The possibility of genistein as a new direct pulp capping agent

Dental Materials Journal

Volumn 32, Issue 6, 2013, Pages 976-985

  Hayashi, Keijiro ^a   Handa, Keisuke ^a   Koike, Toshiyuki ^a   Saito, Takashi ^a  

^a HEALTH SCIENCES UNIVERSITY OF HOKKAIDO   (Japan)

Author keywords

Direct pulp capping; Genistein; Rat dental pulp cells

Indexed keywords

DENTAL PULP CELLS; DIRECT PULP CAPPING; ESTROGEN RECEPTOR; GENES EXPRESSION; GENISTEIN; NATURAL INGREDIENTS; RENAL FUNCTIONS; SOY ISOFLAVONES;

BIOMINERALIZATION; GENE EXPRESSION; RATS;

FLAVONOIDS;

ALKALINE PHOSPHATASE; BIOMEDICAL AND DENTAL MATERIALS; GENISTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; OSTEOCALCIN; PRIMER DNA; PROTEIN TYROSINE KINASE;

ANIMAL; CELL DIFFERENTIATION; CELL PROLIFERATION; CYTOLOGY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYMOLOGY; MALE; METABOLISM; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; RAT; TOOTH PULP; WISTAR RAT;

ALKALINE PHOSPHATASE; ANIMALS; BASE SEQUENCE; CELL DIFFERENTIATION; CELL PROLIFERATION; DENTAL PULP; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENISTEIN; MALE; OSTEOCALCIN; P38 MITOGEN-ACTIVATED PROTEIN KINASES; POLYMERASE CHAIN REACTION; PROTEIN-TYROSINE KINASES; PULP CAPPING AND PULPECTOMY AGENTS; RATS; RATS, WISTAR;

EID: 84888585720     PISSN: 02874547     EISSN: 18811361     Source Type: Journal    
DOI: 10.4012/dmj.2013-091     Document Type: Article

References (48)

