Biocompatibility and biodegradation studies of subconjunctival implants in rabbit eyes

PLoS ONE

Volumn 6, Issue 7, 2011, Pages

  Peng, Yan ^a   Ang, Marcus ^b,c   Foo, Selin ^c   Lee, Wing Sum ^b   Ma, Zhen ^c   Venkatraman, Subbu S ^a   Wong, Tina T ^a,b,c,d  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b Singapore National Eye Centre   (Switzerland)

^c Singapore Eye Research Institute   (Switzerland)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

BIOPOLYMER; DEXAMETHASONE PLUS TOBRAMYCIN; POLYCAPROLACTONE; POLYGLACTIN; DRUG CARRIER; LACTIC ACID; LACTIDE CAPROLACTONE COPOLYMER; LACTIDE-CAPROLACTONE COPOLYMER; POLYESTER; POLYGLYCOLIC ACID; POLYLACTIC ACID POLYGLYCOLIC ACID COPOLYMER; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; WATER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTERIOR EYE SEGMENT; ARTICLE; BIOCOMPATIBILITY; BIODEGRADATION; CHEMOSIS; CONJUNCTIVA; CONJUNCTIVAL HYPEREMIA; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ENUCLEATION; FEASIBILITY STUDY; HISTOPATHOLOGY; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMPLANT; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MICROFILM; MOLECULAR WEIGHT; NONHUMAN; OPTICAL COHERENCE TOMOGRAPHY; RABBIT; SLIT LAMP; SUBCONJUNCTIVAL IMPLANT; VASCULARIZATION; VISCOSITY; WATER ABSORPTION; WEIGHT REDUCTION; ABSORPTION; ANIMAL; CHEMISTRY; CYTOLOGY; DRUG EFFECT; MATERIALS TESTING; METABOLISM; PROSTHESES AND ORTHOSES;

ORYCTOLAGUS CUNICULUS;

ABSORPTION; ANIMALS; CONJUNCTIVA; DRUG CARRIERS; FEASIBILITY STUDIES; LACTIC ACID; MATERIALS TESTING; MOLECULAR WEIGHT; POLYESTERS; POLYGLYCOLIC ACID; PROSTHESES AND IMPLANTS; RABBITS; WATER;

EID: 79960658598     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0022507     Document Type: Article

References (37)

