

ANIMALS; DELAYED-ACTION PREPARATIONS; IMPLANTS, EXPERIMENTAL; POLYESTERS; RABBITS; SCLERA; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TIME FACTORS; TRIAMCINOLONE ACETONIDE; VITREOUS BODY; X-RAY DIFFRACTION;

EID: 84888641773     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2013.09.022     Document Type: Article

References (42)

1. Y. Li, H. Chen, J. Hou, Y. Zhang, G. Li, and X. Gu Further characterization of ocular safety profile of commercially available preserved and preservative-free triamcinolone acetonide Retina 32 2012 364 374
2. C.M. Jermak, J.T. Dellacroce, J. Heffez, and G.A. Peyman Triamcinolone acetonide in ocular therapeutics Surv Ophthalmol 52 2007 503 522
3. H. Kok, C. Lau, N. Maycock, P. McCluskey, and S. Lightman Outcome of intravitreal triamcinolone in uveitis Ophthalmology 112 2005 1916.e1911 1916.e1917
4. A.M. Elbendary, and M.M. Shahin Intravitreal diclofenac versus intravitreal triamcinolone acetonide in the treatment of diabetic macular edema Retina 31 2011 2058 2064
5. W.C. Wu, K.C. Cheng, and H.J. Wu Intravitreal triamcinolone acetonide vs bevacizumab for treatment of macular oedema due to central retinal vein occlusion Eye (Lond) 23 2009 2215 2222
6. H. Ahmadieh, R. Taei, M. Riazi-Esfahani, N. Piri, M. Homayouni, and N. Daftarian Intravitreal bevacizumab versus combined intravitreal bevacizumab and triamcinolone for neovascular age-related macular degeneration: six-month results of a randomized clinical trial Retina 31 2011 1819 1826
7. M.S. Ip, I.U. Scott, P.C. VanVeldhuisen, N.L. Oden, B.A. Blodi, and M. Fisher A randomized trial comparing the efficacy and safety of intravitreal triamcinolone with observation to treat vision loss associated with macular edema secondary to central retinal vein occlusion: the Standard Care vs Corticosteroid for Retinal Vein Occlusion (SCORE) study report 5 Arch Ophthalmol Chic 127 2009 1101 1114
8. J.E. Kim, J.S. Pollack, D.G. Miller, R.A. Mittra, and R.F. Spaide ISIS-DME: a prospective, randomized, dose-escalation intravitreal steroid injection study for refractory diabetic macular edema Retina 28 2008 735 740
9. M.C. Gillies, J.M. Simpson, W. Luo, P. Penfold, A.B. Hunyor, and W. Chua A randomized clinical trial of a single dose of intravitreal triamcinolone acetonide for neovascular age-related macular degeneration: one-year results Arch Ophthalmol Chic 121 2003 667 673
10. M. Cellini, A. Pazzaglia, E. Zamparini, P. Leonetti, and E.C. Campos Intravitreal vs. subtenon triamcinolone acetonide for the treatment of diabetic cystoid macular edema BMC Ophthalmol 8 2008 5
11. K. Iwao, M. Inatani, T. Kawaji, T. Koga, Y. Mawatari, and H. Tanihara Frequency and risk factors for intraocular pressure elevation after posterior sub-tenon capsule triamcinolone acetonide injection J Glaucoma 16 2007 251 256
12. L. Shen, Y. You, S. Sun, Y. Chen, J. Qu, and L. Cheng Intraocular and systemic pharmacokinetics of triamcinolone acetonide after a single 40-mg posterior subtenon application Ophthalmology 117 2010 2365 2371
13. X. Liu, Y. Li, Y. Zhang, W. Du, S. Sun, and B. Lin Comparison of intraocular pressure elevation after anterior versus posterior subtenon triamcinolone acetonide acetate injection: a retrospective study Retina 32 2012 1838 1843
14. L. Cheng, A.S. Banker, M. Martin, I. Kozak, and W.R. Freeman Triamcinolone acetonide concentration of aqueous humor after decanted 20-mg intravitreal injection Ophthalmology 116 2009 1356 1359
15. P.M. Beer, S.J. Bakri, R.J. Singh, W. Liu, G.B. Peters, and M. Miller Intraocular concentration and pharmacokinetics of triamcinolone acetonide after a single intravitreal injection Ophthalmology 110 2003 681 686
16. O.Y. Tektas, C.M. Hammer, J. Danias, O. Candia, R. Gerometta, and S.M. Podos Morphologic changes in the outflow pathways of bovine eyes treated with corticosteroids Invest Ophthalmol Vis Sci 51 2010 4060 4066
17. K.G. Csaky, H. Coleman, S.S. Dahr, E. Chew, J. Rosenthal, and W. Gilmer Anterior subtenon's triamcinolone acetonide (ASTTA) injection for the treatment of diabetic macular edem: animal and clinical findings Invest Ophthalmol Vis Sci 46 2005 ARVO e-abstract 4670
18. E. Chew, S. Strauber, R. Beck, L.P. Aiello, A. Antoszyk, and N. Bressler Randomized trial of peribulbar triamcinolone acetonide with and without focal photocoagulation for mild diabetic macular edema: a pilot study Ophthalmology 114 2007 1190 1196
19. E.Y. Chew, A.R. Glassman, R.W. Beck, N.M. Bressler, G.E. Fish, and F.L. Ferris Ocular side effects associated with peribulbar injections of triamcinolone acetonide for diabetic macular edema Retina 31 2011 284 289