1. Hodgson JM, Croft KD, Puddey IB, Mori TA, Beilin LJ. Soybean isoflavonoids and their metabolic products inhibit in vitro lipoprotein oxidation in serum. J Nutr Biochem 1996; 7: 664-669.
2. Lee HP, Lee J, Gourley L, Duffy SW, Day NE, Estève J. Dietary effects on breast-cancer risk in Singapore. Lancet 1991; 337: 1197-1200.
3. Green CS, Hanna TJ, Anderson JW. Benefits of soy protein in diabetes. Third International Symposium on the Role of Soy in Preventing and Treating Chronic Disease; 1999 Oct 31-Nov 3; Washington DC: USA: J Nutr; 2000. 130. 653S-711S.
4. Kudou S, Uchida T, Fleury Y, Welti D, Mgnolato D, Kitamura K, Okubo K. Malonyl isoflavone glycosides in soybean seeds (Glycine max Merrill). Argic Biol Chem 1991; 55: 2227-2233.
5. Price KR, Fenwick GR. Naturally occurring oestrogens in foods-a review. Food Addit Contam 1985; 2: 73-106.
6. Kuiper G, Lemmen J, Carlsson B, Corton J, Safe S, van der Saag P, van der Burg B, Gustafsson J. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 1998; 139; 4252-4263.
7. Morita K, Hamamatsu Y, Kido S, Taketani Y, Miyamoto K, Takeda E. Effect of soybean isoflavone on bone metabolism. Soy Protein Res 1999; 2: 76-82.
8. Rickard D, Monroe D, Ruesink T, Khosla S, Riggs B, Spelsberg T. Phytoestrogen genistein acts as an estrogen agonist on human osteoblastic cells through estrogen receptors α and β. J Cell Biochem 2003; 89: 633-646.
9. Pan W, Quarles L, Song L, Yu Y, Jiao C, Tang H, Jiang C, Deng H, Li Y, Zhou H, Xiao Z. Genistein stimulate the osteoblastic differentiation via NO/cGMP in bone marrow culture. J Cell Biochem 2005; 94: 307-316.
10. Arjmahdi BH, Alekel L, Mollis BW, Amin D, Sapuntzakis MS, Guo PS, Kukreja C. Dietary soybean protein prevents bone loss in an ovariectomized rat model of osteoporosis. J Nutr 1996; 126: 161-167.
11. Potter S, Baum J, Teng H, Stillman R, Shay N, Erdman Jr J. Soy protein and isoflavones their effects on blood lipids and bone density in postmenopausal women. Am J Clin Nutr 1998; 68: 1375-1379.
12. Goldberg F, Massone E, Spielberg C. Evaluation of the dental bridge after pulptomy and calcium hydroxide dressing. J Endod 1984; 10: 318-320.
13. Cox D, Bergenholtz G, Heys D, Syed S, Fitzgerald M, Heys R. Pulp capping of dental pulp mechanically exposed to oral microflora: a 1-2 year observation of wound healing in the monkey. J Oral Pathol 1985; 14: 156-168.
14. Cox D, Subay R, Ostro E, Suzuki S, Suzuki S. Tunnel defects in dentin bridge their formation following direct pulp capping. Oper Dent 1996; 21: 4-11.
15. Faraco IM Jr, Holland R. Response of the pulp of dogs to capping with mineral trioxide aggregate or a calcium hydroxide cement. Dent Traumatol 2001; 17: 163-166.
16. Katoh Y, Suzuki M, Kato C, Shinkai K, Ogawa M, Yamauchi J. Observation of calcium phosphate powder mixed with an adhesive monomer experimentally developed for direct pulp capping and as a bonding agent. Dent Mater J 2010; 29: 15-24.
17. Lovschall H, Fejerskov O, Flyvbjerg A. Pulp-capping with recombinant human insulin-like growth factor I (rhIGF-I) in rat molars. Adv Dent Res 2001; 15: 108-112.
18. Koike T, Kobayashi F, Izumikawa M, Saito T. Reparative dentin formation by rhBMP-2/FRIOS algipore composite. J Conserv Dent 2004; 47: 666-672.
19. Andelin WE, Shabahang S, Wright K, Torabinejad M. Identification of hard tissue after experimental pulp capping using dentin sialoprotein (DSP) as a marker. J Endod 2003; 29: 646-650.
20. Accorinte MLR, Holland R, Reis A, Bortoluzzi MC, Murata SS, Dezan Jr E, Souza V, Alessandro LD. Evaluation of mineral trioxide aggregate and calcium hydroxide cement as pulp-capping agents in human teeth. J Endod 2008; 34: 1-6.
21. Hasheminia SM, Feizi G, Razavi SM, Feizianfard M, Gutknecht N, Mir M. A comparative study of three treatment 984 Dent Mater J 2013; 32(6): 976-985 methods of direct pulp capping in canine teeth of cats: a histologic evaluation. Lasers Med Sci 2010; 25: 9-15.
22. Handa K, Saito M, Yamauchi M, Kiyono T, Sato S, Teranaka T, Narayanan AS. Cementum matrix formation in vivo by cultured dental follicle cells. Bone 2002; 31: 606-611.
23. Liao QC, Xiao ZS, Qin YF, Zhou HH. Genistein stimulates osteoblastic differentiation via p38 MAPK-Cbfa1 pathway in bone marrow culture. Acta Pharmacologica Sinica 2007; 28: 1597-1602.
24. Morris C, Thorpe J, Ambrosio L, Santin M. The soybean isoflavone genistein induces differentiation of MG63 human osteosarcoma osteoblasts. J Nutr 2006; 136: 1166-1170.
