Further discovery of caffeic acid derivatives as novel influenza neuraminidase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 24, 2013, Pages 7715-7723

  Xie, Yuanchao ^a   Huang, Bing ^b   Yu, Kexiang ^b   Xu, Wenfang ^a  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG PEANUT RESEARCH INSTITUTE   (China)

Author keywords

Caffeic acid; Influenza; Inhibitor; Neuraminidase

Indexed keywords

2 [2 (2 ETHYLBUTANAMIDO) 4 (4 METHYLPHENYLSULFONAMIDO)PHENOXY]ACETIC ACID; 2 [2 (2 ETHYLBUTANAMIDO) 4 (FURAN 2 CARBOXAMIDO)PHENOXY]ACETIC ACID; 2 [2 (2 ETHYLBUTANAMIDO) 4 [3 (1 HYDROXYBUTAN 2 YL)UREIDO]PHENOXY]ACETIC ACID; 2 [2 (2 ETHYLBUTANAMIDO) 4 [3 (PROP 2 YN 1 YL)PHENOXY]UREIDO]ACETIC ACID; 2 [2 (2 ETHYLBUTANAMIDO) 4 GUANIDINOPHENOXY]ACETIC ACID TRIFLUOROACETIC ACID; 2 [2 (2 ETHYLBUTANAMIDO) 5 GUANIDINO 4 ISOBUTYRAMIDOPHENOXY]ACETIC ACID TRIFLUOROACETIC ACID; 2 [2,4 BIS(2 ETHYLBUTANAMIDO)PHENOXY]ACETIC ACID; 2 [4 (3 BENZYLUREIDO) 2 (2 ETHYLBUTANAMIDO)PHENOXY]ACETIC ACID; 2 [4 [2 [3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDO] 3 METHYLBUTANAMIDO] 2 (2 ETHYLBUTANAMIDO)PHENOXY]ACETIC ACID; 2 [4 [2 [3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDO] 3 PHENYLPROPANAMIDO] 2 (2 ETHYLBUTANAMIDO)PHENOXY]ACETIC ACID; 2 [4 [2 [3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDO] 4 METHYLPENTANAMIDO] 2 (2 ETHYLBUTANAMIDO)PHENOXY]ACETIC ACID; 2 [4 [2 [3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDO]ACETAMIDO] 2 (2 ETHYLBUTANAMIDO)PHENOXY]ACETIC ACID; 2 [4 [2 [3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDO]PROPANAMIDO] 2 (2 ETHYLBUTANAMIDO)PHENOXY]ACETIC ACID; 2 [4 [3 (3,4 DIHYDROXYPHENYL) N (2 ETHYLBUTYL)ACRYLAMIDO] 2 (2 ETHYLBUTANAMIDO)PHENOXY]ACETIC ACID; 2 [4 [3 (3,4 DIHYDROXYPHENYL) N (THIOPHEN 2 YLMETHYL)ACRYLAMIDO] 2 (2 ETHYLBUTANAMIDO)PHENOXY]ACETIC ACID; 2 [4 [N BENZYL 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDO] 2 (2 ETHYLBUTANAMIDO)PHENOXY]ACETIC ACID; 2 [4 ACETAMIDO 2 (2 ETHYLBUTANAMIDO) 5 GUANIDINOPHENOXY]ACETIC ACID TRIFLUOROACETIC ACID; 2 [4 ACETAMIDO 5 [3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDO] 2 (2 ETHYLBUTANAMIDO)PHENOXY]ACETIC ACID; 2 [4 ACETAMIDO 5 [3 (3,4 DIHYDROXYPHENYL)PROPANAMIDO] 2 (2 ETHYLBUTANAMIDO)PHENOXY]ACETIC ACID; 2 [4 ACETAMIDO 5 AMINO 2 (2 ETHYLBUTANAMIDO)PHENOXY]ACETIC ACID TRIFLUOROACETIC ACID; 2 [4 AMINO 2 (2 ETHYLBUTANAMIDO)PHENOXY]ACETIC ACID TRIFLUOROACETIC ACID; 2 [5 [3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDO] 2 (2 ETHYLBUTANAMIDO) 4 ISOBUTYRAMIDOPHENOXY]ACETIC ACID; 2 [5 [3 (3,4 DIHYDROXYPHENYL)PROPANAMIDO] 2 (2 ETHYLBUTANAMIDO) 4 ISOBUTYRAMIDOPHENOXY]ACETIC ACID; 2 [5 AMINO 2 (2 ETHYLBUTANAMIDO) 4 ISOBUTYRAMIDOPHENOXY]ACETIC ACID TRIFLUOROACETIC ACID; 4 ACETAMIDO 5 AMINO 3 (1 ETHYLPROPOXY) 1 CYCLOHEXENE 1 CARBOXYLIC ACID; ANTIVIRUS AGENT; CAFFEIC ACID DERIVATIVE; SIALIDASE INHIBITOR; UNCLASSIFIED DRUG; VIRUS SIALIDASE;

ANIMAL CELL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; EMBRYO; ENZYME INHIBITION; ENZYME STRUCTURE; IC 50; IN VITRO STUDY; INFLUENZA VIRUS; MOLECULAR DOCKING; NONHUMAN; STRUCTURE ACTIVITY RELATION;

CAFFEIC ACID; INFLUENZA; INHIBITOR; NEURAMINIDASE;

ANTIVIRAL AGENTS; CAFFEIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; ENZYME INHIBITORS; INFLUENZA A VIRUS, H9N2 SUBTYPE; KINETICS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NEURAMINIDASE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84888437152     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.10.020     Document Type: Article

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