20. K. Nan, S. Sun, Y. Li, J. Qu, G. Li, and L. Luo Characterisation of systemic and ocular drug level of triamcinolone acetonide following a single sub-tenon injection Br J Ophthalmol 94 2010 654 658
21. D.H. Geroski, and H.F. Edelhauser Transscleral drug delivery for posterior segment disease Adv Drug Deliv Rev 52 2001 37 48
22. K.G. Carrasquillo, J.A. Ricker, I.K. Rigas, J.W. Miller, E.S. Gragoudas, and A.P. Adamis Controlled delivery of the anti-VEGF aptamer EYE001 with poly(lactic-co-glycolic)acid microspheres Invest Ophthalmol Vis Sci 44 2003 290 299
23. J. Ambati, C.S. Canakis, J.W. Miller, E.S. Gragoudas, A. Edwards, and D.J. Weissgold Diffusion of high molecular weight compounds through sclera Invest Ophthalmol Vis Sci 41 2000 1181 1185
24. Y.M. Kim, J.O. Lim, H.K. Kim, S.Y. Kim, and J.P. Shin A novel design of one-side coated biodegradable intrascleral implant for the sustained release of triamcinolone acetonide Eur J Pharm Biopharm 70 2008 179 186
25. O. Felt-Baeyens, S. Eperon, P. Mora, D. Limal, S. Sagodira, and P. Breton Biodegradable scleral implants as new triamcinolone acetonide delivery systems Int J Pharm 322 2006 6 12
26. Z.G. Tang, N.P. Rhodes, and J.A. Hunt Control of the domain microstructures of PLGA and PCL binary systems: importance of morphology in controlled drug release Chem Eng Res Des 85 2007 1044 1050
27. H.J. Sung, C. Meredith, C. Johnson, and Z.S. Galis The effect of scaffold degradation rate on three-dimensional cell growth and angiogenesis Biomaterials 25 2004 5735 5742
28. L. Lu, S.J. Peter, M.D. Lyman, H.L. Lai, S.M. Leite, and J.A. Tamada In vitro and in vivo degradation of porous poly(dl-lactic-co-glycolic acid) foams Biomaterials 21 2000 1837 1845
29. S. Li, H. Garreau, B. Pauvert, J. McGrath, A. Toniolo, and M. Vert Enzymatic degradation of block copolymers prepared from epsilon-caprolactone and poly(ethylene glycol) Biomacromolecules 3 2002 525 530
30. M. Hakkarainen, and A.C. Albertsson Heterogeneous biodegradation of polycaprolactone - low molecular weight products and surface changes Macromol Chem Phys 203 2002 1357 1363
31. A. Thakur, R.S. Kadam, and U.B. Kompella Influence of drug solubility and lipophilicity on transscleral retinal delivery of six corticosteroids Drug Metab Dispos 39 2011 771 781
32. R.S. Kadam, N.P.S. Cheruvu, H.F. Edelhauser, and U.B. Kompella Sclera-choroid-RPE transport of eight beta-blockers in human, bovine, porcine, rabbit, and rat models Invest Ophthalmol Vis Sci 52 2011 5387 5399
33. N. Krishnadev, F. Forooghian, C. Cukras, W. Wong, L. Saligan, and E.Y. Chew Subconjunctival sirolimus in the treatment of diabetic macular edema Graef Arch Clin Exp 249 2011 1627 1633
34. D. Ghate, W. Brooks, B.E. McCarey, and H.F. Edelhauser Pharmacokinetics of intraocular drug delivery by periocular injections using ocular fluorophotometry Invest Ophthalmol Vis Sci 48 2007 2230 2237
35. K. Kovacs, S. Wagley, M.T. Quirk, O.M. Ceron, P.A. Silva, and R.J. Singh Pharmacokinetic study of vitreous and serum concentrations of triamcinolone acetonide after posterior sub-tenon's injection Am J Ophthalmol 153 9 2012 39 948
36. I. Kozak, O.R. Kayikcioglu, L. Cheng, I. Falkenstein, G.A. Silva, and D.X. Yu The effect of recombinant human hyaluronidase on dexamethasone penetration into the posterior segment of the eye after sub-tenon's injection J Ocul Pharmacol Ther 22 2006 362 369
37. V.R. Sinha, K. Bansal, R. Kaushik, R. Kumria, and A. Trehan Poly-epsilon-caprolactone microspheres and nanospheres: an overview Int J Pharm 278 2004 1 23
38. D. Jaffuel, C. Roumestan, P. Balaguer, C. Henriquet, C. Gougat, and J. Bousquet Correlation between different gene expression assays designed to measure trans-activation potencies of systemic glucocorticoids Steroids 66 2001 97 604
39. P.A. Campochiaro, D.M. Brown, A. Pearson, T. Ciulla, D. Boyer, and F.G. Holz Long-term benefit of sustained-delivery fluocinolone acetonide vitreous inserts for diabetic macular edema Ophthalmology 118 2011 626 635
40. J.E. Chang-Lin, M. Attar, A.A. Acheampong, M.R. Robinson, S.M. Whitcup, and B.D. Kuppermann Pharmacokinetics and pharmacodynamics of a sustained-release dexamethasone itravitreal implant Invest Ophthalmol Vis Sci 52 2011 80 86
41. D.F. Martin, F.L. Ferris, D.J. Parks, R.C. Walton, S.D. Mellow, and D. Gibbs Ganciclovir implant exchange - timing, surgical procedure, and complications Arch Ophthalmol Chic 115 1997 1389 1394
42. Y. Peng, M. Ang, S. Foo, W.S. Lee, Z. Ma, and S.S. Venkatraman Biocompatibility and biodegradation studies of subconjunctival implants in rabbit eyes Plos One 6 2011 e22507