25. Fitter S, Dewar AL, Kostakis P, To LB, Hughes TP, Roberts MM, Lynch K, Vernon-Roberts B, Zannettino ACW. Longterm imatinib therapy promotes bone formation in CML patients. Blood 2008; 11: 2538-2547.
26. Liu X, Yang L, Mao Y, Wang Q, Huang M, Wang Y, Wu H. Effects of the tyrosine protein kinase inhibitor genistein on the proliferation, activation of cultured rat hepatic stellate cells. World J Gastroenterol 2002; 8: 739-745.
27. Markovits J, Linassier C, Fossé P, Couprie J, Pierre J, Sablon AJ, Saucier JM, Le Pecq JB, Larsen AK. Inhibitory effects of the tyrosine kinase inhibitor Ggenistein on mammalian DNA topoisomerase II. Cancer Res 1989; 49: 5111-5117.
28. Balasubramanian S, Efimova T, Eckert R. Green tea polyphenol Sstimulates a Ras, MEKK1, MEK3, and p38 cascade to increase activator protein 1 factor-dependent involucrin gene expression in normal human keratinocytes. J Biol Chem 2002; 277: 1828-1836.
29. Pavese J, Farmer R, Bergan R. Inhibition of cancer cell invasion and metastasis by genistein. Cancer Metastasis Rev 2010; 29: 465-482.
30. Xu L, Ding Y, Catalona W, Yang X, Anderson W, Jovanovic B, Wellman K, Killmer J, Huang X, Scheidt K, Montgomery R, Bergan R. MEK4 function, genistein treatment and invasion of human prostate cancer cells. J Natl Cancer Inst 2009; 19: 1141-1155.
31. Johnson T, Lai M, Lai J, Bhushan A. Inhibition of cell proliferation and MAP Kinase and Akt Pathways in Oral Squamous cell Carcinoma by Genistein and Biochanin A. Evid Based Complement Alternat Med 2010; 7: 351-358.
32. Li Y, Sarkar F. Inhibition of nuclear factor kB activation in PC3 cells by genistein is mediated via Akt signaling pathway. Clin Cancer Res 2002; 8: 2369-2377.
33. Kim SH, Kim SH, Kim Y, Jeon Y, Lee S, Song Y. Genistein inhibits cell growth by modulating various mitogen-activated protein kinases and AKT in cervical cancer cells. Ann NY Acad Sci 2009; 1171: 495-500.
34. Heitala EL, Larmas M, Salo T. Localization of estrogenreceptor-related antigen in human odontoblasts. J Dent Res 1998; 77: 1384-1387.
35. Caiazza F, Galluzzo P, Lorenzetti S, Marino M. 17β-Estradiol induces ERβ up-regulation via p38 MAPK activation in colon cancer cells. Biochem Biophys Res Commun 2007; 359: 102-107.
36. Accorinte MLR, Loguercio AD, Reis A, Carneiro E, Grande RHM, Murata SS, Holland R. Response of human dental pulp capped with MTA and calcium hydroxide powder. Oper Dent 2008; 33: 488-495.
37. Ohsima H. Dentin. The Quintessence 2003; 22: 155.
38. Kawakami Y, Takahashi Y. Effect of soy isoflavones on cyclooxygenase activity. Soy Protein Res 2010; 13: 182-186.
39. Verdrengh M, Jonsson I, Holmdahl R, Tarkowski A. Genistein as an anti-inflammatory agent. Inflamm Res 2003; 52: 341-346.
40. Trompezinski S, Denis A, Schmitt D, Viac J. Comparative effects of polyphenols from green tea (EGCG) and soybean (genistein) on VEGF and IL-8 release from normal human keratinocytes stimulated with the proinflammatory cytokine TNFα. Arch Dermatol Res 2003; 295: 112-116.
41. Guo Y, Wang S, Hoot DR, Clinton DR. Suppression of VEGFmediated autocrine and paracrine interactions between prostate cancer cells and vascular endothelial cells by soy isoflavones. J Nutr Biol 2007; 18: 408-417.
42. Ripamonti U, Ma S, Reddi A. The critical role of geometry of porous hydroxyapatite delivery system in induction of bone by osteogenin, a bone morphogenetic protein. Matrix 1992; 12: 202-212.
43. Urist M, Lietze A, Dawason E. β-tri-calcium phosphate delivery system for bone morphogenetic protein. Clin Orthop Relat Res 1984; 187: 277-280.
44. Athanasiou K, Agrawal C, Barber F, Burkhart S. Orthopaedic applications for PLA-PGA biodegradable polymers. Arthroscopy 1998; 14: 726-737.
45. Saito N, Okada T, Horiuchi H, Murakami N, Takahashi J, Nawata M, Ota H, Nozaki K, Takaoka K. A biodegradable polymer as a cytokine delivery system for inducing bone formation. Nat Biotechnol 2001; 19: 332-335.
46. Wang N, Wu X. Synthesis, characterization, biodegradation, and drug delivery application of biodegradable lactic/glycolic acid oligomers: Part II. Biodegradation and drug delivery application. J Biomater Sci Polym 1997; 9: 75-87.
47. Miyamoto S, Takaoka K, Okada T, Yoshikawa H, Hashimoto J, Ono K. Polylactic acid-polyethylene glycol block copolymer, A new biodegradable synthetic carrier for bone morphogenetic protein. Clin Orthop Relat Res 1993; 294: 333-343.
48. Hu CC, Zhang C, Qian Q, Tatum NB. Reparative dentin formation in rat molars after direct pulp capping with growth factors. J Endod 1998; 24: 744-751.