1. Ghate D, Edelhauser HF, (2006) Ocular drug delivery. Expert Opin Drug Deliv 3: 275-287.
2. Souto EB, Doktorovova S, Gonzalez-Mira E, Egea MA, Garcia ML, (2010) Feasibility of lipid nanoparticles for ocular delivery of anti-inflammatory drugs. Curr Eye Res 35: 537-552.
3. Barar J, Javadzadeh AR, Omidi Y, (2008) Ocular novel drug delivery: impacts of membranes and barriers. Expert Opin Drug Deliv 5: 567-581.
4. Kato A, Kimura H, Okabe K, Okabe J, Kunou N, et al. (2004) Feasibility of drug delivery to the posterior pole of the rabbit eye with an episcleral implant. Invest Ophthalmol Vis Sci 45: 238-244.
5. Gaudana R, Jwala J, Boddu SH, Mitra AK, (2009) Recent perspectives in ocular drug delivery. Pharm Res 26: 1197-1216.
6. Jaffe GJ, Yang CH, Guo H, Denny JP, Lima C, et al. (2000) Safety and pharmacokinetics of an intraocular fluocinolone acetonide sustained delivery device. Invest Ophthalmol Vis Sci 41: 3569-3575.
7. Kim H, Robinson MR, Lizak MJ, Tansey G, Lutz RJ, et al. (2004) Controlled drug release from an ocular implant: an evaluation using dynamic three-dimensional magnetic resonance imaging. Invest Ophthalmol Vis Sci 45: 2722-2731.
8. Okabe J, Kimura H, Kunou N, Okabe K, Kato A, et al. (2003) Biodegradable intrascleral implant for sustained intraocular delivery of betamethasone phosphate. Invest Ophthalmol Vis Sci 44: 740-744.
9. Okabe K, Kimura H, Okabe J, Kato A, Kunou N, et al. (2003) Intraocular tissue distribution of betamethasone after intrascleral administration using a non-biodegradable sustained drug delivery device. Invest Ophthalmol Vis Sci 44: 2702-2707.
10. Kunou N, Ogura Y, Honda Y, Hyon SH, Ikada Y, (2000) Biodegradable scleral implant for controlled intraocular delivery of betamethasone phosphate. J Biomed Mater Res 51: 635-641.
11. Beeley NR, Rossi JV, Mello-Filho PA, Mahmoud MI, Fujii GY, et al. (2005) Fabrication, implantation, elution, and retrieval of a steroid-loaded polycaprolactone subretinal implant. J Biomed Mater Res A 73: 437-444.
12. Beeley NR, Stewart JM, Tano R, Lawin LR, Chappa RA, et al. (2006) Development, implantation, in vivo elution, and retrieval of a biocompatible, sustained release subretinal drug delivery system. J Biomed Mater Res A 76: 690-698.
13. Ali Y, Lehmussaari K, (2006) Industrial perspective in ocular drug delivery. Adv Drug Deliv Rev 58: 1258-1268.
14. Barbu E, Verestiuc L, Iancu M, Jatariu A, Lungu A, et al. (2009) Hybrid polymeric hydrogels for ocular drug delivery: nanoparticulate systems from copolymers of acrylic acid-functionalized chitosan and N-isopropylacrylamide or 2-hydroxyethyl methacrylate. Nanotechnology 20: 225108.
15. Lewis KJ, Irwin WJ, Akhtar S, (1998) Development of a sustained-release biodegradable polymer delivery system for site-specific delivery of oligonucleotides: characterization of P(LA-GA) copolymer microspheres in vitro. J Drug Target 5: 291-302.
16. Kreuter J, (1996) Nanoparticles and microparticles for drug and vaccine delivery. J Anat 189 (Pt 3): 503-505.
17. Kreuter J, (1995) Nanoparticulate systems in drug delivery and targeting. J Drug Target 3: 171-173.
18. Vega E, Gamisans F, Garcia ML, Chauvet A, Lacoulonche F, et al. (2008) PLGA nanospheres for the ocular delivery of flurbiprofen: drug release and interactions. J Pharm Sci 97: 5306-5317.
19. Araujo J, Vega E, Lopes C, Egea MA, Garcia ML, et al. (2009) Effect of polymer viscosity on physicochemical properties and ocular tolerance of FB-loaded PLGA nanospheres. Colloids Surf B Biointerfaces 72: 48-56.
20. Agnihotri SM, Vavia PR, (2009) Diclofenac-loaded biopolymeric nanosuspensions for ophthalmic application. Nanomedicine 5: 90-95.
21. Giordano GG, Refojo MF, Arroyo MH, (1993) Sustained delivery of retinoic acid from microspheres of biodegradable polymer in PVR. Invest Ophthalmol Vis Sci 34: 2743-2751.
22. Duong-Hong D, Tang YD, Wu W, Venkatraman SS, Boey F, et al. (2010) Fully biodegradable septal defect occluder-a double umbrella design. Catheter Cardiovasc Interv 76: 711-718.
23. Wang X, Venkatraman SS, Boey FY, Loo JS, Tan LP, (2006) Controlled release of sirolimus from a multilayered PLGA stent matrix. Biomaterials 27: 5588-5595.
24. Joachim Loo SC, Jason Tan WL, Khoa SM, Chia NK, Venkatraman S, et al. (2008) Hydrolytic degradation characteristics of irradiated multi-layered PLGA films. Int J Pharm 360: 228-230.
25. Frank A, Rath SK, Venkatraman SS, (2005) Controlled release from bioerodible polymers: effect of drug type and polymer composition. J Control Release 102: 333-344.
26. Munger RJ, (2002) Veterinary ophthalmology in laboratory animal studies. Vet Ophthalmol 5: 167-175.
27. Singh M, Chew PT, Friedman DS, Nolan WP, See JL, et al. (2007) Imaging of trabeculectomy blebs using anterior segment optical coherence tomography. Ophthalmology 114: 47-53.
28. Ramos JL, Li Y, Huang D, (2009) Clinical and research applications of anterior segment optical coherence tomography- a review. Clin Experiment Ophthalmol 37: 81-89.
29. Singh M, See JL, Aquino MC, Thean LS, Chew PT, (2009) High-definition imaging of trabeculectomy blebs using spectral domain optical coherence tomography adapted for the anterior segment. Clin Experiment Ophthalmol 37: 345-351.
30. Koevary SB, (2003) Pharmacokinetics of topical ocular drug delivery: potential uses for the treatment of diseases of the posterior segment and beyond. Curr Drug Metab 4: 213-222.
31. Zhang W, Prausnitz MR, Edwards A, (2004) Model of transient drug diffusion across cornea. J Control Release 99: 241-258.
32. Nomoto H, Shiraga F, Kuno N, Kimura E, Fujii S, et al. (2009) Pharmacokinetics of bevacizumab after topical, subconjunctival, and intravitreal administration in rabbits. Invest Ophthalmol Vis Sci 50: 4807-4813.
33. Houchin ML, Topp EM, (2008) Chemical degradation of peptides and proteins in PLGA: a review of reactions and mechanisms. J Pharm Sci 97: 2395-2404.
34. Wells AP, Crowston JG, Marks J, Kirwan JF, Smith G, et al. (2004) A pilot study of a system for grading of drainage blebs after glaucoma surgery. J Glaucoma 13: 454-460.
35. Hitchings RA, Grierson I, (1983) Clinico pathological correlation in eyes with failed fistulizing surgery. Trans Ophthalmol Soc U K 103 (Pt 1): 84-88.
36. Weijtens O, Feron EJ, Schoemaker RC, Cohen AF, Lentjes EG, et al. (1999) High concentration of dexamethasone in aqueous and vitreous after subconjunctival injection. Am J Ophthalmol 128: 192-197.
37. Hughes PM, Olejnik O, Chang-Lin JE, Wilson CG, (2005) Topical and systemic drug delivery to the posterior segments. Adv Drug Deliv Rev 57: 2010-2032.