Pharmacokinetic study of vitreous and serum concentrations of triamcinolone acetonide after posterior sub-Tenon's injection

American Journal of Ophthalmology

Volumn 153, Issue 5, 2012, Pages 939-948

  Kovacs, Kyle ^a   Wagley, Sushant ^a   Quirk, Matthew T ^a   Ceron, Olga M ^a   Silva, Paolo A ^b,c   Singh, Ravinder J ^d   Gukasyan, Hovhannes J ^e   Arroyo, Jorge G ^a,c  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b JOSLIN DIABETES CENTER   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d MAYO CLINIC   (United States)

^e PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROCORTISONE; TRIAMCINOLONE ACETONIDE;

CILIARY DISK; CLINICAL PRACTICE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DIFFUSION; EXTRACELLULAR MATRIX; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROCORTISONE BLOOD LEVEL; MAJOR CLINICAL STUDY; MASS SPECTROMETRY; PHARMACOKINETICS; PRIORITY JOURNAL; PROSPECTIVE STUDY; REVIEW; TENON CAPSULE; THEORETICAL MODEL; VITRECTOMY; VITREOUS BODY;

EID: 84862789863     PISSN: 00029394     EISSN: 18791891     Source Type: Journal    
DOI: 10.1016/j.ajo.2011.10.021     Document Type: Article

References (41)

1. A. Martidis, J. Duker, P. Greenberg Intravitreal triamcinolone for refractory diabetic macular edema Ophthalmology 109 5 2002 920 927 (Pubitemid 34465226)
2. T. Yilmaz, C. Weaver, M. Gallagher Intravitreal triamcinolone acetonide injection for treatment of refractory diabetic macular edema: a systematic review Ophthalmology 116 5 2009 902 911
3. Isaac D, Abud M, Frantz K, et al. Comparing intravitreal triamcinolone acetonide and bevacizumab injections for the treatment of diabetic macular edema: a randomized double-blind study. Acta Ophthalmol doi: 10.1111/j.1755-3768.2009.01817.x.
4. B. Hogewind, C. Zijlstra, B. Klevering, C. Hoyng Intravitreal triamcinolone for the treatment of refractory macular edema in idiopathic intermediate or posterior uveitis Eur J Ophthalmol 18 3 2008 429 434
5. H. Kok, C. Lau, N. Maycock Outcome of intravitreal triamcinolone in uveitis Ophthalmology 112 11 2005 1916 1917
6. M. Gillies, J. Simpson, F. Billson Safety of an intravitreal injection of triamcinolone: results from a randomized clinical trial Arch Ophthalmol 122 3 2004 336 340 (Pubitemid 38314193)
7. S. Maca, C. Abela-Formanek, C. Kiss Intravitreal triamcinolone for persistent cystoid macular oedema in eyes with quiescent uveitis Clin Experiment Ophthalmol 37 4 2009 389 396
8. A. Ozkiris Intravitreal triamcinolone acetonide injection for the treatment of posterior uveitis Ocul Immunol Inflamm 14 4 2006 233 238 (Pubitemid 44266801)
9. S. Couch, S.J. Bakri Intravitreal triamcinolone for intraocular inflammation and associated macular edema Clin Ophthalmol 3 2009 41 47
10. S. Choudhry, S. Ghosh Intravitreal and posterior subtenon triamcinolone acetonide in idiopathic bilateral uveitic macular oedema Clin Experiment Ophthalmol 35 8 2007 713 718 (Pubitemid 350090527)
11. J. Jonas Intraocular availability of triamcinolone acetonide after intravitreal injection Am J Ophthalmol 137 3 2004 560 562 (Pubitemid 38328652)
12. P. Silva, R. Singh, S. Bakri Vitreous concentration of triamcinolone acetonide after a single transseptal depot injection Ocul Immunol Inflamm 17 3 2009 216 220
13. E. Thomas, J. Wang, E. Ege Intravitreal triamcinolone acetonide concentration after subtenon injection Am J Ophthalmol 142 5 2006 860 861 (Pubitemid 44584127)
14. J. Mason, M. Somaiya, R. Singh Intravitreal concentration and clearance of triamcinolone acetonide in nonvitrectomized human eyes Retina 24 6 2004 900 904 (Pubitemid 39657486)
15. P. Beer, S. Bakri, R. Singh Intraocular concentration and pharmacokinetics of triamcinolone acetonide after a single intravitreal injection Ophthalmology 110 4 2003 681 686 (Pubitemid 36520063)
16. S. Zaka-ur-Rab, S. Mahmood, M. Shukla Systemic absorption of triamcinolone acetonide after posterior sub-Tenon injection Am J Ophthalmol 148 3 2009 414 419
17. R. Degenring, J. Jonas Serum levels of triamcinolone acetonide after intravitreal injection Am J Ophthalmol 137 6 2004 1142 1143 (Pubitemid 38759374)
18. S. Friedrich, Y. Cheng, B. Saville Drug distribution in the vitreous humor of the human eye: the effects of intravitreal injection position and volume Curr Eye Res 16 7 1997 663 669 (Pubitemid 27322718)
19. T. Olsen, S. Aaberg, D. Geroski, H. Edelhauser Human sclera: thickness and surface area Am J Ophthalmol 125 2 1998 237 241 (Pubitemid 28081303)
20. K. Swan, J. Wilkins Extraocular muscle surgery in early infancy - anatomical factors J Pediatr Ophthalmol Strabismus 21 2 1984 44 49 (Pubitemid 14150158)
21. C. Phillips, B. Michniak Transdermal delivery of drugs with differing lipophilicities using azone analogs as dermal penetration enhancers J Pharm Sci 84 12 1995 1427 1433
22. M. Koeberle, P. Hughes, G. Skellern, C. Wilson Binding of memantine to melanin: influence of type of melanin and characteristics Pharm Res 20 10 2003 1702 1709 (Pubitemid 37268290)
23. S. Rohatagi, G. Hochhaus, H. Mollmann Pharmacokinetic and pharmacodynamic evaluation of triamcinolone acetonide after intravenous, oral, and inhaled administration J Clin Pharmacol 35 12 1995 1187 1193 (Pubitemid 26020041)
24. H. Derendorf, G. Hochhaus, S. Rohatagi Pharmacokinetics of triamcinolone acetonide after intravenous, oral, and inhaled administration J Clin Pharmacol 35 3 1995 302 305
25. C. Behl, L. Block, M. Borke Aqueous solubility of 14C-triamcinolone acetonide J Pharm Sci 65 3 1976 429 430
26. M. Oishi, S. Maeda, N. Hashida, N. Ohguro, Y. Tano, N. Kurokawa Pharmacokinetic behavior of intravitreal triamcinolone acetonide prepared by a hospital pharmacy Jpn J Ophthalmol 52 6 2008 489 492
27. C. Bitter, K. Suter, V. Figueiredo, C. Pruente, K. Hatz, C. Surber Preservative-free triamcinolone acetonide suspension developed for intravitreal injection J Ocul Pharmacol Ther 24 1 2008 62 69 (Pubitemid 351156630)
28. P. Missel, M. Horner, R. Muralikrishnan Simulating dissolution of intravitreal triamcinolone acetonide suspensions in an anatomically accurate rabbit eye model Pharm Res 27 8 2010 1530 1546
29. R. Nozik Periocular injection of steroids Trans Am Acad Ophthalmol Otolaryngol 76 3 1972 695 705
30. J. Arroyo, D. Bula, L. Yang, D. Chen Retinal biopsy techniques for the removal of retinal tissue fragments Ophthalmic Surg Lasers Imaging 36 1 2005 76 78 (Pubitemid 40128606)
31. R. Singh, D. Machacek Measurement of triamcinolone acetonide by liquid chromatography tandem mass spectrometry Clin Chem 48 6 Suppl 2002 A122
32. R. Taylor, S. Grebe, R. Singh Quantitative, highly sensitive liquid chromatography-tandem mass spectrometry method for detection of synthetic corticosteroids Clin Chem 50 12 2004 2345 2352 (Pubitemid 39552171)
33. L. Shen, Y. You, S. Sun Intraocular and systemic pharmacokinetics of triamcinolone acetonide after a single 40-mg posterior subtenon application Ophthalmology 117 12 2010 2365 2371
34. J. Jonas, I. Kreissig, R. Degenring Retinal complications of intravitreal injections of triamcinolone acetonide Graefes Arch Clin Exp Ophthalmol 242 2 2004 184 185 (Pubitemid 38324974)
35. M. Inoue, K. Takeda, K. Morita Vitreous concentrations of triamcinolone acetonide in human eyes after intravitreal or subtenon injection Am J Ophthalmol 138 2004 1046 1048 (Pubitemid 40040025)
36. K. Nan, S. Sun, Y. Li Characterisation of systemic and ocular drug level of triamcinolone acetonide following a single sub-Tenon injection Br J Ophthalmol 94 2010 654 658
37. S. Lee, E. Kim, D. Geroski Pharmacokinetics of intraocular drug delivery of Oregon green 488-labeled triamcinolone by subtenon injection using ocular fluorophotometry in rabbit eyes Invest Ophthalmol Vis Sci 49 10 2008 4506 4514
38. J. Jonas, I. Kreissig, R. Degenring Retinal complications of intravitreal injections of triamcinolone acetonide Graefes Arch Clin Exp Ophthalmol 242 2 2004 184 185 (Pubitemid 38324974)
39. M. Lafranco Dafflon, V. Tran, Y. Guex-Crosier, C. Herbort Posterior sub-Tenon's steroid injections for the treatment of posterior ocular inflammation: indications, efficacy and side effects Graefes Arch Clin Exp Ophthalmol 237 4 1999 289 295 (Pubitemid 29145806)
40. Y. Hirano, T. Ito, M. Nozaki Intraocular pressure elevation following triamcinolone acetonide administration as related to administration routes Jpn J Ophthalmol 53 5 2009 519 522
41. H. Younis, M. Shawer, K. Palacio, H. Gukasyan, G. Stevens, W. Evering An assessment of the ocular safety of inactive excipients following sub-tenon injection in rabbits J Ocul Pharmacol Ther 24 2 2008 206 216 (Pubitemid 351450475)